{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:21:13Z","timestamp":1792819273420,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jcrc.2022.154099","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T12:17:40Z","timestamp":1656159460000},"page":"154099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials."],"prefix":"10.1016","volume":"71","author":[{"given":"Ana Luiza Cabrera","family":"Martimbianco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Leite","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela Maria","family":"Bagattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"de F\u00e1tima Carreira Moreira Padovez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Cesar Pontes","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Riera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10219","key":"10.1016\/j.jcrc.2022.154099_bb0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet."},{"issue":"12","key":"10.1016\/j.jcrc.2022.154099_bb0010","article-title":"Sepsis in intensive care unit patients: worldwide data from the intensive care over nations audit. Open forum","volume":"5","author":"Sakr","year":"2018","journal-title":"Infect Dis"},{"issue":"8","key":"10.1016\/j.jcrc.2022.154099_bb0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jcrc.2022.154099_bb0020","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2022.154099_bb0025","first-page":"363","article-title":"Metabolic support in sepsis: corticosteroids and vitamins: the why, the when, the how","volume":"26","author":"Fujii","year":"2020","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.jcrc.2022.154099_bb0030","article-title":"Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis","author":"Fujii","year":"2021","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0035","doi-asserted-by":"crossref","DOI":"10.1177\/0036850421998175","article-title":"Effect of vitamin C in critically ill patients with sepsis and septic shock: a meta-analysis","volume":"104","author":"Feng","year":"2021","journal-title":"Sci Prog"},{"key":"10.1016\/j.jcrc.2022.154099_bb0040","doi-asserted-by":"crossref","DOI":"10.1097\/MEJ.0000000000000812","article-title":"Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis","author":"Ge","year":"2021","journal-title":"Eur J Emerg Med"},{"issue":"4","key":"10.1016\/j.jcrc.2022.154099_bb0045","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3390\/nu11040708","article-title":"Vitamin C can shorten the length of stay in the ICU: a meta-analysis","volume":"11","author":"Hemil\u00e4","year":"2019","journal-title":"Nutrients."},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13054-020-03438-9","article-title":"Mortality in septic patients treated with vitamin C: a systematic meta-analysis","volume":"25","author":"Scholz","year":"2021","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13613-019-0532-9","article-title":"Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis","volume":"9","author":"Wang","year":"2019","journal-title":"Ann Intensive Care"},{"issue":"6","key":"10.1016\/j.jcrc.2022.154099_bb0060","article-title":"Vitamin C supplementation in the critically ill: a systematic review and meta-analysis","volume":"19","author":"Zhang","year":"2018","journal-title":"SAGE Open Med"},{"issue":"11","key":"10.1016\/j.jcrc.2022.154099_bb0065","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2022.154099_bb0070","author":"Higgins"},{"issue":"372","key":"10.1016\/j.jcrc.2022.154099_bb0075","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"29","author":"Page","year":"2021","journal-title":"BMJ."},{"key":"10.1016\/j.jcrc.2022.154099_bb0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan \u2014 a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"issue":"7650","key":"10.1016\/j.jcrc.2022.154099_bb0085","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.jcrc.2022.154099_bb0090","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4037\/ajcc2015335","article-title":"Mechanical ventilation antioxidant trial","volume":"24","author":"Howe","year":"2015","journal-title":"Am J Crit Care"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0095","first-page":"77","article-title":"Early adjuvant intravenous vitamin C treatment in septic shock may resolve the vasopressor dependence","volume":"5","author":"Nabil","year":"2017","journal-title":"Int J Microbiol Adv Immunol"},{"issue":"11","key":"10.1016\/j.jcrc.2022.154099_bb0100","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3390\/medicina56110619","article-title":"Usefulness of antioxidants as adjuvant therapy for septic shock: a randomized clinical trial","volume":"56","author":"Aisa-Alvarez","year":"2020","journal-title":"Medicina (Kaunas)"},{"issue":"6","key":"10.1016\/j.jcrc.2022.154099_bb0105","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.chest.2018.02.025","article-title":"Vitamin C pharmacokinetics in critically ill patients. A randomized trial of four IV regimens","volume":"153","author":"de Grooth","year":"2018","journal-title":"Chest"},{"issue":"Suppl. 1","key":"10.1016\/j.jcrc.2022.154099_bb0110","first-page":"27","article-title":"Pharmacokinetics of four high-dose regimes of intravenous vitamin C in critically ill patients","volume":"4","author":"de Grooth","year":"2016","journal-title":"Intensive Care Med Exp"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0115","doi-asserted-by":"crossref","DOI":"10.1097\/01.ccm.0000529441.66004.1e","article-title":"Use of vitamin C in patients with mild septic shock: a pilot study","volume":"46","author":"Bernardo","year":"2017","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2022.154099_bb0120","first-page":"233","article-title":"High-dose vitamin C in sepsis","volume":"58","author":"Chen","year":"2019","journal-title":"Zhonghua Nei Ke Za Zhi"},{"issue":"12","key":"10.1016\/j.jcrc.2022.154099_bb0125","article-title":"Effects of vitamin C and E on the outcome of critically ill patients required mechanical ventilation","volume":"42","author":"Hegazy","year":"2014","journal-title":"Crit Care Med"},{"issue":"Suppl. 2","key":"10.1016\/j.jcrc.2022.154099_bb0130","first-page":"S1","article-title":"Study of high-dose ascorbic acid on vasopressor\u2019s requirement in septic shock patients: a surgical intensive care unit study","volume":"24","author":"Misha","year":"2020","journal-title":"Indian J Crit Care Med"},{"issue":"12","key":"10.1016\/j.jcrc.2022.154099_bb0135","doi-asserted-by":"crossref","first-page":"934","DOI":"10.4103\/ija.IJA_361_18","article-title":"Hydrocortisone, Vitamin C and thiamine for the treatment of sepsis and septic shock following cardiac surgery","volume":"62","author":"Balakrishnan","year":"2018","journal-title":"Indian J Anaesth"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.chest.2020.02.065","article-title":"Combined treatment with hydrocortisone, vitamin C, and thiamine for sepsis and septic shock: a randomized controlled trial","volume":"158","author":"Chang","year":"2020","journal-title":"Chest"},{"issue":"45","key":"10.1016\/j.jcrc.2022.154099_bb0145","first-page":"944A","article-title":"The effect of using vitamin C, hydrocortisone, and thiamine triple therapy in the treatment of septic shock","volume":"156","author":"Fan","year":"2019","journal-title":"Chest Ann Meeting"},{"issue":"2","key":"10.1016\/j.jcrc.2022.154099_bb0150","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jss.2008.04.024","article-title":"Effect of vitamin C administration on neutrophil apoptosis in septic patients after abdominal surgery","volume":"153","author":"Ferr\u00f3n-Celma","year":"2009","journal-title":"J Surg Res"},{"issue":"12","key":"10.1016\/j.jcrc.2022.154099_bb0155","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1479-5876-12-32","article-title":"Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis","author":"Fowler","year":"2014","journal-title":"J Transl Med"},{"key":"10.1016\/j.jcrc.2022.154099_bb0160","first-page":"A6718","article-title":"Parenteral vitamin C attenuates markers of organ injury and inflammation in severe sepsis","volume":"185","author":"Fowler","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"13","key":"10.1016\/j.jcrc.2022.154099_bb0165","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jama.2019.11825","article-title":"Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI Randomized Clinical Trial","volume":"322","author":"Fowler","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2022.154099_bb0170","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jama.2019.11825","article-title":"Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial","volume":"322","author":"Fowler","year":"2019","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.jcrc.2022.154099_bb0175","article-title":"Reanalysis of the effect of vitamin C on mortality in the CITRIS-ALI trial: important findings dismissed in the trial report","author":"Hemil\u00e4","year":"2020","journal-title":"Front Med"},{"issue":"6","key":"10.1016\/j.jcrc.2022.154099_bb0180","first-page":"575","article-title":"CITRIS-ALI: how statistics were used to obfuscate the true findings","volume":"38","author":"Marik","year":"2019","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.jcrc.2022.154099_bb0185","first-page":"A2100","article-title":"Effects of high dose intravenous vitamin C (IVC) on plasma cell-free DNA levels in patients with sepsis-associated ARDS","volume":"199","author":"Qiao","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcrc.2022.154099_bb0190","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/jama.2019.22176","article-title":"Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS Randomized Clinical Trial","volume":"323","author":"Fujii","year":"2020","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jcrc.2022.154099_bb0195","first-page":"152","article-title":"Comparing apples and oranges: the vasoactive effects of hydrocortisone and studies investigating high dose vitamin C combination therapy in septic shock","volume":"21","author":"Fujii","year":"2019","journal-title":"Crit Care Resusc"},{"issue":"4","key":"10.1016\/j.jcrc.2022.154099_bb0200","first-page":"236","article-title":"Pharmacokinetic data support 6-hourly dosing of intravenous vitamin C to critically ill patients with septic shock","volume":"21","author":"Hudson","year":"2019","journal-title":"Crit Care Resusc"},{"issue":"21","key":"10.1016\/j.jcrc.2022.154099_bb0205","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1001\/jama.2020.5844","article-title":"Hydrocortisone, and thiamine for septic shock","volume":"323","author":"Long","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2022.154099_bb0210","first-page":"P59","article-title":"Effect of supplementation of vitamin C and thiamine on the outcome of sepsis","author":"Gayathri","year":"2020","journal-title":"Indian J Crit Care Med"},{"issue":"11","key":"10.1016\/j.jcrc.2022.154099_bb0215","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00134-020-06191-3","article-title":"Combination therapy of vitamin C and thiamine for septic shock: a multicentre, double-blinded randomized, controlled study","volume":"46","author":"Hwang","year":"2020","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0220","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.chest.2020.02.049","article-title":"Outcomes of metabolic resuscitation using ascorbic acid, thiamine, and glucocorticoids in the early treatment of sepsis: the ORANGES trial","volume":"158","author":"Iglesias","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.jcrc.2022.154099_bb0225","article-title":"A pilot study of transcriptomic septic endotypes in a subset of the ORANGES trial","volume":"591A","author":"Iglesias","year":"2020","journal-title":"Chest Ann Meeting"},{"issue":"5","key":"10.1016\/j.jcrc.2022.154099_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/jpri\/2019\/v29i530248","article-title":"Effects of a high dose of vitamin C along with thiamine in critically-ill patients with septic shock: a preliminary study","volume":"29","author":"Karimpour","year":"2019","journal-title":"JPRI"},{"issue":"3","key":"10.1016\/j.jcrc.2022.154099_bb0235","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s11845-020-02394-1","article-title":"Early use of high-dose vitamin C is beneficial in treatment of sepsis","volume":"190","author":"Lv","year":"2021","journal-title":"Ir J Med Sci"},{"issue":"8","key":"10.1016\/j.jcrc.2022.154099_bb0240","doi-asserted-by":"crossref","first-page":"653","DOI":"10.5005\/jp-journals-10071-23517","article-title":"Vitamin C therapy for routine care in septic shock (ViCTOR) trial: effect of intravenous vitamin c, thiamine, and hydrocortisone administration on inpatient mortality among patients with septic shock","volume":"24","author":"Mohamed","year":"2020","journal-title":"Indian J Crit Care Med"},{"issue":"7","key":"10.1016\/j.jcrc.2022.154099_bb0245","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/jama.2020.11946","article-title":"Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock: the ACTS randomized clinical trial","volume":"324","author":"Moskowitz","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2022.154099_bb0250","first-page":"A2196","article-title":"Cell-free and mitochondrial DNA levels in severe sepsis: effect of intervention with parenteral vitamin C","volume":"189","author":"Natarejan","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.jcrc.2022.154099_bb0255","article-title":"Effect of ascorbic acid, corticosteroids, and thiamine on health-related quality of life in sepsis","volume":"2","author":"Grossestreuer","year":"2020","journal-title":"Crit Care Explor"},{"issue":"12","key":"10.1016\/j.jcrc.2022.154099_bb0260","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-034406","article-title":"Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial","volume":"9","author":"Moskowitz","year":"2019","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.jcrc.2022.154099_bb0265","doi-asserted-by":"crossref","first-page":"649","DOI":"10.5005\/jp-journals-10071-23515","article-title":"Metabolic resuscitation using hydrocortisone, ascorbic acid, and thiamine: do individual components influence reversal of shock independently?","volume":"24","author":"Reddy","year":"2020","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.jcrc.2022.154099_bb0270","first-page":"S1","article-title":"High dose intravenous ascorbic acid in severe sepsis","volume":"25","author":"Rosini","year":"2018","journal-title":"Acad Emerg Med"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0275","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s13063-020-04289-z","article-title":"Letter on update to the vitamin C, thiamine, and steroids in sepsis (VICTAS) protocol","volume":"21","author":"Frommelt","year":"2020","journal-title":"Trials"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0280","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13063-019-3254-2","article-title":"The vitamin C, thiamine and steroids in sepsis (VICTAS) protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial","volume":"20","author":"Hager","year":"2019","journal-title":"Trials"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0285","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s13063-020-04290-6","article-title":"In response: letter on update to the vitamin C, thiamine and steroids in sepsis (VICTAS) protocol","volume":"21","author":"Lindsell","year":"2020","journal-title":"Trials"},{"issue":"1","key":"10.1016\/j.jcrc.2022.154099_bb0290","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1186\/s13063-019-3775-8","article-title":"Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial","volume":"20","author":"Lindsell","year":"2019","journal-title":"Trials"},{"issue":"8","key":"10.1016\/j.jcrc.2022.154099_bb0295","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1001\/jama.2020.24505","article-title":"Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis: the VICTAS randomized clinical trial","volume":"325","author":"Sevransky","year":"2021","journal-title":"JAMA"},{"issue":"0","key":"10.1016\/j.jcrc.2022.154099_bb0300","first-page":"S103","article-title":"To evaluate the efficacy of Marik protocol in sepsis patient causing circulatory or respiratory compromise or both","volume":"25","author":"Singh","year":"2020","journal-title":"Indian J Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2022.154099_bb0305","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/23744235.2020.1718200","article-title":"Combination of vitamin C, thiamine and hydrocortisone added to standard treatment in the management of sepsis: results from an open label randomised controlled clinical trial and a review of the literature","volume":"52","author":"Wani","year":"2020","journal-title":"Infect Dis"},{"issue":"2","key":"10.1016\/j.jcrc.2022.154099_bb0310","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/2279-042X.179569","article-title":"Effect of high-dose ascorbic acid on vasopressor\u2019s requirement in septic shock","volume":"5","author":"Zabet","year":"2016","journal-title":"J Res Pharm Pract"},{"issue":"6","key":"10.1016\/j.jcrc.2022.154099_bb0315","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.chest.2016.11.036","article-title":"Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study","volume":"151","author":"Marik","year":"2017","journal-title":"Chest."},{"issue":"8","key":"10.1016\/j.jcrc.2022.154099_bb0320","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944122001289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944122001289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:51:30Z","timestamp":1760125890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944122001289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":64,"alternative-id":["S0883944122001289"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2022.154099","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials.","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2022.154099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154099"}}