{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:09:05Z","timestamp":1771636145040,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.jcrc.2010.03.006","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T06:29:22Z","timestamp":1272868162000},"page":"656.e1-656.e6","source":"Crossref","is-referenced-by-count":68,"title":["Melatonin in septic shock: Some recent concepts"],"prefix":"10.1016","volume":"25","author":[{"given":"Venkataramanujan","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seithikurippu R.","family":"Pandi-Perumal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Warren","family":"Spence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Cardinali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.jcrc.2010.03.006_bib1","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","article-title":"Melatonin: nature's most versatile biological signal?","volume":"273","author":"Pandi-Perumal","year":"2006","journal-title":"FEBS J"},{"key":"10.1016\/j.jcrc.2010.03.006_bib2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10409230903044914","article-title":"Reducing oxidative\/nitrosative stress: a newly-discovered genre for melatonin","volume":"44","author":"Reiter","year":"2009","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2009.00728.x","article-title":"Malaria: therapeutic implications of melatonin","volume":"48","author":"Srinivasan","year":"2010","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/MCC.0b013e3283307a3b","article-title":"Is MOF an outcome parameter or a transient, adaptive state in critical illness?","volume":"15","author":"Mongardon","year":"2009","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.jcrc.2010.03.006_bib5","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1211\/jpp.58.9.0001","article-title":"Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence","volume":"58","author":"Escames","year":"2006","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0926-6917(95)90052-7","article-title":"Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin","volume":"293","author":"Sewerynek","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1034\/j.1600-079X.2001.300303.x","article-title":"Melatonin prevents endotoxin-induced circulatory failure in rats","volume":"30","author":"Wu","year":"2001","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib8","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1096\/fasebj.13.12.1537","article-title":"Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats","volume":"13","author":"Crespo","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.jcrc.2010.03.006_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/ACO.0b013e328328d1cc","article-title":"Alterations of mitochondrial function in sepsis and critical illness","volume":"22","author":"Harrois","year":"2009","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib10","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1096\/fj.02-0692fje","article-title":"Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats","volume":"17","author":"Escames","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.jcrc.2010.03.006_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1600-079X.1996.tb00244.x","article-title":"Melatonin as a therapeutic agent in experimental endotoxic shock","volume":"20","author":"Maestroni","year":"1996","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1600-079X.2005.00265.x","article-title":"Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-\/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects","volume":"39","author":"Carrillo-Vico","year":"2005","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib13","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.exger.2006.09.002","article-title":"Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment","volume":"41","author":"Escames","year":"2006","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-079X.2008.00621.x","article-title":"Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice","volume":"46","author":"Lee","year":"2009","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-079X.2007.00526.x","article-title":"Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress","volume":"44","author":"De Filippis","year":"2008","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jneuroim.2005.05.002","article-title":"Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages","volume":"165","author":"Mayo","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-2999(98)00673-6","article-title":"Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation","volume":"363","author":"Costantino","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib18","first-page":"1388","article-title":"Melatonin reduces acute lung injury in endotoxemic rats","volume":"122","author":"Shang","year":"2009","journal-title":"Chin Med J (Engl.)"},{"key":"10.1016\/j.jcrc.2010.03.006_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1055\/s-0029-1202790","article-title":"Protective effects of melatonin against the damages of neuroendocrine-immune induced by lipopolysaccharide in diabetic rats","volume":"117","author":"Zhong","year":"2009","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.jcrc.2010.03.006_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1034\/j.1600-079X.2002.01886.x","article-title":"Vascular reactivity in diabetic rats: effect of melatonin","volume":"33","author":"Reyes Toso","year":"2002","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/jsre.1996.0351","article-title":"Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge","volume":"65","author":"Wichmann","year":"1996","journal-title":"J Surg Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib22","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1067\/S0039-6060(03)00253-8","article-title":"The pineal gland hormone melatonin improves survival in a rat model of sepsis\/shock induced by zymosan A","volume":"134","author":"Reynolds","year":"2003","journal-title":"Surgery"},{"key":"10.1016\/j.jcrc.2010.03.006_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-079X.2005.00281.x","article-title":"Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice","volume":"40","author":"Escames","year":"2006","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/cc6950","article-title":"Year in review 2007: critical care\u2014multiple organ failure and sepsis","volume":"12","author":"O'Brien","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2010.03.006_bib25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mam.2004.02.014","article-title":"Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease","volume":"25","author":"Carreras","year":"2004","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jcrc.2010.03.006_bib26","first-page":"623","article-title":"Melatonin restores the mitochondrial production of ATP in septic mice","volume":"27","author":"Lopez","year":"2006","journal-title":"Neuro Endocrinol Lett"},{"key":"10.1016\/j.jcrc.2010.03.006_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-079X.2008.00567.x","article-title":"Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats","volume":"45","author":"Wu","year":"2008","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ejphar.2004.08.002","article-title":"Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum","volume":"499","author":"Paskaloglu","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jcrc.2010.03.006_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1600-079X.2008.00657.x","article-title":"Melatonin inhibits LPS-induced NO production in rat endothelial cells","volume":"46","author":"Tamura","year":"2009","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00003246-200203000-00007","article-title":"Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis","volume":"30","author":"Mundigler","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2010.03.006_bib31","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.0001-5172.2004.00401.x","article-title":"Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients","volume":"48","author":"Olofsson","year":"2004","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jcrc.2010.03.006_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/CS20030374","article-title":"Low melatonin excretion during mechanical ventilation in the intensive care unit","volume":"107","author":"Frisk","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcrc.2010.03.006_bib33","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s00134-006-0069-x","article-title":"Nocturnal melatonin concentration is correlated with illness severity in patients with septic disease","volume":"32","author":"Perras","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2010.03.006_bib34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00134-005-0061-x","article-title":"Melatonin: possible implications for the postoperative and critically ill patient","volume":"32","author":"Bourne","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2010.03.006_bib35","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/cc6871","article-title":"Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial","volume":"12","author":"Bourne","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2010.03.006_bib36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1600-079X.2008.00649.x","article-title":"Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin","volume":"46","author":"Gitto","year":"2009","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jcrc.2010.03.006_bib37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jss.2007.12.753","article-title":"Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?","volume":"152","author":"Kucukakin","year":"2009","journal-title":"J Surg Res"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944110000778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944110000778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T10:49:04Z","timestamp":1711450144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944110000778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0883944110000778"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2010.03.006","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}