{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:31:10Z","timestamp":1793442670987,"version":"4.5.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["NWO-TTW 20002"],"award-info":[{"award-number":["NWO-TTW 20002"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032339","name":"BioNTech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115440","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:38:56Z","timestamp":1791329936000},"page":"115440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["The role of glycocalyx-protein corona interactions in the cell type-specific uptake of mRNA nanocarriers"],"prefix":"10.1016","volume":"399","author":[{"given":"Ward","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klarinda","family":"de Zwaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luco","family":"Rutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"van Wessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Boltje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia Querol","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"B\u00fcll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Sommerdijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Albertazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jconrel.2026.115440_bb0005","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/j.ymthe.2025.03.034","article-title":"Clinical development of therapeutic mRNA applications","volume":"33","author":"\u017bak","year":"2025","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0010","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41392-024-02002-z","article-title":"Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115440_bb0015","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.medj.2024.11.015","article-title":"Clinical advances of mRNA vaccines for cancer immunotherapy","volume":"6","author":"Yaremenko","year":"2025","journal-title":"Med"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115440_bb0025","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41587-022-01294-2","article-title":"The clinical progress of mRNA vaccines and immunotherapies","volume":"40","author":"Barbier","year":"2022","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115440_bb0030","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1021\/acs.molpharmaceut.5c00385","article-title":"Recent advances in mRNA-LNP delivery systems for extrahepatic organs: a review","volume":"22","author":"Bai","year":"2025","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115440_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2023.103041","article-title":"Biological recognition and cellular trafficking of targeted RNA-lipid nanoparticles","volume":"85","author":"Escalona-Rayo","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115440_bb0040","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1002\/anie.201612193","article-title":"Steering siglec\u2013sialic acid interactions on living cells using bioorthogonal chemistry","volume":"56","author":"B\u00fcll","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115440_bb0045","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nri3737","article-title":"Siglec-mediated regulation of immune cell function in disease","volume":"14","author":"Macauley","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115440_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123818","article-title":"Mutual regulation between glycosylation and transforming growth factor-\u03b2 isoforms signaling pathway","volume":"236","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-69242-1","article-title":"Glycocalyx micro- and nanodomains in cell-cell and cell-matrix interactions revealed by enhanced click chemistry","volume":"17","author":"Smits","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115440_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114416","article-title":"The role of lipid components in lipid nanoparticles for vaccines and gene therapy","volume":"188","author":"Hald Albertsen","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1023\/A:1007425803756","article-title":"Cationic lipid-mediated gene transfer: analysis of cellular uptake and nuclear import of plasmid DNA","volume":"14","author":"Escriou","year":"1998","journal-title":"Cell Biol. Toxicol."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115440_bb0070","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1021\/acs.bioconjchem.3c00346","article-title":"Deciphering structural determinants distinguishing active from inactive cell-penetrating peptides for cytosolic mRNA delivery","volume":"34","author":"Egberink","year":"2023","journal-title":"Bioconjug. Chem."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115440_bb0075","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1039\/D0BM01946A","article-title":"Heparin modulates the cellular uptake of nanomedicines","volume":"9","author":"Champanhac","year":"2021","journal-title":"Biomater. Sci."},{"issue":"40","key":"10.1016\/j.jconrel.2026.115440_bb0080","doi-asserted-by":"crossref","first-page":"26164","DOI":"10.1074\/jbc.273.40.26164","article-title":"Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo*","volume":"273","author":"Mounkes","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"42","key":"10.1016\/j.jconrel.2026.115440_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202400643","article-title":"In vivo endothelial cell gene silencing by siRNA-LNPs tuned with lipoamino bundle chemical and ligand targeting","volume":"20","author":"Yazdi","year":"2024","journal-title":"Small"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115440_bb0090","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/j.bbamem.2010.01.022","article-title":"Cell-penetrating peptide exploited syndecans","volume":"1798","author":"Letoha","year":"2010","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"14","key":"10.1016\/j.jconrel.2026.115440_bb0095","first-page":"2717","article-title":"The stoichiometry of peptide-heparan sulfate binding as a determinant of uptake efficiency of cell-penetrating peptides","volume":"71","author":"Wallbrecher","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jconrel.2013.05.001","article-title":"Cell surface clustering of heparan sulfate proteoglycans by amphipathic cell-penetrating peptides does not contribute to uptake","volume":"170","author":"Verdurmen","year":"2013","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115440_bb0105","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1021\/acschembio.6c00344","article-title":"Sweet and bright: illuminating glycoprotein-mediated endocytosis via metabolic labeling and NanoLuciferase","volume":"21","author":"Soliman","year":"2026","journal-title":"ACS Chem. Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijpharm.2004.07.023","article-title":"Effect of cell-surface glycosaminoglycans on cationic carrier combined with low-MW PEI-mediated gene transfection","volume":"284","author":"Lampela","year":"2004","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115440_bb0115","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.ejps.2013.05.022","article-title":"Contribution of syndecans to lipoplex-mediated gene delivery","volume":"49","author":"Letoha","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115440_bb0120","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/mt.2010.85","article-title":"Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms","volume":"18","author":"Akinc","year":"2010","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0125","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1038\/s41467-025-63726-2","article-title":"Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo","volume":"16","author":"Voke","year":"2025","journal-title":"Nat. Commun."},{"issue":"52","key":"10.1016\/j.jconrel.2026.115440_bb0130","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2109256118","article-title":"On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles","volume":"118","author":"Dilliard","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115440_bb0135","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/ja107583h","article-title":"Physical\u2212chemical aspects of protein Corona: relevance to in vitro and in vivo biological impacts of nanoparticles","volume":"133","author":"Monopoli","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1039\/D4NA00783B","article-title":"An investigation of the effect of the protein corona on the cellular uptake of nanoliposomes under flow conditions using quartz crystal microgravimetry with dissipation","volume":"7","author":"Van der Sanden","year":"2025","journal-title":"Nanoscale Adv."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115440_bb0145","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1021\/nn305754c","article-title":"Molecular parameters of siRNA\u2013cell penetrating peptide Nanocomplexes for efficient cellular delivery","volume":"7","author":"van Asbeck","year":"2013","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbrc.2004.12.137","article-title":"The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse","volume":"328","author":"Yan","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115440_bb0155","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid nanoparticlesfrom liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS Nano"},{"issue":"36","key":"10.1016\/j.jconrel.2026.115440_bb0160","doi-asserted-by":"crossref","first-page":"14813","DOI":"10.1073\/pnas.1106420108","article-title":"Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions","volume":"108","author":"Chen","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2026.115440_bb0165","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1194\/jlr.R800069-JLR200","article-title":"Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer\u2019s disease to AIDS","volume":"50","author":"Mahley","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jconrel.2026.115440_bb0170","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jconrel.2020.03.006","article-title":"Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E\/low density lipoprotein receptor and the N-acetyl-d-galactosamine\/asialoglycoprotein receptor pathway","volume":"322","author":"Sato","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115440_bb0175","article-title":"Optimized protocol for efficient transfection of dendritic cells without cell maturation","volume":"53","author":"Bowles","year":"2011","journal-title":"JoVE"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115440_bb0180","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/sj.gt.3300626","article-title":"Nonviral transfection of distinct types of human dendritic cells: high-efficiency gene transfer by electroporation into hematopoietic progenitor- but not monocyte-derived dendritic cells","volume":"5","author":"Van Tendeloo","year":"1998","journal-title":"Gene Ther."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115440_bb0185","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.apsb.2025.11.023","article-title":"Deciphering the biological fate of mRNA-LNP-based biologics: a perspective from tissue to intracellular distribution","volume":"16","author":"Xu","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2026.115440_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102325","article-title":"The dynamic process of mRNA delivery by lipid nanoparticles in vivo","volume":"57","author":"Ma","year":"2024","journal-title":"Nano Today"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0195","doi-asserted-by":"crossref","first-page":"10635","DOI":"10.1038\/s41467-024-54877-9","article-title":"Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity","volume":"15","author":"Hamouda","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0200","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/s41467-023-36598-7","article-title":"Identification of global inhibitors of cellular glycosylation","volume":"14","author":"S\u00f8rensen","year":"2023","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115440_bb0205","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1021\/acschembio.5b00501","article-title":"Sialic acid Glycoengineering using an unnatural sialic acid for the detection of Sialoglycan biosynthesis defects and on-cell synthesis of Siglec ligands","volume":"10","author":"B\u00fcll","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115440_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102330","article-title":"Engineering the sialome of mammalian cells with sialic acid mimetics","volume":"4","author":"Hornikx","year":"2023","journal-title":"STAR Protocols"},{"key":"10.1016\/j.jconrel.2026.115440_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13111944","article-title":"Mimicking the biology of engineered protein and mRNA nanoparticle delivery using a versatile microfluidic platform","volume":"13","author":"Palacio-Casta\u00f1eda","year":"2021","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0220","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1369\/0022155420988661","article-title":"A systems view of the Heparan sulfate Interactome","volume":"69","author":"G\u00f3mez Toledo","year":"2021","journal-title":"J. Histochem. Cytochem."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115440_bb0225","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1021\/acsnano.0c10064","article-title":"Apolipoprotein E binding drives structural and compositional rearrangement of mRNA-containing lipid nanoparticles","volume":"15","author":"Sebastiani","year":"2021","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0230","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-5793(97)00330-X","article-title":"Identification of novel heparin-binding domains of vitronectin","volume":"407","author":"Liang","year":"1997","journal-title":"FEBS Lett."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115440_bb0235","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1021\/bi00411a029","article-title":"The heparin binding domain of S-protein\/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities","volume":"27","author":"Tschopp","year":"1988","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0240","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1038\/s41467-020-16248-y","article-title":"Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver","volume":"11","author":"Miao","year":"2020","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115440_bb0245","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1093\/nar\/gkr072","article-title":"PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation","volume":"39","author":"Ezzat","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115440_bb0250","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/glycob\/cwaa008","article-title":"The manifold roles of sialic acid for the biological functions of endothelial glycoproteins","volume":"30","author":"D\u2019Addio","year":"2020","journal-title":"Glycobiology"},{"key":"10.1016\/j.jconrel.2026.115440_bb0255","series-title":"Sialic Acids","author":"Varki","year":"1999"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115440_bb0260","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2021.1904773","article-title":"Surface charge, glycocalyx, and blood-brain barrier function","volume":"9","author":"Walter","year":"2021","journal-title":"Tissue Barriers"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0265","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1021\/acs.jmedchem.8b01757","article-title":"Potent metabolic sialylation inhibitors based on C-5-modified fluorinated sialic Acids","volume":"62","author":"Heise","year":"2019","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115440_bb0270","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1021\/acs.molpharmaceut.3c00330","article-title":"Controlling antigen fate in therapeutic Cancer vaccines by targeting dendritic cell receptors","volume":"20","author":"Wijfjes","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115440_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02989","article-title":"CD103 (\u03b1E integrin) undergoes endosomal trafficking in human dendritic cells, but does not mediate epithelial adhesion","volume":"9","author":"Swain","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115440_bb0280","doi-asserted-by":"crossref","unstructured":"Kim, M., et al., Exogenous RNA surveillance by proton-sensing TRIM25. Science 388(6742): p. eads4539.","DOI":"10.1126\/science.ads4539"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115440_bb0285","article-title":"Macrophage apolipoprotein E and proliferation of MCF-7 breast cancer cells: role of LXR","volume":"33","author":"El Roz","year":"2013","journal-title":"Anticancer Res."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115440_bb0290","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/jcb.24746","article-title":"Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity","volume":"115","author":"Okolicsanyi","year":"2014","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2023.102083","article-title":"mRNA vaccine trafficking and resulting protein expression after intramuscular administration","volume":"35","author":"Hassett","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"24","key":"10.1016\/j.jconrel.2026.115440_bb0300","doi-asserted-by":"crossref","first-page":"10025","DOI":"10.1021\/acs.nanolett.2c03741","article-title":"The extent to which lipid nanoparticles require apolipoprotein E and low-density lipoprotein receptor for delivery changes with Ionizable lipid structure","volume":"22","author":"Paunovska","year":"2022","journal-title":"Nano Lett."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115440_bb0305","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1021\/acs.nanolett.2c01133","article-title":"Universal barcoding predicts in vivo ApoE-independent lipid nanoparticle delivery","volume":"22","author":"Da Silva Sanchez","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.115440_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114219","article-title":"Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE","volume":"197","author":"Gregersen","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"19","key":"10.1016\/j.jconrel.2026.115440_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202505862","article-title":"CORE: cholesterol altered lipid nanoparticles for splenic expression of mRNA payloads","volume":"15","author":"Narasipura","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115440_bb0320","first-page":"429","article-title":"Splenic dendritic cell-targeting mRNA transfection of H-type ionizable lipid-based LNPs for enhancing tumor immunotherapy","volume":"61","author":"Chen","year":"2026","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115440_bb0325","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nano.2013.12.003","article-title":"Cationic lipid nanocarriers activate toll-like receptor 2 and NLRP3 inflammasome pathways","volume":"10","author":"Lonez","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2026.115440_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines8030433","article-title":"Lipid nanoparticle acts as a potential adjuvant for influenza split vaccine without inducing inflammatory responses","volume":"8","author":"Shirai","year":"2020","journal-title":"Vaccines"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115440_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116150","article-title":"Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways","volume":"44","author":"Rennen","year":"2025","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115440_bb0340","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3346\/jkms.2012.27.3.300","article-title":"Acute UV irradiation increases Heparan sulfate proteoglycan levels in human skin","volume":"27","author":"Jung","year":"2012","journal-title":"J. Korean Med. Sci."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0345","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jcp.20450","article-title":"Heparan sulfates in skeletal muscle development and physiology","volume":"206","author":"Jenniskens","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2026.115440_bb0350","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-026-03099-z","article-title":"mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression","author":"Marks","year":"2026","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115440_bb0355","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1021\/jacs.5c23209","article-title":"Structure\u2013activity-driven multicompartment lipid nanoparticles for synergistic mRNA and siRNA Codelivery in acute myeloid leukemia","volume":"148","author":"Xin","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.115440_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114671","article-title":"Dendritic cell-targeted tumor antigen delivery by glucosylated lipid nanoparticles for precision tumor immunotherapy","volume":"392","author":"Liu","year":"2026","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115440_bb0365","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.metabol.2010.08.013","article-title":"Up-regulation of hepatic low-density lipoprotein receptor\u2013related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl\u2013coenzyme a reductase inhibitor: atorvastatin and hepatic LRP1 expression","volume":"60","author":"Moon","year":"2011","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0370","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s42003-022-03873-0","article-title":"LDLR, LRP1, and megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin","volume":"5","author":"Zhou","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jconrel.2026.115440_bb0375","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15041184","article-title":"Key design features of lipid nanoparticles and electrostatic charge-based lipid nanoparticle targeting","volume":"15","author":"Gyanani","year":"2023","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115440_bb0380","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.cell.2020.09.033","article-title":"SARS-CoV-2 infection depends on cellular Heparan sulfate and ACE2","volume":"183","author":"Clausen","year":"2020","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115440_bb0385","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1021\/acs.bioconjchem.7b00224","article-title":"Metabolic oligosaccharide engineering with alkyne sialic Acids confers neuraminidase resistance and inhibits influenza reproduction","volume":"28","author":"Heise","year":"2017","journal-title":"Bioconjug. Chem."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115440_bb0390","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.pharmthera.2009.05.001","article-title":"Sulfated K5 Escherichia coli polysaccharide derivatives: a novel class of candidate antiviral microbicides","volume":"123","author":"Rusnati","year":"2009","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0395","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(00)80058-6","article-title":"A novel role for 3-O-sulfated Heparan sulfate in herpes simplex virus 1 entry","volume":"99","author":"Shukla","year":"1999","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115440_bb0400","doi-asserted-by":"crossref","first-page":"20163","DOI":"10.1021\/acsnano.2c04829","article-title":"Interaction kinetics of individual mRNA-containing lipid nanoparticles with an endosomal membrane mimic: dependence on pH, protein Corona formation, and lipoprotein depletion","volume":"16","author":"Aliakbarinodehi","year":"2022","journal-title":"ACS Nano"},{"issue":"5373","key":"10.1016\/j.jconrel.2026.115440_bb0405","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.281.5373.78","article-title":"An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery","volume":"281","author":"Koltover","year":"1998","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.jconrel.2026.115440_bb0410","doi-asserted-by":"crossref","first-page":"11493","DOI":"10.1073\/pnas.93.21.11493","article-title":"Mechanism of oligonucleotide release from cationic liposomes","volume":"93","author":"Zelphati","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115440_bb0415","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bbamem.2009.11.007","article-title":"Surface adsorption of protein corona controls the cell internalization mechanism of DC-Chol\u2013DOPE\/DNA lipoplexes in serum","volume":"1798","author":"Caracciolo","year":"2010","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"44","key":"10.1016\/j.jconrel.2026.115440_bb0420","doi-asserted-by":"crossref","first-page":"17254","DOI":"10.1039\/C7NR06437C","article-title":"An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles","volume":"9","author":"Digiacomo","year":"2017","journal-title":"Nanoscale"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115440_bb0425","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1016\/j.bbamem.2015.09.019","article-title":"The role of endocytosis in the uptake and intracellular trafficking of PepFect14\u2013nucleic acid nanocomplexes via class a scavenger receptors","volume":"1848","author":"Juks","year":"2015","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.jconrel.2026.115440_bb0430","doi-asserted-by":"crossref","DOI":"10.3390\/ph14070667","article-title":"Internalisation and biological activity of nucleic acids delivering cell-penetrating peptide nanoparticles is controlled by the biomolecular corona","volume":"14","author":"Lorents","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"47","key":"10.1016\/j.jconrel.2026.115440_bb0435","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202207551","article-title":"Structure\u2013uptake relationship study of DABCYL derivatives linked to cyclic cell-penetrating peptides for live-cell delivery of synthetic proteins","volume":"61","author":"Saha","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0440","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jconrel.2010.06.030","article-title":"Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: implications for uptake","volume":"147","author":"Verdurmen","year":"2010","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115440_bb0445","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12668-025-02002-5","article-title":"Introducing a single-point modification to the cell-penetrating peptide PepFect14 analogue sequence for optimising oligonucleotide delivery","volume":"15","author":"Porosk","year":"2025","journal-title":"BioNanoScience"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115440_bb0450","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1208\/s12248-008-9055-2","article-title":"CNS delivery via adsorptive transcytosis","volume":"10","author":"Herv\u00e9","year":"2008","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2026.115440_bb0455","series-title":"Proteoglycans and Sulfated Glycosaminoglycans","author":"Lindahl","year":"2015"},{"issue":"43","key":"10.1016\/j.jconrel.2026.115440_bb0460","doi-asserted-by":"crossref","first-page":"9377","DOI":"10.1021\/bi200218s","article-title":"The structural role of N-linked Glycans on human Glypican-1","volume":"50","author":"Svensson","year":"2011","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0465","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/abio.1994.1576","article-title":"An enzyme-linked immunosorbent assay method to measure human apolipoprotein E levels using commercially available reagents: effect of apolipoprotein E polymorphism on serum apolipoprotein E concentration","volume":"223","author":"Gracia","year":"1994","journal-title":"Anal. Biochem."},{"issue":"6779","key":"10.1016\/j.jconrel.2026.115440_bb0470","doi-asserted-by":"crossref","DOI":"10.1126\/science.adx2678","article-title":"A human pan-disease blood atlas of the circulating proteome","volume":"390","author":"\u00c1lvez","year":"2026","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115440_bb0475","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ijpharm.2016.07.057","article-title":"Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles","volume":"511","author":"Ne\u0161porov\u00e1","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115440_bb0480","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acs.molpharmaceut.6b01029","article-title":"Hyaluronic acid coated albumin nanoparticles for targeted peptide delivery to the retina","volume":"14","author":"Huang","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115440_bb0485","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212360","article-title":"Albumin\u2013hyaluronan interactions: influence of ionic composition probed by molecular dynamics","volume":"22","author":"Be\u0142dowski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"42","key":"10.1016\/j.jconrel.2026.115440_bb0490","doi-asserted-by":"crossref","first-page":"38865","DOI":"10.1021\/jacs.5c14870","article-title":"Computationally aided design of ionizable cholesteryl lipids for lipid nanoparticles to modulate hepatic mRNA accumulation","volume":"147","author":"Teng","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115440_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102380","article-title":"A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy","volume":"35","author":"Sawamura","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115440_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111015","article-title":"Targeting nanoparticles to lung cancer-derived A549 cells based on changes on interstitial stiffness in biomimetic models","volume":"27","author":"Kohon","year":"2024","journal-title":"iScience"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115440_bb0505","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202401712","article-title":"Cholesterol-derived mannosylated polypeptide-formed lipid nanoparticles for efficient in vivo mRNA delivery","volume":"9","author":"Zeng","year":"2025","journal-title":"Small Methods"},{"key":"10.1016\/j.jconrel.2026.115440_bb0510","article-title":"Engineered lipid nanoparticles with synergistic dendritic cell targeting and enhanced endosomal escape for boosted mRNA cancer vaccines","volume":"34","author":"Wang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.jconrel.2026.115440_bb0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114598","article-title":"CD44-targeted lipid nanoparticles for enhanced CRISPR\/Cas9 delivery in cancer gene editing","volume":"391","author":"Zeng","year":"2026","journal-title":"J. Control. Release"},{"issue":"17","key":"10.1016\/j.jconrel.2026.115440_bb0520","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1021\/acs.nanolett.2c02226","article-title":"Controlling nanoparticle uptake in innate immune cells with Heparosan polysaccharides","volume":"22","author":"Yang","year":"2022","journal-title":"Nano Lett."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:42:59Z","timestamp":1793439779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926008448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":104,"alternative-id":["S0168365926008448"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115440","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of glycocalyx-protein corona interactions in the cell type-specific uptake of mRNA nanocarriers","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115440"}}