{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:31:30Z","timestamp":1793442690553,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,10,14]],"date-time":"2027-10-14T00:00:00Z","timestamp":1823472000000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K26509"],"award-info":[{"award-number":["23K26509"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K19906"],"award-info":[{"award-number":["21K19906"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Project No. 23KJ1245"],"award-info":[{"award-number":["Project No. 23KJ1245"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Project No. 24ym0126814"],"award-info":[{"award-number":["Project No. 24ym0126814"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Project No. 25ym0126192"],"award-info":[{"award-number":["Project No. 25ym0126192"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Project No. 22ym01268808"],"award-info":[{"award-number":["Project No. 22ym01268808"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115445","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:11:19Z","timestamp":1791414679000},"page":"115445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Systemic tumor eradication by single-modality immunogenic neutron radiotherapy via size-controlled boron-10-enriched nanoparticles"],"prefix":"10.1016","volume":"399","author":[{"given":"Weian","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heon Gyu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takushi","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115445_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011061","article-title":"The abscopal effect: a review of pre-clinical and clinical advances","volume":"22","author":"Janopaul-Naylor","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115445_bb0010","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/imr.12573","article-title":"Abscopal, immunological effects of radiotherapy: narrowing the gap between clinical and preclinical experiences","volume":"280","author":"Brix","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jconrel.2026.115445_bb0015","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41571-023-00782-x","article-title":"Emerging evidence for adapting radiotherapy to immunotherapy","volume":"20","author":"Galluzzi","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0020","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41568-025-00903-x","article-title":"Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy","volume":"26","author":"Darragh","year":"2026","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.115445_bb0025","first-page":"1351","article-title":"Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect","volume":"3","author":"Nishiga","year":"2022","journal-title":"Nat. Can."},{"key":"10.1016\/j.jconrel.2026.115445_bb0030","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1172\/JCI67313","article-title":"Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice","volume":"124","author":"Deng","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2026.115445_bb0035","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41551-018-0203-4","article-title":"Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy","volume":"2","author":"Lu","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115445_bb0040","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s41587-024-02448-0","article-title":"Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors","volume":"43","author":"Jiang","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0045","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1056\/NEJMoa1112824","article-title":"Immunologic correlates of the abscopal effect in a patient with melanoma","volume":"366","author":"Postow","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115445_bb0050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nrc2587","article-title":"Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype","volume":"9","author":"Barnett","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.115445_bb0055","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrd3974","article-title":"Challenges and approaches for the development of safer immunomodulatory biologics","volume":"12","author":"Sathish","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115445_bb0060","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrd3003","article-title":"The safety and side effects of monoclonal antibodies","volume":"9","author":"Hansel","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115445_bb0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrd3010","article-title":"Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application","volume":"9","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115445_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10147-019-01480-4","article-title":"Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era","volume":"25","author":"Suzuki","year":"2020","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0075","article-title":"Radiobiological effect of alpha particles. The scientific basis of targeted alpha-particle therapy","volume":"146\u2013147","author":"Cruz-Nova","year":"2025","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0080","article-title":"Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse model","volume":"17","author":"Sun","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115445_bb0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00411-017-0704-7","article-title":"Abscopal effect of boron neutron capture therapy (BNCT): proof of principle in an experimental model of colon cancer","volume":"56","author":"Trivillin","year":"2017","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.jconrel.2026.115445_bb0090","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1111\/cas.16298","article-title":"Overcoming immunotherapy resistance and inducing abscopal effects with boron neutron immunotherapy (B-NIT)","volume":"115","author":"Fujimoto","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jconrel.2026.115445_bb0095","article-title":"Boronophenylalanine-functionalized platinum nanozymes sensitizing neutron capture therapy","volume":"35","author":"Li","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.115445_bb0100","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20210593","article-title":"Evaluation of local, regional and abscopal effects of boron neutron capture therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model","volume":"94","author":"Trivillin","year":"2021","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12951-025-03916-8","article-title":"Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy","volume":"24","author":"Zhang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0110","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1021\/acsptsci.5c00613","article-title":"L-boronophenylalanine (l-BPA) dipeptide prodrugs enhance boron delivery to tumors, facilitate tumor eradication and induce tumor vaccine effect in mice following neutron irradiation","volume":"9","author":"Torgov","year":"2026","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.jconrel.2026.115445_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202419418","article-title":"A PD-L1 siRNA-loaded boron nanoparticle for targeted cancer radiotherapy and immunotherapy","volume":"37","author":"Deng","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115445_bb0120","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jrr\/rrac012","article-title":"Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study","volume":"63","author":"Hirose","year":"2022","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.jconrel.2026.115445_bb0125","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4103\/jcrt.jcrt_2743_23","article-title":"Side effects of boron neutron capture therapy","volume":"21","author":"Zhang","year":"2025","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.jconrel.2026.115445_bb0130","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00006123-199803000-00004","article-title":"Biodistribution of p-boronophenylalanine in patients with glioblastoma multiforme for sse in boron neutron capture therapy","volume":"42","author":"Elowitz","year":"1998","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jconrel.2026.115445_bb0135","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.21037\/qims-23-1769","article-title":"Prognostic assessment of (18)F-boronophenylalanine positron emission tomography (BPA-PET) in salvage boron neutron capture therapy for malignant brain tumors","volume":"14","author":"Lin","year":"2024","journal-title":"Quant. Imaging Med. Surg."},{"key":"10.1016\/j.jconrel.2026.115445_bb0140","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz1722","article-title":"Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism","volume":"6","author":"Nomoto","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.115445_bb0145","article-title":"Tumor eradication by boron neutron capture therapy with 10B-enriched hexagonal boron nitride nanoparticles grafted with poly(glycerol)","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115445_bb0150","article-title":"Polyglycerol functionalized 10B enriched boron carbide nanoparticle as an effective bimodal anticancer nanosensitizer for boron neutron capture and photothermal therapies","volume":"18","author":"Wang","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.115445_bb0155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/bc300527n","article-title":"Development of high boron content liposomes and their promising antitumor effect for neutron capture therapy of cancers","volume":"24","author":"Koganei","year":"2013","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2026.115445_bb0160","doi-asserted-by":"crossref","first-page":"25077","DOI":"10.1021\/acsami.6c01675","article-title":"Size-controllable mechanochemical synthesis of boron carbide nanoparticles and their surface modification","volume":"18","author":"Huang","year":"2026","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.115445_bb0165","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/anie.201006310","article-title":"Chromatographic separation of highly soluble diamond nanoparticles prepared by polyglycerol grafting","volume":"50","author":"Zhao","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.115445_bb0170","doi-asserted-by":"crossref","first-page":"7216","DOI":"10.1021\/acsnano.0c02289","article-title":"Polyglycerol grafting shields nanoparticles from protein corona formation to avoid macrophage uptake","volume":"14","author":"Zou","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115445_bb0175","doi-asserted-by":"crossref","DOI":"10.1088\/0953-8984\/22\/39\/395401","article-title":"Isotopic effects on the phonon modes in boron carbide","volume":"22","author":"Werheit","year":"2010","journal-title":"J. Phys. Condens. Matter"},{"key":"10.1016\/j.jconrel.2026.115445_bb0180","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1002\/adfm.201304298","article-title":"Platinum on nanodiamond: a promising prodrug conjugated with stealth polyglycerol, targeting peptide and acid-responsive antitumor drug","volume":"24","author":"Zhao","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.115445_bb0185","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0167-5087(83)90082-0","article-title":"Microanalysis system of ppm-order 10B concentrations in tissue for neutron capture therapy by prompt gamma-ray spectrometry","volume":"204","author":"Kobayashi","year":"1983","journal-title":"Nucl. Inst. Methods Phys. Res. A"},{"key":"10.1016\/j.jconrel.2026.115445_bb0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115445_bb0195","article-title":"Boron delivery agents for neutron capture therapy of cancer","volume":"38","author":"Barth","year":"2018","journal-title":"Cancer Commun."},{"key":"10.1016\/j.jconrel.2026.115445_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.jconrel.2026.115445_bb0205","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/s41563-023-01630-0","article-title":"The exit of nanoparticles from solid tumours","volume":"22","author":"Nguyen","year":"2023","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2026.115445_bb0210","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/physrev.00055.2006","article-title":"Properties of the glomerular barrier and mechanisms of proteinuria","volume":"88","author":"Haraldsson","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jconrel.2026.115445_bb0215","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41565-025-01903-6","article-title":"Discovering nanoparticle corona ligands for liver macrophage capture","volume":"20","author":"Bussin","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0220","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/0192623315625859","article-title":"Recommendations from the INHAND apoptosis\/necrosis working group","volume":"44","author":"Elmore","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0225","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/smll.200800944","article-title":"A facile and scalable process for size-controllable separation of nanodiamond particles as small as 4 nm","volume":"4","author":"Morita","year":"2008","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.115445_bb0230","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1021\/nn301282m","article-title":"Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo","volume":"6","author":"Huang","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115445_bb0235","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1038\/s41467-021-26646-5","article-title":"Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope","volume":"12","author":"Ebrahimi-Nik","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115445_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2022.101405","article-title":"Anti-CTLA-4 and anti-PD-1 immunotherapies repress tumor progression in preclinical breast and colon model with independent regulatory T cells response","volume":"20","author":"Rupp","year":"2022","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.jconrel.2026.115445_bib316","article-title":"Preferential tumor accumulation of polyglycerol functionalized nanodiamond conjugated with cyanine dye leading to near-Infrared fluorescence in vivo tumor imaging","volume":"15","author":"Yoshino","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.115445_bb0245","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1118\/1.1509444","article-title":"The medical-irradiation characteristics for neutron capture therapy at the heavy water neutron irradiation Facility of Kyoto University Research Reactor","volume":"29","author":"Sakurai","year":"2002","journal-title":"Med. Phys."},{"key":"10.1016\/j.jconrel.2026.115445_bb0250","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","article-title":"Understanding the tumor immune microenvironment (TIME) for effective therapy","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2026.115445_bb0255","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115445_bb0260","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000325","article-title":"Cellular cytotoxicity is a form of immunogenic cell death","volume":"8","author":"Minute","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2026.115445_bb0265","first-page":"488","article-title":"Local cancer recurrence: the realities, challenges, and opportunities for new therapies","volume":"68","author":"Mahvi","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jconrel.2026.115445_bb0270","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0275","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41577-024-01040-6","article-title":"A guide to adaptive immune memory","volume":"24","author":"Lam","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0280","doi-asserted-by":"crossref","DOI":"10.4161\/onci.26889","article-title":"Murine leukemia virus envelope gp70 is a shared biomarker for the high-sensitivity quantification of murine tumor burden","volume":"2","author":"Scrimieri","year":"2013","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jconrel.2026.115445_bb0285","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1021\/acsnano.9b01383","article-title":"Elimination pathways of nanoparticles","volume":"13","author":"Poon","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115445_bb0290","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.addr.2011.09.001","article-title":"Toxicology of nanoparticles","volume":"64","author":"Elsaesser","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115445_bb0295","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1021\/acs.accounts.2c00615","article-title":"Poly(glycerol)-based biomedical nanodevices constructed by functional programming on inorganic nanoparticles for cancer nanomedicine","volume":"56","author":"Komatsu","year":"2023","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2026.115445_bb0300","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nnano.2011.166","article-title":"Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size","volume":"6","author":"Cabral","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115445_bb0305","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nrc3958","article-title":"The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence","volume":"15","author":"Barker","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.115445_bb0310","article-title":"Patient-derived xenograft models in cancer therapy: technologies and applications","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115445_bb0315","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s10495-021-01663-3","article-title":"Release mechanisms of major DAMPs","volume":"26","author":"Murao","year":"2021","journal-title":"Apoptosis"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:45:56Z","timestamp":1793439956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926008497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":64,"alternative-id":["S0168365926008497"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115445","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic tumor eradication by single-modality immunogenic neutron radiotherapy via size-controlled boron-10-enriched nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115445"}}