{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:18:27Z","timestamp":1777515507894,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Klaus Tschira Charitable Foundation","award":["00.271.2015"],"award-info":[{"award-number":["00.271.2015"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jcrc.2018.06.003","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T16:02:55Z","timestamp":1527955375000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["The evolution of activated protein C plasma levels in septic shock and its association with mortality: A prospective observational study"],"prefix":"10.1016","volume":"47","author":[{"given":"Tobias","family":"Becher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenija","family":"Stach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Borggrefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"P\u00f6tzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Lo\u00dfnitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2018.06.003_bb0005","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13054-015-1011-9","article-title":"Early goal-directed resuscitation of patients with septic shock: current evidence and future directions","volume":"19","author":"Gupta","year":"2015","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.jcrc.2018.06.003_bb0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2018.06.003_bb0015","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/CCM.0000000000002262","article-title":"Increased time to initial antimicrobial administration is associated with progression to septic shock in severe sepsis patients","volume":"45","author":"Whiles","year":"2017","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.jcrc.2018.06.003_bb0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13613-015-0058-8","article-title":"Timing and causes of death in septic shock","volume":"5","author":"Daviaud","year":"2015","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jcrc.2018.06.003_bb0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40560-016-0149-0","article-title":"Sepsis and disseminated intravascular coagulation","volume":"4","author":"Okamoto","year":"2016","journal-title":"J Intensive Care"},{"key":"10.1016\/j.jcrc.2018.06.003_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb Res"},{"issue":"Suppl. 1","key":"10.1016\/j.jcrc.2018.06.003_bb0035","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jth.12247","article-title":"Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway","volume":"11","author":"Bouwens","year":"2013","journal-title":"J Thromb Haemost"},{"issue":"8","key":"10.1016\/j.jcrc.2018.06.003_bb0040","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1182\/blood-2006-09-003004","article-title":"The cytoprotective protein C pathway","volume":"109","author":"Mosnier","year":"2007","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jcrc.2018.06.003_bb0045","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-2001-18863","article-title":"Disseminated intravascular coagulation in sepsis","volume":"27","author":"Hardaway","year":"2001","journal-title":"Semin Thromb Hemost"},{"issue":"10","key":"10.1016\/j.jcrc.2018.06.003_bb0050","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1074\/jbc.274.10.6704","article-title":"Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation","volume":"274","author":"Xu","year":"1999","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.jcrc.2018.06.003_bb0055","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/CCM.0B013E31816537D8","article-title":"Serum thrombomodulin level relates to the clinical course of disseminated intravascular coagulation, multiorgan dysfunction syndrome, and mortality in patients with sepsis","volume":"36","author":"Lin","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2018.06.003_bb0060","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1186\/s13054-015-1145-9","article-title":"Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study","volume":"19","author":"Orwoll","year":"2015","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.jcrc.2018.06.003_bb0065","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00134-015-3648-x","article-title":"Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome","volume":"41","author":"Sapru","year":"2015","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2018.06.003_bb0070","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1538-7836.2012.04623.x","article-title":"Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay","volume":"10","author":"Muller","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1016\/j.jcrc.2018.06.003_bb0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"issue":"5","key":"10.1016\/j.jcrc.2018.06.003_bb0080","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0037-1616068","article-title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","volume":"86","author":"Taylor","year":"2001","journal-title":"Thromb Haemost"},{"issue":"10","key":"10.1016\/j.jcrc.2018.06.003_bb0085","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"issue":"24","key":"10.1016\/j.jcrc.2018.06.003_bb0090","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study","volume":"270","author":"Le Gall","year":"1993","journal-title":"JAMA"},{"issue":"13","key":"10.1016\/j.jcrc.2018.06.003_bb0095","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1182\/blood-2004-03-1203","article-title":"Patients with severe sepsis vary markedly in their ability to generate activated protein C","volume":"104","author":"Liaw","year":"2004","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jcrc.2018.06.003_bb0100","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1097\/01.CCM.0000072121.61120.D8","article-title":"Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study","volume":"31","author":"de Kleijn","year":"2003","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.jcrc.2018.06.003_bb0105","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1097\/00003246-200007000-00005","article-title":"Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications","volume":"28","author":"Mesters","year":"2000","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.jcrc.2018.06.003_bb0110","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1164\/rccm.200611-1692OC","article-title":"A comparative study of the protein C pathway in septic and nonseptic patients with organ failure","volume":"176","author":"Borgel","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.jcrc.2018.06.003_bb0115","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1182\/blood-2014-05-578328","article-title":"Endothelial cell protein C receptor: a multiliganded and multifunctional receptor","volume":"124","author":"Mohan Rao","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jcrc.2018.06.003_bb0120","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1182\/blood.V91.5.1542","article-title":"Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma","volume":"91","author":"Elisen","year":"1998","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jcrc.2018.06.003_bb0125","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ccm.2016.01.009","article-title":"Endothelial and microcirculatory function and dysfunction in sepsis","volume":"37","author":"Colbert","year":"2016","journal-title":"Clin Chest Med"},{"issue":"2","key":"10.1016\/j.jcrc.2018.06.003_bb0130","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/ACO.0000000000000163","article-title":"The coagulopathy of acute sepsis","volume":"28","author":"Simmons","year":"2015","journal-title":"Curr Opin Anaesthesiol"},{"issue":"3","key":"10.1016\/j.jcrc.2018.06.003_bb0135","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajh.20089","article-title":"Hemostatic markers and the sepsis-related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit","volume":"76","author":"Okabayashi","year":"2004","journal-title":"Am J Hematol"},{"issue":"6","key":"10.1016\/j.jcrc.2018.06.003_bb0140","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/SHK.0000000000000727","article-title":"Antithrombin supplementation and mortality in sepsis-induced disseminated intravascular coagulation: a multicenter retrospective observational study","volume":"46","author":"Hayakawa","year":"2016","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.jcrc.2018.06.003_bb0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2253-13-25","article-title":"The aPC treatment improves microcirculation in severe sepsis\/septic shock syndrome","volume":"13","author":"Donati","year":"2013","journal-title":"BMC Anesthesiol"},{"issue":"4","key":"10.1016\/j.jcrc.2018.06.003_bb0150","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1097\/01.CCM.0000120058.88975.42","article-title":"Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia","volume":"32","author":"Hoffmann","year":"2004","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcrc.2018.06.003_bb0155","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/01.sla.0000256862.79374.31","article-title":"Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?","volume":"245","author":"Brohi","year":"2007","journal-title":"Ann Surg"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944118305598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944118305598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T01:02:08Z","timestamp":1571446928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944118305598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":31,"alternative-id":["S0883944118305598"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2018.06.003","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The evolution of activated protein C plasma levels in septic shock and its association with mortality: A prospective observational study","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2018.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}