{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:50:55Z","timestamp":1790117455476,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","journal-cot.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jcot.2018.08.004","type":"journal-article","created":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T17:54:10Z","timestamp":1533405250000},"page":"750-754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of monocytic cytokines in polytrauma patients with orthopedics injures"],"prefix":"10.1016","volume":"10","author":[{"given":"Vijay","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surbhi","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelu","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purva","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcot.2018.08.004_bib1","first-page":"1","article-title":"The impact of the increasing burden of trauma in Malawi on orthopedic trauma service priorities at Kamuzu Central Hospital","volume":"Sep 2","author":"Sven","year":"2016","journal-title":"Acta Orthop"},{"issue":"11","key":"10.1016\/j.jcot.2018.08.004_bib2","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.injury.2009.09.016","article-title":"Bilateral femoral fractures: does intramedullary nailing increase systemic complications and mortality rates?","volume":"40","author":"Stavlas","year":"2009","journal-title":"Injury"},{"issue":"38","key":"10.1016\/j.jcot.2018.08.004_bib3","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.injury.2007.10.003","article-title":"Systemic inflammationafter trauma","author":"Lenz","year":"2007","journal-title":"Injury"},{"issue":"1","key":"10.1016\/j.jcot.2018.08.004_bib4","first-page":"46","article-title":"Impact of trauma integration treatment system on the mortality of patients with severe trauma","volume":"32","author":"Sun","year":"2016","journal-title":"Zhonghua Shaoshang Zazhi"},{"key":"10.1016\/j.jcot.2018.08.004_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/01.blo.0000130840.64528.1e","article-title":"Cytokines in patients with polytrauma","volume":"422","author":"Delong","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jcot.2018.08.004_bib6","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00264-013-2261-2","article-title":"Cytokine levels (IL-4, IL-6, IL-8 and TGF\u03b2) as potential biomarkers of systemic inflammatory response in trauma patientsl assaf & tamar meir & rina katz & shimon pollack","volume":"38","author":"Volpin","year":"2014","journal-title":"Int Orthop"},{"key":"10.1016\/j.jcot.2018.08.004_bib7","first-page":"1407","article-title":"The \u201cT\u201d in trauma: the helper t-cell response and the role of immunomodulation in trauma and burn patients","volume":"63","author":"Miller","year":"2007","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.jcot.2018.08.004_bib8","first-page":"1379","article-title":"Systemic inflammatory response after extremity or truncal fracture operations","volume":"65","author":"Pape Hans","year":"2008","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.jcot.2018.08.004_bib9","first-page":"1273","article-title":"Suppression and recovery of LPS-stimulated monocyte activity after trauma is correlated with increasing injury severity: a prospective clinical study","volume":"66","author":"Wutzler","year":"2009","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.jcot.2018.08.004_bib10","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.injury.2007.10.003","article-title":"Systemic inflammation after trauma","volume":"38","author":"Lenz","year":"2007","journal-title":"Injury"},{"key":"10.1016\/j.jcot.2018.08.004_bib11","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.injury.2004.12.037","article-title":"Pathophysiology of polytrauma. Injury","volume":"36","author":"Keel","year":"2005","journal-title":"Int. J. Care Injured"},{"issue":"3","key":"10.1016\/j.jcot.2018.08.004_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033095","article-title":"Early Interleukin-6 and slope of monocyte human leukocyte antigen-DR: a powerful association to predict the development of sepsis after major trauma","volume":"7","author":"Gouel-Ch\u00e9ron","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jcot.2018.08.004_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1757-7241-17-49","article-title":"IL-6 predicts organ dysfunction and mortality in patients with multiple injuries","volume":"17","author":"Frink","year":"2009","journal-title":"Scand J Trauma Resuscitat Emerg Med"},{"issue":"3","key":"10.1016\/j.jcot.2018.08.004_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1302\/0301-620X.86B3.15035","article-title":"Inflammatory serum markers in patients with multiple trauma. Can they predict outcome?","volume":"86","author":"Giannoudis","year":"2004","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.jcot.2018.08.004_bib15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.injury.2008.08.007","article-title":"Elevated systemic IL-18 and neopterin levels are associated with posttraumatic complications among patients with multiple injuries: a prospective cohort study","volume":"40","author":"Mommsena","year":"2009","journal-title":"Injury, Int. J. Care Injured"},{"key":"10.1016\/j.jcot.2018.08.004_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1749-7922-6-34","article-title":"Intramedullary nailing of the femur and the systemic activation of monocytes and neutrophils","volume":"6","author":"Hietbrink","year":"2011","journal-title":"World J Emerg Surg"},{"issue":"7","key":"10.1016\/j.jcot.2018.08.004_bib17","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.injury.2010.06.025","article-title":"Coagulation, fibrinolysis and cytokine responses to intramedullary nailing of the femur: an experimental study in pigs comparing traditional reaming and reaming with a one-step reamer-irrigator-aspirator system","volume":"42","author":"Husebye","year":"2011","journal-title":"Injury"},{"issue":"373","key":"10.1016\/j.jcot.2018.08.004_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00003086-200004000-00028","article-title":"Interleukin-10 release and monocyte human leukocyte antigen-DR expression during femoral nailing","author":"Smith","year":"2000","journal-title":"Clin Orthop Relat Res"}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566217305672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566217305672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T10:51:06Z","timestamp":1568199066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0976566217305672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0976566217305672"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2018.08.004","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of monocytic cytokines in polytrauma patients with orthopedics injures","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2018.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018","name":"copyright","label":"Copyright"}]}}