{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:13:35Z","timestamp":1774311215039,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jcrc.2020.12.005","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T21:27:00Z","timestamp":1608154020000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Interactions between carbapenems and valproic acid among the patients in the intensive care units"],"prefix":"10.1016","volume":"62","author":[{"given":"I-Ling","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Hsiang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Chen","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Yuan","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2020.12.005_bb0005","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/phar.1636","article-title":"Infections caused by resistant gram-negative Bacteria: epidemiology and management","volume":"35","author":"Kaye","year":"2015","journal-title":"Pharmacother J Hum Pharmacol Drug Ther"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/668770","article-title":"Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009\u20132010","volume":"34","author":"Sievert","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0015","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1474-4422(15)00314-2","article-title":"Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug","volume":"15","author":"Tomson","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0020","series-title":"Applied clinical pharmacokinetics","author":"Bauer","year":"2008"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0025","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/FTD.0b013e318260f7b3","article-title":"Reduced Valproic acid serum concentrations due to drug interactions with Carbapenem antibiotics: overview of 6 cases","volume":"34","author":"Park","year":"2012","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0030","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s40262-018-0720-z","article-title":"Interactions between antiepileptic and antibiotic drugs: a systematic review and meta-analysis with dosing implications","volume":"58","author":"Carnovale","year":"2019","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0035","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00134-005-2695-0","article-title":"Pharmacokinetic interaction between valproic acid and meropenem","volume":"31","author":"Clause","year":"2005","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0040","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/03602530701690341","article-title":"Interaction between Valproic acid and Carbapenem antibiotics","volume":"39","author":"Mori","year":"2007","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0045","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1345\/aph.1K079","article-title":"Interaction between valproate and meropenem: a retrospective study","volume":"41","author":"Spriet","year":"2007","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/jcpt.12501","article-title":"Drug-drug interaction between valproic acid and meropenem: a retrospective analysis of electronic medical records from neurosurgery inpatients","volume":"42","author":"Wen","year":"2017","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0055","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus \u2013 report of the ILAE task force on classification of status epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0060","first-page":"751","article-title":"Missing covariates in competing risks analysis","volume":"17","author":"Bartlett","year":"2016","journal-title":"Biostat Oxf Engl"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0065","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2125.2005.02529.x","article-title":"Clinically relevant drug interactions with antiepileptic drugs","volume":"61","author":"Perucca","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0070","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1345\/aph.1M296","article-title":"The effect of carbapenem antibiotics on plasma concentrations of valproic acid","volume":"43","author":"Mancl","year":"2009","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0075","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1515\/DMDI.2009.24.2-4.153","article-title":"Valproic acid-carbapenem interaction: report of six cases and a review of the literature","volume":"24","author":"Tobin","year":"2009","journal-title":"Drug Metabol Drug Interact"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0080","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1124\/dmd.110.034231","article-title":"Characterization of inhibitory effect of Carbapenem antibiotics on the Deconjugation of Valproic acid glucuronide","volume":"38","author":"Masuo","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0085","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.kjms.2016.12.001","article-title":"Drug interaction between valproic acid and carbapenems in patients with epileptic seizures","volume":"33","author":"Huang","year":"2017","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0090","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/FTD.0000000000000316","article-title":"The effect of different Carbapenem antibiotics (Ertapenem, imipenem\/Cilastatin, and Meropenem) on serum Valproic acid concentrations","volume":"38","author":"Wu","year":"2016","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0095","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1046\/j.1528-1157.2001.34701.x","article-title":"Seizures in the critically ill: the role of imipenem","volume":"42","author":"Koppel","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0100","series-title":"Epileptogenic potential of carbapenem agents: mechanism of action, seizure rates, and clinical considerations Pharmacotherapy","first-page":"408","volume":"31","author":"Miller","year":"2011"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0105","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s40264-017-0578-2","article-title":"Neurological adverse effects attributable to \u03b2-lactam antibiotics: a literature review","volume":"40","author":"Deshayes","year":"2017","journal-title":"Drug Saf"},{"key":"10.1016\/j.jcrc.2020.12.005_bb0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0002-9343(88)90171-4","article-title":"Controlled trials of double beta-lactam therapy with cefoperazone plus piperacillin in febrile granulocytopenic patients","volume":"85","author":"Winston","year":"1988","journal-title":"Am J Med"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944120307991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944120307991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:47:01Z","timestamp":1760125621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944120307991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":22,"alternative-id":["S0883944120307991"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2020.12.005","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interactions between carbapenems and valproic acid among the patients in the intensive care units","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2020.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}