{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:20:26Z","timestamp":1771654826249,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Comparative Pathology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.jcpa.2005.06.011","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T19:00:46Z","timestamp":1137697246000},"page":"56-62","source":"Crossref","is-referenced-by-count":40,"title":["Cytokine and Toll-like Receptor mRNAs in the Nasal-associated Lymphoid Tissues of Cattle During Foot-and-mouth Disease Virus Infection"],"prefix":"10.1016","volume":"134","author":[{"given":"Z.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.B.","family":"Bashiruddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Doel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Horsington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Alexandersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcpa.2005.06.011_bib2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0021-9975(03)00045-8","article-title":"Studies of quantitative parameters of virus excretion and transmission in pigs and cattle experimentally infected with foot-and-mouth disease virus","volume":"129","author":"Alexandersen","year":"2003","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1286-4579(02)01634-9","article-title":"Aspects of the persistence of foot-and-mouth disease virus in animals\u2014the carrier problem","volume":"4","author":"Alexandersen","year":"2002","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.jcpa.2005.06.011_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9975(03)00041-0","article-title":"The pathogenesis and diagnosis of foot-and-mouth disease","volume":"129","author":"Alexandersen","year":"2003","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1128\/JCM.33.1.79-84.1995","article-title":"Detection of foot-and-mouth disease virus-infected cattle by assessment of antibody response in oropharyngeal fluids","volume":"33","author":"Archetti","year":"1995","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib5","first-page":"69","article-title":"Foot-and-mouth disease and the African buffalo (Syncerus caffer). 1. Carriers as a source of infection for cattle","volume":"53","author":"Bengis","year":"1986","journal-title":"Onderstepoort Journal of Veterinary Research"},{"key":"10.1016\/j.jcpa.2005.06.011_bib6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1189\/jlb.0203082","article-title":"How we detect microbes and respond to them: the Toll-like receptors and their transducers","volume":"74","author":"Beutler","year":"2003","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1099\/0022-1317-80-3-663","article-title":"Demonstration of bovine CD8+ T-cell responses to foot-and-mouth disease virus","volume":"80","author":"Childerstone","year":"1999","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib8","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1128\/JVI.75.12.5498-5503.2001","article-title":"Inhibition of L-deleted foot-and-mouth disease virus replication by alpha\/beta interferon involves double-stranded RNA-dependent protein kinase","volume":"75","author":"Chinsangaram","year":"2001","journal-title":"Journal of Virology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib9","doi-asserted-by":"crossref","first-page":"9891","DOI":"10.1128\/JVI.73.12.9891-9898.1999","article-title":"Ability of foot-and-mouth disease virus to form plaques in cell culture is associated with suppression of alpha\/beta interferon","volume":"73","author":"Chinsangaram","year":"1999","journal-title":"Journal of Virology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/vr.134.10.230","article-title":"Natural transmission of foot-and-mouth disease virus from African buffalo (Syncerus caffer) to cattle in a wildlife area of Zimbabwe","volume":"134","author":"Dawe","year":"1994","journal-title":"Veterinary Record"},{"key":"10.1016\/j.jcpa.2005.06.011_bib11","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.4049\/jimmunol.170.7.3565","article-title":"Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4","volume":"170","author":"Doyle","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virol.2004.01.033","article-title":"Does Toll-like receptor 3 play a biological role in virus infections?","volume":"322","author":"Edelmann","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1084\/jem.20021652","article-title":"The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense","volume":"197","author":"Harte","year":"2003","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.jcpa.2005.06.011_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/clin.1996.4291","article-title":"Membrane tumor necrosis factor-alpha (TNF-alpha) expressed on HTLV-I-infected T cells mediates a costimulatory signal for B cell activation\u2014characterization of membrane TNF-alpha","volume":"82","author":"Higuchi","year":"1997","journal-title":"Clinical Immunology and Immunopathology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1017\/S0950268896007376","article-title":"Dexamethasone inhibits virus production and the secretory IgA response in oesophageal-pharyngeal fluid in cattle persistently infected with foot-and-mouth disease virus","volume":"118","author":"Ilott","year":"1997","journal-title":"Epidemiology and Infection"},{"key":"10.1016\/j.jcpa.2005.06.011_bib16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jcpa.2005.06.011_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0301-472X(02)00787-7","article-title":"Quantitative assessment of gene expression in highly purified hematopoietic cells using real-time reverse transcriptase polymerase chain reaction","volume":"30","author":"Raaijmakers","year":"2002","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0007-1935(05)80168-X","article-title":"The carrier state in foot and mouth disease\u2014an immunological review","volume":"149","author":"Salt","year":"1993","journal-title":"British Veterinary Journal"},{"key":"10.1016\/j.jcpa.2005.06.011_bib19","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/1981228a0","article-title":"Multiplication, interferon production and sensitivity of virulent and attenuated strains of the virus of foot-and-mouth disease","volume":"198","author":"Sellers","year":"1963","journal-title":"Nature"},{"key":"10.1016\/j.jcpa.2005.06.011_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF01242110","article-title":"Interference between modified and virulent strains of foot-and-mouth disease virus","volume":"23","author":"Sellers","year":"1968","journal-title":"Archiv Gesamte Virusforsch"},{"key":"10.1016\/j.jcpa.2005.06.011_bib21","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/2101079a0","article-title":"Growth of foot-and mouth disease virus in monolayer cultures of calf thyroid cells","volume":"210","author":"Snowdon","year":"1966","journal-title":"Nature"},{"key":"10.1016\/j.jcpa.2005.06.011_bib22","doi-asserted-by":"crossref","first-page":"8426","DOI":"10.1128\/JVI.77.15.8426-8439.2003","article-title":"Role of alpha\/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins","volume":"77","author":"Valarcher","year":"2003","journal-title":"Journal of Virology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/10428199409051650","article-title":"TNF receptors in chronic lymphocytic leukemia","volume":"13","author":"Waage","year":"1994","journal-title":"Leukemia & Lymphoma"},{"key":"10.1016\/j.jcpa.2005.06.011_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/jcpa.2000.0431","article-title":"The localization of persistent foot and mouth disease virus in the epithelial cells of the soft palate and pharynx","volume":"124","author":"Zhang","year":"2001","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib25","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s00705-002-0867-6","article-title":"The effects of gamma interferon on replication of foot-and-mouth disease virus in persistently infected bovine cells","volume":"147","author":"Zhang","year":"2002","journal-title":"Archives of Virology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib26","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1099\/vir.0.80011-0","article-title":"Quantitative analysis of foot-and-mouth disease virus RNA loads in bovine tissues: implications for the site of viral persistence","volume":"85","author":"Zhang","year":"2004","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2005.06.011_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1099\/vir.0.19538-0","article-title":"Extent of reduction of foot-and-mouth disease virus RNA load in oesophageal-pharyngeal fluid after peak levels may be a critical determinant of virus persistence in infected cattle","volume":"85","author":"Zhang","year":"2004","journal-title":"Journal of General Virology"}],"container-title":["Journal of Comparative Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997505000794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997505000794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T05:35:13Z","timestamp":1586669713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021997505000794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0021997505000794"],"URL":"https:\/\/doi.org\/10.1016\/j.jcpa.2005.06.011","relation":{},"ISSN":["0021-9975"],"issn-type":[{"value":"0021-9975","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}