{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:35:34Z","timestamp":1793730934121,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015733","name":"Lo-Hsu Medical Foundation Lotung Poh-Ai Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82422023"],"award-info":[{"award-number":["82422023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jcrc.2025.155100","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T15:14:42Z","timestamp":1746285282000},"page":"155100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Sepsis on dementia risk: A population-based cohort study with dose-dependent analysis"],"prefix":"10.1016","volume":"89","author":[{"given":"Mingyang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengrong","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jcrc.2025.155100_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Health"},{"issue":"7","key":"10.1016\/j.jcrc.2025.155100_bb0010","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/alz.12901","article-title":"The worldwide costs of dementia in 2019","volume":"19","author":"Wimo","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155100_bb0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jcbfm.2015.164","article-title":"The neuropathology and cerebrovascular mechanisms of dementia","volume":"36","author":"Raz","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jcrc.2025.155100_bb0020","article-title":"The impact of systemic inflammation on Alzheimer\u2019s disease pathology","volume":"12","author":"Xie","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155100_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020616","article-title":"Neuroinflammation: a potential risk for dementia","volume":"23","author":"Ahmad","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155100_bb0030","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.3233\/JAD-200303","article-title":"Common bacterial infections and risk of dementia or cognitive decline: a systematic review","volume":"76","author":"Muzambi","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155100_bb0035","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/brain\/awab094","article-title":"Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer\u2019s disease","volume":"144","author":"Asby","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.jcrc.2025.155100_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105292","article-title":"Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer\u2019s disease","volume":"152","author":"Basak","year":"2021","journal-title":"Neurobiol Dis"},{"issue":"16","key":"10.1016\/j.jcrc.2025.155100_bb0045","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1001\/jama.2010.1553","article-title":"Long-term cognitive impairment and functional disability among survivors of severe sepsis","volume":"304","author":"Iwashyna","year":"2010","journal-title":"Jama"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155100_bb0050","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S1474-4422(14)70017-1","article-title":"Long-term cerebral consequences of sepsis","volume":"13","author":"Widmann","year":"2014","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155100_bb0055","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/jnnp-2012-302883","article-title":"Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors","volume":"84","author":"Semmler","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"10.1016\/j.jcrc.2025.155100_bb0060","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrneurol.2014.181","article-title":"Classifying neurocognitive disorders: the DSM-5 approach","volume":"10","author":"Sachdev","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155100_bb0065","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155100_bb0070","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000911","article-title":"Time course of dementia following sepsis in German health claims data","volume":"8","author":"Fritze","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155100_bb0075","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jocn.2015.02.035","article-title":"Association between sepsis and dementia","volume":"22","author":"Kao","year":"2015","journal-title":"J Clin Neurosci"},{"issue":"7","key":"10.1016\/j.jcrc.2025.155100_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/S2666-7568(21)00118-5","article-title":"Assessment of common infections and incident dementia using UK primary and secondary care data: a historical cohort study","volume":"2","author":"Muzambi","year":"2021","journal-title":"Lancet Healthy Longev"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155100_bb0085","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/CCM.0000000000005313","article-title":"Risk of dementia and structural brain changes following nonneurological infections during 9-year follow-up","volume":"50","author":"Peters van Ton","year":"2022","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155100_bb0090","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.32635","article-title":"Hospital-diagnosed infections, autoimmune diseases, and subsequent dementia incidence","volume":"6","author":"Janbek","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jcrc.2025.155100_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.839472","article-title":"Risk of dementia or cognitive impairment in Sepsis survivals: a systematic review and Meta-analysis","volume":"14","author":"Lei","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"11","key":"10.1016\/j.jcrc.2025.155100_bb0100","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S1473-3099(21)00144-4","article-title":"Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort","volume":"21","author":"Sipila","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jcrc.2025.155100_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101727","article-title":"Dementia risk after major elective surgery based on the route of anaesthesia: a propensity score-matched population-based cohort study","volume":"55","author":"Sun","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155100_bb0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bja.2022.11.014","article-title":"Dementia risk amongst older adults with hip fracture receiving general anaesthesia or regional anaesthesia: a propensity-score-matched population-based cohort study","volume":"130","author":"Sun","year":"2023","journal-title":"Br J Anaesth"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155100_bb0115","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jamda.2023.06.035","article-title":"Long-term opioid use and dementia risk in patients with chronic pain","volume":"24","author":"Sun","year":"2023","journal-title":"J Am Med Dir Assoc"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155100_bb0120","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/brain\/awad366","article-title":"Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction","volume":"147","author":"Sun","year":"2024","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155100_bb0125","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-023-00640-5","article-title":"Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer\u2019s disease","volume":"18","author":"Inoue","year":"2023","journal-title":"Mol Neurodegener"},{"issue":"7","key":"10.1016\/j.jcrc.2025.155100_bb0130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41577-021-00643-7","article-title":"Cerebral dysfunctions caused by sepsis during ageing","volume":"22","author":"Manabe","year":"2022","journal-title":"Nat Rev Immunol"},{"issue":"7701","key":"10.1016\/j.jcrc.2025.155100_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-018-0023-4","article-title":"Innate immune memory in the brain shapes neurological disease hallmarks","volume":"556","author":"Wendeln","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155100_bb0140","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1172\/JCI124485","article-title":"Circulating heparan sulfate fragments mediate septic cognitive dysfunction","volume":"129","author":"Hippensteel","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcrc.2025.155100_bb0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.clinbiochem.2019.04.001","article-title":"Neuro-inflammation and anti-inflammatory treatment options for Alzheimer\u2019s disease","volume":"72","author":"Ozben","year":"2019","journal-title":"Clin Biochem"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155100_bb0150","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1161\/STROKEAHA.122.040578","article-title":"Blood-brain barrier dysfunction in Normal aging and neurodegeneration: mechanisms, impact, and treatments","volume":"54","author":"Andjelkovic","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.jcrc.2025.155100_bb0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fnagi.2014.00171","article-title":"Systemic inflammation, blood-brain barrier vulnerability and cognitive\/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy","volume":"6","author":"Takeda","year":"2014","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155100_bb0160","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"11","key":"10.1016\/j.jcrc.2025.155100_bb0165","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1097\/CCM.0000000000003924","article-title":"Association between Sepsis and microvascular brain injury","volume":"47","author":"Ehlenbach","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2025.155100_bb0170","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbi.2016.02.020","article-title":"Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication","volume":"56","author":"Frohlich","year":"2016","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155100_bb0175","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10456-023-09878-5","article-title":"Damage to endothelial barriers and its contribution to long COVID","volume":"27","author":"Wu","year":"2024","journal-title":"Angiogenesis"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155100_bb0180","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pds.2087","article-title":"Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan","volume":"20","author":"Cheng","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"10","key":"10.1016\/j.jcrc.2025.155100_bb0185","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/pds.4267","article-title":"Validity of cancer diagnosis in the National Health Insurance database compared with the linked National Cancer Registry in Taiwan","volume":"27","author":"Kao","year":"2018","journal-title":"Pharmacoepidemiol Drug Saf"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125000875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125000875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:10:59Z","timestamp":1762312259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944125000875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":37,"alternative-id":["S0883944125000875"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155100","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sepsis on dementia risk: A population-based cohort study with dose-dependent analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155100"}}