{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:33:36Z","timestamp":1793126016190,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jconrel.2026.115458","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:41:26Z","timestamp":1792046486000},"page":"115458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Hierarchically sequential targeting nanoplatform suppresses NETosis-promoted angiogenesis for corneal neovascularization therapy"],"prefix":"10.1016","volume":"400","author":[{"given":"Chaoqun","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxuan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jconrel.2026.115458_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/biology15020136","article-title":"Corneal neovascularization: pathogenesis, current insights and future strategies","volume":"15","author":"Muller","year":"2026","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0010","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-025-07102-0","article-title":"Transforming corneal alkali burn treatment: unveiling mechanisms and pioneering therapies from bench to bedside","volume":"23","author":"Xie","year":"2025","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115458_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens15020186","article-title":"Molecular pathways driving corneal neovascularization in herpes simplex keratitis","volume":"15","author":"Akinsiku","year":"2026","journal-title":"Pathogens"},{"key":"10.1016\/j.jconrel.2026.115458_bb0020","series-title":"Ocular Burns","author":"Patek","year":"2026"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115458_bb0025","article-title":"Engineered neutrophil nanovesicles for inhibiting corneal neovascularization by synergistic anti-inflammatory, anti-VEGF and chemoexcited photodynamic therapy (vol 37, 2411030, 2025)","volume":"38","author":"Liu","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115458_bb0030","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconrel.2024.08.002","article-title":"Biomimetic nanocomplex based corneal neovascularization theranostics","volume":"374","author":"Ye","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115458_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115084","article-title":"Up-to-date molecular medicine strategies for management of ocular surface neovascularization","volume":"201","author":"Yang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"23","key":"10.1016\/j.jconrel.2026.115458_bb0040","doi-asserted-by":"crossref","first-page":"e05182","DOI":"10.1002\/adhm.202505182","article-title":"Aptamer-based delivery systems for VEGF and NGF modulation in ocular therapies","volume":"15","author":"Best","year":"2026","journal-title":"Adv. Healthc. Mater."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115458_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105479","article-title":"Available therapeutic options for corneal neovascularization: a review","volume":"25","author":"Drzyzga","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0050","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.65.1.21","article-title":"Exploring corneal neovascularization: an integrated approach using transcriptomics and proteomics in an alkali burn mouse model","volume":"65","author":"Wang","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-026-07813-y","article-title":"Icariin alleviates corneal neovascularization by regulating inflammation through inhibition of macrophage polarization and the NF-\u03baB pathway","volume":"24","author":"Zhao","year":"2026","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.115458_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106902","article-title":"Neutrophil extracellular traps promote corneal neovascularization-induced by alkali burn","volume":"88","author":"Yuan","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jconrel.2026.115458_bb0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.trsl.2026.01.001","article-title":"Neutrophil extracellular traps exacerbate endothelial tight junction dysfunction via the Wnt7a\/beta-catenin\/HDAC5 pathway in sepsis-associated lung injury","volume":"287","author":"Hong","year":"2026","journal-title":"Transl. Res."},{"key":"10.1016\/j.jconrel.2026.115458_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117149","article-title":"Neutrophil extracellular traps mediate inflammation and coagulation dysregulation in primary blast lung injury","volume":"241","author":"Meng","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"17","key":"10.1016\/j.jconrel.2026.115458_bb0075","doi-asserted-by":"crossref","first-page":"9221","DOI":"10.7150\/thno.115746","article-title":"Neutrophil extracellular traps induce endothelial damage and exacerbate vasospasm in traumatic brain injury","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0080","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13046-023-02817-8","article-title":"Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression","volume":"42","author":"Kong","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115458_bb0085","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1073\/pnas.1909546117","article-title":"NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture","volume":"117","author":"Thiam","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"45","key":"10.1016\/j.jconrel.2026.115458_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202412253","article-title":"Engineered enucleated mesenchymal stem cells regulating immune microenvironment and promoting wound healing","volume":"36","author":"Chen","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115458_bb0095","doi-asserted-by":"crossref","first-page":"17010","DOI":"10.1038\/sigtrans.2017.10","article-title":"A novel peptide specifically binding to VEGF receptor suppresses angiogenesis in vitro and in vivo","volume":"2","author":"Zhang","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115458_bb0100","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/s41565-022-01161-w","article-title":"Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an alpha(1)-antitrypsin-derived peptide motif","volume":"17","author":"Cruz","year":"2022","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-023-02903-w","article-title":"Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1\u03b1\/ASK1\/JNK signaling pathway in mice with traumatic brain injury","volume":"20","author":"Shi","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2026.115458_bb0110","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.actbio.2022.09.061","article-title":"ROS-cleavable diselenide nanomedicine for NIR-controlled drug release and on-demand synergistic chemo-photodynamic therapy","volume":"153","author":"Zhu","year":"2022","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0115","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-03023-0","article-title":"Polydopamine(PDA)-coated diselenide-bridged mesoporous silica-based nanoplatform for neuroprotection by reducing oxidative stress and targeting neuroinflammation in intracerebral hemorrhage","volume":"22","author":"Zhou","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61112-4","article-title":"Trimebutine prevents corneal inflammation in a rat alkali burn model","volume":"14","author":"Goto","year":"2024","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.jconrel.2026.115458_bb0125","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","article-title":"Neutrophils and NETs in modulating acute and chronic inflammation","volume":"133","author":"Castanheira","year":"2019","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115458_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads0282","article-title":"Long-lasting comfort ocular surface drug delivery by in situ formation of an adhesive lubricative Janus nanocoating","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"issue":"36","key":"10.1016\/j.jconrel.2026.115458_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202000673","article-title":"Safety considerations of cancer nanomedicine-a key step toward translation","volume":"16","author":"Liu","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.115458_bb0140","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jconrel.2023.07.036","article-title":"Inflammation-responsive molecular-gated contact lens for the treatment of corneal neovascularization","volume":"360","author":"Sun","year":"2023","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115458_bb0145","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1167\/iovs.19-27591","article-title":"Repeat corneal neovascularization is characterized by more aggressive inflammation and vessel invasion than in the initial phase","volume":"60","author":"Mukwaya","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115458_bb0150","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/s41385-022-00555-2","article-title":"Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization","volume":"15","author":"Lee","year":"2022","journal-title":"Mucosal Immunol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115458_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10276","article-title":"Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis","volume":"7","author":"Wang","year":"2022","journal-title":"Bioeng. Transl. Med."},{"issue":"42","key":"10.1016\/j.jconrel.2026.115458_bb0160","doi-asserted-by":"crossref","first-page":"e73114","DOI":"10.1002\/adma.73114","article-title":"Disrupting the oxidative stress-inflammation-corneal neovascularization cycle with ultrasmall nanoparticles","volume":"38","author":"Wu","year":"2026","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0165","doi-asserted-by":"crossref","DOI":"10.1007\/s40820-024-01477-3","article-title":"Advances in polysaccharide-based microneedle systems for the treatment of ocular diseases","volume":"16","author":"Bao","year":"2024","journal-title":"Nano Micro Lett."},{"key":"10.1016\/j.jconrel.2026.115458_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114770","article-title":"Polymer- and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"43","key":"10.1016\/j.jconrel.2026.115458_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202508726","article-title":"Advanced nanotechnology-driven innovations for corneal neovascularization therapy: smart drug delivery and enhanced treatment strategies","volume":"37","author":"Huang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115458_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.169707","article-title":"Bioactive nanofiber hydrogel acts on VEGF and VEGF receptor to unleash inhibition effects on corneal neovascularization","volume":"524","author":"Liu","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0185","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-026-04314-4","article-title":"Functionalized metal-organic framework-based photosensitive hydrogel eye drops for inhibition of corneal neovascularization and promotion of epithelial repair","volume":"24","author":"Meng","year":"2026","journal-title":"J. Nanobiotechnol."},{"issue":"25","key":"10.1016\/j.jconrel.2026.115458_bb0190","article-title":"Genome editing prevents corneal neovascularization in vivo","volume":"11","author":"Zeng","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0195","doi-asserted-by":"crossref","first-page":"156","DOI":"10.7150\/thno.117085","article-title":"Advancements in CRISPR-based therapies for ocular pathologies: from disease mechanisms to intervention strategies","volume":"16","author":"Li","year":"2026","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115458_bb0200","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41434-026-00607-3","article-title":"Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury","volume":"33","author":"Lee","year":"2026","journal-title":"Gene Ther."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115458_bb0205","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1167\/iovs.18-26277","article-title":"MMP14-containing exosomes cleave VEGFR1 and promote VEGFA-induced migration and proliferation of vascular endothelial cells","volume":"60","author":"Han","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2026.115458_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114394","article-title":"Multifunctional macrophage membrane biomimetic nanoparticles for targeted therapy of neovascular age-related macular degeneration","volume":"388","author":"Yin","year":"2025","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115458_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03589-3","article-title":"Recent advances in engineered exosome-based therapies for ocular vascular disease","volume":"23","author":"Guan","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115458_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123205","article-title":"Platelet-derived extracellular vesicle drug delivery system loaded with kaempferol for treating corneal neovascularization","volume":"319","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115458_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114930","article-title":"M2 macrophage-derived exosomes deliver NGF-modified mRNA to promote comprehensive corneal repair","volume":"395","author":"Gong","year":"2026","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115458_bb0230","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jtos.2024.10.005","article-title":"Target specification and therapeutic potential of extracellular vesicles for regulating corneal angiogenesis, lymphangiogenesis, and nerve repair","volume":"34","author":"Pedersen","year":"2024","journal-title":"Ocul. Surf."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115458_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310917","article-title":"Mesenchymal stem cells and exosomes: a novel therapeutic approach for corneal diseases","volume":"24","author":"Bhujel","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115458_bb0240","article-title":"Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization","volume":"7","author":"Han","year":"2017","journal-title":"Sci. Rep. UK"},{"issue":"50","key":"10.1016\/j.jconrel.2026.115458_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307624","article-title":"Microenvironment self-adaptive nanomedicine promotes spinal cord repair by suppressing inflammation cascade and neural apoptosis","volume":"36","author":"Qian","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115458_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110576","article-title":"Lipid-PLGA hybrid nanoparticles of paclitaxel: preparation, characterization, and evaluation","volume":"109","author":"Godara","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115458_bb0255","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.67.2.22","article-title":"AIF-1 drives corneal neovascularization by promoting inflammatory macrophage activation via the MAPK and PI3K\/AKT\/mTOR signaling pathways","volume":"67","author":"Li","year":"2026","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592600862X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592600862X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:50:24Z","timestamp":1793123424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592600862X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":51,"alternative-id":["S016836592600862X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115458","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hierarchically sequential targeting nanoplatform suppresses NETosis-promoted angiogenesis for corneal neovascularization therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115458"}}