{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:50:29Z","timestamp":1777463429095,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Comparative Pathology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.jcpa.2007.03.003","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T14:49:32Z","timestamp":1177944572000},"page":"30-40","source":"Crossref","is-referenced-by-count":26,"title":["Expression of Vascular Endothelial Growth Factor and its Receptors in Canine Lymphoma"],"prefix":"10.1016","volume":"137","author":[{"given":"B.","family":"Wolfesberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Guija de Arespacohaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Willmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Gerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Schwendenwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kleiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Egerbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Thalhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Muellauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Skalicky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcpa.2007.03.003_bib1","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1182\/blood.V87.8.3336.bloodjournal8783336","article-title":"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1","volume":"87","author":"Barleon","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jcpa.2007.03.003_bib2","first-page":"728","article-title":"Expression of vascular endothelial growth factor and its receptor in hematopoietic malignancies","volume":"59","author":"Bellamy","year":"1999","journal-title":"Cancer Research"},{"key":"10.1016\/j.jcpa.2007.03.003_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1091\/mbc.3.2.211","article-title":"Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors","volume":"3","author":"Berse","year":"1992","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.jcpa.2007.03.003_bib4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jcpa.2007.03.003_bib5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0046-8177(95)90119-1","article-title":"Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer","volume":"26","author":"Brown","year":"1995","journal-title":"Human Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1582-4934.2005.tb00379.x","article-title":"Angiogenetic and cell survival functions of vascular endothelial growth factor (VEGF)","volume":"9","author":"Byrne","year":"2005","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.jcpa.2007.03.003_bib7","first-page":"154","article-title":"The cytology, histology and prevalence of cell types in canine lymphoma classified according to the National Cancer Institute Working Formulation","volume":"50","author":"Carter","year":"1986","journal-title":"Canadian Journal of Veterinary Research"},{"key":"10.1016\/j.jcpa.2007.03.003_bib8","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1172\/JCI114322","article-title":"Tumor vesicular permeability factor stimulates endothelial cell growth and angiogenesis","volume":"84","author":"Connolly","year":"1989","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.jcpa.2007.03.003_bib9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/path.1151","article-title":"Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin-Reed-Sternberg cells in Hodgkin's disease","volume":"197","author":"Doussis-Anagnostopoulou","year":"2002","journal-title":"Journal of Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/bjc.1977.89","article-title":"Effect of X-irradiation on host-cell infiltration and growth of a murine fibrosarcoma","volume":"35","author":"Evans","year":"1977","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.jcpa.2007.03.003_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jcpa.2007.03.003_bib12","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nature Medicine"},{"key":"10.1016\/j.jcpa.2007.03.003_bib13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1210\/edrv-13-1-18","article-title":"Molecular and biological properties of the vascular endothelial growth factor family of proteins","volume":"13","author":"Ferrara","year":"1992","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.jcpa.2007.03.003_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/(SICI)1096-9896(199709)183:1<44::AID-PATH1103>3.0.CO;2-I","article-title":"Expression of vascular endothelial growth factor in lymphomas and Castleman's disease","volume":"183","author":"Foss","year":"1997","journal-title":"Journal of Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib15","first-page":"4140","article-title":"Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis","volume":"55","author":"Freeman","year":"1995","journal-title":"Cancer Research"},{"key":"10.1016\/j.jcpa.2007.03.003_bib16","first-page":"859","article-title":"Expression of vascular endothelial growth factor and its receptor mRNA in angiosarcoma","volume":"73","author":"Hashimoto","year":"1995","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.jcpa.2007.03.003_bib17","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1080\/1042819031000123519","article-title":"Prognostic significance of microvessel density and vascular endothelial growth factor (VEGF) expression in non-Hodgkin's lymphoma","volume":"44","author":"Hazar","year":"2003","journal-title":"Leukemia and Lymphoma"},{"key":"10.1016\/j.jcpa.2007.03.003_bib18","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1073\/pnas.95.16.9349","article-title":"Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice","volume":"95","author":"Hiratsuka","year":"1998","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jcpa.2007.03.003_bib19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00129039-200212000-00005","article-title":"Immunohistochemical expression of basic fibroblast growth factor, vascular endothelial growth factor and their receptors in stage IV Non-Hodgkin lymphoma","volume":"10","author":"Ho","year":"2002","journal-title":"Applied Immunohistochemistry and Molecular Morphology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/adpa.2003.50000","article-title":"Immunohistochemical expression of angiogenic cytokines and their receptors in reactive benign lymph nodes and non-Hodgkin lymphoma","volume":"7","author":"Ho","year":"2003","journal-title":"Annals of Diagnostic Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib21","first-page":"891","article-title":"Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber","volume":"42","author":"Ide","year":"1939","journal-title":"American Journal of Roentgenology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib22","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1440-1827.1995.tb03387.x","article-title":"Expression of vascular permeability factor (VPF\/VEGF) messenger RNA by plasma cells: possible involvement in the development of edema in chronic inflammation","volume":"45","author":"Ito","year":"1995","journal-title":"Pathology International"},{"key":"10.1016\/j.jcpa.2007.03.003_bib23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2141.2005.05695.x","article-title":"Accelerated lymphangiogenesis in malignant lymphoma: possible role of VEGF-A and VEGF-C","volume":"130","author":"Kadowaki","year":"2005","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib24","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/362841a0","article-title":"Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo","volume":"362","author":"Kim","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jcpa.2007.03.003_bib25","first-page":"1033","article-title":"Differential expression of vascular endothelial growth factors and their receptors in multiple myeloma","volume":"91","author":"Kimlinger","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.jcpa.2007.03.003_bib26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jcpa.2007.03.003_bib27","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen","volume":"246","author":"Leung","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jcpa.2007.03.003_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/jcpa.2000.0404","article-title":"Expression of vascular endothelial growth factor in basal cell tumours and in squamous cell carcinomas of canine skin","volume":"123","author":"Maiolino","year":"2000","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib29","first-page":"1054","article-title":"In vitro release of vascular endothelial growth factor during platelet aggregation","volume":"275","author":"Maloney","year":"1998","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib30","series-title":"Tumors of Domestic Animals","first-page":"150","article-title":"Tumors of lymphoid and hematopoietic tissue","author":"Moulton","year":"1990"},{"key":"10.1016\/j.jcpa.2007.03.003_bib31","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to FLK-1\/KDR","volume":"269","author":"Park","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jcpa.2007.03.003_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2559.2005.02081.x","article-title":"The expression and cellular localization of phosphorylated VEGFR2 in lymphoma and non-neoplastic lymphadenopathy: an immunohistochemical study","volume":"46","author":"Pillai","year":"2005","journal-title":"Histopathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib33","first-page":"2899","article-title":"Immunohistochemical detection of c-kit (CD117) and vascular endothelial growth factor (VEGF) overexpression in mantle cell lymphoma","volume":"22","author":"Potti","year":"2002","journal-title":"Anticancer Research"},{"key":"10.1016\/j.jcpa.2007.03.003_bib34","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1073\/pnas.90.16.7533","article-title":"Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium","volume":"90","author":"Quinn","year":"1993","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jcpa.2007.03.003_bib35","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2741\/1839","article-title":"VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy","volume":"11","author":"Rahimi","year":"2006","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.jcpa.2007.03.003_bib36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1053\/jcpa.2002.0630","article-title":"Evaluation of angiogenesis in canine seminomas by quantitative immunohistochemistry","volume":"128","author":"Restucci","year":"2003","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib37","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1354\/vp.39-4-488","article-title":"Expression of vascular endothelial growth factor in canine mammary tumors","volume":"39","author":"Restucci","year":"2002","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib38","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1515\/BC.1999.187","article-title":"Vascular endothelial growth factor (VEGF) and its receptors in tumor-bearing dogs","volume":"380","author":"Scheidegger","year":"1999","journal-title":"Biological Chemistry"},{"key":"10.1016\/j.jcpa.2007.03.003_bib39","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid","volume":"219","author":"Senger","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.jcpa.2007.03.003_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2559.2003.01644.x","article-title":"The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study","volume":"43","author":"Stewart","year":"2003","journal-title":"Histopathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1096-9896(1998110)186:3<313::AID-PATH188>3.0.CO;2-X","article-title":"Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1","volume":"186","author":"Turley","year":"1998","journal-title":"Journal of Pathology"},{"key":"10.1016\/j.jcpa.2007.03.003_bib42","doi-asserted-by":"crossref","first-page":"26988","DOI":"10.1016\/S0021-9258(18)47116-5","article-title":"Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor","volume":"269","author":"Waltenberger","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jcpa.2007.03.003_bib43","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/labinvest.3700145","article-title":"Vascular endothelial growth factor-A is expressed both on lymphoma cells and endothelial cells in angioimmunoblastic T-cell lymphoma and related to lymphoma progression","volume":"84","author":"Zhao","year":"2004","journal-title":"Laboratory Investigation"}],"container-title":["Journal of Comparative Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997507000321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997507000321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:21:56Z","timestamp":1628814116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021997507000321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0021997507000321"],"URL":"https:\/\/doi.org\/10.1016\/j.jcpa.2007.03.003","relation":{},"ISSN":["0021-9975"],"issn-type":[{"value":"0021-9975","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}