{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:45:01Z","timestamp":1777038301579,"version":"3.51.4"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Comparative Pathology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jcpa.2024.08.003","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T07:11:34Z","timestamp":1726297894000},"page":"10-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease)"],"prefix":"10.1016","volume":"215","author":[{"given":"John","family":"Finnie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1038-9884","authenticated-orcid":false,"given":"Kim","family":"Hemsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Manavis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Beard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Brealey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6152-5511","authenticated-orcid":false,"given":"Thomas","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Blumbergs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcpa.2024.08.003_bib1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.79830","article-title":"Neuroinflammation in neuronopathic Gaucher disease: role of microglia and NK cells, biomarkers, and response to substrate reduction therapy","volume":"11","author":"Boddupalli","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jcpa.2024.08.003_bib2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81890","article-title":"Microglia orchestrate neuroinflammation","volume":"11","author":"Feldman","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jcpa.2024.08.003_bib3","series-title":"Greenfield's neuropathology","first-page":"458","article-title":"Lysosomal diseases","author":"Walkley","year":"2015"},{"issue":"3","key":"10.1016\/j.jcpa.2024.08.003_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/030098587301000302","article-title":"Neurovisceral glucocerebroside storage (Gaucher's disease) in a dog","volume":"10","author":"Hartley","year":"1973","journal-title":"Vet Pathol"},{"issue":"1","key":"10.1016\/j.jcpa.2024.08.003_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10545-010-9230-3","article-title":"Gaucher disease in sheep","volume":"34","author":"Karageorgos","year":"2011","journal-title":"J\u00a0Inherit Metab Dis"},{"key":"10.1016\/j.jcpa.2024.08.003_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.nbd.2016.03.011","article-title":"Glycosphingolipid analysis in naturally occurring model of acute neuronopathic Gaucher disease","volume":"91","author":"Karageorgos","year":"2016","journal-title":"Neurobiol Dis"},{"issue":"4","key":"10.1016\/j.jcpa.2024.08.003_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166658","article-title":"The ovine type II Gaucher disease model recapitulates aspects of human brain disease","volume":"1869","author":"Winner","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"6","key":"10.1016\/j.jcpa.2024.08.003_bib8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1242\/dmm.008185","article-title":"Animal models for Gaucher disease research","volume":"4","author":"Farfel-Becker","year":"2011","journal-title":"Dis Model Mech"},{"issue":"1","key":"10.1016\/j.jcpa.2024.08.003_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(98)00040-0","article-title":"Microglia-specific localisation of a novel calcium-binding protein, Iba1","volume":"57","author":"Ito","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.jcpa.2024.08.003_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neuroscience.2015.06.038","article-title":"TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects","volume":"302","author":"Probert","year":"2015","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.jcpa.2024.08.003_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.immuni.2023.01.008","article-title":"Direct activation of microglia by \u03b2-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease","volume":"56","author":"Shimizu","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.jcpa.2024.08.003_bib12","series-title":"Greenfield's neuropathology","first-page":"1","article-title":"General pathology of the central nervous system","author":"Vinters","year":"2015"},{"issue":"6","key":"10.1016\/j.jcpa.2024.08.003_bib13","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10571-020-00790-w","article-title":"Silencing the cytoskeleton protein Iba1 (ionized calcium binding adaptor molecule 1) interferes with BV2 microglia functioning","volume":"40","author":"Gheorghe","year":"2020","journal-title":"Cell Mol Neurobiol"},{"issue":"11","key":"10.1016\/j.jcpa.2024.08.003_bib14","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jcpa.2024.08.003_bib15","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/brain\/aws095","article-title":"Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease","volume":"135","author":"Vitner","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.jcpa.2024.08.003_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.944883","article-title":"A\u00a0multifaceted evaluation of microgliosis and differential cellular dysregulation of mammalian target of rapamycin signalling in neuronopathic Gaucher disease","volume":"15","author":"Zhang","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.jcpa.2024.08.003_bib17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12974-021-02272-2","article-title":"Inhibition of microglial \u03b2-glucocerebrosidase hampers microglial-mediated antioxidant and protective response in neurons","volume":"18","author":"Brunialti","year":"2021","journal-title":"J\u00a0Neuroinflammation"}],"container-title":["Journal of Comparative Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997524002962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021997524002962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T03:15:08Z","timestamp":1733368508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021997524002962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":17,"alternative-id":["S0021997524002962"],"URL":"https:\/\/doi.org\/10.1016\/j.jcpa.2024.08.003","relation":{},"ISSN":["0021-9975"],"issn-type":[{"value":"0021-9975","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease)","name":"articletitle","label":"Article Title"},{"value":"Journal of Comparative Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcpa.2024.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 University of Adelaide. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}