{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:45:10Z","timestamp":1791819910686,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-cot.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Orthopaedics and Trauma"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jcot.2026.103539","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:37:20Z","timestamp":1781678240000},"page":"103539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Guideline-concordant cefazolin prophylaxis in penicillin allergy labeled arthroplasty patients: Progress and persistent barriers"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7793-1474","authenticated-orcid":false,"given":"Chiara Anna","family":"Giordani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-3336","authenticated-orcid":false,"given":"David","family":"Dallas-Orr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8312-415X","authenticated-orcid":false,"given":"Francesca Anna","family":"Giordani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-8539","authenticated-orcid":false,"given":"Zachary C.","family":"Lum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Meehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-3361","authenticated-orcid":false,"given":"Mauro","family":"Giordani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcot.2026.103539_bib1","author":"Alsarraj"},{"issue":"5","key":"10.1016\/j.jcot.2026.103539_bib2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/jor.24293","article-title":"International Consensus meeting on musculoskeletal infection: research priorities from the general assembly questions","volume":"37","author":"Schwarz","year":"2018","journal-title":"J Orthop Res"},{"issue":"6_Supple_B","key":"10.1016\/j.jcot.2026.103539_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1302\/0301-620X.101B6.BJJ-2018-1407.R1","article-title":"John Charnley Award: increased risk of prosthetic joint infection following primary total knee and hip arthroplasty with the use of alternative antibiotics to cefazolin: the value of allergy testing for antibiotic prophylaxis","volume":"101-B","author":"Wyles","year":"2019","journal-title":"Bone Jt J"},{"key":"10.1016\/j.jcot.2026.103539_bib4","series-title":"StatPearls","article-title":"Penicillin allergy","author":"Patterson","year":"2024"},{"issue":"18","key":"10.1016\/j.jcot.2026.103539_bib5","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1001\/archinte.160.18.2819","article-title":"The incidence of antimicrobial allergies in hospitalized patients: implications regarding prescribing patterns and emerging bacterial resistance","volume":"160","author":"Lee","year":"2000","journal-title":"Arch Intern Med"},{"issue":"2","key":"10.1016\/j.jcot.2026.103539_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/pharmacy7020069","article-title":"Strategies for clarifying penicillin allergies when skin testing is not an option","volume":"7","author":"Covington E","year":"2019","journal-title":"Pharmacy"},{"issue":"2","key":"10.1016\/j.jcot.2026.103539_bib7","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.5435\/JAAOS-D-22-00122","article-title":"Documented penicillin allergies should not preclude use of preoperative Cefazolin in hip and knee arthroplasty","volume":"31","author":"Kurcz","year":"2023","journal-title":"J Am Acad Orthop Surg"},{"issue":"5","key":"10.1016\/j.jcot.2026.103539_bib8","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jpedsurg.2014.10.048","article-title":"Penicillin allergy and surgical prophylaxis: cephalosporin cross-reactivity risk in a pediatric tertiary care center","volume":"50","author":"Beltran","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"8","key":"10.1016\/j.jcot.2026.103539_bib9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0952-8180(01)00329-4","article-title":"Cephalosporins can be given to penicillin-allergic patients who do not exhibit an anaphylactic response","volume":"13","author":"Goodman","year":"2001","journal-title":"J Clin Anesth"},{"issue":"9, Supplement","key":"10.1016\/j.jcot.2026.103539_bib10","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/j.arth.2017.01.012","article-title":"Screening for beta-lactam allergy in joint arthroplasty patients to improve surgical prophylaxis practice","volume":"32","author":"McDanel","year":"2017","journal-title":"J Arthroplast"},{"issue":"1","key":"10.1016\/j.jcot.2026.103539_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jaip.2020.07.056","article-title":"Testing strategies and predictors for evaluating immediate and delayed reactions to cephalosporins","volume":"9","author":"Stone","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.jcot.2026.103539_bib12","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5435\/JAAOS-D-21-00422","article-title":"Understanding penicillin allergy, cross-reactivity, and antibiotic selection in the preoperative setting","volume":"30","author":"Sarfani","year":"2022","journal-title":"JAAOS - Journal of the American Academy of Orthopaedic Surgeons"},{"issue":"24","key":"10.1016\/j.jcot.2026.103539_bib13","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.2106\/JBJS.21.00027","article-title":"A simple algorithmic approach allows the safe use of cephalosporin in \u201cPenicillin-Allergic\u201d patients without the need for allergy testing","volume":"103","author":"Goh","year":"2021","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jcot.2026.103539_bib14","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM196601272740401","article-title":"Coombs-Positive hemolytic anemia caused by Penicillin administration","author":"Petz","year":"1966","journal-title":"N Engl J Med"},{"issue":"Suppl","key":"10.1016\/j.jcot.2026.103539_bib15","first-page":"64","article-title":"Immunologic reactions of humans to cephalosporins","volume":"47","author":"Petz","year":"1971","journal-title":"Postgrad Med J"},{"issue":"suppl_3","key":"10.1016\/j.jcot.2026.103539_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jac\/1.suppl_3.107","article-title":"Penicillin allergy and the cephalosporins","volume":"1","author":"Dash","year":"1975","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jcot.2026.103539_bib17","series-title":"Ten Percent of Patients who are Allergic to Penicillin will Have Serious Reactions if Exposed to Cephalosporins - Proquest","author":"Herbert","year":"2000"},{"issue":"5","key":"10.1016\/j.jcot.2026.103539_bib18","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.jaip.2018.01.020","article-title":"Cross-Reactivity and tolerability of cephalosporins in patients with IgE-Mediated hypersensitivity to penicillins","volume":"6","author":"Romano","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"6","key":"10.1016\/j.jcot.2026.103539_bib19","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1067\/mai.2000.111147","article-title":"Immediate allergic reactions to cephalosporins: Cross-reactivity and selective responses","volume":"106","author":"Romano","year":"2000","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.jcot.2026.103539_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/all.13848","article-title":"The challenge of de-labeling penicillin allergy","volume":"75","author":"Stone","year":"2020","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.jcot.2026.103539_bib21","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jemermed.2011.05.035","article-title":"The use of cephalosporins in penicillin-allergic patients: a literature review","volume":"42","author":"Campagna","year":"2012","journal-title":"J Emerg Med"},{"issue":"5","key":"10.1016\/j.jcot.2026.103539_bib22","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.3928\/01477447-20190604-03","article-title":"Despite the safety of preoperative Cefazolin for patients with non-anaphylactic penicillin allergy, 20% of practitioners avoid its use","volume":"42","author":"Pettett","year":"2019","journal-title":"Orthopedics"},{"issue":"2","key":"10.1016\/j.jcot.2026.103539_bib23","article-title":"Penicillin allergies: referral and management practices of anesthesiologists","volume":"10","author":"Jain","year":"2014","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.1016\/j.jcot.2026.103539_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/jama.2017.6510","article-title":"Penicillin allergy is not necessarily forever","volume":"318","author":"Trubiano","year":"2017","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jcot.2026.103539_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3390\/antibiotics13020157","article-title":"Management of Penicillin Allergy in the perioperative setting","volume":"13","author":"Sexton","year":"2024","journal-title":"Antibiotics (Basel)"},{"issue":"7","key":"10.1016\/j.jcot.2026.103539_bib26","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1097\/CORR.0000000000001739","article-title":"Antibiotic stewardship interventions improve choice of antibiotic prophylaxis in total joint arthroplasty in patients with reported Penicillin allergies","volume":"479","author":"Jones","year":"2021","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"10.1016\/j.jcot.2026.103539_bib27","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.arth.2020.08.045","article-title":"Preoperative allergy testing for patients reporting penicillin and cephalosporin allergies is cost-effective in preventing infection after total knee and hip arthroplasty","volume":"36","author":"Pagani","year":"2021","journal-title":"J Arthroplast"}],"container-title":["Journal of Clinical Orthopaedics and Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566226002079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0976566226002079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:46:16Z","timestamp":1791816376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0976566226002079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":27,"alternative-id":["S0976566226002079"],"URL":"https:\/\/doi.org\/10.1016\/j.jcot.2026.103539","relation":{},"ISSN":["0976-5662"],"issn-type":[{"value":"0976-5662","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guideline-concordant cefazolin prophylaxis in penicillin allergy labeled arthroplasty patients: Progress and persistent barriers","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Orthopaedics and Trauma","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcot.2026.103539","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"103539"}}