{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:07:15Z","timestamp":1793934435610,"version":"4.8.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM19\/00223"],"award-info":[{"award-number":["CM19\/00223"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jcrc.2022.154069","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:05:40Z","timestamp":1654214740000},"page":"154069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Red blood cell distribution width as prognostic factor in sepsis: A new use for a classical parameter"],"prefix":"10.1016","volume":"71","author":[{"given":"V\u00edctor","family":"Moreno-Torres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Royuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"M\u00fa\u00f1ez-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Gutierrez-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mills-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Tejado-Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garc\u00eda-Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mu\u00f1oz-Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Calder\u00f3n-Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fern\u00e1ndez-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ramos-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2022.154069_bb0005","first-page":"380","article-title":"ICON investigators. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. Lancet","volume":"2","author":"Vincent","year":"2014","journal-title":"Respir Med"},{"issue":"395","key":"10.1016\/j.jcrc.2022.154069_bb0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"18","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jcrc.2022.154069_bb0015","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2022.154069_bb0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/jama.2014.5804","article-title":"Hospital deaths in patients with sepsis from 2 independent cohorts","volume":"312","author":"Liu","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2022.154069_bb0025","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2022.154069_bb0030","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis campaign: international guidelines for Management of Sepsis and Septic Shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0035","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-020-02993-5","article-title":"Biomarkers of sepsis: time for a reappraisal","volume":"24","author":"Pierrakos","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2022.154069_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ajh.10011","article-title":"Importance of RDW value in differential diagnosis of hypochrome anemias","volume":"69","author":"Aslan","year":"2002","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jcrc.2022.154069_bb0045","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMra041809","article-title":"Anemia of chronic disease","volume":"352","author":"Weiss","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0050","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/blood-2018-06-856500","article-title":"Anemia of inflammation","volume":"133","author":"Weiss","year":"2019","journal-title":"Blood."},{"key":"10.1016\/j.jcrc.2022.154069_bb0055","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cardfail.2009.11.003","article-title":"Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure","volume":"16","author":"Allen","year":"2010","journal-title":"J Card Fail"},{"key":"10.1016\/j.jcrc.2022.154069_bb0060","doi-asserted-by":"crossref","first-page":"S651","DOI":"10.1097\/01.CCM.0000098036.90796.ED","article-title":"Red blood cell physiology in critical illness","volume":"31","author":"Scharte","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/10408363.2014.992064","article-title":"Red blood cell distribution width: a simple parameter with multiple clinical applications","volume":"52","author":"Salvagno","year":"2015","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.jcrc.2022.154069_bb0070","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM consensus conference committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest."},{"key":"10.1016\/j.jcrc.2022.154069_bb0075","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for Sepsis: for the third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2022.154069_bb0080","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related organ failure assessment) score to describe organ dysfunction\/failure. On behalf of the working group on Sepsis-related problems of the European Society of Intensive Care Medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0085","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","article-title":"Use of the SOFA score to assess the incidence of organ dysfunction\/failure in intensive care units: results of a multicenter, prospective study. Working group on \u201csepsis-related problems\u201d of the European Society of Intensive Care Medicine","volume":"26","author":"Vincent","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0090","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jama.1996.03540100046027","article-title":"The logistic organ dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU scoring group","volume":"276","author":"Le Gall","year":"1996","journal-title":"JAMA."},{"key":"10.1016\/j.jcrc.2022.154069_bb0095","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0100","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new simplified acute physiology score (SAPS II) based on a European\/north American multicenter study","volume":"270","author":"Le Gall","year":"1993","journal-title":"JAMA."},{"key":"10.1016\/j.jcrc.2022.154069_bb0105","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin Definition","volume":"307","author":"Definition Task Force","year":"2012","journal-title":"JAMA."},{"key":"10.1016\/j.jcrc.2022.154069_bb0110","series-title":"Applied logistic regression","first-page":"160","author":"Hosmer","year":"2000"},{"key":"10.1016\/j.jcrc.2022.154069_bb0115","article-title":"Better prognostic ability of NEWS2, SOFA and SAPS-II in septic patients","volume":"S0025-7753","author":"Moreno-Torres","year":"2021","journal-title":"Med Clin (Barc)"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154069_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13613-019-0542-7","article-title":"Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational study","volume":"9","author":"Jiang","year":"2019","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jcrc.2022.154069_bb0125","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1001\/jama.2022.1816","article-title":"Causal directed acyclic graphs","volume":"327","author":"Lipsky","year":"2022","journal-title":"JAMA."},{"key":"10.1016\/j.jcrc.2022.154069_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinbiochem.2020.01.001","article-title":"Diagnostic and prognostic value of red blood cell distribution width in sepsis: a narrative review","volume":"77","author":"Hu","year":"2020","journal-title":"Clin Biochem"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154069_bb0135","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12865-020-00369-6","article-title":"Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jcrc.2022.154069_bb0140","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ajem.2017.10.056","article-title":"Red blood cell distribution width is associated with mortality in elderly patients with sepsis","volume":"36","author":"Wang","year":"2018","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0145","article-title":"STARD-compliant article: the utility of red cell distribution width to predict mortality for septic patients visiting the emergency department","volume":"95","author":"Chen","year":"2016","journal-title":"Med (Baltimore)"},{"key":"10.1016\/j.jcrc.2022.154069_bb0150","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/2229-5151.147518","article-title":"Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis","volume":"4","author":"Mahmood","year":"2014","journal-title":"Int J Crit Illn Inj Sci"},{"key":"10.1016\/j.jcrc.2022.154069_bb0155","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/0885066612452838","article-title":"Red cell distribution width and outcome in patients with septic shock","volume":"28","author":"Sadaka","year":"2013","journal-title":"J Int Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0160","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ajem.2012.10.017","article-title":"Red cell distribution width is a prognostic factor in severe sepsis and septic shock","volume":"31","author":"Jo","year":"2013","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0885066618787448","article-title":"A simple scoring system using the red blood cell distribution width, Delta neutrophil index, and platelet count to predict mortality in patients with severe Sepsis and septic shock","volume":"34","author":"Kim","year":"2019","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0170","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/0885066620933245","article-title":"A modified simple scoring system using the red blood cell distribution width, Delta neutrophil index, and mean platelet volume-to-platelet count to predict 28-day mortality in patients with Sepsis","volume":"36","author":"Kim","year":"2020","journal-title":"J Int Care Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0175","doi-asserted-by":"crossref","first-page":"R282","DOI":"10.1186\/cc13145","article-title":"An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock","volume":"17","author":"Kim","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2022.154069_bb0180","doi-asserted-by":"crossref","first-page":"155","DOI":"10.15441\/ceem.15.037","article-title":"Red cell distribution width and early mortality in elderly patients with severe sepsis and septic shock","volume":"2","author":"Kim","year":"2015","journal-title":"Clin Exp Emerg Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199654","article-title":"Red cell distribution width at hospital discharge and out-of hospital outcomes in critically ill non-cardiac vascular surgery patients","volume":"13","author":"von Meijenfeldt","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jcrc.2022.154069_bb0190","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ajem.2016.10.075","article-title":"Development and validation of a parsimonious and pragmatic CHARM score to predict mortality in patients with suspected sepsis","volume":"35","author":"Chen","year":"2017","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0195","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/ijlh.12261","article-title":"Sepsis affects most routine and cell population data (CPD) obtained using the Sysmex XN-2000 blood cell analyzer: neutrophil-related CPD NE-SFL and NE-WY provide useful information for detecting sepsis","volume":"37","author":"Park","year":"2015","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.jcrc.2022.154069_bb0200","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cca.2018.09.019","article-title":"Red blood cell distribution width predicts long-term outcomes in sepsis patients admitted to the intensive care unit","volume":"487","author":"Han","year":"2018","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jcrc.2022.154069_bb0205","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4103\/0366-6999.205858","article-title":"Dynamic change of red cell distribution width levels in prediction of hospital mortality in Chinese elderly patients with septic shock","volume":"130","author":"Ju","year":"2017","journal-title":"Chin Med J"},{"key":"10.1016\/j.jcrc.2022.154069_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105436","article-title":"Red blood cell distribution width during the first week is associated with severity and mortality in septic patients","volume":"9","author":"Lorente","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcrc.2022.154069_bb0215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12873-020-00337-8","article-title":"The utility of red cell distribution width to predict mortality of septic patients in a tertiary hospital of Nepal","volume":"20","author":"Ghimire","year":"2020","journal-title":"BMC Emerg Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106145","article-title":"Prognostic value of an inflammatory biomarker-based clinical algorithm in septic patients in the emergency department: An observational study","volume":"80","author":"Zhao","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jcrc.2022.154069_bb0225","first-page":"730","article-title":"Red cell distribution width is associated with hospital mortality in unselected critically ill patients","volume":"5","author":"Zhang","year":"2013","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jcrc.2022.154069_bb0230","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3233\/CH-160154","article-title":"No relationship between red blood cell distribution width and microcirculatory alterations in septic patients","volume":"66","author":"Fontana","year":"2017","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.jcrc.2022.154069_bb0235","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/SHK.0b013e31815077ca","article-title":"Prognostic value of mortality in emergency department sepsis score, procalcitonin, and C-reactive protein in patients with sepsis at the emergency department","volume":"29","author":"Lee","year":"2008","journal-title":"Shock."},{"key":"10.1016\/j.jcrc.2022.154069_bb0240","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/SHK.0b013e31825e2a85","article-title":"Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia","volume":"38","author":"Ku","year":"2012","journal-title":"Shock."},{"key":"10.1016\/j.jcrc.2022.154069_bb0245","article-title":"Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus","volume":"5","author":"Moreno-Torres","year":"2022","journal-title":"J Trans Autoimmun"},{"key":"10.1016\/j.jcrc.2022.154069_bb0250","article-title":"Red blood cell distribution width as a marker of hyperinflammation and mortality in COVID-19","volume":"22","author":"Moreno-Torres","year":"2022","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.jcrc.2022.154069_bb0255","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1136\/bmj.332.7549.1080","article-title":"The cost of dichotomising continuous variables","volume":"332","author":"Altman","year":"2006","journal-title":"BMJ."}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944122000983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944122000983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:50:14Z","timestamp":1760125814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944122000983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":51,"alternative-id":["S0883944122000983"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2022.154069","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Red blood cell distribution width as prognostic factor in sepsis: A new use for a classical parameter","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2022.154069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154069"}}