{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:33:26Z","timestamp":1793338406028,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2026QNB30"],"award-info":[{"award-number":["YG2026QNB30"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115444","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:11:09Z","timestamp":1791414669000},"page":"115444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Lysostaphin bioengineered cascade nanoreactor for bacterial eradication and inflammatory remodeling in MRSA pneumonia"],"prefix":"10.1016","volume":"399","author":[{"given":"Xiuhua","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueru","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115444_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114234","article-title":"Sono-triggered nanoamplifier mediates ferroptosis-immune regulation against bacterial pneumonia","volume":"387","author":"Wang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115444_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1639783","article-title":"Advances in nanotechnology for the therapy of bacterial pneumonia","volume":"15","author":"Tian","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0015","doi-asserted-by":"crossref","first-page":"10415","DOI":"10.1038\/s41467-025-66564-4","article-title":"Large-scale characterisation of the nasal microbiome redefines Staphylococcus aureus colonisation status","volume":"16","author":"Aggarwal","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115444_bb0020","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.tim.2024.04.003","article-title":"Staphylococcus aureus membrane vesicles: an evolving story","volume":"32","author":"Wang","year":"2024","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0025","article-title":"Infective endocarditis by biofilm-producing methicillin-resistant Staphylococcus aureus-pathogenesis, diagnosis, and management","volume":"13","author":"Kaushik","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jconrel.2026.115444_bb0030","doi-asserted-by":"crossref","first-page":"12139","DOI":"10.1021\/jacs.6c00209","article-title":"A \u201clung-trap\u201d theranostic strategy for precision management of drug-resistant bacterial pneumonia and bacteremia","volume":"148","author":"Hou","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.115444_bb0035","doi-asserted-by":"crossref","first-page":"16625","DOI":"10.1021\/acsnano.1c06460","article-title":"Lung-targeting lysostaphin microspheres for methicillin-resistant Staphylococcus aureus pneumonia treatment and prevention","volume":"15","author":"Lin","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115444_bb0040","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuac025","article-title":"Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence","volume":"46","author":"Wang","year":"2022","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jconrel.2026.115444_bb0045","first-page":"269","article-title":"Vancomycin resistance in Staphylococcus aureus","volume":"90","author":"McGuinness","year":"2017","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.jconrel.2026.115444_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.pep.2023.106274","article-title":"The choice of chromatographic resin for the purification of recombinant lysostaphin affects its activity","volume":"207","author":"Shestak","year":"2023","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.jconrel.2026.115444_bb0055","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/bit.28360","article-title":"Engineering active lysostaphin variants that incorporate noncanonical amino acids and characterizing the effects of site-specific PEGylation","volume":"120","author":"Batugal","year":"2023","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jconrel.2026.115444_bb0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12934-025-02653-9","article-title":"Review on bacterial outer membrane vesicles: structure, vesicle formation, separation and biotechnological applications","volume":"24","author":"Zhao","year":"2025","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.jconrel.2026.115444_bb0065","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.tibtech.2025.05.009","article-title":"Inflammation-targeting and self-limited neutrophilic membrane-encapsulated teicoplanin for the treatment of infectious pneumonia","volume":"43","author":"Lu","year":"2025","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0070","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.1021\/acsnano.3c02365","article-title":"Hybrid biomimetic membrane coated particles-mediated bacterial ferroptosis for acute MRSA pneumonia","volume":"17","author":"Hu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115444_bb0075","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41589-022-00994-9","article-title":"Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus","volume":"18","author":"Brawley","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0080","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1021\/jacs.5c22376","article-title":"Chemical evolution of natural product for discovery and mechanistic exploration of antibiotic against MRSA","volume":"148","author":"Chen","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.115444_bb0085","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1001\/jama.2023.17219","article-title":"Nasal iodophor antiseptic vs nasal mupirocin antibiotic in the setting of chlorhexidine bathing to prevent infections in adult ICUs: a randomized clinical trial","volume":"330","author":"Huang","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.jconrel.2026.115444_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106301","article-title":"Future scope of plant-derived bioactive compounds in the management of methicillin-resistant Staphylococcus aureus: in vitro antimicrobial and antivirulence prospects to combat MRSA","volume":"183","author":"Abdel-Raheem","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jconrel.2026.115444_bb0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1139\/cjm-2014-0481","article-title":"Effect of a Vietnamese Cinnamomum cassia essential oil and its major component trans-cinnamaldehyde on the cell viability, membrane integrity, membrane fluidity, and proton motive force of Listeria innocua","volume":"61","author":"Trinh","year":"2015","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1001865","article-title":"Inhibition of growth, biofilm formation, virulence, and surface attachment of Agrobacterium tumefaciens by cinnamaldehyde derivatives","volume":"13","author":"Ahmed","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/fpd.2022.0073","article-title":"Inhibitory effects of trans-Cinnamaldehyde against Pseudomonas aeruginosa biofilm formation","volume":"20","author":"Song","year":"2023","journal-title":"Foodborne Pathog. Dis."},{"key":"10.1016\/j.jconrel.2026.115444_bb0110","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1080\/10408398.2021.1977236","article-title":"Encapsulation of cinnamaldehyde: an insight on delivery systems and food applications","volume":"63","author":"Muhoza","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jconrel.2026.115444_bb0115","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1016\/j.apsb.2021.10.027","article-title":"Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis","volume":"12","author":"Chen","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2026.115444_bb0120","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00011-023-01743-x","article-title":"Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages","volume":"72","author":"Ciszek-Lenda","year":"2023","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jconrel.2026.115444_bb0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-023-01512-7","article-title":"Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy","volume":"16","author":"Liu","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0130","first-page":"873","article-title":"Macrophage migration inhibitory factor promotes lung fibrosis via reactive oxygen species-mediated up-regulation of aerobic glycolysis","volume":"38","author":"Gao","year":"2018","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.jconrel.2026.115444_bb0135","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-024-05349-2","article-title":"Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation","volume":"81","author":"Zhao","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jconrel.2026.115444_bb0140","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ijc.35229","article-title":"Tumor-derived lactic acid promotes acetylation of histone H3K27 and differentiation of IL-10-producing regulatory B cells through direct and indirect signaling pathways","volume":"156","author":"Muraoka","year":"2025","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jconrel.2026.115444_bb0145","article-title":"Microneedle-delivered PDA@Exo for multifaceted osteoarthritis treatment via PI3K-Akt-mTOR pathway","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.jconrel.2026.115444_bb0150","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/ps.5338","article-title":"Association of zein nanoparticles with botanical compounds for effective pest control systems","volume":"75","author":"de Oliveira","year":"2019","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.jconrel.2026.115444_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70150","article-title":"Outer membrane vesicles as a versatile platform for vaccine development: engineering strategies, applications and challenges","volume":"14","author":"Garling","year":"2025","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2026.115444_bb0160","doi-asserted-by":"crossref","DOI":"10.1007\/s00253-025-13460-y","article-title":"Optimization of methods for isolation and purification of outer membrane vesicles (OMVs) from Neisseria lactamica","volume":"109","author":"Preto","year":"2025","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124575","article-title":"Gelatin\/dopamine\/zinc-doped ceria\/curcumin nanocomposite hydrogels for repair of chronic refractory wounds","volume":"663","author":"Zhao","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115444_bb0170","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03863-4","article-title":"Self-reinforcing nanomedicine orchestrates EPR effect and neutrophil hitchhiking for spatiotemporal accumulation in solid tumors","volume":"24","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0175","doi-asserted-by":"crossref","first-page":"7733","DOI":"10.1021\/acsnano.3c00363","article-title":"Cloaking mesoporous polydopamine with bacterial membrane vesicles to amplify local and systemic antitumor immunity","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115444_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2026.119464","article-title":"Synergistic antibacterial food packaging enabled by photothermal cinnamaldehyde release from mesoporous polydopamine functionalized chitosan films","volume":"239","author":"Yang","year":"2026","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jconrel.2026.115444_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114819","article-title":"Self-propelled Janus platinum mesoporous-silica nanoparticles for enhanced endodontic treatment","volume":"393","author":"Escudero","year":"2026","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115444_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112443","article-title":"Degradation of methylene blue through Fenton-like reaction catalyzed by MoS2-doped sodium alginate\/Fe hydrogel","volume":"214","author":"Xie","year":"2022","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2026.115444_bb0195","doi-asserted-by":"crossref","first-page":"13603","DOI":"10.1039\/D5RA00301F","article-title":"Metal-polydopamine coordinated coatings on titanium surface: enhancing corrosion resistance and biological property","volume":"15","author":"Mei","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2026.115444_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113702","article-title":"Pathogen-targeting biomineralized bacterial outer membrane vesicles for eradicating both intracellular and extracellular Staphylococcus aureus","volume":"382","author":"Yang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115444_bb0205","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1099\/mic.0.000692","article-title":"Cinnamaldehyde disrupts biofilm formation and swarming motility of Pseudomonas aeruginosa","volume":"164","author":"Topa","year":"2018","journal-title":"Microbiology (Reading)"},{"key":"10.1016\/j.jconrel.2026.115444_bb0210","doi-asserted-by":"crossref","first-page":"11441","DOI":"10.1021\/acs.jafc.2c03459","article-title":"Lysostaphin: engineering and potentiation toward better applications","volume":"70","author":"Zha","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jconrel.2026.115444_bb0215","doi-asserted-by":"crossref","DOI":"10.1172\/JCI177872","article-title":"Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus","volume":"135","author":"Ulrich","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2026.115444_bb0220","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-0716-1550-8_9","article-title":"Quantification of Staphylococcus aureus biofilm formation by crystal violet and confocal microscopy","volume":"2341","author":"Grossman","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0225","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12602-021-09857-6","article-title":"Functional mechanism of antimicrobial peptide Bomidin and its safety for Macrobrachium rosenbergii, probiotics","volume":"14","author":"Zhang","year":"2022","journal-title":"Antimicrob. Proteins"},{"key":"10.1016\/j.jconrel.2026.115444_bb0230","doi-asserted-by":"crossref","DOI":"10.1007\/s11274-025-04414-7","article-title":"Sonoporation-enhanced the antibacterial efficacy of aminoglycosides against gram-negative persisters","volume":"41","author":"Chen","year":"2025","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0235","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01608-17","article-title":"Metabolic mitigation of Staphylococcus aureus vancomycin intermediate-level susceptibility","volume":"62","author":"Gardner","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2026.115444_bb0240","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/15548627.2021.1943177","article-title":"The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy","volume":"18","author":"Deneubourg","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.jconrel.2026.115444_bb0245","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1530\/REP-16-0409","article-title":"Mitochondrial ATP is required for the maintenance of membrane integrity in stallion spermatozoa, whereas motility requires both glycolysis and oxidative phosphorylation","volume":"152","author":"Davila","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.jconrel.2026.115444_bb0250","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1128\/JB.01406-13","article-title":"Regulation of expression of abcA and its response to environmental conditions","volume":"196","author":"Villet","year":"2014","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0255","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2480698","article-title":"Hypermutability of Mycolicibacterium smegmatis due to ribonucleotide reductase-mediated oxidative homeostasis and imbalanced dNTP pools","volume":"14","author":"Zhang","year":"2025","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.jconrel.2026.115444_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73707-y","article-title":"Cooperative dynamics of PARP-1 zinc-finger domains in the detection of DNA single-strand breaks","volume":"14","author":"Sarma","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.115444_bb0265","article-title":"A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis","volume":"14","author":"Zhou","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115444_bb0270","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00259-004-1626-6","article-title":"Comparison of different SUV-based methods for monitoring cytotoxic therapy with FDG PET","volume":"31","author":"Stahl","year":"2004","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.jconrel.2026.115444_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1138539","article-title":"Development of innate immune memory by non-immune cells during Staphylococcus aureus infection depends on reactive oxygen species","volume":"14","author":"Chaumond","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115444_bb0280","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1016\/j.apsb.2024.07.008","article-title":"Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetin-mediated leverage of glycolysis and OXPHOS","volume":"14","author":"Zhang","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2026.115444_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2021.104922","article-title":"Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2\/HIF-1\u03b1 axis","volume":"152","author":"Pei","year":"2021","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jconrel.2026.115444_bb0290","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.cell.2026.01.023","article-title":"Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation","volume":"189","author":"Zuo","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2026.115444_bb0295","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.7150\/ijbs.75434","article-title":"Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jconrel.2026.115444_bb0300","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.stem.2024.04.020","article-title":"Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells","volume":"31","author":"Dellorusso","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jconrel.2026.115444_bb0305","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/all.16361","article-title":"Blocking the HIF-1\u03b1\/glycolysis axis inhibits allergic airway inflammation by reducing ILC2 metabolism and function","volume":"80","author":"Zhang","year":"2025","journal-title":"Allergy"},{"key":"10.1016\/j.jconrel.2026.115444_bb0310","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1038\/s41380-025-02988-0","article-title":"RVG engineered extracellular vesicles-transmitted miR-137 improves autism by modulating glucose metabolism and neuroinflammation","volume":"30","author":"Qin","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jconrel.2026.115444_bb0315","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00149-19","article-title":"Efficacy of azithromycin in a mouse pneumonia model against hospital-acquired methicillin-resistant Staphylococcus aureus","volume":"63","author":"Yamashita","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2026.115444_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2024.108751","article-title":"Dihydroethidium-derived fluorescence in electrically stressed cells indicates intracellular microenvironment modifications independent of ROS","volume":"160","author":"S\u00f6zer","year":"2024","journal-title":"Bioelectrochemistry"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:16:20Z","timestamp":1793337380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926008485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":64,"alternative-id":["S0168365926008485"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115444","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysostaphin bioengineered cascade nanoreactor for bacterial eradication and inflammatory remodeling in MRSA pneumonia","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115444"}}