{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:08:32Z","timestamp":1791821312141,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jccjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.jcrc.2016.07.016","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T22:44:49Z","timestamp":1469659489000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Inter-hospital transfer is associated with increased mortality and costs in severe sepsis and septic shock: An instrumental variables approach"],"prefix":"10.1016","volume":"36","author":[{"given":"Nicholas M.","family":"Mohr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karisa K.","family":"Harland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Shane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeemuddin","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Torner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2016.07.016_bb0005","series-title":"Inpatient care for septicemia or sepsis: A challenge for patients and hospitals","author":"Hall","year":"2011"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0010","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/CCM.0000000000000037","article-title":"Sepsis visits and antibiotic utilization in U.S. emergency departments","volume":"42","author":"Filbin","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0015","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0020","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1378\/chest.10-1405","article-title":"Point: adherence to early goal-directed therapy: does it really matter? Yes. After a decade, the scientific proof speaks for itself","volume":"138","author":"Rivers","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0025","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/CCM.0000000000000026","article-title":"Two Decades of Mortality Trends Among Patients With Severe Sepsis: A Comparative Meta-Analysis","volume":"42","author":"Stevenson","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0030","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.annemergmed.2014.06.008","article-title":"Emergency Department Hospitalization Volume and Mortality in the United States","volume":"64","author":"Kocher","year":"2014","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0035","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ahj.2012.06.014","article-title":"Regionalization of post-cardiac arrest care: implementation of a cardiac resuscitation center","volume":"164","author":"Heffner","year":"2012","journal-title":"Am Heart J"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0040","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/01.CIR.0000091088.63921.8C","article-title":"Transfer for primary angioplasty versus immediate thrombolysis in acute myocardial infarction: a meta-analysis","volume":"108","author":"Dalby","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5853\/jos.2013.15.1.57","article-title":"Organized Comprehensive Stroke Center is Associated with Reduced Mortality: Analysis of Consecutive Patients in a Single Hospital","volume":"15","author":"Kim","year":"2013","journal-title":"J Stroke"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.annemergmed.2008.09.022","article-title":"A regional system of stroke care provides thrombolytic outcomes comparable with the NINDS stroke trial","volume":"54","author":"LaMonte","year":"2009","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0055","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1553-2712.2010.00918.x","article-title":"Survival benefit of transfer to tertiary trauma centers for major trauma patients initially presenting to nontertiary trauma centers","volume":"17","author":"Garwe","year":"2010","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0060","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1097\/CCM.0b013e3181f3e09c","article-title":"Volume of emergency department admissions for sepsis is related to inpatient mortality: results of a nationwide cross-sectional analysis","volume":"38","author":"Powell","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0065","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1164\/rccm.201402-0289OC","article-title":"The relationship between hospital volume and mortality in severe sepsis","volume":"190","author":"Gaieski","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0070","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1097\/CCM.0000000000001301","article-title":"Interhospital Transfer Delays Appropriate Treatment for Patients With Severe Sepsis and Septic Shock: A Retrospective Cohort Study","volume":"43","author":"Faine","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0075","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0080","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11739-011-0625-4","article-title":"Lung ultrasonography for the assessment of rapid extravascular water variation: evidence from hemodialysis patients","volume":"8","author":"Trezzi","year":"2013","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0085","author":"Cromartie"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/01.mlr.0000118861.56848.ee","article-title":"Comparison of the Elixhauser and Charlson\/Deyo methods of comorbidity measurement in administrative data","volume":"42","author":"Southern","year":"2004","journal-title":"Med Care"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0095","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/MLR.0000000000000465","article-title":"Comparison of Comorbidity Scores in Predicting Surgical Outcomes","volume":"54","author":"Mehta","year":"2016","journal-title":"Med Care"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0100","author":"Elixhauser"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0120","author":"IRS Announces"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0125","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1378\/chest.14-2195","article-title":"The volume-outcome relationship in critical care: A systematic review and meta-analysis","volume":"148","author":"Nguyen","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0140","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ajem.2008.10.016","article-title":"Increased rate of central venous catheterization procedures in community EDs","volume":"28","author":"Glickman","year":"2010","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2310\/8000.2011.110610","article-title":"Canadian Association of Emergency Physicians sepsis treatment checklist: optimizing sepsis care in Canadian emergency departments","volume":"14","author":"Djogovic","year":"2012","journal-title":"CJEM"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0150","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.annemergmed.2013.11.018","article-title":"Access to Care for Patients With Time-Sensitive Conditions in Pennsylvania","volume":"63","author":"Salhi","year":"2014","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0155","series-title":"Developing Disease State Management Guidelines for Rural Health Care","author":"Burenheide","year":"2008"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0160","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"MOrtality related to severe sepsis and septic shock among critically ill patients in australia and new zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0165","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00001888-199603000-00019","article-title":"Comparing the hospitalizations of transfer and non-transfer patients in an academic medical center","volume":"71","author":"Bernard","year":"1996","journal-title":"Acad Med"},{"key":"10.1016\/j.jcrc.2016.07.016_bb0170","unstructured":"Surgery Flag Software. Agency for Healthcare Research and Quality. Rockville, Maryland. [Available from: http:\/\/www.hcup-us.ahrq.gov\/toolssoftware\/surgflags\/surgeryflags.jsp (accessed 6 Dec 2015)]"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944116302532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944116302532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T06:24:21Z","timestamp":1536560661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944116302532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":31,"alternative-id":["S0883944116302532"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2016.07.016","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inter-hospital transfer is associated with increased mortality and costs in severe sepsis and septic shock: An instrumental variables approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2016.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}