{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:36:12Z","timestamp":1778200572572,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Comparative Pathology"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.jcpa.2009.11.004","type":"journal-article","created":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T09:08:32Z","timestamp":1262336912000},"page":"284-290","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of Synaptophysin as an Immunohistochemical Marker for Equine Grass Sickness"],"prefix":"10.1016","volume":"142","author":[{"given":"B.E.","family":"Waggett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.C.","family":"McGorum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.S.","family":"Pirie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"MacIntyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Wernery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.M.","family":"Milne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcpa.2009.11.004_bib1","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1021\/bi602396x","article-title":"Association of botulinum neurotoxin serotypes A and B with synaptic vesicle protein complexes","volume":"46","author":"Baldwin","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.jcpa.2009.11.004_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.39.6.827","article-title":"An histological study of the central nervous system in experimental botulinum poisoning","volume":"39","author":"Cowdry","year":"1924","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.jcpa.2009.11.004_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF01839331","article-title":"The equine enteric nervous system\u00a0\u2013 neuron characterization and distribution in adults and juveniles","volume":"19","author":"Doxey","year":"1995","journal-title":"Veterinary Research Communications"},{"key":"10.1016\/j.jcpa.2009.11.004_bib4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0034-5288(92)90093-H","article-title":"Clinical equine dysautonomia and autonomic neuron damage","volume":"53","author":"Doxey","year":"1992","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.jcpa.2009.11.004_bib5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.2042-3306.1991.tb03739.x","article-title":"A comparative study of normal equine populations and those with grass sickness (dysautonomia) in eastern Scotland","volume":"23","author":"Doxey","year":"1991","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.jcpa.2009.11.004_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0021-9975(89)90080-7","article-title":"Histological examination of the central nervous system in diagnosis of botulism","volume":"101","author":"France","year":"1989","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2009.11.004_bib7","first-page":"1","article-title":"Grass sickness in horses: a review of present knowledge of the disease, with particular reference to the nature of the causal agent","volume":"54","author":"Greig","year":"1942","journal-title":"Transactions of the Highland and Agricultural Society of Scotland"},{"key":"10.1016\/j.jcpa.2009.11.004_bib8","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.2042-3306.1993.tb02988.x","article-title":"Immunocytochemical and lectin histochemical study of neuronal lesions in autonomic ganglia of horses\u00a0with grass sickness","volume":"25","author":"Griffiths","year":"1993","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.jcpa.2009.11.004_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcpa.2004.07.002","article-title":"Synaptophysin: an immunohistochemical marker for animal dysautonomias","volume":"132","author":"Hilbe","year":"2005","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2009.11.004_bib10","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2746\/042516401776563418","article-title":"Systemic antibodies to Clostridium botulinum type C: do they protect horses from grass sickness (dysautonomia)?","volume":"33","author":"Hunter","year":"2001","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.jcpa.2009.11.004_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.2042-3306.1999.tb03857.x","article-title":"The association of Clostridium botulinum type C with equine grass sickness: a toxicoinfection?","volume":"31","author":"Hunter","year":"1999","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.jcpa.2009.11.004_bib12","doi-asserted-by":"crossref","first-page":"29391","DOI":"10.1074\/jbc.M602740200","article-title":"Neurotropic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons","volume":"281","author":"Jiang","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jcpa.2009.11.004_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1023\/A:1005998505369","article-title":"Light microscopy of the enteric nervous systems of horses with and without equine dysautonomia (grass sickness): its correlation with motor effects of physostigmine","volume":"21","author":"Murray","year":"1997","journal-title":"Veterinary Research Communications"},{"key":"10.1016\/j.jcpa.2009.11.004_bib14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0368-1742(55)80034-3","article-title":"Studies on grass sickness. The morphological picture with special reference to the vegetative nervous system","volume":"65","author":"Obel","year":"1955","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2009.11.004_bib15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1439-0442.1954.tb00039.x","article-title":"Haemorrhagic encephalomyelitis due to botulism in cattle in Turkey","volume":"1","author":"Pamukcu","year":"1954","journal-title":"Zentralblatt fur Veterinarmedizin"},{"key":"10.1016\/j.jcpa.2009.11.004_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0021-9975(92)90003-D","article-title":"Autonomic neuron degeneration in equine dysautonomia (grass sickness)","volume":"107","author":"Pogson","year":"1992","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2009.11.004_bib17","first-page":"S33","article-title":"Synaptophysin in the nervous system and endocrine cells","volume":"42","author":"Redecker","year":"1992","journal-title":"Acta Histochemica"},{"key":"10.1016\/j.jcpa.2009.11.004_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2004.02472.x","article-title":"The synaptophysin\/synaptobrevin complex dissociates independently of neuroexocytosis","volume":"90","author":"Reisinger","year":"2004","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.jcpa.2009.11.004_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/vr.133.1.7","article-title":"Diagnosis of grass sickness by ileal biopsy","volume":"133","author":"Scholes","year":"1993","journal-title":"Veterinary Record"},{"key":"10.1016\/j.jcpa.2009.11.004_bib20","first-page":"65","article-title":"Grass sickness in horses","volume":"36","author":"Tocher","year":"1924","journal-title":"Transactions of the Royal Highland Agricultural Society"},{"key":"10.1016\/j.jcpa.2009.11.004_bib21","article-title":"Grass sickness investigation report","volume":"3","author":"Tocher","year":"1923","journal-title":"Veterinary Record"},{"key":"10.1016\/j.jcpa.2009.11.004_bib22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/bies.20012","article-title":"Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis?","volume":"26","author":"Valtorta","year":"2004","journal-title":"BioEssays"},{"key":"10.1016\/j.jcpa.2009.11.004_bib23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3109\/02841869109092398","article-title":"Synaptophysin. A widespread constituent of small neuroendocrine vesicles and a new tool in tumour diagnosis","volume":"30","author":"Wiedenmann","year":"1991","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.jcpa.2009.11.004_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1090-0233(98)80055-5","article-title":"A case\u2013control study of grass sickness (equine dysautonomia) in the United Kingdom","volume":"156","author":"Wood","year":"1998","journal-title":"Veterinary Journal"}],"container-title":["Journal of Comparative Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997509003673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997509003673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T06:52:26Z","timestamp":1544770346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021997509003673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0021997509003673"],"URL":"https:\/\/doi.org\/10.1016\/j.jcpa.2009.11.004","relation":{},"ISSN":["0021-9975"],"issn-type":[{"value":"0021-9975","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}