{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:03:19Z","timestamp":1792465399338,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jcrc.2021.10.022","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T23:41:25Z","timestamp":1637106085000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Effect of sodium administration on fluid balance and sodium balance in health and the perioperative setting. Extended summary with additional insights from the MIHMoSA and TOPMAST studies"],"prefix":"10.1016","volume":"67","author":[{"given":"Niels","family":"Van Regenmortel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"De Weerdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Roelant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Malbrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Van den Wyngaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jorens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jcrc.2021.10.022_bb0005","first-page":"390","article-title":"Fluid management before, during and after elective surgery","volume":"20","author":"Van Regenmortel","year":"2014","journal-title":"Curr Opin Crit Care"},{"issue":"4","key":"10.1016\/j.jcrc.2021.10.022_bb0010","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1441-2772(23)01429-1","article-title":"Sodium administration in critically ill patients in Australia and New Zealand: a multicentre point prevalence study","volume":"15","author":"Bihari","year":"2013","journal-title":"Crit Care Resuscitation"},{"issue":"2","key":"10.1016\/j.jcrc.2021.10.022_bb0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1441-2772(23)01010-4","article-title":"Maintenance fluid practices in intensive care units in Australia and New Zealand","volume":"18","author":"Bihari","year":"2016","journal-title":"Crit Care Resuscitation"},{"issue":"4","key":"10.1016\/j.jcrc.2021.10.022_bb0020","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00134-018-5147-3","article-title":"Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population","volume":"44","author":"Van Regenmortel","year":"2018","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.jcrc.2021.10.022_bb0025","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13613-018-0402-x","article-title":"Principles of fluid management and stewardship in septic shock: it is time to consider the four D\u2019s and the four phases of fluid therapy","volume":"8","author":"Malbrain","year":"2018","journal-title":"Ann Intensive Care"},{"issue":"1","key":"10.1016\/j.jcrc.2021.10.022_bb0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13613-020-00679-3","article-title":"Intravenous fluid therapy in the perioperative and critical care setting: executive summary of the international fluid academy (IFA)","volume":"10","author":"Malbrain","year":"2020","journal-title":"Ann Intensive Care"},{"issue":"6","key":"10.1016\/j.jcrc.2021.10.022_bb0035","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1136\/adc.2006.106377","article-title":"Fluid therapy for children: facts, fashions and questions","volume":"92","author":"Holliday","year":"2007","journal-title":"Arch Dis Child"},{"issue":"1","key":"10.1016\/j.jcrc.2021.10.022_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13613-021-00851-3","article-title":"Fluid-induced harm in the hospital: look beyond volume and start considering sodium. From physiology towards recommendations for daily practice in hospitalized adults","volume":"11","author":"Van Regenmortel","year":"2021","journal-title":"Ann Intensive Care"},{"issue":"9974","key":"10.1016\/j.jcrc.2021.10.022_bb0045","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0140-6736(14)61459-8","article-title":"140 mmol\/L of sodium versus 77 mmol\/L of sodium in maintenance intravenous fluid therapy for children in hospital (PIMS): a randomised controlled double-blind trial","volume":"385","author":"McNab","year":"2015","journal-title":"Lancet."},{"issue":"6","key":"10.1016\/j.jcrc.2021.10.022_bb0050","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/bja\/aex118","article-title":"Effect of isotonic versus hypotonic maintenance fluid therapy on urine output, fluid balance, and electrolyte homeostasis: a crossover study in fasting adult volunteers","volume":"118","author":"Van Regenmortel","year":"2017","journal-title":"Br J Anaesth"},{"issue":"10","key":"10.1016\/j.jcrc.2021.10.022_bb0055","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1007\/s00134-019-05772-1","article-title":"154 compared to 54 mmol per liter of sodium in intravenous maintenance fluid therapy for adult patients undergoing major thoracic surgery (TOPMAST): a single-center randomized controlled double-blind trial","volume":"45","author":"Van Regenmortel","year":"2019","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2021.10.022_bb0060","series-title":"Clinical disorders of fluid and electrolyte metabolism","author":"Early","year":"1972"},{"issue":"Suppl. 1","key":"10.1016\/j.jcrc.2021.10.022_bb0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000463831","article-title":"Relationship between sodium intake and water intake: the false and the true","volume":"70","author":"Bankir","year":"2017","journal-title":"Ann Nutr Metab"},{"issue":"6644","key":"10.1016\/j.jcrc.2021.10.022_bb0070","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/bmj.297.6644.319","article-title":"Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group","volume":"297","year":"1988","journal-title":"BMJ"},{"key":"10.1016\/j.jcrc.2021.10.022_bb0075","doi-asserted-by":"crossref","first-page":"231063","DOI":"10.1155\/2015\/231063","article-title":"Twenty-four-hour urine osmolality as a physiological index of adequate water intake","volume":"2015","author":"Perrier","year":"2015","journal-title":"Dis Markers"},{"issue":"5","key":"10.1016\/j.jcrc.2021.10.022_bb0080","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s00394-019-02065-7","article-title":"Urinary markers of hydration during 3-day water restriction and graded rehydration","volume":"59","author":"Johnson","year":"2020","journal-title":"Eur J Nutr"},{"issue":"5","key":"10.1016\/j.jcrc.2021.10.022_bb0085","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1172\/JCI88530","article-title":"Increased salt consumption induces body water conservation and decreases fluid intake","volume":"127","author":"Rakova","year":"2017","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.jcrc.2021.10.022_bb0090","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1172\/JCI88532","article-title":"High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation","volume":"127","author":"Kitada","year":"2017","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.jcrc.2021.10.022_bb0095","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1007\/s00134-020-05989-5","article-title":"Don\u2019t lose sight of maintenance fluids\u2019 main role: to provide free water!","volume":"46","author":"Van Regenmortel","year":"2020","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2021.10.022_bb0100","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/bja\/aer515","article-title":"Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy","volume":"108","author":"Woodcock","year":"2012","journal-title":"Br J Anaesth"},{"issue":"2","key":"10.1016\/j.jcrc.2021.10.022_bb0105","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.CCM.0000194725.48928.3A","article-title":"Sepsis in European intensive care units: results of the SOAP study","volume":"34","author":"Vincent","year":"2006","journal-title":"Crit Care Med"},{"issue":"24","key":"10.1016\/j.jcrc.2021.10.022_bb0110","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1056\/NEJMoa1801601","article-title":"Restrictive versus liberal fluid therapy for major abdominal surgery","volume":"378","author":"Myles","year":"2018","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.jcrc.2021.10.022_bb0115","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1164\/rccm.201111-2025OC","article-title":"The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury","volume":"185","author":"Mikkelsen","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcrc.2021.10.022_bb0120","first-page":"R1726","article-title":"Low urine flow reduces the capacity to excrete a sodium load in humans","volume":"273","author":"Choukroun","year":"1997","journal-title":"Am J Physiol"},{"issue":"4","key":"10.1016\/j.jcrc.2021.10.022_bb0125","doi-asserted-by":"crossref","first-page":"F585","DOI":"10.1152\/ajprenal.2000.278.4.F585","article-title":"High dietary sodium chloride consumption may not induce body fluid retention in humans","volume":"278","author":"Heer","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"10.1016\/j.jcrc.2021.10.022_bb0130","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1053\/ajkd.2002.34908","article-title":"Long-term sodium balance in humans in a terrestrial space station simulation study","volume":"40","author":"Titze","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.jcrc.2021.10.022_bb0135","doi-asserted-by":"crossref","first-page":"F1108","DOI":"10.1152\/ajprenal.00200.2003","article-title":"Osmotically inactive skin Na+ storage in rats","volume":"285","author":"Titze","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"10.1016\/j.jcrc.2021.10.022_bb0140","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/ki.2012.314","article-title":"Seeing the sodium in a patient with hypernatremia","volume":"82","author":"Kopp","year":"2012","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.jcrc.2021.10.022_bb0145","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1681\/ASN.2014050430","article-title":"Role of the vascular wall in sodium homeostasis and salt sensitivity","volume":"26","author":"Olde Engberink","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.jcrc.2021.10.022_bb0150","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ki.2013.367","article-title":"Spooky sodium balance","volume":"85","author":"Titze","year":"2014","journal-title":"Kidney Int"},{"issue":"9","key":"10.1016\/j.jcrc.2021.10.022_bb0155","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1017\/S0007114508088041","article-title":"Increasing sodium intake from a previous low or high intake affects water, electrolyte and acid-base balance differently","volume":"101","author":"Heer","year":"2009","journal-title":"Br J Nutr"},{"issue":"3","key":"10.1016\/j.jcrc.2021.10.022_bb0160","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.kint.2016.12.004","article-title":"Quantification of nonosmotic sodium storage capacity following acute hypertonic saline infusion in healthy individuals","volume":"91","author":"Olde Engberink","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.jcrc.2021.10.022_bb0165","first-page":"9571583","article-title":"The development of intensive care unit acquired hypernatremia is not explained by sodium overload or water deficit: a retrospective cohort study on water balance and sodium handling","volume":"2016","author":"van IJzendoorn MC, Buter H, Kingma WP, Navis GJ, Boerma EC.","year":"2016","journal-title":"Crit Care Res Prac"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944121002458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944121002458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:50:16Z","timestamp":1760125816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944121002458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":33,"alternative-id":["S0883944121002458"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2021.10.022","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of sodium administration on fluid balance and sodium balance in health and the perioperative setting. Extended summary with additional insights from the MIHMoSA and TOPMAST studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2021.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}