{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:20:04Z","timestamp":1776223204918,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"am","delay-in-days":283,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jcrc.2020.08.025","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T12:25:58Z","timestamp":1599049558000},"page":"253-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A low dose heparinized saline protocol is associated with improved duration of arterial line patency in critically ill COVID-19 patients"],"prefix":"10.1016","volume":"60","author":[{"given":"Lydia R.","family":"Maurer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey M.","family":"Luckhurst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzo","family":"Hamidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly A.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan E.","family":"Barra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majed","family":"El Hechi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ava","family":"Mokhtari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Breen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Prout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarone","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Bittner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haytham M.A.","family":"Kaafarani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel P.","family":"Rosovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russel J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2020.08.025_bb0005","doi-asserted-by":"crossref","DOI":"10.1097\/SLA.0000000000004004","article-title":"Gastrointestinal complications in critically ill patients with COVID-19","author":"Kaafarani","year":"2020","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.thromres.2020.04.024","article-title":"Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy","volume":"191","author":"Lodigiani","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0020","doi-asserted-by":"crossref","DOI":"10.1097\/SLA.0000000000004089","article-title":"Design and impact of a COVID-19 multidisciplinary bundled procedure team","author":"Albutt","year":"2020","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0025","article-title":"Arterial and vein related catheters thrombosis in a patient with COVID-19: a case report","author":"Haoudar","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0030","first-page":"115","article-title":"Comparison of normal saline and heparin solutions for maintenance of arterial catheter patency","volume":"20","author":"Clifton","year":"1991","journal-title":"Heart Lung J Crit Care"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0035","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/08880010290097404","article-title":"The efficacy of heparinization in prolonging patency of arterial and central venous catheters in children: a randomized double-blind trial","volume":"19","author":"De Neef","year":"2002","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0040","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/1751143716653763","article-title":"Finding a solution: heparinised saline versus normal saline in the maintenance of invasive arterial lines in intensive care","volume":"17","author":"Everson","year":"2016","journal-title":"J Intensive Care Soc"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0045","doi-asserted-by":"crossref","DOI":"10.5812\/aapm28056","article-title":"Heparinized and saline solutions in the maintenance of arterial and central venous catheters after cardiac surgery","volume":"5","author":"Ziyaeifard","year":"2015","journal-title":"Anesthesiol Pain Med"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0050","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00134-007-0886-6","article-title":"Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial","volume":"34","author":"Del Cotillo","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0055","first-page":"37","article-title":"Heparinized saline versus normal saline in maintaining patency of the radial artery catheter","volume":"37","author":"Kulkarni","year":"1994","journal-title":"Can J Surg"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13019-019-0860-8","article-title":"A comparison of heparinised and non-heparinised normal saline solutions for maintaining the patency of arterial pressure measurement cannulae after heart surgery","volume":"14","author":"Xiong","year":"2019","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0065","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/jth.13140","article-title":"Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH","volume":"13","author":"Kaatz","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0070","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.202004-1163LE","article-title":"Respiratory pathophysiology of mechanically ventilated patients with COVID-19: a cohort study","author":"Ziehr","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0075","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1056\/NEJMoa2004500","article-title":"Covid-19 in critically ill patients in the Seattle region \u2014 case series","volume":"382","author":"Bhatraju","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0080","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0085","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00134-018-5149-1","article-title":"Impact of intravascular thrombosis on failure of radial arterial catheters in critically ill patients: a nested case-control study","volume":"44","author":"Fleury","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0090","first-page":"527","article-title":"Histopathologic changes of the radial artery wall secondary to transradial catheterization","volume":"5","author":"Staniloae","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0095","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/00003246-197801000-00016","article-title":"Long-term radial artery cannulation: effects on subsequent vessel function","volume":"6","author":"Bedford","year":"1978","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0100","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4037\/ajcc2001.10.2.104","article-title":"Patency of radial arterial catheters","volume":"10","author":"Kaye","year":"2001","journal-title":"Am J Crit Care"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0105","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/cvr\/cvt110","article-title":"The effects of arterial flow on platelet activation, thrombus growth, and stabilization","volume":"99","author":"Cosemans","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0110","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1182\/blood.V90.4.1558","article-title":"Fluid shear stress modulates von Willebrand factor release from human vascular endothelium","volume":"90","author":"Galbusera","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/jth.14850","article-title":"Hypercoagulability of COVID-19 patients in Intensive Care Unit. A report of thromboelastography findings and other parameters of hemostasis","author":"Panigada","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0120","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007364.pub2","article-title":"Heparin versus normal saline for patency of arterial lines","author":"Robertson-Malt","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4037\/ajcc1993.2.1.3","article-title":"Evaluation of the effects of heparinized and nonheparinized flush solutions on the patency of arterial pressure monitoring lines: the AACN Thunder Project. By the American Association of Critical-Care Nurses","volume":"2","year":"1993","journal-title":"Am J Crit Care"},{"key":"10.1016\/j.jcrc.2020.08.025_bb0135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00000542-198107000-00016","article-title":"The effect of method of radial artery cannulation on postcannulation blood flow and thrombus formation","volume":"55","author":"Jones","year":"1981","journal-title":"Anesthesiology"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944120306717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944120306717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:47:06Z","timestamp":1760125626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944120306717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":27,"alternative-id":["S0883944120306717"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2020.08.025","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A low dose heparinized saline protocol is associated with improved duration of arterial line patency in critically ill COVID-19 patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2020.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}