{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:53:05Z","timestamp":1770040385192,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-cot.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jcot.2022.101949","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T02:08:34Z","timestamp":1657332514000},"page":"101949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Venous thromboembolism prophylaxis with low molecular weight heparin versus unfractionated heparin for patients undergoing operative treatment of closed femoral shaft fractures"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-2023","authenticated-orcid":false,"given":"Nicholas C.","family":"Danford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanket","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-2234","authenticated-orcid":false,"given":"Venkat","family":"Boddapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3421-5363","authenticated-orcid":false,"given":"Justin E.","family":"Hellwinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-868X","authenticated-orcid":false,"given":"Charles M.","family":"Jobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin K.","family":"Greisberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jcot.2022.101949_bib1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1001\/archinte.162.11.1245","article-title":"Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study","volume":"162","author":"Ja","year":"2002","journal-title":"Arch Intern Med"},{"issue":"7","key":"10.1016\/j.jcot.2022.101949_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/bjs.1800780725","article-title":"Autopsy-verified pulmonary embolism in a surgical department: analysis of the period from 1951 to 1988","volume":"78","author":"Lindblad","year":"1991","journal-title":"Br J Surg"},{"issue":"2","key":"10.1016\/j.jcot.2022.101949_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/bjs.1800720211","article-title":"A\u00a030-year survey of pulmonary embolism verified at autopsy: an analysis of 1274 surgical patients","volume":"72","author":"Bergqvist","year":"1985","journal-title":"Br J Surg"},{"issue":"1","key":"10.1016\/j.jcot.2022.101949_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjmed.2004.01.018","article-title":"Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology","volume":"117","author":"Cushman","year":"2004","journal-title":"Am J Med"},{"issue":"1","key":"10.1016\/j.jcot.2022.101949_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.injury.2009.06.010","article-title":"Venous thromboembolism after severe trauma: incidence, risk factors and outcome","volume":"41","author":"T","year":"2010","journal-title":"Injury"},{"issue":"8","key":"10.1016\/j.jcot.2022.101949_bib6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/BOT.0000000000001790","article-title":"The incidence of venous thromboembolism following pelvic and lower extremity trauma despite adherence to modern prophylactic protocols","volume":"34","author":"Ja","year":"2020","journal-title":"J\u00a0Orthop Trauma"},{"issue":"11","key":"10.1016\/j.jcot.2022.101949_bib7","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1097\/CCM.0b013e31825bcb60","article-title":"Venous thromboembolism after trauma: a never event?","volume":"40","author":"Cm","year":"2012","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcot.2022.101949_bib8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00005131-199605000-00002","article-title":"Incidence of deep-vein thrombosis in patients with fractures of the lower extremity distal to the hip","volume":"10","author":"G","year":"1996","journal-title":"J\u00a0Orthop Trauma"},{"issue":"23","key":"10.1016\/j.jcot.2022.101949_bib9","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1097\/BRS.0000000000003664","article-title":"Lower mortality and morbidity with low-molecular-weight heparin for venous thromboembolism prophylaxis in spine trauma","volume":"45","author":"Neifert","year":"2020","journal-title":"Spine"},{"key":"10.1016\/j.jcot.2022.101949_bib10","article-title":"Efficacy and safety of low molecular weight heparin versus unfractionated heparin for prevention of venous thromboembolism in trauma patients: a systematic review and meta-analysis","author":"Tran","year":"2021","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.jcot.2022.101949_bib11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/SLA.0000000000002359","article-title":"Pharmacological thromboembolic prophylaxis in traumatic brain injuries: low molecular weight heparin is superior to unfractionated heparin","volume":"266","author":"Benjamin","year":"2017","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.jcot.2022.101949_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/TA.0000000000001494","article-title":"Unfractionated heparin versus low-molecular-weight heparin for venous thromboembolism prophylaxis in trauma","volume":"83","author":"Jacobs","year":"2017","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"9","key":"10.1016\/j.jcot.2022.101949_bib13","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1001\/jamasurg.2018.0483","article-title":"Practical guide to surgical data sets: national trauma Data Bank (NTDB)","volume":"153","author":"Zg","year":"2018","journal-title":"JAMA Surg"},{"issue":"12","key":"10.1016\/j.jcot.2022.101949_bib14","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0895-4356(96)00271-5","article-title":"Practical considerations on the use of the Charlson comorbidity index with administrative data bases","volume":"49","author":"D'Hoore","year":"1996","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"13","key":"10.1016\/j.jcot.2022.101949_bib15","doi-asserted-by":"crossref","first-page":"E782","DOI":"10.1097\/BRS.0000000000002970","article-title":"Preoperative risk stratification in spine tumor surgery: a comparison of the modified Charlson index, frailty index, and ASA score","volume":"44","author":"Lakomkin","year":"2019","journal-title":"Spine"},{"key":"10.1016\/j.jcot.2022.101949_bib16","series-title":"National Trauma Data Standard","author":"Trauma","year":"2013"},{"key":"10.1016\/j.jcot.2022.101949_bib17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.thromres.2017.10.004","article-title":"Assessment of the coding accuracy of warfarin-related bleeding events","volume":"159","author":"Delate","year":"2017","journal-title":"Thromb Res"},{"issue":"3","key":"10.1016\/j.jcot.2022.101949_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/aje\/kwg115","article-title":"Comparison of logistic regression versus propensity score when the number of events is low and there are multiple confounders","volume":"158","author":"Cepeda","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jcot.2022.101949_bib19","series-title":"Trauma Scoring Systems: A Review","author":"Senkowski","year":"1999"},{"issue":"7","key":"10.1016\/j.jcot.2022.101949_bib20","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/j.injury.2021.04.031","article-title":"Evolution of treatment of femoral shaft fracture in polytrauma: did damage control orthopaedics improve the outcome? A retrospective study","volume":"52","author":"Feldman","year":"2021","journal-title":"Injury"},{"issue":"5","key":"10.1016\/j.jcot.2022.101949_bib21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/TA.0b013e3182701ded","article-title":"Timing of definitive treatment of femoral shaft fractures in patients with multiple injuries: a systematic review of randomized and nonrandomized trials","volume":"73","author":"Nj","year":"2012","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"4","key":"10.1016\/j.jcot.2022.101949_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ocl.2013.06.004","article-title":"The evolution of damage control orthopedics: current evidence and practical applications of early appropriate care","volume":"44","author":"Jc","year":"2013","journal-title":"Orthop Clin N Am"},{"issue":"1","key":"10.1016\/j.jcot.2022.101949_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2106\/JBJS.H.00338","article-title":"Delayed internal fixation of femoral shaft fracture reduces mortality among patients with multisystem trauma","volume":"91","author":"Morshed","year":"2009","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"6","key":"10.1016\/j.jcot.2022.101949_bib24","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1097\/TA.0000000000000230","article-title":"In-hospital mortality from femoral shaft fracture depends on the initial delay to fracture fixation and Injury Severity Score: a retrospective cohort study from the NTDB 2002-2006","volume":"76","author":"Rv","year":"2014","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"1","key":"10.1016\/j.jcot.2022.101949_bib25","first-page":"175","article-title":"Early appropriate care: definitive stabilization of femoral fractures within 24 hours of injury is safe in most patients with multiple injuries","volume":"71","author":"Nahm","year":"2011","journal-title":"J\u00a0Trauma Inj Infect Crit Care"},{"issue":"5","key":"10.1016\/j.jcot.2022.101949_bib26","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/TA.0b013e3182701ded","article-title":"Timing of definitive treatment of femoral shaft fractures in patients with multiple injuries: a systematic review of randomized and nonrandomized trials","volume":"73","author":"Nahm","year":"2012","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"7","key":"10.1016\/j.jcot.2022.101949_bib27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/0003134820934419","article-title":"The impact of anticoagulation on trauma outcomes : an national trauma Data Bank study","volume":"86","author":"Rk","year":"2020","journal-title":"Am Surg"},{"issue":"4","key":"10.1016\/j.jcot.2022.101949_bib29","first-page":"874","article-title":"Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients","volume":"68","author":"D","year":"2010","journal-title":"J\u00a0Trauma"},{"issue":"6","key":"10.1016\/j.jcot.2022.101949_bib30","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1097\/TA.0000000000001193","article-title":"Anti-Xa-guided enoxaparin thromboprophylaxis reduces rate of deep venous thromboembolism in high-risk trauma patients","volume":"81","author":"Singer","year":"2016","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"3","key":"10.1016\/j.jcot.2022.101949_bib31","article-title":"PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients","volume":"11","author":"Rv","year":"2021","journal-title":"BMJ Open"},{"issue":"10","key":"10.1016\/j.jcot.2022.101949_bib32","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1097\/BOT.0000000000000387","article-title":"Venous thromboembolism prophylaxis in orthopaedic trauma patients: a survey of OTA member practice patterns and OTA expert panel recommendations","volume":"29","author":"Hc","year":"2015","journal-title":"J\u00a0Orthop Trauma"}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566222001850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566222001850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:02:21Z","timestamp":1760860941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0976566222001850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":31,"alternative-id":["S0976566222001850"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2022.101949","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venous thromboembolism prophylaxis with low molecular weight heparin versus unfractionated heparin for patients undergoing operative treatment of closed femoral shaft fractures","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2022.101949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022","name":"copyright","label":"Copyright"}],"article-number":"101949"}}