{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:33:05Z","timestamp":1770215585397,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Comparative Pathology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.jcpa.2007.01.006","type":"journal-article","created":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T06:51:22Z","timestamp":1174373482000},"page":"133-144","source":"Crossref","is-referenced-by-count":27,"title":["Vaccination of Porcine Circovirus type 2 (PCV2)-infected Sows against Porcine Parvovirus (PPV) and Erysipelas: Effect on Post-weaning Multisystemic Wasting Syndrome (PMWS) and on PCV2 Genome Load in the Offspring"],"prefix":"10.1016","volume":"136","author":[{"given":"N.","family":"Rose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cariolet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Grasland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Amenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Oger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Balasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jestin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Madec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcpa.2007.01.006_bib1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1053\/jcpa.2001.0508","article-title":"An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets","volume":"125","author":"Albina","year":"2001","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/104063870001200102","article-title":"Porcine circoviruses: a review","volume":"12","author":"Allan","year":"2000","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.jcpa.2007.01.006_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/jcpa.1998.0295","article-title":"Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus","volume":"121","author":"Allan","year":"1999","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib4","unstructured":"Allan, G. M., McNeilly, F., McNair, I., Meehan, B. M., Marshall, M., Ellis, J. A., Lasagna, C., Boriosi, G., Krakowka, S. J., Reynaud, G., Boeuf-Tedeschi, L., Bublot, M. and Charreyre, C. (2002). Passive transfer of maternal antibodies to PCV2 protects against development of PMWS: experimental infections and a field study. Pig Journal, 50, 59\u201367."},{"key":"10.1016\/j.jcpa.2007.01.006_bib5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/104063870301500607","article-title":"Reproduction of postweaning multisystemic wasting syndrome in pigs experimentally inoculated with a Swedish porcine circovirus 2 isolate","volume":"15","author":"Allan","year":"2003","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.jcpa.2007.01.006_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/jcpa.1999.0310","article-title":"Experimental inoculation of conventional pigs with tissue homogenates from pigs with post-weaning multisystemic wasting syndrome","volume":"121","author":"Balasch","year":"1999","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1191\/0962280202sm293ra","article-title":"Repeated measures with zeros","volume":"11","author":"Berk","year":"2002","journal-title":"Statistical Methods in Medical Research"},{"key":"10.1016\/j.jcpa.2007.01.006_bib8","first-page":"327","article-title":"Quantification du g\u00e9nome du circovirus porcin de type 2 (PCV2) par PCR en temps r\u00e9el et corr\u00e9lation avec la maladie de l\u2019amaigrissement du porcelet (MAP)","volume":"36","author":"Blanchard","year":"2004","journal-title":"Les Journ\u00e9es de la Recherche Porcine"},{"key":"10.1016\/j.jcpa.2007.01.006_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-1135(03)00131-7","article-title":"An ORF2 protein-based ELISA for porcine circovirus type 2 (PCV2) antibodies in post-weaning multisystemic wasting syndrome (PMWS)","volume":"94","author":"Blanchard","year":"2003","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib10","unstructured":"Calsamiglia, M., Segales, J., Fraile, L., Espinal, A., Seminati, C., Martin, M., Mateu, E. and Domingo, M. (2004). Sow effect on litter mortality in a swine integration system experiencing postweaning multisystemic wasting syndrome (PMWS). In: Proceedings of the 18th International Pig Veterinary Society Congress, Hamburg, Germany, p. 78."},{"key":"10.1016\/j.jcpa.2007.01.006_bib11","first-page":"317","article-title":"Etude de diff\u00e9rentes modalit\u00e9s d\u2019inoculation du circovirus porcin de type 2 (PCV2) \u00e0 des truies EOPS","volume":"34","author":"Cariolet","year":"2002","journal-title":"Les Journ\u00e9es de la Recherche Porcine"},{"key":"10.1016\/j.jcpa.2007.01.006_bib12","unstructured":"Cariolet, R., Le Diguerher, G., Ecobichon, P., Julou, P., Jolly, J. P. and Madec, F. (2004). Production of long term, low-cost specific pathogen free pigs. In: Proceedings of the Symposium of the International Society for Animal Hygiene, Saint-Malo, France, p. 149."},{"key":"10.1016\/j.jcpa.2007.01.006_bib13","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0264-410X(94)90229-1","article-title":"Experimental quantification of vaccine-induced reduction in virus transmission","volume":"12","author":"De Jong","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/j.jcpa.2007.01.006_bib14","first-page":"108","article-title":"Isolation and characterization of porcine circovirus type-2 from sera of stillborn fetuses","volume":"67","author":"Farnham","year":"2003","journal-title":"Canadian Journal of Veterinary Research"},{"key":"10.1016\/j.jcpa.2007.01.006_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1051\/vetres:2005024","article-title":"Reproduction of PMWS in immunostimulated SPF piglets transfected with infectious cloned genomic DNA of type 2 porcine circovirus","volume":"36","author":"Grasland","year":"2005","journal-title":"Veterinary Research"},{"key":"10.1016\/j.jcpa.2007.01.006_bib16","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1354\/vp.38-5-528","article-title":"Experimental reproduction of severe disease in CD\/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus","volume":"38","author":"Harms","year":"2001","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2307\/1390807","article-title":"R: a language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"Journal of Computational Graphical Statistics"},{"key":"10.1016\/j.jcpa.2007.01.006_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1053\/jcpa.1999.0337","article-title":"Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus","volume":"122","author":"Kennedy","year":"2000","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib19","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1292\/jvms.65.741","article-title":"Simultaneous detection and differentiation between porcine circovirus and porcine parvovirus in boar semen by multiplex seminested polymerase chain reaction","volume":"65","author":"Kim","year":"2003","journal-title":"Journal of Veterinary Medical Science"},{"key":"10.1016\/j.jcpa.2007.01.006_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/vr.155.16.489","article-title":"Prevalence of porcine circovirus type 2 in aborted fetuses and stillborn piglets","volume":"155","author":"Kim","year":"2004","journal-title":"Veterinary Record"},{"key":"10.1016\/j.jcpa.2007.01.006_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1354\/vp.38-1-31","article-title":"Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2)","volume":"38","author":"Krakowka","year":"2001","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1354\/vp.37-3-254","article-title":"Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus","volume":"37","author":"Krakowka","year":"2000","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib23","unstructured":"Kroese, A. H. and De Jong, M. C. (2001). Design and analysis of transmission experiment. In: Proceedings of the Annual Meeting of the Society for Veterinary Epidemiology and Preventive Medicine, Noordwijkerhout, The Netherlands, pp. 21\u201337."},{"key":"10.1016\/j.jcpa.2007.01.006_bib24","first-page":"4629","article-title":"PCR detection and evidence of shedding of porcine circovirus type 2 in boar semen","volume":"38","author":"Larochelle","year":"2000","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib25","unstructured":"Le Tallec, B., Pozzi, N., Blanchard, P., Mah\u00e9, D., Jestin, A. and Gu\u00e9rin, B. (2001). Longitudinal study of boars naturally infected by PCV2. In: Proceedings of \u201cssDNA Viruses of Plants, Birds, Pigs and Primates\u201d, Saint-Malo, France, September 24\u201327, p. 120."},{"key":"10.1016\/j.jcpa.2007.01.006_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.prevetmed.2004.11.015","article-title":"An exploratory study on risk factors for postweaning multisystemic wasting syndrome (PMWS) in Spain","volume":"69","author":"Lopez-Soria","year":"2005","journal-title":"Preventive Veterinary Medicine"},{"key":"10.1016\/j.jcpa.2007.01.006_bib27","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1053\/jcpa.2000.0413","article-title":"Experimental transmission of porcine circovirus type 2 (PCV2) in weaned pigs: a sequential study","volume":"123","author":"Magar","year":"2000","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib28","unstructured":"McIntosh, K. A., Harding, J. C. S., Ellis, J. A. and Appleyard, G. D. (2005). Nested PCR detection and duration of porcine circovirus type 2 in semen collected from naturally infected boars. In: Proceedings of the International Conference on Animal Circoviruses and Associated Diseases, Belfast, September, 11\u201313, p. 93."},{"key":"10.1016\/j.jcpa.2007.01.006_bib29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s007050170152","article-title":"Isolation and characterization of porcine circovirus 2 from cases of sow abortion and porcine dermatitis and nephropathy syndrome","volume":"146","author":"Meehan","year":"2001","journal-title":"Archives of Virology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/104063870301500204","article-title":"Experimental reproduction of postweaning multisystemic wasting syndrome in caesarean-derived, colostrum-deprived piglets inoculated with porcine circovirus type 2 (PCV2): investigation of quantitative PCV2 distribution and antibody responses","volume":"15","author":"Okuda","year":"2003","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.jcpa.2007.01.006_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jcpa.2004.09.003","article-title":"Birth abnormalities in pregnant sows infected intranasally with porcine circovirus 2","volume":"132","author":"Park","year":"2005","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.vetmic.2003.10.011","article-title":"Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection","volume":"98","author":"Pensaert","year":"2004","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.livprodsci.2004.12.020","article-title":"Effect of the Pietrain breed used as terminal boar on post-weaning multisystemic wasting syndrome (PMWS) in the offspring in four PMWS-affected farms","volume":"95","author":"Rose","year":"2005","journal-title":"Livestock Production Science"},{"key":"10.1016\/j.jcpa.2007.01.006_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.prevetmed.2003.07.003","article-title":"Risk factors for porcine post-weaning multisystemic wasting syndrome (PMWS) in 149 French farrow-to-finish herds","volume":"61","author":"Rose","year":"2003","journal-title":"Preventive Veterinary Medicine"},{"key":"10.1016\/j.jcpa.2007.01.006_bib35","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1128\/JVI.76.7.3232-3239.2002","article-title":"Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2","volume":"76","author":"Rovira","year":"2002","journal-title":"Journal of Virology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0378-1135(03)00120-2","article-title":"Change of porcine circovirus 2 target cells in pigs during development from fetal to early postnatal life","volume":"95","author":"Sanchez","year":"2003","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-1135(01)00425-4","article-title":"Porcine circovirus 2 infection in swine foetuses inoculated at different stages of gestation","volume":"83","author":"Sanchez","year":"2001","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.jcpa.2007.01.006_bib38","series-title":"SAS\/STAT User's Guide","year":"2000"},{"key":"10.1016\/j.jcpa.2007.01.006_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/01652176.2002.9695132","article-title":"Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review","volume":"24","author":"Segales","year":"2002","journal-title":"Veterinary Quarterly"},{"key":"10.1016\/j.jcpa.2007.01.006_bib40","first-page":"133","article-title":"Update on porcine circovirus and post-weaning multisystemic wasting syndrome (PMWS)","volume":"8","author":"Sorden","year":"2000","journal-title":"Swine Health and Production"},{"key":"10.1016\/j.jcpa.2007.01.006_bib41","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/104063879901100608","article-title":"Myocarditis and abortion associated with intrauterine infection of sows with porcine circovirus 2","volume":"11","author":"West","year":"1999","journal-title":"Journal of Veterinary Diagnostic Investigation"}],"container-title":["Journal of Comparative Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997507000072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997507000072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T13:51:16Z","timestamp":1546955476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021997507000072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":41,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0021997507000072"],"URL":"https:\/\/doi.org\/10.1016\/j.jcpa.2007.01.006","relation":{},"ISSN":["0021-9975"],"issn-type":[{"value":"0021-9975","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}