{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:05:14Z","timestamp":1776441914298,"version":"3.51.2"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009396","name":"University Hospital Zurich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-cot.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jcot.2025.103017","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T16:22:48Z","timestamp":1744820568000},"page":"103017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Time-related predictors for adverse events in polytrauma patients undergoing stand-alone definitive surgery"],"prefix":"10.1016","volume":"66","author":[{"given":"Philipp","family":"Vetter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9996-7494","authenticated-orcid":false,"given":"C\u00e9dric","family":"Niggli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hambrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Christoph","family":"Pape","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"Mica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcot.2025.103017_bib1","first-page":"35","article-title":"Gender differences in trauma, shock and sepsis","volume":"5","author":"B\u00f6sch","year":"2018","journal-title":"Mil Med Res"},{"key":"10.1016\/j.jcot.2025.103017_bib2","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1097\/BOT.0000000000001999","article-title":"Definitive surgery is safe in borderline patients who respond to resuscitation","volume":"35","author":"Tan","year":"2021","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jcot.2025.103017_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jcot.2020.10.018","article-title":"Damage control orthopaedics in polytraumatized patients- current concepts","volume":"12","author":"Volpin","year":"2021","journal-title":"J Clin Orthop Trauma"},{"key":"10.1016\/j.jcot.2025.103017_bib4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/BOT.0b013e31829efda1","article-title":"Timing of orthopaedic surgery in multiple trauma patients: development of a protocol for early appropriate care","volume":"27","author":"Vallier","year":"2013","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jcot.2025.103017_bib5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/TA.0000000000000810","article-title":"Failure to clear elevated lactate predicts 24-hour mortality in trauma patients","volume":"79","author":"Dezman","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jcot.2025.103017_bib6","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1213\/ANE.0000000000005252","article-title":"Musculoskeletal trauma in critically injured patients: factors leading to delayed operative fixation and multiple organ failure","volume":"131","author":"Richards","year":"2020","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jcot.2025.103017_bib7","article-title":"The association between serum lactate concentration, base deficit, and mortality in polytrauma patients as a prognostic factor: an observational study","volume":"14","author":"Jyoti","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jcot.2025.103017_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/joacp.joacp_157_21","article-title":"Early total care to early appropriate care - what every anesthesiologist must know","volume":"39","author":"Gupta","year":"2023","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"10.1016\/j.jcot.2025.103017_bib9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/00005373-200011000-00033","article-title":"Damage control:Collective review","volume":"49","author":"Shapiro","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.jcot.2025.103017_bib10","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00068-020-01599-4","article-title":"Strategies for the treatment of femoral fractures in severely injured patients: trends in over two decades from the TraumaRegister DGU","volume":"48","author":"Bl\u00e4sius","year":"2022","journal-title":"Eur J Trauma Emerg Surg"},{"key":"10.1016\/j.jcot.2025.103017_bib11","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.injury.2021.02.091","article-title":"Factors influencing management of bilateral femur fractures: a multicenter retrospective cohort of early versus delayed definitive Fixation","volume":"52","author":"Flagstad","year":"2021","journal-title":"Injury"},{"key":"10.1016\/j.jcot.2025.103017_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care","volume":"14","author":"Baker","year":"1974","journal-title":"J Trauma"},{"key":"10.1016\/j.jcot.2025.103017_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00005373-198801000-00010","article-title":"The injury severity score revisited","volume":"28","author":"Copes","year":"1988","journal-title":"J Trauma"},{"key":"10.1016\/j.jcot.2025.103017_bib14","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","article-title":"Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"20","year":"1992","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcot.2025.103017_bib15","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"International sepsis definitions conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcot.2025.103017_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-64314-8","article-title":"The SIRS criteria have better performance for predicting infection than qSOFA scores in the emergency department","volume":"10","author":"Gando","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcot.2025.103017_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-014-0241-z","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement","volume":"13","author":"Collins","year":"2015","journal-title":"BMC Med"},{"key":"10.1016\/j.jcot.2025.103017_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40560-016-0142-7","article-title":"Prognostic utility of plasma lactate measured between 24 and 48 h after initiation of early goal-directed therapy in the management of sepsis, severe sepsis and septic shock","volume":"12","author":"Chertoff","year":"2016","journal-title":"J Intensive Care"},{"key":"10.1016\/j.jcot.2025.103017_bib19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/TA.0000000000000199","article-title":"Epidemiology and risk factors of multiple-organ failure after multiple trauma: an analysis of 31,154 patients from the TraumaRegister DGU","volume":"76","author":"Fr\u00f6hlich","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jcot.2025.103017_bib20","doi-asserted-by":"crossref","first-page":"618","DOI":"10.26502\/jsr.10020268","article-title":"The role of lactate for sepsis in polytrauma patients, a time related analysis using the IBM watson trauma Pathway Explorer\u00ae","volume":"5","author":"Vetter","year":"2022","journal-title":"J Surg Res"},{"key":"10.1016\/j.jcot.2025.103017_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.26502\/jsr.10020311","article-title":"The time-related role of early pH, base excess and lactate for the development in sepsis in polytrauma patients. An analysis using the IBM Watson Trauma Pathway Explorer","volume":"6","author":"Vetter","year":"2023","journal-title":"J Surg Res"},{"key":"10.1016\/j.jcot.2025.103017_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.injury.2014.12.001","article-title":"Safe definitive orthopaedic surgery (SDS): repeated assessment for tapered application of Early Definitive Care and Damage Control?: an inclusive view of recent advances in polytrauma management","volume":"46","author":"Pape","year":"2015","journal-title":"Injury"},{"key":"10.1016\/j.jcot.2025.103017_bib23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.26502\/jsr.10020358","article-title":"Prothrombin time as a mirror of immunological capability in polytrauma patients, an IBM watson trauma Pathway Explorer\u00a9 analysis and statistical proof of sepsis","volume":"7","author":"Vetter","year":"2024","journal-title":"J Surg Res"},{"key":"10.1016\/j.jcot.2025.103017_bib24","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.3390\/jcm13103017","article-title":"The surgical stress response and anesthesia: a narrative review","volume":"13","author":"Ivascu","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcot.2025.103017_bib25","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3390\/jcm9061760","article-title":"Early spinal injury stabilization in multiple-injured patients: do all patients benefit?","volume":"9","author":"Kobbe","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcot.2025.103017_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/cc2912","article-title":"Clinical review: acid-base abnormalities in the intensive care unit -- part II","volume":"9","author":"Kaplan","year":"2005","journal-title":"Crit Care"}],"updated-by":[{"DOI":"10.1016\/j.jcot.2026.103378","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000}},{"DOI":"10.1016\/j.jcot.2026.103378","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000}}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566225001146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566225001146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T20:15:23Z","timestamp":1750709723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0976566225001146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":26,"alternative-id":["S0976566225001146"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2025.103017","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time-related predictors for adverse events in polytrauma patients undergoing stand-alone definitive surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2025.103017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"103017"}}