{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:06:42Z","timestamp":1791320802574,"version":"4.3.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.jcrc.2013.06.017","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T04:02:37Z","timestamp":1375934557000},"page":"182.e1-182.e4","source":"Crossref","is-referenced-by-count":40,"title":["Heparin\/N-acetylcysteine: An adjuvant in the management of burn inhalation injury"],"prefix":"10.1016","volume":"29","author":[{"given":"Noha M.","family":"Elsharnouby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala E.A.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla F.","family":"Abou Elezz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser A.","family":"Aboelatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jcrc.2013.06.017_bb0005","first-page":"S6","article-title":"Smoke inhalation & acute cyanide poisoning. Hydrogen cyanide poisoning proves increasingly common in smoke-inhalation victims","volume":"29","author":"Alcorta","year":"2004","journal-title":"JEMS"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/CS20040135","article-title":"Pathophysiology of acute lung injury in combined burn and smoke inhalation injury","volume":"107","author":"Enkhbaatar","year":"2004","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"10.1016\/j.jcrc.2013.06.017_bb0015","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/BCR.0b013e3181e4d680","article-title":"Predicting prognosis in thermal burns with associated inhalational injury: a systematic review of prognostic factors in adult burn victims","volume":"31","author":"Colohan","year":"2010","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/BCR.0b013e318198a268","article-title":"Influence of nebulized unfractionated heparin and N-acetylcysteine in acute lung injury after smoke inhalation injury","volume":"30","author":"Miller","year":"2009","journal-title":"J Burn Care Res"},{"issue":"4","key":"10.1016\/j.jcrc.2013.06.017_bb0025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1046\/j.1365-2168.2001.01726.x","article-title":"Determinants of death following burn injury","volume":"88","author":"Muller","year":"2001","journal-title":"Br J Surg"},{"issue":"1","key":"10.1016\/j.jcrc.2013.06.017_bb0030","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.burns.2003.07.003","article-title":"Influence of demographics and inhalation injury on burn mortality in children","volume":"30","author":"Barrow","year":"2004","journal-title":"Burns"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0035","first-page":"125","article-title":"Pathophysiological basis of smoke inhalation injury","volume":"18","author":"Murakami","year":"2003","journal-title":"News Physiol Sci"},{"issue":"3 Pt 1","key":"10.1016\/j.jcrc.2013.06.017_bb0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1165\/rcmb.4860","article-title":"Airway obstruction in sheep with burn and smoke inhalation injuries","volume":"29","author":"Cox","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0045","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/jappl.1985.58.2.326","article-title":"Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer","volume":"58","author":"Seeger","year":"1985","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1016\/j.jcrc.2013.06.017_bb0050","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1586\/ers.09.21","article-title":"Pathophysiology, management and treatment of smoke inhalation injury","volume":"3","author":"Rehberg","year":"2009","journal-title":"Expert Rev Respir Med"},{"issue":"3","key":"10.1016\/j.jcrc.2013.06.017_bb0055","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/01.shk.0000208805.23182.a7","article-title":"Aerosolized \u03b1-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep","volume":"25","author":"Morita","year":"2006","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.jcrc.2013.06.017_bb0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.freeradbiomed.2008.04.037","article-title":"\u03b3-tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury","volume":"45","author":"Hamahata","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0065","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/BCR.0b013e31815f596b","article-title":"Use of inhaled heparin\/N-acetylcystine in inhalation injury: does it help?","volume":"29","author":"Holt","year":"2008","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0070","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00004630-199805000-00004","article-title":"Reduction in mortality in pediatric patients with inhalation injury with aerosolized heparin\/N-acetylcystine [correction of acetylcystine] therapy","volume":"19","author":"Desai","year":"1998","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0075","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0094-1298(20)30126-7","article-title":"Fluid volume and electrolyte changes of the early postburn period","volume":"1","author":"Baxter","year":"1974","journal-title":"Clin Plast Surg"},{"issue":"6 Pt 1","key":"10.1016\/j.jcrc.2013.06.017_bb0080","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00004630-199611000-00013","article-title":"Inhalation injury severity scoring system: a quantitative method","volume":"17","author":"Brown","year":"1996","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0085","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/ajrccm\/138.3.720","article-title":"An expanded definition of the adult respiratory distress syndrome","volume":"138","author":"Murray","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0090","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/00005373-197508000-00004","article-title":"Fiberoptic bronchoscopy in acute inhalation injury","volume":"15","author":"Hunt","year":"1975","journal-title":"J Trauma"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0095","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.burns.2009.06.205","article-title":"Assessing the severity of inhalation injuries in adults","volume":"36","author":"Hassan","year":"2010","journal-title":"Burns"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0100","first-page":"339","article-title":"Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in an ovine model","volume":"176","author":"Cox","year":"1993","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0105","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00024382-200209000-00006","article-title":"Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep","volume":"18","author":"Murakami","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00004630-198801000-00007","article-title":"Dimethyl sulfoxide with heparin in the treatment of smoke inhalation injury","volume":"9","author":"Brown","year":"1988","journal-title":"J Burn Care Rehabil"},{"issue":"1","key":"10.1016\/j.jcrc.2013.06.017_bb0115","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.thromres.2010.08.022","article-title":"Pre-operative heparin reduces pulmonary microvascular fibrin deposition following cardiac surgery","volume":"127","author":"Dixon","year":"2011","journal-title":"Thromb Res"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0120","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1007\/s00134-008-1042-7","article-title":"Elevated pulmonary dead space and coagulation abnormalities suggest lung microvascular thrombosis in patients undergoing cardiac surgery","volume":"34","author":"Dixon","year":"2008","journal-title":"Intensive Care Med"},{"issue":"R180","key":"10.1016\/j.jcrc.2013.06.017_bb0125","first-page":"1","article-title":"Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial","volume":"14","author":"Dixon","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0130","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1186\/cc6894","article-title":"A phase 1 trial of nebulised heparin in acute lung injury","volume":"12","author":"Dixon","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0135","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1164\/ajrccm.160.5.9809123","article-title":"Lung deposition and clearance of inhaled (99m)Tc-heparin in healthy volunteers","volume":"160","author":"Bendstrup","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcrc.2013.06.017_bb0140","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1096\/fj.00-0526hyp","article-title":"Protective effects of N-acetylcystine on lung injury and red blood cell modification induced by carrageenan in the rat","volume":"15","author":"Cuzzocrea","year":"2001","journal-title":"FASEB J"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944113001925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944113001925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T16:11:28Z","timestamp":1596298288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944113001925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0883944113001925"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2013.06.017","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}