{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:55:59Z","timestamp":1784937359594,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","journal-cot.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jcot.2025.102946","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T21:13:18Z","timestamp":1739567598000},"page":"102946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Orthopaedic fracture site and wound healing risk among end-stage renal disease patients undergoing open reduction internal fixation: A database analysis"],"prefix":"10.1016","volume":"63","author":[{"given":"Gabriel","family":"Hanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Tischler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-517X","authenticated-orcid":false,"given":"Paul G.","family":"Mastrokostas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Mesimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-0999","authenticated-orcid":false,"given":"Eli","family":"Bryk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Pipitone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcot.2025.102946_bib1","series-title":"2023 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States","year":"2023"},{"issue":"3","key":"10.1016\/j.jcot.2025.102946_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s40620-016-0284-7","article-title":"Roles of the kidney in the formation, remodeling and repair of bone","volume":"29","author":"Wei","year":"2016","journal-title":"J Nephrol"},{"key":"10.1016\/j.jcot.2025.102946_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3485785","article-title":"Molecular abnormalities underlying bone fragility in chronic kidney disease","volume":"2017","author":"Iwasaki","year":"2017","journal-title":"BioMed Res Int"},{"issue":"6","key":"10.1016\/j.jcot.2025.102946_bib4","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1053\/j.jvca.2017.04.019","article-title":"Perioperative management of patients with end-stage renal disease","volume":"31","author":"Kanda","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"8","key":"10.1016\/j.jcot.2025.102946_bib5","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1681\/ASN.2007010022","article-title":"Fracture risk after parathyroidectomy among chronic hemodialysis patients","volume":"18","author":"Rudser","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"10.1016\/j.jcot.2025.102946_bib6","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1093\/ndt\/gfu055","article-title":"A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan","volume":"29","author":"Maruyama","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1016\/j.jcot.2025.102946_bib7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jbmr.263","article-title":"Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men","volume":"26","author":"Mirza","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"11","key":"10.1016\/j.jcot.2025.102946_bib8","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1002\/jbmr.1985","article-title":"Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) study","volume":"28","author":"Lane","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2369-13-122","article-title":"Applicability of fibroblast growth factor 23 for evaluation of risk of vertebral fracture and chronic kidney disease-mineral bone disease in elderly chronic kidney disease patients","volume":"13","author":"Kanda","year":"2012","journal-title":"BMC Nephrol"},{"issue":"6","key":"10.1016\/j.jcot.2025.102946_bib10","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2215\/CJN.09280915","article-title":"Bone parameters and risk of hip and femur fractures in patients on hemodialysis","volume":"11","author":"Fishbane","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"10.1016\/j.jcot.2025.102946_bib11","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1681\/ASN.2012090916","article-title":"Temporal trends in fracture rates and postdischarge outcomes among hemodialysis patients","volume":"24","author":"Beaubrun","year":"2013","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"10.1016\/j.jcot.2025.102946_bib12","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1681\/ASN.2005111194","article-title":"Relationship between moderate to severe kidney disease and hip fracture in the United States","volume":"17","author":"Nickolas","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"23","key":"10.1016\/j.jcot.2025.102946_bib13","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1001\/jama.288.23.3014","article-title":"Risk of hip fracture among dialysis and renal transplant recipients","volume":"288","author":"Ball","year":"2002","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","article-title":"Increased risk of hip fracture among patients with end-stage renal disease","volume":"58","author":"Alem","year":"2000","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.jcot.2025.102946_bib15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2106\/JBJS.E.01320","article-title":"Analysis of outcomes for surgically treated hip fractures in patients undergoing chronic hemodialysis","volume":"89","author":"Karaeminogullari","year":"2007","journal-title":"J Bone Joint Surg Am"},{"issue":"6","key":"10.1016\/j.jcot.2025.102946_bib16","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00402-020-03490-8","article-title":"End-stage renal disease increases risk of postoperative complications after lower extremity fracture","volume":"141","author":"Endo","year":"2021","journal-title":"Arch Orthop Trauma Surg"},{"issue":"19","key":"10.1016\/j.jcot.2025.102946_bib17","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.2106\/JBJS.19.00203","article-title":"Validated risk-stratification system for prediction of early adverse events following open reduction and internal fixation of closed ankle fractures","volume":"101","author":"Bohl","year":"2019","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib18","first-page":"2","article-title":"Wound healing in patients with impaired kidney function","volume":"5","author":"Maroz","year":"2013","journal-title":"J Am Coll Clin Wound Spec"},{"issue":"3","key":"10.1016\/j.jcot.2025.102946_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1525-1594.2004.47315.x","article-title":"Biochemical and clinical evidence for uremic toxicity","volume":"28","author":"Bour\u00e9","year":"2004","journal-title":"Artif Organs"},{"issue":"9","key":"10.1016\/j.jcot.2025.102946_bib20","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1681\/ASN.2013101062","article-title":"The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review","volume":"25","author":"Vanholder","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.jcot.2025.102946_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9020052","article-title":"p-Cresyl Sulfate","volume":"9","author":"Gryp","year":"2017","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.jcot.2025.102946_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126048","article-title":"Free levels of selected organic solutes and cardiovascular morbidity and mortality in hemodialysis patients: results from the retained organic solutes and clinical outcomes (ROSCO) investigators","volume":"10","author":"Shafi","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-4804(77)90188-3","article-title":"The effect of uremia on wound tensile strength and collagen formation","volume":"23","author":"Kursh","year":"1977","journal-title":"J Surg Res"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF02469015","article-title":"Effects of chronic renal failure on wound healing in rats. II. Microscopic study and hydroxyproline assay","volume":"12","author":"Shindo","year":"1982","journal-title":"Jpn J Surg"},{"issue":"11","key":"10.1016\/j.jcot.2025.102946_bib25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/bjs.1800661113","article-title":"The effect of uraemia upon wound healing: an experimental study","volume":"66","author":"Colin","year":"1979","journal-title":"Br J Surg"},{"key":"10.1016\/j.jcot.2025.102946_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jseint.2022.05.015","article-title":"Renal disease is a risk factor for complications and mortality after open reduction internal fixation of proximal humerus fractures","author":"Ahlquist","year":"2022","journal-title":"JSES Int"},{"issue":"5","key":"10.1016\/j.jcot.2025.102946_bib27","article-title":"Assessing the risk of postoperative complications for proximal humeral fractures treated by open reduction and internal fixation in patients with diabetes and chronic kidney disease","volume":"7","author":"Baker","year":"2023","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s12882-015-0099-0","article-title":"Mortality and complications after hip fracture among elderly patients undergoing hemodialysis","volume":"16","author":"Lin","year":"2015","journal-title":"BMC Nephrol"},{"issue":"11","key":"10.1016\/j.jcot.2025.102946_bib29","article-title":"Rates of infection and revision in patients with renal disease undergoing total knee replacement in Scotland","volume":"92","author":"Mccleery","year":"2010"},{"issue":"9","key":"10.1016\/j.jcot.2025.102946_bib30","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s00198-006-0133-y","article-title":"Impaired muscle strength is associated with fractures in hemodialysis patients","volume":"17","author":"Jamal","year":"2006","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/ndt\/gfr326","article-title":"Incidence, complications and risk factors for severe falls in patients on maintenance haemodialysis","volume":"27","author":"Rossier","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1525-139X.2006.00122a.x","article-title":"Hip fractures in end-stage renal disease patients: incidence, risk factors, and prevention","volume":"19","author":"Leinau","year":"2006","journal-title":"Semin Dial"},{"issue":"11","key":"10.1016\/j.jcot.2025.102946_bib33","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1345\/aph.1G523","article-title":"Doxercalciferol treatment of secondary hyperparathyroidism","volume":"40","author":"Dennis","year":"2006","journal-title":"Ann Pharmacother"},{"issue":"6","key":"10.1016\/j.jcot.2025.102946_bib34","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/jbmr.309","article-title":"Renal osteodystrophy in the first decade of the new millennium: analysis of 630 bone biopsies in black and white patients","volume":"26","author":"Malluche","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12882-020-02224-7","article-title":"A retrospective study of end-stage kidney disease patients on maintenance hemodialysis with renal osteodystrophy-associated fragility fractures","volume":"22","author":"Xie","year":"2021","journal-title":"BMC Nephrol"},{"issue":"1","key":"10.1016\/j.jcot.2025.102946_bib36","article-title":"Characteristics of fracture in patients who firstly starts kidney replacement therapy in Korea: a retrospective population-based study","volume":"12","author":"Kim","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcot.2025.102946_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcot.2022.101940","article-title":"Comparative risk stratification for prediction of early postoperative morbidity and mortality after open fixation of periarticular lower extremity fractures","volume":"31","author":"Xu","year":"2022","journal-title":"J Clin Orthop Trauma"},{"issue":"3","key":"10.1016\/j.jcot.2025.102946_bib38","first-page":"775","article-title":"Surgical infections in patients with chronic renal failure","volume":"15","author":"Cheung","year":"2001","journal-title":"Infect Dis Clin"},{"issue":"3","key":"10.1016\/j.jcot.2025.102946_bib39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1492-7535.2003.00045.x","article-title":"Management of the surgical patient with end-stage renal disease","volume":"7","author":"Friedman","year":"2003","journal-title":"Hemodial Int"},{"issue":"2","key":"10.1016\/j.jcot.2025.102946_bib40","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ocl.2014.11.002","article-title":"Uses of negative pressure wound therapy in orthopedic trauma","volume":"46","author":"Gage","year":"2015","journal-title":"Orthop Clin N Am"},{"key":"10.1016\/j.jcot.2025.102946_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00638","article-title":"Recent advances in the controlled release of growth factors and cytokines for improving cutaneous wound healing","volume":"8","author":"Nurkesh","year":"2020","journal-title":"Front Cell Dev Biol"}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566225000426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566225000426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T10:24:09Z","timestamp":1744367049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0976566225000426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":41,"alternative-id":["S0976566225000426"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2025.102946","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orthopaedic fracture site and wound healing risk among end-stage renal disease patients undergoing open reduction internal fixation: A database analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2025.102946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Delhi Orthopedic Association. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102946"}}