{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:32:09Z","timestamp":1793442729538,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2023-00265981"],"award-info":[{"award-number":["RS-2023-00265981"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2023R1A6C103A026"],"award-info":[{"award-number":["2023R1A6C103A026"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022M3H4A1A03067401"],"award-info":[{"award-number":["2022M3H4A1A03067401"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115439","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:38:53Z","timestamp":1791329933000},"page":"115439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Barrier-reinforcing hyaluronic acid-bilirubin nanodelivery of methylprednisolone for synergistic modulation of the intestinal barrier, immune system, and gut microbiome in colitis"],"prefix":"10.1016","volume":"399","author":[{"given":"Bom","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeeeun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Jeong","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115439_bb0005","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0010","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.aat0835","article-title":"Intestinal barriers protect against disease","volume":"359","author":"Citi","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.115439_bb0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nri.2017.7","article-title":"Dysbiosis and the immune system","volume":"17","author":"Levy","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0020","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.cell.2019.07.045","article-title":"Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships","volume":"178","author":"Plichta","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2026.115439_bb0025","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115439_bb0030","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115439_bb0035","first-page":"371","article-title":"Understanding the therapeutic toolkit for inflammatory bowel disease, nature reviews","volume":"22","author":"Vieujean","year":"2025","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115439_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114021","article-title":"Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome","volume":"179","author":"Lee","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115439_bb0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","article-title":"Hyaluronic acid\u2013bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2026.115439_bb0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1053\/gast.2001.26279","article-title":"The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study","volume":"121","author":"Faubion","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jconrel.2026.115439_bb0060","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1053\/j.gastro.2011.02.045","article-title":"Conventional medical management of inflammatory bowel disease","volume":"140","author":"Burger","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jconrel.2026.115439_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0070","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2010.02.043","article-title":"Anti-inflammatory agents: present and future","volume":"140","author":"Dinarello","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2026.115439_bb0075","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/MIB.0000000000000332","article-title":"Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases","volume":"21","author":"Huang","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jconrel.2026.115439_bb0080","doi-asserted-by":"crossref","DOI":"10.1172\/JCI155880","article-title":"Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage","volume":"134","author":"Arnhold","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2026.115439_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bcp.2016.07.010","article-title":"The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice","volume":"116","author":"Oc\u00f3n","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0090","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/003655201750305495","article-title":"Corticosteroids impair intestinal epithelial wound repair mechanisms in vitro","volume":"36","author":"Jung","year":"2001","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0095","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1111\/j.1572-0241.1998.00697.x","article-title":"Corticosteroid therapy augments gastroduodenal permeability to sucrose","volume":"93","author":"K\u0131z\u0131lta\u015f","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/flgastro-2019-101288","article-title":"Steroid use and misuse: a key performance indicator in the management of IBD","volume":"12","author":"Blackwell","year":"2021","journal-title":"Frontline Gastroenterol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0105","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/jgh3.12841","article-title":"Chronic steroid use: an overlooked impact on patients with inflammatory bowel disease","volume":"6","author":"Farraj","year":"2022","journal-title":"JGH Open"},{"key":"10.1016\/j.jconrel.2026.115439_bb0110","article-title":"Unmet needs in inflammatory bowel disease, current research in pharmacology and drug discovery","volume":"2","author":"Rev\u00e9s","year":"2021"},{"key":"10.1016\/j.jconrel.2026.115439_bb0115","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/17474124.2019.1685872","article-title":"Inflammatory bowel disease: long-term therapeutic challenges","volume":"13","author":"Ashton","year":"2019","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0120","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.clinthera.2017.09.011","article-title":"Long-term systemic corticosteroid exposure: a systematic literature review","volume":"39","author":"Rice","year":"2017","journal-title":"Clin. Ther."},{"key":"10.1016\/j.jconrel.2026.115439_bb0125","doi-asserted-by":"crossref","first-page":"10676","DOI":"10.1002\/anie.201604858","article-title":"Multistimuli-responsive bilirubin nanoparticles for anticancer therapy","volume":"55","author":"Lee","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.115439_bb0130","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1002\/anie.201602525","article-title":"Bilirubin nanoparticles as a nanomedicine for anti-inflammation therapy","volume":"55","author":"Lee","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.115439_bb0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.biomaterials.2017.04.029","article-title":"PEGylated bilirubin nanoparticle as an anti-oxidative and anti-inflammatory demulcent in pancreatic islet xenotransplantation","volume":"133","author":"Kim","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115439_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.706244","article-title":"Thymus degeneration and regeneration","volume":"12","author":"Duah","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0145","article-title":"Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity","volume":"31","author":"Lopez-Escalera","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.jconrel.2026.115439_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087427","article-title":"Development of an inflammation-triggered in vitro \u201cleaky gut\u201d model using Caco-2\/HT29-MTX-E12 combined with macrophage-like THP-1 cells or primary human-derived macrophages","volume":"24","author":"Le","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115439_bb0155","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/s13099-024-00635-7","article-title":"The influence of Akkermansia muciniphila on intestinal barrier function","volume":"16","author":"Mo","year":"2024","journal-title":"Gut Pathog."},{"key":"10.1016\/j.jconrel.2026.115439_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1089600","article-title":"The role of Akkermansia muciniphila in inflammatory bowel disease: current knowledge and perspectives","volume":"13","author":"Zheng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0170","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.115439_bb0175","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1097\/MIB.0000000000000972","article-title":"A single species of Clostridium subcluster XIVa decreased in ulcerative colitis patients","volume":"22","author":"Takeshita","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jconrel.2026.115439_bb0180","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.4049\/jimmunol.176.2.1228","article-title":"Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells","volume":"176","author":"Tien","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0185","article-title":"Anti-inflammatory and immunomodulatory effects of Lactobacillus spp. as a preservative and therapeutic agent for IBD control","volume":"10","author":"Aghamohammad","year":"2022","journal-title":"Immunity, Inflamm. Dis."},{"key":"10.1016\/j.jconrel.2026.115439_bb0190","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1212\/WNL.53.9.2093","article-title":"Gastric tolerance of high-dose pulse oral prednisone in multiple sclerosis","volume":"53","author":"Metz","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.jconrel.2026.115439_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106056","article-title":"Modulation of intestinal barrier function by glucocorticoids: lessons from preclinical models","volume":"177","author":"Tena-Garitaonaindia","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2026.115439_bb0200","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jconrel.2014.03.039","article-title":"Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases","volume":"183","author":"Ali","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115439_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113948","article-title":"Oral delivery of tunable oxidation-responsive budesonide-loaded nanoparticles enhances inflammation modulation in intestinal colitis","volume":"384","author":"Cristelo","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115439_bb0210","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.7150\/thno.18183","article-title":"Dexamethasone-loaded polymeric nanoconstructs for monitoring and treating inflammatory bowel disease","volume":"7","author":"Lee","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.115439_bb0215","doi-asserted-by":"crossref","first-page":"10676","DOI":"10.1002\/anie.201604858","article-title":"Multistimuli-responsive bilirubin nanoparticles for anticancer therapy","volume":"55","author":"Lee","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.115439_bb0220","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","article-title":"Hyaluronic acid\u2013bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2026.115439_bb0225","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4490\/algae.2020.35.5.14","article-title":"Protective effects of extracts from six local strains of Pyropia yezoensis against oxidative damage in vitro and in zebrafish model","volume":"35","author":"Dai","year":"2020","journal-title":"Algae"},{"key":"10.1016\/j.jconrel.2026.115439_bb0230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/rb\/rbz002","article-title":"Modeling the oxidative consumption of curcumin from controlled released poly (beta-amino ester) microparticles in the presence of a free radical generating system","volume":"6","author":"Jordan","year":"2019","journal-title":"Regener. Biomater."},{"key":"10.1016\/j.jconrel.2026.115439_bb0235","doi-asserted-by":"crossref","first-page":"32953","DOI":"10.1039\/D0RA07080G","article-title":"Lipoic acid capped silver nanoparticles: a facile route to covalent protein capping and oxidative stability within biological systems","volume":"10","author":"Guzm\u00e1n-Soto","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2026.115439_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/cpim.25","article-title":"Gut microbiome standardization in control and experimental mice","volume":"117","author":"McCoy","year":"2017","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0245","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0250","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1128\/IAI.00459-15","article-title":"Fecal microbiota transplantation eliminates Clostridium difficile in a murine model of relapsing disease","volume":"83","author":"Seekatz","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jconrel.2026.115439_bb0255","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jconrel.2026.115439_bb0260","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:52:32Z","timestamp":1793440352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926008436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":52,"alternative-id":["S0168365926008436"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115439","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Barrier-reinforcing hyaluronic acid-bilirubin nanodelivery of methylprednisolone for synergistic modulation of the intestinal barrier, immune system, and gut microbiome in colitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115439"}}