{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T11:17:44Z","timestamp":1768043864005,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.jcrc.2009.07.005","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T16:36:56Z","timestamp":1253896616000},"page":"363.e1-363.e7","source":"Crossref","is-referenced-by-count":19,"title":["Acetaminophen has limited antipyretic activity in critically ill patients"],"prefix":"10.1016","volume":"25","author":[{"given":"Rachel S.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hegang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Hasday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2009.07.005_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1001\/jama.273.2.117","article-title":"The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study","volume":"273","author":"Rangel-Frausto","year":"1995","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jcrc.2009.07.005_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1286-4579(00)01337-X","article-title":"The role of fever in the infected host","volume":"2","author":"Hasday","year":"2000","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jcrc.2009.07.005_bib3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/01.STR.31.2.410","article-title":"Effects of poststroke pyrexia on stroke outcome: a meta-analysis of studies in patients","volume":"31","author":"Hajat","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.jcrc.2009.07.005_bib4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1089\/08977150260190456","article-title":"Early indicators of prognosis in 846 cases of severe traumatic brain injury","volume":"19","author":"Jiang","year":"2002","journal-title":"J Neurotrauma"},{"issue":"13","key":"10.1016\/j.jcrc.2009.07.005_bib5","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1056\/NEJM199703273361303","article-title":"The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group","volume":"336","author":"Bernard","year":"1997","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jcrc.2009.07.005_bib6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/sur.2005.6.369","article-title":"The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study","volume":"6","author":"Schulman","year":"2005","journal-title":"Surg Infect (Larchmt)"},{"issue":"5-2017","key":"10.1016\/j.jcrc.2009.07.005_bib7","first-page":"162","article-title":"Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicity","volume":"200","author":"Hasday","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcrc.2009.07.005_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1152\/jappl.2001.90.1.90","article-title":"Exposure to febrile temperature modifies endothelial cell response to tumor necrosis factor-\u03b1","volume":"90","author":"Hasday","year":"2001","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jcrc.2009.07.005_bib9","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.4049\/jimmunol.174.6.3676","article-title":"Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia","volume":"174","author":"Rice","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jcrc.2009.07.005_bib10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/3-211-30714-1_88","article-title":"Whole-body hyperthermia in the rat disrupts the blood-cerebrospinal fluid barrier and induces brain edema","volume":"96","author":"Sharma","year":"2006","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.jcrc.2009.07.005_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0079-6123(06)62023-2","article-title":"Blood\u2013cerebrospinal fluid barrier in hyperthermia","volume":"162","author":"Sharma","year":"2007","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.jcrc.2009.07.005_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1164\/ajrccm.151.1.7812538","article-title":"Effect of cooling on oxygen consumption in febrile critically ill patients","volume":"151","author":"Manthous","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcrc.2009.07.005_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0002-9343(90)90124-V","article-title":"Antipyretic orders in a university hospital","volume":"88","author":"Isaacs","year":"1990","journal-title":"Am J Med"},{"key":"10.1016\/j.jcrc.2009.07.005_bib14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4037\/ajcc2001.10.4.276","article-title":"Comparison of fever treatments in the critically ill: a pilot stud","volume":"10","author":"Henker","year":"2001","journal-title":"Am J Crit Care"},{"key":"10.1016\/j.jcrc.2009.07.005_bib15","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/s001340000614","article-title":"Effects of acetaminophen administration to patients in intensive care","volume":"26","author":"Mackenzie","year":"2000","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2009.07.005_bib16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00134-003-2087-2","article-title":"Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response","volume":"30","author":"Gozzoli","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2009.07.005_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/bja\/78.2.123","article-title":"Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients","volume":"78","author":"Poblete","year":"1997","journal-title":"Br J Anethesia"},{"key":"10.1016\/j.jcrc.2009.07.005_bib18","series-title":"Generalized, linear, and mixed models","author":"McCulloch","year":"2001"},{"issue":"6","key":"10.1016\/j.jcrc.2009.07.005_bib19","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.jcrc.2009.07.005_bib20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/clinids\/18.3.421","article-title":"Purpose of quality standards for infectious diseases. Infectious Diseases Society of America","volume":"18","author":"Gross","year":"1994","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcrc.2009.07.005_bib21","first-page":"27","article-title":"Clinical thermometric measurements","author":"Mackowiak","year":"1997"},{"key":"10.1016\/j.jcrc.2009.07.005_bib22","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/00003246-199111000-00006","article-title":"Effect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group","volume":"19","author":"Haupt","year":"1991","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2009.07.005_bib23","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1161\/STROKEAHA.108.523654","article-title":"Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale","volume":"39","author":"Badjatia","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jcrc.2009.07.005_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/jappl.1956.8.6.595","article-title":"Metabolic cost of shivering","volume":"8","author":"Horvath","year":"1956","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1016\/j.jcrc.2009.07.005_bib25","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/01.STR.0000068787.76670.A4","article-title":"Dexmedetomidine and meperidine additively reduce the shivering threshold in humans","volume":"34","author":"Doufas","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jcrc.2009.07.005_bib26","article-title":"A prospective, observational clinical trial of fever reduction to reduce systemic oxygen consumption in the setting of acute brain injury","author":"Hata","year":"2007","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.jcrc.2009.07.005_bib27","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1749-6632.1997.tb51784.x","article-title":"Magnesium sulfate stops postanesthetic shivering","volume":"813","author":"Kizilirmak","year":"1997","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.1016\/j.jcrc.2009.07.005_bib28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/00000542-199705000-00007","article-title":"Meperidine decreases the shivering threshold twice as much as the vasoconstriction threshold","volume":"86","author":"Kurz","year":"1997","journal-title":"Anesthesiology"},{"issue":"6","key":"10.1016\/j.jcrc.2009.07.005_bib29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/bja\/aei105","article-title":"Magnesium sulphate only slightly reduces the shivering threshold in humans","volume":"94","author":"Wadhwa","year":"2005","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jcrc.2009.07.005_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0736-4679(02)00526-7","article-title":"Chronic acetaminophen toxicity: a case report and review of the literature","volume":"23","author":"Lane","year":"2002","journal-title":"J Emerg Med"},{"key":"10.1016\/j.jcrc.2009.07.005_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1345\/aph.1A035","article-title":"Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors","volume":"36","author":"Bolesta","year":"2002","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jcrc.2009.07.005_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nut.2007.10.004","article-title":"Depletion of plasma antioxidants in surgical intensive care unit patients requiring parenteral feeding: effects of parenteral nutrition with or without alanyl-glutamine dipeptide supplementation","volume":"24","author":"Luo","year":"2008","journal-title":"Nutrition"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944109002196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944109002196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T13:31:09Z","timestamp":1590154269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944109002196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0883944109002196"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2009.07.005","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}