{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:28:56Z","timestamp":1777620536095,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","journal-cot.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jcot.2024.102426","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T18:46:25Z","timestamp":1714502785000},"page":"102426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Role of STIMULAN in chronic osteomyelitis-A randomised blinded study on 95 patients comparing 3 antibiotic compositions, bead quality, forming & absorption time"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-3313","authenticated-orcid":false,"given":"Nishit","family":"Palo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4970-3625","authenticated-orcid":false,"given":"Binayak","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-6576","authenticated-orcid":false,"given":"Mahima","family":"Lakhanpal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-9493","authenticated-orcid":false,"given":"Madhan","family":"Jeyaraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4455-6636","authenticated-orcid":false,"given":"Govind Narayan","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8110-6639","authenticated-orcid":false,"given":"Aditya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcot.2024.102426_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155186","article-title":"Osteomyelitis and non-coding RNAS: a new dimension in disease understanding","volume":"255","author":"Hussain","year":"2024","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.jcot.2024.102426_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s00256-024-04639-x","article-title":"Bacterial osteomyelitis in pediatric patients: a comprehensive review","author":"Restrepo","year":"2024","journal-title":"Skeletal Radiol."},{"issue":"7","key":"10.1016\/j.jcot.2024.102426_bib3","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1302\/0301-620X.100B7.BJJ-2018-0052.R1","article-title":"The value of quantitative histology in the diagnosis of fracture-related infection","volume":"100-B","author":"Morgenstern","year":"2018","journal-title":"Bone Joint Lett J"},{"issue":"11","key":"10.1016\/j.jcot.2024.102426_bib4","article-title":"Wound leakage with the use of calcium sulphate beads in prosthetic joint surgeries: a systematic review","volume":"13","author":"Tarar","year":"2021","journal-title":"Cureus"},{"issue":"Pt 3","key":"10.1016\/j.jcot.2024.102426_bib5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1107\/S1600576723002881","article-title":"Hierarchical synchrotron diffraction and imaging study of the calcium sulfate hemihydrate-gypsum transformation","volume":"56","author":"La Bella","year":"2023","journal-title":"J Appl Crystallogr"},{"issue":"7","key":"10.1016\/j.jcot.2024.102426_bib6","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1128\/AAC.01490-08","article-title":"In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan","volume":"53","author":"Kanellakopoulou","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.jcot.2024.102426_bib7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s002640050252","article-title":"Treatment of chronic osteomyelitis using calcium hydroxyapatite ceramic implants impregnated with antibiotic","volume":"22","author":"Yamashita","year":"1998","journal-title":"Int Orthop"},{"issue":"6","key":"10.1016\/j.jcot.2024.102426_bib8","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/antibiotics12061049","article-title":"Efficacy and safety of antibiotic impregnated microporous nanohydroxyapatite beads for chronic osteomyelitis treatment: a multicenter, open-label, prospective cohort study","volume":"12","author":"Jiamton","year":"2023","journal-title":"Antibiotics"},{"issue":"2","key":"10.1016\/j.jcot.2024.102426_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/BOT.0000000000000454","article-title":"Dead space management after orthopaedic trauma: tips, tricks and pitfalls","volume":"30","author":"Gage","year":"2016","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jcot.2024.102426_bib10","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilm: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jcot.2024.102426_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1302\/0301-620X.86B1.14040","article-title":"Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute","volume":"86","author":"Nilsson","year":"2004","journal-title":"J Bone Jt Surg Br"},{"key":"10.1016\/j.jcot.2024.102426_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00003086-200101000-00008","article-title":"The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial","volume":"382","author":"Kelly","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jcot.2024.102426_bib13","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/0142-9612(95)91048-4","article-title":"Osteoblast adherence and resorption activity of isolated osteoclasts on calcium sulphate hemihydrate","volume":"16","author":"Sidqui","year":"1995","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcot.2024.102426_bib14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jbm.a.30569","article-title":"Biological effects of calcium sulfate as a bone graft substitute in bovine metaphyseal defects","volume":"76","author":"Peters","year":"2006","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jcot.2024.102426_bib15","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00005131-200210000-00002","article-title":"The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial","volume":"16","author":"McKee","year":"2002","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jcot.2024.102426_bib16","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1021\/cr800427g","article-title":"Calcium phosphate-based osteoinductive materials","volume":"108","author":"LeGeros","year":"2008","journal-title":"Chem Rev"},{"key":"10.1016\/j.jcot.2024.102426_bib17","series-title":"Antibiotic Stability in a Synthetic Calcium Sulphate Carrier for Local Delivery in 32nd Annual Meeting of the European Bone and Joint Infection Society","author":"Cooper","year":"2013"},{"key":"10.1016\/j.jcot.2024.102426_bib18","series-title":"ASM Microbe. 2019: San Francisco, USA","article-title":"Determining the efficacy of antibiotic-loaded calcium sulfate beads against pre-formed biofilms: an in vitro study","author":"Delury","year":"2019"},{"issue":"1 Suppl","key":"10.1016\/j.jcot.2024.102426_bib19","first-page":"s131","article-title":"Treatment of benign bone lesions with an injectable calcium sulfate-based bone graft substitute","volume":"27","author":"Kelly","year":"2004","journal-title":"Orthopedics"},{"issue":"10","key":"10.1016\/j.jcot.2024.102426_bib20","article-title":"Comparison of the therapeutic efficacy of antibiotic-loaded polymeric tissue scaffold and bone cement in the regeneration of infected bone tissue","volume":"15","author":"Konya","year":"2023","journal-title":"Cureus"}],"updated-by":[{"DOI":"10.1016\/j.jcot.2025.103312","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000}},{"DOI":"10.1016\/j.jcot.2026.103339","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000}},{"DOI":"10.1016\/j.jcot.2026.103339","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000}},{"DOI":"10.1016\/j.jcot.2025.103312","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000}}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S097656622400095X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S097656622400095X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:16:29Z","timestamp":1718928989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S097656622400095X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":20,"alternative-id":["S097656622400095X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2024.102426","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of STIMULAN in chronic osteomyelitis-A randomised blinded study on 95 patients comparing 3 antibiotic compositions, bead quality, forming & absorption time","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2024.102426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Delhi Orthopedic Association. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102426"}}