{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:09Z","timestamp":1790834469108,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jccjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jcrc.2015.05.017","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T11:24:37Z","timestamp":1432898677000},"page":"908-913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Levosimendan reduces mortality in patients with severe sepsis and septic shock: A meta-analysis of randomized trials"],"prefix":"10.1016","volume":"30","author":[{"given":"Alberto","family":"Zangrillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Putzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Oriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Frau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Di Tomasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-3182","authenticated-orcid":false,"given":"Elena","family":"Bignami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Lomivorotov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-6950","authenticated-orcid":false,"given":"Valery","family":"Likhvantsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Landoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jcrc.2015.05.017_bb0005","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0010","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/CCM.0000000000000026","article-title":"Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis","volume":"42","author":"Stevenson","year":"2014","journal-title":"Crit Care Med"},{"issue":"13","key":"10.1016\/j.jcrc.2015.05.017_bb0015","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jcrc.2015.05.017_bb0020","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","article-title":"Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012","volume":"41","author":"Dellinger","year":"2013","journal-title":"Crit Care Med"},{"issue":"18","key":"10.1016\/j.jcrc.2015.05.017_bb0025","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A randomized trial of protocol-based care for early septic shock","volume":"370","author":"Pro","year":"2014","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jcrc.2015.05.017_bb0030","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1378\/chest.113.4.1055","article-title":"Serum cardiac troponin T as a prognostic marker in early sepsis","volume":"113","author":"Spies","year":"1998","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.jcrc.2015.05.017_bb0035","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/01.CCM.0000266683.64081.02","article-title":"Mechanisms of sepsis-induced cardiac dysfunction","volume":"35","author":"Rudiger","year":"2007","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0040","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/01.CCM.0000114827.93410.D8","article-title":"Brain natriuretic peptide: a marker of myocardial dysfunction and prognosis during severe sepsis","volume":"32","author":"Charpentier","year":"2004","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2015.05.017_bb0045","first-page":"227","article-title":"Levosimendan: current data, clinical use and future development","volume":"5","author":"Nieminen","year":"2013","journal-title":"Heart Lung Vessel"},{"issue":"1\u20132","key":"10.1016\/j.jcrc.2015.05.017_bb0050","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/B:MCBI.0000049141.37823.19","article-title":"The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c","volume":"266","author":"Sorsa","year":"2004","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"10.1016\/j.jcrc.2015.05.017_bb0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1527-3466.2005.tb00158.x","article-title":"Pharmacological mechanisms contributing to the clinical efficacy of levosimendan","volume":"23","author":"Papp","year":"2005","journal-title":"Cardiovasc Drug Rev"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0060","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/bja\/aeu446","article-title":"A Bayesian network meta-analysis on the effect of inodilatatory agents on mortality","volume":"114","author":"Greco","year":"2015","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0065","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0009-9236(97)90139-9","article-title":"Myocardial efficiency during calcium sensitization with levosimendan: a noninvasive study with positron emission tomography and echocardiography in healthy volunteers","volume":"61","author":"Ukkonen","year":"1997","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.jcrc.2015.05.017_bb0070","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10557-013-6485-6","article-title":"Renal effects of levosimendan: a consensus report","volume":"27","author":"Yilmaz","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0075","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1097\/01.CCM.0000261889.18102.84","article-title":"Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone","volume":"35","author":"Barraud","year":"2007","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0080","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/SHK.0b013e3181cd8c5b","article-title":"Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock","volume":"34","author":"Garcia-Septien","year":"2010","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.jcrc.2015.05.017_bb0085","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1097\/CCM.0b013e31817cede9","article-title":"Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock","volume":"36","author":"Fries","year":"2008","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.jcrc.2015.05.017_bb0090","doi-asserted-by":"crossref","first-page":"F1453","DOI":"10.1152\/ajprenal.00485.2005","article-title":"Levosimendan protects against experimental endotoxemic acute renal failure","volume":"290","author":"Zager","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0095","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.acthis.2008.09.010","article-title":"Effects of levosimendan and dobutamine on experimental acute lung injury in rats","volume":"111","author":"Erbuyun","year":"2009","journal-title":"Acta Histochem"},{"issue":"8","key":"10.1016\/j.jcrc.2015.05.017_bb0100","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/s00134-009-1481-9","article-title":"Effects of intravenous and inhaled levosimendan in severe rodent sepsis","volume":"35","author":"Scheiermann","year":"2009","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2015.05.017_bb0105","doi-asserted-by":"crossref","first-page":"R166","DOI":"10.1186\/cc10307","article-title":"Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: a prospective observational study","volume":"15","author":"Hasslacher","year":"2011","journal-title":"Crit Care"},{"issue":"7","key":"10.1016\/j.jcrc.2015.05.017_bb0110","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1399-6576.2011.02436.x","article-title":"No beneficial effects of levosimendan in acute porcine endotoxaemia","volume":"55","author":"Chew","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0115","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1213\/ane.0b013e3181af3fe3","article-title":"Inotropic support during experimental endotoxemic shock: part I. The effects of levosimendan on splanchnic perfusion","volume":"109","author":"Cunha-Goncalves","year":"2009","journal-title":"Anesth Analg"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0120","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1213\/ane.0b013e3181af40e0","article-title":"Inotropic support during experimental endotoxemic shock: part II. A comparison of levosimendan with dobutamine","volume":"109","author":"Cunha-Goncalves","year":"2009","journal-title":"Anesth Analg"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0125","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/SHK.0b013e3181cd877b","article-title":"Direct cardiac effects of dobutamine, dopamine, epinephrine, and levosimendan in isolated septic rat hearts","volume":"34","author":"Zausig","year":"2010","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.jcrc.2015.05.017_bb0130","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jcrc.2013.06.014","article-title":"Levosimendan: a retrospective single-center case series","volume":"28","author":"Berry","year":"2013","journal-title":"J Crit Care"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0135","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/bja\/aem225","article-title":"Levosimendan in septic shock: a case series","volume":"99","author":"Powell","year":"2007","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0140","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0310057X0703500316","article-title":"Myocardial depression associated with pneumococcal septic shock reversed by levosimendan","volume":"35","author":"Ramaswamykanive","year":"2007","journal-title":"Anaesth Intensive Care"},{"issue":"1","key":"10.1016\/j.jcrc.2015.05.017_bb0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1399-6576.2005.00541.x","article-title":"Successful reversal of resistant hypodynamic septic shock with levosimendan","volume":"49","author":"Matejovic","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jcrc.2015.05.017_bb0150","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.biochi.2014.03.006","article-title":"Effects of levosimendan on mitochondrial function in patients with septic shock: a randomized trial","volume":"102","author":"Torraco","year":"2014","journal-title":"Biochimie"},{"issue":"10","key":"10.1016\/j.jcrc.2015.05.017_bb0155","first-page":"692","article-title":"Effects of levosimendan on hemodynamics and cardiac function in patients with septic shock","volume":"26","author":"Fang","year":"2014","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0160","doi-asserted-by":"crossref","first-page":"18.e1","DOI":"10.1016\/j.jcrc.2011.06.008","article-title":"The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock","volume":"27","author":"Memis","year":"2012","journal-title":"J Crit Care"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0165","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s00134-005-2619-z","article-title":"Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression","volume":"31","author":"Morelli","year":"2005","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.jcrc.2015.05.017_bb0170","doi-asserted-by":"crossref","first-page":"R232","DOI":"10.1186\/cc9387","article-title":"Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study","volume":"14","author":"Morelli","year":"2010","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0175","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/j.jcrc.2009.06.006","article-title":"Levosimendan vs dobutamine in septic shock","volume":"24","author":"Alhashemi","year":"2009","journal-title":"J Crit Care"},{"issue":"Suppl. 1","key":"10.1016\/j.jcrc.2015.05.017_bb0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/cc7329","article-title":"Use of levosimendan in myocardial dysfunction due to sepsis","volume":"13","author":"Vaitsis","year":"2009","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.jcrc.2015.05.017_bb0185","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/CCM.0b013e318232962a","article-title":"Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies","volume":"40","author":"Landoni","year":"2012","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0190","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1631\/jzus.B1200290","article-title":"Levosimendan versus dobutamine in critically ill patients: a meta-analysis of randomized controlled trials","volume":"14","author":"Huang","year":"2013","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.jcrc.2015.05.017_bb0195","series-title":"Cochrane book series","article-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins","year":"2008"},{"issue":"1","key":"10.1016\/j.jcrc.2015.05.017_bb0200","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/EDE.0b013e3181fe7825","article-title":"PRISMA statement","volume":"22","author":"Moher","year":"2011","journal-title":"Epidemiology"},{"issue":"4","key":"10.1016\/j.jcrc.2015.05.017_bb0205","first-page":"219","article-title":"Meta-analysis: pitfalls and hints","volume":"5","author":"Greco","year":"2013","journal-title":"Heart Lung Vessel"},{"issue":"9","key":"10.1016\/j.jcrc.2015.05.017_bb0210","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1097\/01.CCM.0000230244.17174.4F","article-title":"Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study","volume":"34","author":"Morelli","year":"2006","journal-title":"Crit Care Med"},{"issue":"Suppl. 2","key":"10.1016\/j.jcrc.2015.05.017_bb0215","doi-asserted-by":"crossref","first-page":"P222","DOI":"10.1186\/cc5382","article-title":"The calcium sensitizer levosimendan reduces the brain natriuretic peptide levels as compared with dobutamine in intensive care unit septic patients with decompensated heart failure","volume":"11","author":"Michalopoulou","year":"2007","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.jcrc.2015.05.017_bb0230","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/ACO.0b013e3282f43c56","article-title":"Role of levosimendan in sepsis and septic shock","volume":"21","author":"Pinto","year":"2008","journal-title":"Curr Opin Anaesthesiol"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0235","doi-asserted-by":"crossref","first-page":"832.e5","DOI":"10.1016\/j.ajem.2011.02.030","article-title":"Sepsis-associated takotsubo cardiomyopathy can be reversed with levosimendan","volume":"30","author":"Karvouniaris","year":"2012","journal-title":"Am J Emerg Med"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0240","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/bja\/aei225","article-title":"Treatment of cardiogenic shock with levosimendan in combination with beta-adrenergic antagonists","volume":"95","author":"Alhashemi","year":"2005","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.jcrc.2015.05.017_bb0245","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00134-004-2502-3","article-title":"Levosimendan in septic cardiac failure","volume":"31","author":"Noto","year":"2005","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2015.05.017_bb0255","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/aas.12056","article-title":"Association between inotrope treatment and 90-day mortality in patients with septic shock","volume":"57","author":"Wilkman","year":"2013","journal-title":"Acta Anaesthesiol Scand"},{"issue":"Suppl. 2","key":"10.1016\/j.jcrc.2015.05.017_bb0260","doi-asserted-by":"crossref","first-page":"P226","DOI":"10.1186\/cc5386","article-title":"Levosimendan in myocardial depression due to severe sepsis","volume":"11","author":"Malik","year":"2007","journal-title":"Crit Care"},{"issue":"Suppl. 1","key":"10.1016\/j.jcrc.2015.05.017_bb0265","doi-asserted-by":"crossref","first-page":"P170","DOI":"10.1186\/cc7334","article-title":"Effects of levosimendan on renal function in septic shock: a case-control study","volume":"13","author":"Morelli","year":"2009","journal-title":"Crit Care"},{"issue":"Suppl. 1","key":"10.1016\/j.jcrc.2015.05.017_bb0270","doi-asserted-by":"crossref","first-page":"P169","DOI":"10.1186\/cc7333","article-title":"Effects of levosimendan and inhaled nitric oxide on microcirculation in septic shock","volume":"13","author":"Morelli","year":"2009","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.jcrc.2015.05.017_bb0275","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijcard.2008.04.043","article-title":"The use of levosimendan for myocardiopathy due to acute Chagas' disease","volume":"136","author":"de March Ronsoni","year":"2009","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.jcrc.2015.05.017_bb0280","first-page":"324","article-title":"Tratamiento de la depresi\u00f3n mioc\u00e1rdica por sepsis con levosimendan. Serie de casos y revisi\u00f3n de la bibliograf\u00eda","volume":"26","author":"Rinc\u00f3n Villegas","year":"2010","journal-title":"Med Int Mex"},{"issue":"2","key":"10.1016\/j.jcrc.2015.05.017_bb0290","article-title":"The role of calcium desensitization in the pathophysiology of septic myocardial depression and effects of levosimendan: results of fifteen septic shock patients","volume":"10","author":"Adanir","year":"2006","journal-title":"Int J Thorac Cardiovasc Surg"},{"issue":"6","key":"10.1016\/j.jcrc.2015.05.017_bb0295","first-page":"508","article-title":"BET 1: levosimendan in septic shock","volume":"31","author":"Coates","year":"2014","journal-title":"Emerg Med J"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0300","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jcrc.2014.04.011","article-title":"Mortality benefit of vasopressor and inotropic agents in septic shock: a Bayesian network meta-analysis of randomized controlled trials","volume":"29","author":"Oba","year":"2014","journal-title":"J Crit Care"},{"issue":"3","key":"10.1016\/j.jcrc.2015.05.017_bb0310","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/cc13853","article-title":"Deeper understanding of mechanisms contributing to sepsis-induced myocardial dysfunction","volume":"18","author":"Walley","year":"2014","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.jcrc.2015.05.017_bb0315","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00134-008-1022-y","article-title":"Is myocardial adrenergic responsiveness depressed in human septic shock?","volume":"34","author":"Cariou","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2015.05.017_bb0320","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1745-6215-15-199","article-title":"An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial","volume":"15","author":"Orme","year":"2014","journal-title":"Trials"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944115003196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944115003196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T16:23:21Z","timestamp":1566750201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944115003196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0883944115003196"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2015.05.017","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Levosimendan reduces mortality in patients with severe sepsis and septic shock: A meta-analysis of randomized trials","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2015.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}