{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:29:23Z","timestamp":1771982963102,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-cot.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jcot.2025.103245","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:32:52Z","timestamp":1761355972000},"page":"103245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Oral antibiotics demonstrate superior success and fewer complications compared to parenteral antibiotics for pediatric bone and joint Infections:A systematic review and meta-analysis"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7501-3883","authenticated-orcid":false,"given":"Gabriella","family":"Schreiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Mejia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Fucaloro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Krivicich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Salzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jcot.2025.103245_bib1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/INF.0000000000000686","article-title":"National trends in the incidence, outcomes and charges of pediatric osteoarticular infections, 1997-2012","volume":"34","author":"Stockmann","year":"2015","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.1016\/j.jcot.2025.103245_bib2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ocl.2016.12.007","article-title":"Acute hematogenous osteomyelitis in children: pathogenesis, diagnosis, and treatment","volume":"48","author":"Funk","year":"2017","journal-title":"Orthop Clin N Am"},{"issue":"11","key":"10.1016\/j.jcot.2025.103245_bib3","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1093\/cid\/ciz109","article-title":"Clinical and microbiologic variables predictive of orthopedic complications following Staphylococcus aureus acute hematogenous osteoarticular infections in children","volume":"69","author":"McNeil","year":"2019","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"issue":"1 Suppl","key":"10.1016\/j.jcot.2025.103245_bib4","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1016\/j.otsr.2014.07.029","article-title":"Sequelae of pediatric osteoarticular infection","volume":"101","author":"Ilharreborde","year":"2015","journal-title":"Orthop Traumatol Surg Res OTSR"},{"issue":"13","key":"10.1016\/j.jcot.2025.103245_bib5","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2106\/JBJS.20.01685","article-title":"Children with primary septic arthritis have a markedly lower risk of adverse outcomes than those with contiguous osteomyelitis","volume":"103","author":"Hamilton","year":"2021","journal-title":"J Bone Joint Surg Am"},{"issue":"4","key":"10.1016\/j.jcot.2025.103245_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1258\/004947507782332775","article-title":"For how long should antibiotics be given in acute paediatric septic arthritis? A prospective audit of 96 cases","volume":"37","author":"Lavy","year":"2007","journal-title":"Trop Doct"},{"issue":"5","key":"10.1016\/j.jcot.2025.103245_bib7","first-page":"400","article-title":"Risks and complications of prolonged parenteral antibiotic treatment in children with acute osteoarticular infections","volume":"69","author":"Ceroni","year":"2003","journal-title":"Acta Orthop Belg"},{"issue":"5","key":"10.1016\/j.jcot.2025.103245_bib8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1302\/0301-620X.94B5.28523","article-title":"Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature","volume":"94","author":"Dartnell","year":"2012","journal-title":"J Bone Joint Surg Br"},{"issue":"10","key":"10.1016\/j.jcot.2025.103245_bib9","first-page":"1792","article-title":"Outpatients with acute osteoarticular infections had favourable outcomes when they received just oral antibiotics without intravenous antibiotics","volume":"107","author":"Alcobendas","year":"2018","journal-title":"Acta Paediatr Oslo Nor 1992"},{"issue":"2","key":"10.1016\/j.jcot.2025.103245_bib10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1542\/peds.2008-0596","article-title":"Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children","volume":"123","author":"Zaoutis","year":"2009","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.jcot.2025.103245_bib11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/PEC.0000000000000725","article-title":"Oral ambulatory treatment of acute osteomyelitis in children: a case-control study","volume":"32","author":"Roul-Levy","year":"2016","journal-title":"Pediatr Emerg Care"},{"issue":"1","key":"10.1016\/j.jcot.2025.103245_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst Rev"},{"issue":"1","key":"10.1016\/j.jcot.2025.103245_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13643-017-0644-y","article-title":"Optimal database combinations for literature searches in systematic reviews: a prospective exploratory study","volume":"6","author":"Bramer","year":"2017","journal-title":"Syst Rev"},{"issue":"11","key":"10.1016\/j.jcot.2025.103245_bib14","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/ajhp\/zxaa036","volume":"77","author":"Rybak","year":"2020","journal-title":"Am J Health Syst Pharm"},{"issue":"4","key":"10.1016\/j.jcot.2025.103245_bib15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijantimicag.2018.12.014","article-title":"The dosing and monitoring of vancomycin: what is the best way forward?","volume":"53","author":"Drennan","year":"2019","journal-title":"Int J Antimicrob Agents"},{"issue":"11","key":"10.1016\/j.jcot.2025.103245_bib16","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"Suppl 1","key":"10.1016\/j.jcot.2025.103245_bib17","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.4103\/sja.SJA_559_18","article-title":"The CONSORT statement","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J Anaesth"},{"issue":"9","key":"10.1016\/j.jcot.2025.103245_bib18","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","article-title":"Methodological index for non-randomized studies (minors): development and validation of a new instrument","volume":"73","author":"Slim","year":"2003","journal-title":"ANZ J Surg"},{"issue":"1","key":"10.1016\/j.jcot.2025.103245_bib19","article-title":"Coefficient of agreement for nominal scales","volume":"20","author":"Cohen","year":"1960","journal-title":"Sage Journals"},{"issue":"2","key":"10.1016\/j.jcot.2025.103245_bib20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1001\/jamapediatrics.2014.2822","article-title":"Comparative effectiveness of intravenous vs oral antibiotics for postdischarge treatment of acute osteomyelitis in children","volume":"169","author":"Keren","year":"2015","journal-title":"JAMA Pediatr"},{"issue":"9","key":"10.1016\/j.jcot.2025.103245_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S2352-4642(24)00133-0","article-title":"Oral versus intravenous empirical antibiotics in children and adolescents with uncomplicated bone and joint infections: a nationwide, randomised, controlled, non-inferiority trial in Denmark","volume":"8","author":"Nielsen","year":"2024","journal-title":"Lancet Child Adolesc Health"},{"issue":"1","key":"10.1016\/j.jcot.2025.103245_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s40121-024-01074-2","article-title":"Association of antibiotic route and outcomes in children with methicillin-resistant Staphylococcus aureus Bacteremic osteomyelitis","volume":"14","author":"Olson","year":"2025","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.jcot.2025.103245_bib23","series-title":"Duration of Intravenous Antibiotic Therapy for Children with Acute Osteomyelitis or Septic Arthritis: A Feasibility Study","article-title":"Scientific summary","author":"Graaf","year":"2017"},{"key":"10.1016\/j.jcot.2025.103245_bib24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jpeds.2021.09.057","article-title":"Microbiology and treatment outcomes of community-acquired hematogenous osteoarticular infections in infants \u226412 months of Age","volume":"241","author":"Diamond","year":"2022","journal-title":"J Pediatr"},{"issue":"11","key":"10.1016\/j.jcot.2025.103245_bib25","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1111\/apa.16510","article-title":"Simplified antibiotic treatment for paediatric osteoarticular infections achieved good outcomes","volume":"111","author":"Ossurarson","year":"1992","journal-title":"Acta Paediatr Oslo Nor"},{"key":"10.1016\/j.jcot.2025.103245_bib26","first-page":"208","article-title":"Intravenous versus oral outpatient antibiotic therapy for pediatric acute osteomyelitis","volume":"33","author":"Liu","year":"2013","journal-title":"Iowa Orthop J"},{"issue":"11","key":"10.1016\/j.jcot.2025.103245_bib27","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1177\/0009922810374210","article-title":"Complications associated with outpatient parenteral antibiotic therapy in children","volume":"49","author":"Le","year":"2010","journal-title":"Clin Pediatr"},{"issue":"6","key":"10.1016\/j.jcot.2025.103245_bib28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/INF.0b013e318193ef38","article-title":"The high rate of adverse drug events in children receiving prolonged outpatient parenteral antibiotic therapy for osteomyelitis","volume":"28","author":"Faden","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.1016\/j.jcot.2025.103245_bib29","first-page":"425","article-title":"Bone and joint infections","volume":"60","author":"P\u00e4\u00e4kk\u00f6nen","year":"2013","journal-title":"Pediatr Clin"},{"issue":"5","key":"10.1016\/j.jcot.2025.103245_bib30","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/CORR.0000000000001607","article-title":"Low reinfection rates but a high rate of complications in THA for infection sequelae in childhood: a systematic review","volume":"479","author":"D'Apolito","year":"2021","journal-title":"Clin Orthop"},{"issue":"10","key":"10.1016\/j.jcot.2025.103245_bib31","doi-asserted-by":"crossref","first-page":"923","DOI":"10.5301\/ijao.5000168","article-title":"Epidemiology and new developments in the diagnosis of prosthetic joint infection","volume":"35","author":"Corvec","year":"2012","journal-title":"Int J Artif Organs"},{"issue":"9","key":"10.1016\/j.jcot.2025.103245_bib32","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1530\/EOR-23-0078","article-title":"Mortality, patient-reported outcome measures, and the health economic burden of prosthetic joint infection","volume":"8","author":"Xu","year":"2023","journal-title":"EFORT Open Rev"},{"issue":"5","key":"10.1016\/j.jcot.2025.103245_bib33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/INF.0b013e31824657dd","article-title":"Management of osteoarticular infections caused by Staphylococcus aureus is similar to that of other etiologies: analysis of 199 staphylococcal bone and joint infections","volume":"31","author":"P\u00e4\u00e4kk\u00f6nen","year":"2012","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"10.1016\/j.jcot.2025.103245_bib34","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/01241398-200207000-00017","article-title":"Outpatient parenteral antimicrobial therapy in osteoarticular infections in children","volume":"22","author":"Maraqa","year":"2002","journal-title":"J Pediatr Orthop"},{"issue":"5","key":"10.1016\/j.jcot.2025.103245_bib35","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00006454-200105000-00015","article-title":"Complications of outpatient parenteral antibiotic therapy in childhood","volume":"20","author":"Gomez","year":"2001","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"10.1016\/j.jcot.2025.103245_bib36","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1542\/peds.2005-1465","article-title":"Complications of central venous catheters used for the treatment of acute hematogenous osteomyelitis","volume":"117","author":"Ruebner","year":"2006","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.jcot.2025.103245_bib37","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/PEC.0b013e31821dc9b6","article-title":"Peripherally inserted central catheters","volume":"27","author":"Bourgeois","year":"2011","journal-title":"Pediatr Emerg Care"},{"issue":"1","key":"10.1016\/j.jcot.2025.103245_bib38","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/BPO.0000000000000237","article-title":"Pediatric osteoarticular infection update","volume":"35","author":"Montgomery","year":"2015","journal-title":"J Pediatr Orthop"},{"key":"10.1016\/j.jcot.2025.103245_bib39","doi-asserted-by":"crossref","DOI":"10.1007\/s00256-024-04639-x","article-title":"Bacterial osteomyelitis in pediatric patients: a comprehensive review","author":"Restrepo","year":"2024","journal-title":"Skelet Radiol"},{"key":"10.1016\/j.jcot.2025.103245_bib40","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jpeds.2021.03.028","article-title":"Clinical epidemiology and outcomes of pediatric musculoskeletal infections","volume":"234","author":"Yi","year":"2021","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcot.2025.103245_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jpeds.2017.11.025","article-title":"The contemporary bacteriologic epidemiology of osteoarticular infections in children in Switzerland","volume":"194","author":"Juchler","year":"2018","journal-title":"J Pediatr"},{"issue":"4","key":"10.1016\/j.jcot.2025.103245_bib42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/004947559502500406","article-title":"Salmonella septic arthritis in Zambian children","volume":"25","author":"Lavy","year":"1995","journal-title":"Trop Doct"}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566225003431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566225003431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T22:09:52Z","timestamp":1764626992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0976566225003431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":42,"alternative-id":["S0976566225003431"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2025.103245","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral antibiotics demonstrate superior success and fewer complications compared to parenteral antibiotics for pediatric bone and joint Infections:A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2025.103245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Delhi Orthopedic Association. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103245"}}