{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:33:16Z","timestamp":1793136796076,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:00:00Z","timestamp":1793059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014489","name":"Johnson & Johnson Pharmaceutical Research and Development LLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jconrel.2026.115471","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:57:11Z","timestamp":1792684631000},"page":"115471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Patient-specific pharmacokinetics of intratumoral cisplatin track pathologic necrosis in early-stage lung cancer"],"prefix":"10.1016","volume":"400","author":[{"given":"Vitor","family":"Mori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kooperkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Butnor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Norotsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard F.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.T.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Matthew","family":"Kinsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jconrel.2026.115471_bb0005","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2217\/imt.15.35","article-title":"Talimogene laherparepvec (T-VEC) for the treatment of advanced melanoma","volume":"7","author":"Johnson","year":"2015","journal-title":"Immunotherapy"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115471_bb0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1513\/AnnalsATS.201408-358BC","article-title":"Endobronchial ultrasound\u2013guided transbronchial needle injection for local control of recurrent non\u2013small cell lung cancer","volume":"12","author":"Khan","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.jconrel.2026.115471_bb0015","doi-asserted-by":"crossref","DOI":"10.21037\/amj.2018.06.05","article-title":"Endobronchial ultrasound-guided-transbronchial needle injection for direct therapy of lung cancer","volume":"3","author":"Kinsey","year":"2018","journal-title":"AME Med. J."},{"key":"10.1016\/j.jconrel.2026.115471_bb0020","article-title":"Endobronchial ultrasound-guided transbronchial needle injection of cisplatin results in dynamic changes in the tumor immune microenvironment","volume":"84","author":"DuComb","year":"2023","journal-title":"Respir. Med. Res."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115471_bb0025","doi-asserted-by":"crossref","first-page":"544","DOI":"10.7150\/jca.81793","article-title":"Visualizing intratumoral injections in lung tumors by endobronchial ultrasound","volume":"14","author":"Mori","year":"2023","journal-title":"J. Cancer"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115471_bb0030","article-title":"Initial safety and feasibility results from a phase 1, diagnose-and-treat trial of neoadjuvant intratumoral cisplatin for stage IV NSCLC","volume":"5","author":"Khan","year":"2024","journal-title":"JTO Clin. Res. Rep."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115471_bb0035","first-page":"925","article-title":"Relative dose intensity of first-line chemotherapy and overall survival in patients with advanced non-small-cell lung cancer","volume":"28","author":"Crawford","year":"2020","journal-title":"Support. Care Cancer"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115471_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/onco.13822","article-title":"Relative dose intensity of chemotherapy and survival in patients with advanced stage solid tumor cancer: a systematic review and meta-analysis","volume":"26","author":"Nielson","year":"2021","journal-title":"Oncologist"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115471_bb0045","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00030-2018","article-title":"30-day mortality after the start of systemic anticancer therapy for lung cancer: is it really a useful performance indicator?","volume":"4","author":"Burgers","year":"2018","journal-title":"ERJ Open Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115471_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-03849-w","article-title":"A computational modeling approach for dosing endoscopic intratumoral chemotherapy for advanced non-small cell lung cancer","volume":"12","author":"Mori","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.115471_bb0055","series-title":"A Phase 1 Diagnose-and-Treat Trial of Intratumoral Cisplatin for Early-Stage Resectable Non-Small Cell Lung Cancer","author":"Mori","year":"2026"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115471_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-43270-y","article-title":"Cisplatin pharmacodynamics following endobronchial ultrasound-guided transbronchial needle injection into lung tumors","volume":"9","author":"Mori","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115471_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-27390-6","article-title":"Maximizing response to intratumoral immunotherapy in mice by tuning local retention","volume":"13","author":"Momin","year":"2022","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115471_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1011740","article-title":"Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes","volume":"19","author":"Harkos","year":"2023","journal-title":"PLoS Comput. Biol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115471_bb0075","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3390\/pharmaceutics15041132","article-title":"Pharmacokinetics and pharmacodynamics of antibody-drug conjugates administered via subcutaneous and intratumoral routes","volume":"15","author":"Chang","year":"2023","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115471_bb0080","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001800","article-title":"Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy","volume":"9","author":"Mu\u00f1oz","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115471_bb0085","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/bjc.1996.296","article-title":"Relationship between the exposure to cisplatin, DNA-adduct formation in leucocytes and tumour response in patients with solid tumours","volume":"73","author":"Schellens","year":"1996","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115471_bb0090","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1476-5586(03)80008-8","article-title":"A mathematical model for cisplatin cellular pharmacodynamics","volume":"5","author":"El-Kareh","year":"2003","journal-title":"Neoplasia"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115471_bb0095","article-title":"Inter-and intratumoral disposition of platinum in solid tumors after administration of cisplatin","volume":"8","author":"Zamboni","year":"2002","journal-title":"Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115471_bb0100","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.7911","article-title":"Assessment of image-guided intratumoral delivery of immunotherapeutics in patients with cancer","volume":"3","author":"Sheth","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jconrel.2026.115471_bb0105","doi-asserted-by":"crossref","DOI":"10.1007\/s10439-026-04340-1","article-title":"Fracking in tumors \u2013 a key drug transport mechanism","author":"Mori","year":"2026","journal-title":"Ann. Biomed. Eng."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115471_bb0110","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1023\/A:1016054807555","article-title":"Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system","volume":"13","author":"Saikawa","year":"1996","journal-title":"Pharm. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115471_bb0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/clpt.1986.24","article-title":"Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of cisplatin","volume":"39","author":"Vermorken","year":"1986","journal-title":"Clin. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115471_bb0120","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1365-2125.2004.02082.x","article-title":"Population pharmacokinetics of total and unbound plasma cisplatin in adult patients","volume":"57","author":"Urien","year":"2004","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115471_bb0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2125.1991.tb03878.x","article-title":"Disposition and tumour concentrations of platinum in hypoalbuminaemic patients after treatment with cisplatin for cancer of the head and neck","volume":"32","author":"Holding","year":"1991","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115471_bb0130","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1093\/annonc\/mdy423","article-title":"Starting the fight in the tumor: expert recommendations for the development of human intratumoral immunotherapy (HIT-IT)","volume":"29","author":"Marabelle","year":"2018","journal-title":"Ann. Oncol."},{"issue":"23","key":"10.1016\/j.jconrel.2026.115471_bb0135","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1200\/JCO.19.02985","article-title":"Response criteria for intratumoral immunotherapy in solid tumors: itRECIST","volume":"38","author":"Goldmacher","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115471_bb0140","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008378","article-title":"Society for Immunotherapy of Cancer (SITC) recommendations on intratumoral immunotherapy clinical trials (IICT): from premalignant to metastatic disease","volume":"12","author":"Luke","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"25","key":"10.1016\/j.jconrel.2026.115471_bb0145","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1200\/JCO.2014.58.3377","article-title":"Talimogene laherparepvec improves durable response rate in patients with advanced melanoma","volume":"33","author":"Andtbacka","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115471_bb0150","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.chest.2017.11.004","article-title":"Impact of rapid on-site cytological evaluation (ROSE) on the diagnostic yield of transbronchial needle aspiration during mediastinal lymph node sampling: systematic review and meta-analysis","volume":"153","author":"Sehgal","year":"2018","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115471_bb0155","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1093\/annonc\/mdy218","article-title":"Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)","volume":"29","author":"Cottrell","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jconrel.2026.115471_bb0160","series-title":"2004 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro (IEEE Cat No 04EX821)","article-title":"3D Slicer","year":"2004"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115471_bb0165","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"A threshold selection method from gray-level histograms","volume":"9","author":"Otsu","year":"1979","journal-title":"IEEE Transact. Syst. Man Cybern."},{"key":"10.1016\/j.jconrel.2026.115471_bb0170","series-title":"Image Analysis and Mathematical Morphology","author":"Serra","year":"1983"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115471_bb0175","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler","year":"1962","journal-title":"Surgery"},{"issue":"D1","key":"10.1016\/j.jconrel.2026.115471_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926008758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:56:17Z","timestamp":1793134577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926008758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S0168365926008758"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115471","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient-specific pharmacokinetics of intratumoral cisplatin track pathologic necrosis in early-stage lung cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115471","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115471"}}