{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:04:06Z","timestamp":1762866246779},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Comparative Pathology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.jcpa.2013.06.006","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T23:30:18Z","timestamp":1379028618000},"page":"47-56","source":"Crossref","is-referenced-by-count":9,"title":["Identical Pathogenesis and Neuropathological Phenotype of Scrapie in Valine, Arginine, Glutamine\/Valine, Arginine, Glutamine Sheep Infected Experimentally by the Oral and Conjunctival Routes"],"prefix":"10.1016","volume":"150","author":[{"given":"L.","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Pitarch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Thurston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ac\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jeffrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcpa.2013.06.006_bib1","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1099\/0022-1317-81-12-3115","article-title":"Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie","volume":"81","author":"Andr\u00e9oletti","year":"2000","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib2","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1128\/JVI.76.11.5759-5768.2002","article-title":"Retrograde transport of transmissible mink encephalopathy within descending motor tracts","volume":"76","author":"Bartz","year":"2002","journal-title":"Journal of Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/JVI.77.1.583-591.2003","article-title":"Rapid prion neuroinvasion following tongue infection","volume":"77","author":"Bartz","year":"2003","journal-title":"Journal of Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/NEN.0b013e3181db2497","article-title":"Ovine PrP genotype is linked with lesion profile and immunohistochemistry patterns after primary transmission of classical scrapie to wild-type mice","volume":"69","author":"Beck","year":"2010","journal-title":"Journal of Neuropathology and Experimental Neurobiology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib5","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1099\/0022-1317-77-10-2669","article-title":"PrP genotype contributes to determining survival times of sheep with natural scrapie","volume":"77","author":"Bossers","year":"1996","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.vetimm.2013.01.005","article-title":"Pathogenesis of scrapie in ARQ\/ARQ sheep after subcutaneous infection: effect of lymphadenectomy and immune cell subset changes in relation to prion protein accumulation","volume":"152","author":"Chianini","year":"2013","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/295149a0","article-title":"Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway","volume":"295","author":"Fraser","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.jcpa.2013.06.006_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1099\/vir.0.034652-0","article-title":"Factors influencing temporal variation of scrapie incidence within a closed Suffolk sheep flock","volume":"93","author":"Gonz\u00e1lez","year":"2012","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1297-9716-43-55","article-title":"Susceptibility to scrapie and disease phenotype in sheep: cross-PRNP genotype experimental transmissions with natural sources","volume":"43","author":"Gonz\u00e1lez","year":"2012","journal-title":"Veterinary Research"},{"key":"10.1016\/j.jcpa.2013.06.006_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/jcpa.2001.0516","article-title":"Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie","volume":"126","author":"Gonz\u00e1lez","year":"2002","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1051\/vetres\/2010020","article-title":"Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions","volume":"41","author":"Gonz\u00e1lez","year":"2010","journal-title":"Veterinary Research"},{"key":"10.1016\/j.jcpa.2013.06.006_bib11","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1099\/vir.0.80299-0","article-title":"Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep","volume":"86","author":"Gonz\u00e1lez","year":"2005","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib13","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1099\/vir.0.022574-0","article-title":"Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe","volume":"91","author":"Gonz\u00e1lez","year":"2010","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib14","first-page":"63","article-title":"Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculation","volume":"72","author":"Hamir","year":"2008","journal-title":"Canadian Journal of Veterinary Research"},{"key":"10.1016\/j.jcpa.2013.06.006_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1354\/vp.45-1-7","article-title":"Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep","volume":"45","author":"Hamir","year":"2008","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.prevetmed.2004.06.002","article-title":"A paired case\u2013control study of risk factors for scrapie in Irish sheep flocks","volume":"64","author":"Healy","year":"2004","journal-title":"Preventive Veterinary Medicine"},{"key":"10.1016\/j.jcpa.2013.06.006_bib17","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1099\/vir.0.18874-0","article-title":"Disease-associated PrP in the enteric nervous system of scrapie affected Suffolk sheep","volume":"84","author":"Heggeb\u00f8","year":"2003","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib18","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1099\/0022-1317-81-9-2327","article-title":"Distribution of prion protein in the ileal Peyer's patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent","volume":"81","author":"Heggebo","year":"2000","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib19","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1099\/0022-1317-83-5-1247","article-title":"New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP\/1)","volume":"83","author":"Houston","year":"2002","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib20","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1182\/blood-2008-04-152520","article-title":"Prion diseases are efficiently transmitted by blood transfusion in sheep","volume":"112","author":"Houston","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jcpa.2013.06.006_bib21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1053\/jcpa.2002.0592","article-title":"Occurrence and distribution of infection-specific PrP in tissues of clinical scrapie cases and cull sheep from scrapie-affected farms in Shetland","volume":"127","author":"Jeffrey","year":"2002","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/path.1962","article-title":"Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep","volume":"209","author":"Jeffrey","year":"2006","journal-title":"Journal of Pathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1053\/jcpa.2001.0476","article-title":"Onset and distribution of tissue PrP accumulation in scrapie-affected Suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies","volume":"125","author":"Jeffrey","year":"2001","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1746-6148-4-14","article-title":"Evidence of scrapie transmission via milk","volume":"4","author":"Konold","year":"2008","journal-title":"BMC Veterinary Research"},{"key":"10.1016\/j.jcpa.2013.06.006_bib25","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1099\/vir.0.82218-0","article-title":"Dynamics and genetics of PrPSc placental accumulation in sheep","volume":"88","author":"Lacroux","year":"2007","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jcpa.2003.10.008","article-title":"Distribution of vascular amyloid in scrapie-affected sheep with different genotypes","volume":"131","author":"Ligios","year":"2004","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib27","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.addr.2003.09.008","article-title":"Involvement of gut-associated lymphoid tissue of ruminants in the spread of transmissible spongiform encephalopathies","volume":"56","author":"Press","year":"2004","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.jcpa.2013.06.006_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1746-6148-5-9","article-title":"Accumulation and dissemination of prion protein in experimental sheep scrapie in the natural host","volume":"5","author":"Ryder","year":"2009","journal-title":"BMC Veterinary Research"},{"key":"10.1016\/j.jcpa.2013.06.006_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/747892","article-title":"Neuroinvasion in prion diseases: the roles of ascending neural infection and blood dissemination","volume":"2010","author":"Sis\u00f3","year":"2010","journal-title":"Interdisciplinary Perspectives on Infectious Diseases"},{"key":"10.1016\/j.jcpa.2013.06.006_bib29","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2990.2008.00978.x","article-title":"Neuroinvasion in sheep transmissible spongiform encephalopathies: the role of the haematogenous route","volume":"35","author":"Sis\u00f3","year":"2009","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jcpa.2009.12.003","article-title":"Characterization of strains of ovine transmissible spongiform encephalopathy with a short PrPd profiling method","volume":"142","author":"Sis\u00f3","year":"2010","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2990.2009.01013.x","article-title":"Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the BSE agent","volume":"35","author":"Sis\u00f3","year":"2009","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib33","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2990.2007.00800.x","article-title":"Immunohistochemistry for PrPSc in natural scrapie reveals patterns which are associated with the PrP genotype","volume":"33","author":"Spiropoulos","year":"2007","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib34","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1099\/vir.0.021311-0","article-title":"Relevance of oral experimental challenge with classical scrapie in sheep","volume":"91","author":"Tabouret","year":"2010","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib35","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/JCM.34.5.1228-1231.1996","article-title":"Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie","volume":"34","author":"van Keulen","year":"1996","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1053\/jcpa.1998.0300","article-title":"Scrapie-associated prion-protein in the gastro-intestinal tract of sheep with natural scrapie","volume":"121","author":"van Keulen","year":"1999","journal-title":"Journal of Comparative Pathology"},{"issue":"Suppl.","key":"10.1016\/j.jcpa.2013.06.006_bib37","first-page":"57","article-title":"Pathogenesis of natural scrapie in sheep","volume":"16","author":"van Keulen","year":"2000","journal-title":"Archives of Virology"},{"key":"10.1016\/j.jcpa.2013.06.006_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1034\/j.1600-0463.2002.100104.x","article-title":"Early and late pathogenesis of natural scrapie infection in sheep","volume":"110","author":"van Keulen","year":"2002","journal-title":"Acta Pathologica, Microbiologica et Immunologica Scandinavica"}],"container-title":["Journal of Comparative Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997513001084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997513001084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T23:55:20Z","timestamp":1596498920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021997513001084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0021997513001084"],"URL":"https:\/\/doi.org\/10.1016\/j.jcpa.2013.06.006","relation":{},"ISSN":["0021-9975"],"issn-type":[{"value":"0021-9975","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}