{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:15:35Z","timestamp":1788974135281,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-cot.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jcot.2021.01.019","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T14:55:43Z","timestamp":1612709743000},"page":"54-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Present and future scope of recombinant parathyroid hormone therapy in orthopaedics"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3614-9750","authenticated-orcid":false,"given":"Arnab","family":"Sain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-3804","authenticated-orcid":false,"given":"Hemant","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7455-6541","authenticated-orcid":false,"given":"Kirubakaran","family":"Pattabiraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jcot.2021.01.019_bib1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/00016470410004012","article-title":"Perspective parathyroid hormone\u2014a drug for orthopedic surgery?","volume":"75","author":"Skripitz","year":"2004","journal-title":"Acta Orthop Scand"},{"issue":"3","key":"10.1016\/j.jcot.2021.01.019_bib2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF03339657","article-title":"The role of parathyroid hormone in the pathogenesis, prevention and treatment of postmenopausal osteoporosis","volume":"10","author":"Masiukiewicz","year":"1998","journal-title":"Aging Clin Exp Res"},{"issue":"2","key":"10.1016\/j.jcot.2021.01.019_bib3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11914-017-0353-4","article-title":"Parathyroid hormone and parathyroid hormone-related protein analogs in osteoporosis therapy","volume":"15","author":"Leder","year":"2017","journal-title":"Curr Osteoporos Rep"},{"issue":"10","key":"10.1016\/j.jcot.2021.01.019_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00006254-200110000-00018","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"56","author":"Neer","year":"2001","journal-title":"Obstet Gynecol Surv"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1503\/cmaj.050929","article-title":"Parathyroid hormone for the treatment of osteoporosis: a systematic review","volume":"175","author":"Cranney","year":"2006","journal-title":"CMAJ (Can Med Assoc J)"},{"issue":"11","key":"10.1016\/j.jcot.2021.01.019_bib6","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1210\/jc.2003-030768","article-title":"Efficacy and safety of human parathyroid hormone-(1-84) in increasing bone mineral density in postmenopausal osteoporosis","volume":"88","author":"Hodsman","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"key":"10.1016\/j.jcot.2021.01.019_bib7","article-title":"Update on the safety and efficacy of teriparatide in the treatment of osteoporosis","volume":"11","author":"Minisola","year":"2019","journal-title":"Therapeut Adv Musculoskelet Dis"},{"issue":"5","key":"10.1016\/j.jcot.2021.01.019_bib8","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1210\/er.2004-0006","article-title":"Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use","volume":"26","author":"Hodsman","year":"2005","journal-title":"Endocr Rev"},{"issue":"9","key":"10.1016\/j.jcot.2021.01.019_bib9","first-page":"3069","article-title":"Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers","volume":"85","author":"Kurland","year":"2000","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1359\/jbmr.2003.18.1.9","article-title":"The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis","volume":"18","author":"Orwoll","year":"2003","journal-title":"J\u00a0Bone Miner Res"},{"issue":"5","key":"10.1016\/j.jcot.2021.01.019_bib11","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1359\/jbmr.2001.16.5.925","article-title":"Parathyroid hormone added to established hormone therapy: effects on vertebral fracture and maintenance of bone mass after parathyroid hormone withdrawal","volume":"16","author":"Cosman","year":"2001","journal-title":"J\u00a0Bone Miner Res : Off J Am Soc Bone Miner Res"},{"issue":"9077","key":"10.1016\/j.jcot.2021.01.019_bib12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(97)02342-8","article-title":"Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis","volume":"350","author":"Lindsay","year":"1997","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jcot.2021.01.019_bib13","first-page":"2129","article-title":"Enhancement of bone mass in osteoporotic women with parathyroid hormone followed by Alendronate1","volume":"85","author":"Rittmaster","year":"2000","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"issue":"13","key":"10.1016\/j.jcot.2021.01.019_bib14","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa031975","article-title":"The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis","volume":"349","author":"Black","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.jcot.2021.01.019_bib15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJMoa050336","article-title":"One year of alendronate after one year of parathyroid hormone (1\u201384) for osteoporosis","volume":"353","author":"Black","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.jcot.2021.01.019_bib16","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1007\/s00198-016-3534-6","article-title":"Teriparatide for osteoporosis: importance of the full course","volume":"27","author":"Lindsay","year":"2016","journal-title":"Osteoporos Int"},{"issue":"3","key":"10.1016\/j.jcot.2021.01.019_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4103\/2230-8210.95661","article-title":"Teriparatide - indications beyond osteoporosis","volume":"16","author":"Cheng","year":"2012","journal-title":"Indian J Endocrinol Metabol"},{"issue":"3","key":"10.1016\/j.jcot.2021.01.019_bib18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/ajhp\/zxy022","article-title":"Abaloparatide: a new pharmacological option for osteoporosis","volume":"76","author":"Sleeman","year":"2019","journal-title":"Am J Health Syst Pharm"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-010-9360-5","article-title":"Parathyroid hormone and bone healing","volume":"87","author":"Ellegaard","year":"2010","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"10.1016\/j.jcot.2021.01.019_bib20","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1359\/jbmr.1999.14.6.960","article-title":"Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures","volume":"14","author":"Andreassen","year":"1999","journal-title":"J\u00a0Bone Miner Res"},{"issue":"3","key":"10.1016\/j.jcot.2021.01.019_bib21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/00016470152846673","article-title":"Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone","volume":"72","author":"Andreassen","year":"2001","journal-title":"Acta Orthop Scand"},{"issue":"2","key":"10.1016\/j.jcot.2021.01.019_bib22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1359\/jbmr.090731","article-title":"Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures","volume":"25","author":"Aspenberg","year":"2009","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jcot.2021.01.019_bib23","doi-asserted-by":"crossref","DOI":"10.6061\/clinics\/2019\/e800","article-title":"The effectiveness and safety of parathyroid hormone in fracture healing: a meta-analysis","volume":"74","author":"Hong","year":"2019","journal-title":"Clinics"},{"issue":"12","key":"10.1016\/j.jcot.2021.01.019_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168691","article-title":"Effectiveness of teriparatide on fracture healing: a systematic review and meta-analysis","volume":"11","author":"Shi","year":"2016","journal-title":"PloS One"},{"issue":"19","key":"10.1016\/j.jcot.2021.01.019_bib25","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003626","article-title":"Teriparatide improves fracture healing and early functional recovery in treatment of osteoporotic intertrochanteric fractures","volume":"95","author":"Huang","year":"2016","journal-title":"Medicine"},{"issue":"7","key":"10.1016\/j.jcot.2021.01.019_bib26","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.injury.2019.06.002","article-title":"Short-term daily teriparatide improve postoperative functional outcome and fracture healing in unstable intertrochanteric fractures","volume":"50","author":"Kim","year":"2019","journal-title":"Injury"},{"issue":"6","key":"10.1016\/j.jcot.2021.01.019_bib27","doi-asserted-by":"crossref","first-page":"918","DOI":"10.18203\/issn.2455-4510.IntJResOrthop20184386","article-title":"Effect of teriparatide in fracture healing of intertrochanteric fracture: a prospective study","volume":"4","author":"Singhal","year":"2018","journal-title":"Int J Res Orthopaed"},{"issue":"17","key":"10.1016\/j.jcot.2021.01.019_bib28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.2106\/JBJS.J.01379","article-title":"Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women","volume":"93","author":"Peichl","year":"2011","journal-title":"J\u00a0Bone Jt Surg Am Vol"},{"issue":"5","key":"10.1016\/j.jcot.2021.01.019_bib29","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1007\/s11999-015-4669-z","article-title":"Does teriparatide improve femoral neck fracture healing: results from A randomized placebo-controlled trial","volume":"474","author":"Bhandari","year":"2016","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"10.1016\/j.jcot.2021.01.019_bib30","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3109\/17453671003761946","article-title":"Teriparatide improves early callus formation in distal radial fractures","volume":"81","author":"Aspenberg","year":"2010","journal-title":"Acta Orthop"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/17453674.2015.1073050","article-title":"PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures","volume":"87","author":"Johansson","year":"2015","journal-title":"Acta Orthop"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib32","article-title":"Effect of teriparatide (rh-PTH 1\u201334) versus bisphosphonate on the healing of osteoporotic vertebral compression fracture: a retrospective comparative study","volume":"18","author":"Iwata","year":"2017","journal-title":"BMC Muscoskel Disord"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib33","first-page":"19","article-title":"Can three months of teriparatide Be one of treatment options for osteoporotic vertebral compression fracture patients?","volume":"15","author":"Kang","year":"2019","journal-title":"Korean J Nutr"},{"issue":"12","key":"10.1016\/j.jcot.2021.01.019_bib34","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/BOT.0b013e31826f5b9e","article-title":"Prevention of atrophic nonunion by the systemic administration of parathyroid hormone (PTH 1\u201334) in an experimental animal model","volume":"26","author":"Lin","year":"2012","journal-title":"J\u00a0Orthop Trauma"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00590-018-2269-9","article-title":"Therapy of aseptic nonunions with parathyroid hormone","volume":"29","author":"Kastirr","year":"2018","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.jcot.2021.01.019_bib36","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/j.jcot.2019.10.009","article-title":"Teriparatide for treating delayed union and nonunion: a systematic review","volume":"11","author":"Canintika","year":"2020","journal-title":"J\u00a0Clin Orthop Trauma"},{"key":"10.1016\/j.jcot.2021.01.019_bib37","first-page":"11","article-title":"Nonunion of the humeral shaft successfully treated with teriparatide [rh (1-34) PTH]","volume":"2","author":"Oteo-\u00c1lvaro","year":"2013","journal-title":"Case Rep Clin Med"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1302\/0301-620X.93B1.24261","article-title":"The combined effect of parathyroid hormone and bone graft on implant fixation","volume":"93-B","author":"Daugaard","year":"2011","journal-title":"J\u00a0Bone Joint Surg"},{"issue":"4","key":"10.1016\/j.jcot.2021.01.019_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00223-010-9458-9","article-title":"Parathyroid hormone treatment increases fixation of orthopedic implants with gap healing: a biomechanical and histomorphometric canine study of porous coated titanium alloy implants in cancellous bone","volume":"88","author":"Daugaard","year":"2011","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.jcot.2021.01.019_bib40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3109\/17453674.2012.702388","article-title":"Systemic intermittent parathyroid hormone treatment improves osseointegration of press-fit inserted implants in cancellous bone","volume":"83","author":"Daugaard","year":"2012","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jcot.2021.01.019_bib41","series-title":"Teriparatide (Rh [1\u201334] PTH) Improved Osteointegration of a Hemiarthroplasty with Signs of Aseptic Loosening","author":"Oteo-\u00c1lvaro","year":"2011"},{"key":"10.1016\/j.jcot.2021.01.019_bib42","first-page":"7","article-title":"Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: a pilot study","volume":"5","author":"Almirol","year":"2016","journal-title":"J\u00a0Clin Transl Endocrinol"},{"issue":"2","key":"10.1016\/j.jcot.2021.01.019_bib43","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4103\/ortho.IJOrtho_315_17","article-title":"Intermittent parathyroid hormone injection can decrease femoral head collapse in the vascular deprivation of rat femoral head model","volume":"53","author":"Chiang","year":"2019","journal-title":"Indian J Orthop"},{"issue":"5","key":"10.1016\/j.jcot.2021.01.019_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178781","article-title":"PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization","volume":"12","author":"Zhou","year":"2017","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.jcot.2021.01.019_bib45","article-title":"Efficacy of teriparatide in the treatment of nontraumatic osteonecrosis of the femoral head: a retrospective comparative study with alendronate","volume":"18","author":"Arai","year":"2017","journal-title":"BMC Muscoskel Disord"},{"issue":"101","key":"10.1016\/j.jcot.2021.01.019_bib46","doi-asserted-by":"crossref","first-page":"101ra93","DOI":"10.1126\/scitranslmed.3002214","article-title":"Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis","volume":"3","author":"Sampson","year":"2011","journal-title":"Sci Transl Med"}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566221000850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566221000850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:21:35Z","timestamp":1760854895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0976566221000850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":46,"alternative-id":["S0976566221000850"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2021.01.019","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Present and future scope of recombinant parathyroid hormone therapy in orthopaedics","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2021.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Delhi Orthopedic Association. All rights reserved.","name":"copyright","label":"Copyright"}]}}