{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:45:21Z","timestamp":1793832321226,"version":"4.6.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006392","name":"Lausanne University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jcrc.2025.155032","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T21:47:21Z","timestamp":1739569641000},"page":"155032","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Generalization of regional citrate anticoagulation for continuous renal replacement therapy is not associated with an increased rate of severe complications"],"prefix":"10.1016","volume":"87","author":[{"given":"Doreen","family":"Bachmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Monard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kelevina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno","family":"Pruijm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Daniel","family":"Chiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine Guillaume","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2025.155032_bb0005","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00134-015-3934-7","article-title":"Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study","volume":"41","author":"Hoste","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2025.155032_bb0010","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/S0140-6736(15)60126-X","article-title":"International Society of Nephrology\u2019s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology","volume":"385","author":"Mehta","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jcrc.2025.155032_bb0015","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/jama.2020.18618","article-title":"Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on Dialysis filter life span and mortality among critically ill patients with acute kidney injury: a randomized clinical trial","volume":"324","author":"Zarbock","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2025.155032_bb0020","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.jcrc.2025.155032_bb0025","first-page":"19","article-title":"Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury","author":"Disease","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.jcrc.2025.155032_bb0030","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1159\/000506253","article-title":"Complications of regional citrate anticoagulation for continuous renal replacement therapy: an observational study","volume":"49","author":"Bianchi","year":"2020","journal-title":"Blood Purif"},{"key":"10.1016\/j.jcrc.2025.155032_bb0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13054-015-0822-z","article-title":"Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial","volume":"19","author":"Stucker","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0040","doi-asserted-by":"crossref","first-page":"c131","DOI":"10.1159\/000079171","article-title":"Metabolic complications during regional citrate anticoagulation in continuous Venovenous hemodialysis: single-center experience","volume":"97","author":"Morgera","year":"2004","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.jcrc.2025.155032_bb0045","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.2215\/CJN.01280214","article-title":"Regional citrate anticoagulation for RRTs in critically ill patients with AKI","volume":"9","author":"Morabito","year":"2014","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"10.1016\/j.jcrc.2025.155032_bb0050","first-page":"439","article-title":"Citrate anticoagulation for continuous renal replacement therapy (CRRT) in patients with acute kidney injury admitted to the intensive care unit","volume":"2","author":"Davenport","year":"2009","journal-title":"NDT Plus"},{"key":"10.1016\/j.jcrc.2025.155032_bb0055","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/sdi.12959","article-title":"Anticoagulation strategies in continuous renal replacement therapy","volume":"34","author":"Legrand","year":"2021","journal-title":"Semin Dial"},{"key":"10.1016\/j.jcrc.2025.155032_bb0060","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1186\/cc11363","article-title":"Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients","volume":"16","author":"Link","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s44158-023-00091-w","article-title":"Regional citrate anticoagulation (RCA) in critically ill patients undergoing renal replacement therapy (RRT): expert opinion from the SIAARTI-SIN joint commission","volume":"3","author":"Pistolesi","year":"2023","journal-title":"J Anesth Analg Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s13054-017-1880-1","article-title":"Complications of regional citrate anticoagulation: accumulation or overload?","volume":"21","author":"Schneider","year":"2017","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0075","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jcrc.2013.10.015","article-title":"Incidence and outcome of metabolic disarrangements consistent with citrate accumulation in critically ill patients undergoing continuous venovenous hemodialysis with regional citrate anticoagulation","volume":"29","author":"Khadzhynov","year":"2014","journal-title":"J Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0080","doi-asserted-by":"crossref","DOI":"10.1097\/CCM.0000000000002501","article-title":"Hyperlactatemia, lactate kinetics and prediction of citrate accumulation in critically ill patients undergoing continuous renal replacement therapy with regional citrate anticoagulation","volume":"45","author":"Khadzhynov","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2025.155032_bb0085","doi-asserted-by":"crossref","first-page":"20176","DOI":"10.1038\/s41598-023-47644-1","article-title":"Hypercitratemia is a mortality predictor among patients on continuous venovenous hemodiafiltration and regional citrate anticoagulation","volume":"13","author":"dos Santos","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcrc.2025.155032_bb0090","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/00003246-200104000-00010","article-title":"Increased total to ionized calcium ratio during continuous venovenous hemodialysis with regional citrate anticoagulation","volume":"29","author":"Meier-Kriesche","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2025.155032_bb0095","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13054-015-1066-7","article-title":"Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure: the liver citrate anticoagulation threshold (L-CAT) observational study","volume":"19","author":"Slowinski","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13054-019-2317-9","article-title":"Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients: a systematic review and meta-analysis","volume":"23","author":"Zhang","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0105","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jcrc.2013.10.015","article-title":"Incidence and outcome of metabolic disarrangements consistent with citrate accumulation in critically ill patients undergoing continuous venovenous hemodialysis with regional citrate anticoagulation","volume":"29","author":"Khadzhynov","year":"2014","journal-title":"J Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0110","doi-asserted-by":"crossref","first-page":"192","DOI":"10.34067\/KID.0005342020","article-title":"Regional citrate anticoagulation protocol for patients with presumed absent citrate metabolism","volume":"2","author":"Szamosfalvi","year":"2020","journal-title":"Kidney360"},{"key":"10.1016\/j.jcrc.2025.155032_bb0115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13054-017-1870-3","article-title":"Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction","volume":"21","author":"Klingele","year":"2017","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0120","author":"Fresenius Medical Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/0004563213517628","article-title":"Contemporary view of the clinical relevance of magnesium homeostasis","volume":"51","author":"Ayuk","year":"2014","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.jcrc.2025.155032_bb0130","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1053\/j.ajkd.2012.03.024","article-title":"Approach to treatment of hypophosphatemia","volume":"60","author":"Felsenfeld","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jcrc.2025.155032_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2023.154364","article-title":"Impact of increasing post-filter ionized calcium target on filter lifespan in renal replacement therapy with regional citrate anticoagulation: a before-and-after study","volume":"78","author":"Assefi","year":"2023","journal-title":"J Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0140","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1186\/cc11403","article-title":"Regional citrate anticoagulation in cardiac surgery patients at high risk of bleeding: a continuous veno-venous hemofiltration protocol with a low concentration citrate solution","volume":"16","author":"Morabito","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0145","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/nep.13656","article-title":"Regional citrate anticoagulation for continuous renal replacement therapy - a safe and effective low-dose protocol","volume":"25","author":"Poh","year":"2020","journal-title":"Nephrology"},{"key":"10.1016\/j.jcrc.2025.155032_bb0150","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/s13054-014-0472-6","article-title":"Citrate anticoagulation versus systemic heparinisation in continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a multi-center randomized clinical trial","volume":"18","author":"Schilder","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0155","doi-asserted-by":"crossref","DOI":"10.1177\/10760296231174001","article-title":"Regional citrate anticoagulation or heparin anticoagulation for renal replacement therapy in patients with liver failure: a systematic review and Meta-analysis","volume":"29","author":"Qi","year":"2023","journal-title":"Clin Appl Thromb"},{"key":"10.1016\/j.jcrc.2025.155032_bb0160","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10877-021-00719-8","article-title":"Electrolyte monitoring during regional citrate anticoagulation in continuous renal replacement therapy","volume":"36","author":"Warnar","year":"2022","journal-title":"J Clin Monit Comput"},{"key":"10.1016\/j.jcrc.2025.155032_bb0165","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1097\/CCM.0b013e3181a00a92","article-title":"A safe citrate anticoagulation protocol with variable treatment efficacy and excellent control of the acid\u2013base status*","volume":"37","author":"Morgera","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2025.155032_bb0170","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/MNH.0000000000000953","article-title":"Let\u2019s stop talking about \u201ccitrate toxicity.\u201d","volume":"33","author":"Israni","year":"2024","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.jcrc.2025.155032_bb0175","doi-asserted-by":"crossref","first-page":"12905","DOI":"10.1038\/s41598-023-40075-y","article-title":"Kinetics of small and middle molecule clearance during continuous hemodialysis","volume":"13","author":"Whiting","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcrc.2025.155032_bb0180","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1007\/s00134-015-4099-0","article-title":"Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs","volume":"41","author":"Bai","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcrc.2025.155032_bb0185","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1097\/CCM.0000000000001004","article-title":"A randomized controlled trial of regional citrate versus regional heparin anticoagulation for continuous renal replacement therapy in critically ill adults","volume":"43","author":"Gattas","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2025.155032_bb0190","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3390\/life13051198","article-title":"Regional citrate anticoagulation in continuous renal replacement therapy: is metabolic fear the enemy of logic? A systematic review and Meta-analysis of randomised controlled trials","volume":"13","author":"Jacobs","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.jcrc.2025.155032_bb0195","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jcrc.2021.10.010","article-title":"Efficacy and complications of regional citrate anticoagulation during continuous renal replacement therapy in critically ill patients with COVID-19","volume":"67","author":"Khadzhynov","year":"2022","journal-title":"J Crit Care"},{"key":"10.1016\/j.jcrc.2025.155032_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278550","article-title":"CVVHD results in longer filter life than pre-filter CVVH: results of a quasi-randomized clinical trial","volume":"18","author":"Mann","year":"2023","journal-title":"PloS One"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088394412500019X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088394412500019X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T19:24:07Z","timestamp":1741721047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088394412500019X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":40,"alternative-id":["S088394412500019X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155032","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generalization of regional citrate anticoagulation for continuous renal replacement therapy is not associated with an increased rate of severe complications","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"155032"}}