{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:31:42Z","timestamp":1793442702815,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271042"],"award-info":[{"award-number":["82271042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03090"],"award-info":[{"award-number":["2023C03090"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFE0204400"],"award-info":[{"award-number":["2020YFE0204400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115385","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:34:59Z","timestamp":1790033699000},"page":"115385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Dendrimer-mediated co-delivery of curcumin and miR-146a attenuates dry eye disease"],"prefix":"10.1016","volume":"399","author":[{"given":"Dan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siting","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jconrel.2026.115385_bb0005","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"issue":"23","key":"10.1016\/j.jconrel.2026.115385_bb0010","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1056\/NEJMra1407936","article-title":"Dry eye","volume":"378","author":"Clayton","year":"2018","journal-title":"New Engl. J. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115385_bb0015","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115385_bb0020","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.08.020503","article-title":"Variations of dry eye disease prevalence by age, sex and geographic characteristics in China: a systematic review and meta-analysis","volume":"8","author":"Song","year":"2018","journal-title":"J. Glob. Health"},{"key":"10.1016\/j.jconrel.2026.115385_bb0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jtos.2021.05.006","article-title":"The physical and mental burden of dry eye disease: a large population-based study investigating the relationship with health-related quality of life and its determinants","volume":"21","author":"Morthen","year":"2021","journal-title":"Ocul. Surf."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115385_bb0030","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II management and therapy report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115385_bb0035","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The pathophysiology of dry eye disease what we know and future directions for research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115385_bb0040","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.drudis.2019.02.006","article-title":"Emerging targets of inflammation and tear secretion in dry eye disease","volume":"24","author":"Markoulli","year":"2019","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115385_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aopr.2024.08.003","article-title":"The alterations of ocular surface metabolism and the related immunity inflammation in dry eye","volume":"5","author":"Wan","year":"2025","journal-title":"Adv. Ophthalmol. Pract."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115385_bb0050","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.jconrel.2026.115385_bb0055","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-immunol-020711-075013","article-title":"microRNA regulation of inflammatory responses","volume":"30","author":"O\u2019Connell","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115385_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101374","article-title":"miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases","volume":"70","author":"Olivieri","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"16","key":"10.1016\/j.jconrel.2026.115385_bb0065","doi-asserted-by":"crossref","first-page":"12767","DOI":"10.3390\/ijms241612767","article-title":"MiRNA-146a-A key player in immunity and diseases","volume":"24","author":"Gilyazova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115385_bb0070","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1111\/aos.13526","article-title":"Dry eye disease and oxidative stress","volume":"96","author":"Seen","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.jconrel.2026.115385_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123329","article-title":"Aminated fullerene for comprehensive dry eye therapy: promoting epithelial-barrier reconstruction and nerve regeneration by suppressing oxidation and inflammation","volume":"321","author":"Lyu","year":"2025","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115385_bb0080","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3390\/antiox10010089","article-title":"Antioxidant defenses in the human eye: a focus on metallothioneins","volume":"10","author":"Alvarez-Barrios","year":"2021","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115385_bb0085","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2174\/092986732102131206115810","article-title":"Curcumin and curcumin-like molecules: from spice to drugs","volume":"21","author":"Marchiani","year":"2014","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115385_bb0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115385_bb0095","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5114\/ceji.2019.87070","article-title":"Therapeutic potential of curcumin in eye diseases","volume":"44","author":"Radomska-Lesniewska","year":"2019","journal-title":"Cent. Eur. J. Immunol."},{"key":"10.1016\/j.jconrel.2026.115385_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114394","article-title":"Multifunctional macrophage membrane biomimetic nanoparticles for targeted therapy of neovascular age-related macular degeneration","volume":"388","author":"Yin","year":"2025","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115385_bb0105","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrg2968","article-title":"Current prospects for RNA interference-based therapies","volume":"12","author":"Davidson","year":"2011","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115385_bb0110","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1208\/s12248-010-9210-4","article-title":"Delivery of siRNA therapeutics: barriers and carriers","volume":"12","author":"Wang","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2026.115385_bb0115","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jconrel.2019.10.053","article-title":"Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application","volume":"316","author":"Ma","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115385_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114770","article-title":"Polymer- and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115385_bb0125","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jconrel.2025.01.040","article-title":"Fluorinated multifunctional polymer vesicles for enhanced ocular surface penetration and synergistic treatment of dry eye disease","volume":"379","author":"Liu","year":"2025","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115385_bb0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jconrel.2011.11.022","article-title":"Ocular antisense oligonucleotide delivery by cationic nanoemulsion for improved treatment of ocular neovascularization: an in-vivo study in rats and mice","volume":"160","author":"Hagigit","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115385_bb0135","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2023.01.018","article-title":"Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases","volume":"354","author":"Onugwu","year":"2023","journal-title":"J. Control. Release"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2026.115385_bb0140","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijpharm.2018.05.045","article-title":"Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA\/siRNA for cancer therapy","volume":"546","author":"Li","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115385_bb0145","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.progpolymsci.2013.07.005","article-title":"Dendrimer as nanocarrier for drug delivery","volume":"39","author":"Kesharwani","year":"2014","journal-title":"Prog. Polym. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115385_bb0150","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.biomaterials.2012.10.024","article-title":"Lipid modified triblock PAMAM-based nanocarriers for siRNA drug co-delivery","volume":"34","author":"Biswas","year":"2013","journal-title":"Biomaterials"},{"issue":"41","key":"10.1016\/j.jconrel.2026.115385_bb0155","article-title":"A PD-L1 antibody-conjugated PAMAM dendrimer nanosystem for simultaneously inhibiting glycolysis and promoting immune response in fighting breast cancer","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115385_bb0160","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/03639045.2020.1724132","article-title":"Curcumin loaded poly (amidoamine) dendrimer-plamitic acid core-shell nanoparticles as anti-stress therapeutics","volume":"46","author":"Tripathi","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2026.115385_bb0165","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.apmt.2018.05.002","article-title":"PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy","volume":"12","author":"Abedi-Gaballu","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.jconrel.2026.115385_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.05.031","article-title":"Synthesis, photophysical and solvatochromic properties of diacetoxyboron complexes with curcumin derivatives","volume":"220","author":"Lyu","year":"2019","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.jconrel.2026.115385_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121303","article-title":"Dendrimers in vaccine delivery: recent progress and advances","volume":"280","author":"Chowdhury","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115385_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2026.124132","article-title":"PEG chains modulate electrostatic interactions between PAMAM and articular cartilage","volume":"331","author":"Johnston","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115385_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108295","article-title":"The cornea in keratoconjunctivitis sicca","volume":"201","author":"Pflugfelder","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115385_bb0190","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s40123-025-01115-0","article-title":"Parainflammation in the ocular system: considerations on the underlying mechanisms and treatment of dry eye disease","volume":"14","author":"Barabino","year":"2025","journal-title":"Ophthalmol Therapy"},{"key":"10.1016\/j.jconrel.2026.115385_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113640","article-title":"Effects of silica nanoparticles with varied physicochemical properties on the survival and functionality of saturated macrophages","volume":"381","author":"Saha","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115385_bb0200","first-page":"506","article-title":"Antioxidant and anti-senescence supramolecular complexes for managing dry eye diseases","volume":"65","author":"Song","year":"2026","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115385_bb0205","article-title":"Research advances in pathogenic mechanisms underlying air pollution-induced ocular surface diseases","volume":"1","author":"Song","year":"2021","journal-title":"Adv. Ophthalmol. Pract."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115385_bb0210","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3390\/biomedicines11020292","article-title":"Oxidative stress in the anterior ocular diseases: diagnostic and treatment","volume":"11","author":"Dammak","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115385_bb0215","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023328119","article-title":"Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome","volume":"119","author":"Montllor-Albalate","year":"2022","journal-title":"P. Natl. Acad. Sci. Usa"},{"key":"10.1016\/j.jconrel.2026.115385_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2024.100515","article-title":"The cellular response and molecular mechanism of superoxide dismutase interacting with superparamagnetic iron oxide nanoparticles","volume":"35","author":"Ju","year":"2024","journal-title":"Nanoimpact"},{"key":"10.1016\/j.jconrel.2026.115385_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110632","article-title":"Imbalanced mitochondrial homeostasis in ocular diseases: unique pathogenesis and targeted therapy","volume":"260","author":"Sun","year":"2025","journal-title":"Exp. Eye Res."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115385_bb0230","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.3382\/ps\/pey405","article-title":"Oxidative metabolism and efficiency: the delicate balancing act of mitochondria","volume":"98","author":"Bottje","year":"2019","journal-title":"Poult. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115385_bb0235","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2174\/1871527318666190212111650","article-title":"Grape seed proanthocyanidins protect N2a cells against ischemic injury via endoplasmic reticulum stress and mitochondrial-associated pathways","volume":"18","author":"Fu","year":"2019","journal-title":"CNS Neurol. Disord-Dr."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115385_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137278","article-title":"Targeting macrophage polarization for reinstating homeostasis following tissue damage","volume":"25","author":"Du","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.jconrel.2026.115385_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202415341","article-title":"M6A modified miR-31-5p suppresses M1 macrophage polarization and autoimmune dry eye by targeting P2RX7","volume":"12","author":"Zhao","year":"2025","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115385_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2024.152840","article-title":"TLR4\/TNFR1 blockade suppresses STAT1\/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses","volume":"229","author":"Sawoo","year":"2024","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115385_bb0255","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1038\/s41467-026-70388-1","article-title":"Self-polymerized polyphenol-based platform for the management of dry eye pathogenesis","volume":"17","author":"Wang","year":"2026","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115385_bb0260","doi-asserted-by":"crossref","first-page":"16424","DOI":"10.1038\/s41598-025-01286-7","article-title":"Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1\u03b1 signaling pathway","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115385_bb0265","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.bcp.2010.06.020","article-title":"The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling","volume":"80","author":"Flannery","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115385_bb0270","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtos.2024.08.001","article-title":"Preservatives and ocular surface disease: a review","volume":"34","author":"Kahook","year":"2024","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.jconrel.2026.115385_bb0275","article-title":"Topical cyclosporine a therapy for dry eye syndrome","volume":"9","author":"de Paiva","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jconrel.2026.115385_bb0280","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jconrel.2024.07.026","article-title":"Rosmarinic acid-grafted gelatin nanogels for efficient diquafosol delivery in dry eye disease therapy","volume":"373","author":"Zhou","year":"2024","journal-title":"J. Control. Release"},{"issue":"21","key":"10.1016\/j.jconrel.2026.115385_bb0285","doi-asserted-by":"crossref","first-page":"27040","DOI":"10.1021\/acsami.4c01732","article-title":"Combination of PEGylation and cationization on phospholipid-coated cyclosporine Nanosuspensions for enhanced ocular drug delivery","volume":"16","author":"Ma","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"17","key":"10.1016\/j.jconrel.2026.115385_bb0290","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200435","article-title":"Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle","volume":"9","author":"Li","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115385_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110762","article-title":"Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells","volume":"188","author":"Ghaffari","year":"2020","journal-title":"Colloids Surf. B: Biointerfaces"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926007893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926007893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:48:09Z","timestamp":1793440089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926007893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":59,"alternative-id":["S0168365926007893"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115385","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendrimer-mediated co-delivery of curcumin and miR-146a attenuates dry eye disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115385"}}