{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:36:29Z","timestamp":1770514589751,"version":"3.49.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jccjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.jcrc.2017.06.016","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T20:53:19Z","timestamp":1497905599000},"page":"6-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Concomitant vasopressin and hydrocortisone therapy on short-term hemodynamic effects and vasopressor requirements in refractory septic shock"],"prefix":"10.1016","volume":"42","author":[{"given":"Mitchell S.","family":"Buckley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"MacLaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2017.06.016_bb0005","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0010","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1001\/jama.1995.03530120060042","article-title":"Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: a multicenter prospective study in intensive care units","volume":"274","author":"Brun-Buisson","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0015","first-page":"107","article-title":"Hospital-related cost of sepsis: a systematic review","volume":"74","author":"Arefian","year":"2017","journal-title":"J Inf Secur"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0020","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/CCM.0000000000002255","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"45","author":"Rhodes","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0025","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/ACO.0000000000000210","article-title":"Emerging therapies for the treatment of sepsis","volume":"28","author":"Vincent","year":"2015","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0030","article-title":"Hydrocortisone, vitamin c and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study","volume":"6","author":"Marik","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0035","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMra020529","article-title":"Corticosteroid insufficiency in acutely ill patients","volume":"348","author":"Cooper","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0040","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1056\/NEJM199710303371807","article-title":"Corticosteroid therapy in severe illness","volume":"337","author":"Lamberts","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00003246-200301000-00022","article-title":"Adrenal insufficiency during septic shock","volume":"31","author":"Marik","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0050","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1378\/chest.120.3.989","article-title":"Physiology of vasopressin relevant to management of septic shock","volume":"120","author":"Holmes","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0055","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/01.CIR.95.5.1122","article-title":"Vasopressin deficiency contributes to vasodilation of septic shock","volume":"95","author":"Landry","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0060","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00003246-199804000-00010","article-title":"Reversal of late septic shock with supraphysiologic doses of hydrocortisone","volume":"26","author":"Bollaert","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0065","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/00003246-199904000-00025","article-title":"Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study","volume":"27","author":"Breigel","year":"1999","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0070","doi-asserted-by":"crossref","first-page":"A33","DOI":"10.1097\/00003246-199901001-00022","article-title":"Hydrocortisone reverses refractory septic shock","volume":"27","author":"Chawla","year":"1999","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0075","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/jama.288.7.862","article-title":"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock","volume":"288","author":"Annane","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0080","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1097\/01.CCM.0000186370.78639.23","article-title":"Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock","volume":"33","author":"Oppert","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0085","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/bmj.38181.482222.55","article-title":"Corticosteriods for severe sepsis and septic shock: a systemic review and meta-analysis","volume":"28","author":"Annane","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7326\/0003-4819-141-1-200407060-00014","article-title":"Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose","volume":"141","author":"Minneci","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0095","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1001\/jama.2009.815","article-title":"Corticosteroids for treating severe sepsis and septic shock in adults: a systematic review","volume":"301","author":"Annane","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0100","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1001\/jama.2011.360","article-title":"Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study","volume":"305","author":"Roquilly","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":"Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/01.CCM.0000194723.78632.62","article-title":"Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome","volume":"34","author":"Annane","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0115","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1164\/rccm.200205-446OC","article-title":"Immunologic and hemodynamic effects of \u201clow-dose\u201d hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study","volume":"167","author":"Keh","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0120","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00005373-199910000-00014","article-title":"Low-dose vasopressin in the treatment of vasodilatory septic shock","volume":"47","author":"Malay","year":"1999","journal-title":"J Trauma"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0125","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00003246-200103000-00004","article-title":"Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock","volume":"29","author":"Tsuneyoshi","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0130","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00000542-200203000-00011","article-title":"Beneficial effects of short-term vasopressin infusion during severe septic shock","volume":"96","author":"Patel","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0135","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/01.CIR.0000066692.71008.BB","article-title":"Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study","volume":"107","author":"Dunser","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0140","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1345\/aph.1D513","article-title":"Effects of continuous vasopressin infusion in patients with septic shock","volume":"38","author":"Obritsch","year":"2004","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0145","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1097\/01.CCM.0000281853.50661.23","article-title":"Comparison of two dose regimens of arginine vasopressin in advanced vasodilatory shock","volume":"35","author":"Luckner","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0150","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa067373","article-title":"Vasopressin versus norepinephrine infusion in patients with septic shock","volume":"358","author":"Russell","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0155","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00134-009-1687-x","article-title":"The effects of vasopressin on acute kidney injury in septic shock","volume":"36","author":"Gordon","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00134-009-1630-1","article-title":"Comparing two different arginine vasopressin doses in advanced vasodilatory shock: a randomized, controlled, open-label trial","volume":"36","author":"Torgersen","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00134-011-2407-x","article-title":"Vasopressin for treatment of vasodilatory shock: an ESICM systematic review and meta-analysis","volume":"38","author":"Polito","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0170","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000081314","article-title":"Mineralocorticoid treatment upregulates the hypothalamic vasopressinergic system of spontaneously hypertensive rats","volume":"80","author":"Pietranaera","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0175","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s00134-006-0378-0","article-title":"Vasopressin or norepinephrine in early hyperdynamic septic shock: a randomized clinical trial","volume":"32","author":"Lauzier","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0180","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/01.shk.0000235140.97903.90","article-title":"Methylprednisolone reverses vasopressin hyporesponsiveness in ovine endotoxemia","volume":"27","author":"Ertmer","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuroscience.2007.04.021","article-title":"Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation","volume":"147","author":"Lauand","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0190","doi-asserted-by":"crossref","first-page":"10231","DOI":"10.1523\/JNEUROSCI.23-32-10231.2003","article-title":"Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures","volume":"23","author":"Kuwahara","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0195","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-2826.2002.00834.x","article-title":"Overexpression of the V3 vasopressin receptor in transgenic mice corticotropes leads to increased basal corticosterone","volume":"14","author":"Rene","year":"2002","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0200","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1006\/bbrc.2001.6114","article-title":"Role of glucocorticoid hormones in arginine vasopressin gene regulation","volume":"289","author":"Kim","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-0115(00)00196-8","article-title":"Vasopressinergic regulation of the hypothalamic-pituitaryadrenal axis: implications for stress adaptation","volume":"96","author":"Aguilera","year":"2000","journal-title":"Regul Pept"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0210","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1172\/JCI200419656","article-title":"The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions","volume":"113","author":"Tanoue","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0215","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1210\/endo.139.7.6121","article-title":"Glucocorticoids increase vasopressin V1b receptor coupling to phospholipase C","volume":"139","author":"Rabadan-Diehl","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0220","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1097\/01.CCM.0000127264.54807.B7","article-title":"Endocrinologic response to vasopressin infusion in advanced vasodilatory shock","volume":"32","author":"Dunser","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0225","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00508-011-1568-5","article-title":"Influences of hydrocortisone therapy on arginine vasopressin plasma levels in septic shock","volume":"123","author":"Jochberger","year":"2011","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0230","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/CCM.0000000000000212","article-title":"The interaction of vasopressin and corticosteroids in septic shock: a pilot randomized controlled trial","volume":"42","author":"Gordon","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0235","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jcrc.2008.04.002","article-title":"Effect of corticosteroids on arginine vasopressin-containing vasopressor therapy for septic shock: a case control study","volume":"23","author":"Bauer","year":"2008","journal-title":"J Crit Care"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0240","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/CCM.0b013e3181961ace","article-title":"Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock","volume":"37","author":"Russell","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0245","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1007\/s00134-011-2312-3","article-title":"Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality","volume":"37","author":"Torgersen","year":"2011","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0255","doi-asserted-by":"crossref","first-page":"R217","DOI":"10.1186\/cc10453","article-title":"Effects of vasopresinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock","volume":"15","author":"Morelli","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0260","first-page":"15","article-title":"The therapeutic role of vasopressin on improving lactate clearance during and after vasogenic shock: microcirculation, is it the black box?","volume":"54","author":"Barzegar","year":"2016","journal-title":"Acta Med Iran"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0265","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/jama.2016.10485","article-title":"Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial","volume":"316","author":"Gordon","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0270","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","article-title":"Use of the SOFA score to assess the incidence of organ dysfunction\/failure in intensive care units: results of a multicenter, prospective study","volume":"26","author":"Vincent","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0275","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1213\/ANE.0000000000000050","article-title":"Low-dose hydrocortisone therapy attenuates septic shock in adult patients but does not reduce 28-day mortality: a meta-analysis of randomized controlled trials","volume":"118","author":"Wang","year":"2014","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jcrc.2017.06.016_bb0280","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/cc8224","article-title":"Bench-to-bedside review: vasopressin in the management of septic shock","volume":"15","author":"Russell","year":"2011","journal-title":"Crit Care"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088394411730641X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088394411730641X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T05:13:14Z","timestamp":1569474794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088394411730641X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":55,"alternative-id":["S088394411730641X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2017.06.016","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concomitant vasopressin and hydrocortisone therapy on short-term hemodynamic effects and vasopressor requirements in refractory septic shock","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2017.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}