{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:28:38Z","timestamp":1789687718334,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5nes universitetssjukhus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jcrc.2025.155116","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T15:34:47Z","timestamp":1747236887000},"page":"155116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cystatin C-derived measures of renal function as risk factors for mortality and renal replacement therapy in the critically ill \u2013 An analysis of the SWECRIT cohort"],"prefix":"10.1016","volume":"89","author":[{"given":"Erik","family":"Linn\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"\u00c5kesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lengquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Friberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Frigyesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders O.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Grubb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bentzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jcrc.2025.155116_bb0005","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.2215\/CJN.00830110","article-title":"Chronic kidney disease: an inherent risk factor for acute kidney injury?","volume":"5","author":"Singh","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155116_bb0010","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00134-012-2796-5","article-title":"Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study","volume":"39","author":"Nisula","year":"2013","journal-title":"Intensive Care Med"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155116_bb0015","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1097\/CCM.0000000000001077","article-title":"Transient and persistent acute kidney injury and the risk of hospital mortality in critically ill patients: results of a multicenter cohort study","volume":"43","author":"Perinel","year":"2015","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155116_bb0020","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/ki.2011.339","article-title":"AKI in the ICU: definition, epidemiology, risk stratification, and outcomes","volume":"81","author":"Singbartl","year":"2012","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155116_bb0025","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.amjmed.2012.01.016","article-title":"Risk of chronic dialysis and death following acute kidney injury","volume":"125","author":"Wald","year":"2012","journal-title":"Am J Med"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155116_bb0030","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1164\/rccm.201311-2097OC","article-title":"Small acute increases in serum creatinine are associated with decreased long-term survival in the critically ill","volume":"189","author":"Linder","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.jcrc.2025.155116_bb0035","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1053\/j.ajkd.2021.04.016","article-title":"Measurement and estimation of GFR for use in clinical practice: Core curriculum 2021","volume":"78","author":"Inker","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jcrc.2025.155116_bb0040","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/clinchem\/40.10.1921","article-title":"Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate","volume":"40","author":"Kyhse-Andersen","year":"1994","journal-title":"Clin Chem"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155116_bb0045","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/00365519950185076","article-title":"Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults","volume":"59","author":"Vinge","year":"1999","journal-title":"Scand J Clin Lab Invest"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155116_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/ajkd.2002.34487","article-title":"Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis","volume":"40","author":"Dharnidharka","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155116_bb0055","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/oby.2011.366","article-title":"Cystatin C may better reflect the effect of obesity on renal function","volume":"20","author":"Salgado","year":"2012","journal-title":"Obesity"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155116_bb0060","doi-asserted-by":"crossref","first-page":"c224","DOI":"10.1159\/000317203","article-title":"Measuring the glomerular filtration rate in obese individuals without overt kidney disease","volume":"116","author":"Friedman","year":"2010","journal-title":"Nephron Clin Pract"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155116_bb0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5414\/CNP62092","article-title":"Estimation of glomerular filtration rate in obese patients with chronic renal impairment based on serum cystatin C levels","volume":"62","author":"Sch\u00fcck","year":"2004","journal-title":"Clin Nephrol"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155116_bb0070","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/ndt\/gfp474","article-title":"Age and cystatin C in healthy adults: a collaborative study","volume":"25","author":"Odden","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155116_bb0075","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1080\/00365510701397538","article-title":"Estimated glomerular filtration rate (eGFRCystC) from serum cystatin C shows strong agreement with iohexol clearance in patients with low GFR","volume":"67","author":"Jonsson","year":"2007","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155116_bb0080","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1038\/s41598-021-85370-8","article-title":"Cystatin C predicts long term mortality better than creatinine in a nationwide study of intensive care patients","volume":"11","author":"Helmersson-Karlqvist","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcrc.2025.155116_bb0085","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/heartjnl-2020-318860","article-title":"Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care","volume":"108","author":"Helmersson-Karlqvist","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.jcrc.2025.155116_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2022.154148","article-title":"Cystatin C and derived measures of renal function as risk factors for mortality and acute kidney injury in sepsis - a post-hoc analysis of the FINNAKI cohort","volume":"72","author":"Linn\u00e9","year":"2022","journal-title":"J Crit Care"},{"issue":"5","key":"10.1016\/j.jcrc.2025.155116_bb0095","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/00365513.2020.1759139","article-title":"Shrunken pore syndrome and mortality: a cohort study of patients with measured GFR and known comorbidities","volume":"80","author":"\u00c5kesson","year":"2020","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.jcrc.2025.155116_bb0100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.clinbiochem.2020.06.002","article-title":"Shrunken pore syndrome - a common kidney disorder with high mortality. Diagnosis, prevalence, pathophysiology and treatment options","volume":"83","author":"Grubb","year":"2020","journal-title":"Clin Biochem"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155116_bb0105","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/s41598-022-05320-w","article-title":"Impaired selective renal filtration captured by eGFRcysC\/eGFRcrea ratio is associated with mortality in a population based cohort of older women","volume":"12","author":"Malmgren","year":"2022","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155116_bb0110","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/00365513.2015.1025427","article-title":"Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: \u2018shrunken pore syndrome\u2019","volume":"75","author":"Grubb","year":"2015","journal-title":"Scand J Clin Lab Invest"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155116_bb0115","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00134-018-5126-8","article-title":"Biomarkers for prediction of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis","volume":"44","author":"Klein","year":"2018","journal-title":"Intensive Care Med"},{"issue":"10","key":"10.1016\/j.jcrc.2025.155116_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040297","article-title":"Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration","volume":"4","author":"Vandenbroucke","year":"2007","journal-title":"PLoS Med"},{"issue":"10","key":"10.1016\/j.jcrc.2025.155116_bb0125","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00134-005-2763-5","article-title":"SAPS 3--from evaluation of the patient to evaluation of the intensive care unit. Part 2: development of a prognostic model for hospital mortality at ICU admission [published correction appears in intensive care med. 2006 may;32(5):796]","volume":"31","author":"Moreno","year":"2005","journal-title":"Intensive Care Med"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155116_bb0130","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155116_bb0135","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1515\/cclm-2013-0741","article-title":"The revised Lund-Malmo GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population","volume":"52","author":"Nyman","year":"2014","journal-title":"Clin Chem Lab Med"},{"issue":"7","key":"10.1016\/j.jcrc.2025.155116_bb0140","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1373\/clinchem.2013.220707","article-title":"Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator","volume":"60","author":"Grubb","year":"2014","journal-title":"Clin Chem"},{"key":"10.1016\/j.jcrc.2025.155116_bb0145","article-title":"Statistical analysis plan for \u2013 \u201ccystatin C and derived variables as risk factors for mortality and renal replacement therapy in the critically ill \u2013 an analysis of the SWECRIT cohort\u201d","author":"Linn\u00e9","year":"2023","journal-title":"Zenodo"},{"key":"10.1016\/j.jcrc.2025.155116_bb0150","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41512-018-0037-2","article-title":"Quantifying the added value of new biomarkers: how and how not","volume":"2","author":"Cook","year":"2018","journal-title":"Diagn Progn Res"},{"key":"10.1016\/j.jcrc.2025.155116_bb0155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/00365513.2015.1099724","article-title":"Shrunken pore syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting","volume":"76","author":"Dardashti","year":"2016","journal-title":"Scand J Clin Lab Invest"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155116_bb0160","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3109\/00365513.2016.1149882","article-title":"Ratio of cystatin C and creatinine-based estimates of the glomerular filtration rate predicts mortality in healthy seniors independent of kidney function","volume":"76","author":"Purde","year":"2016","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155116_bb0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ekir.2018.09.002","article-title":"Shrunken pore syndrome is associated with increased levels of atherosclerosis-promoting proteins","volume":"4","author":"Alm\u00e9n","year":"2018","journal-title":"Kidney Int Rep"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155116_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22433-4","article-title":"Reduced renal elimination of larger molecules is a strong predictor for mortality","volume":"12","author":"Herou","year":"2022","journal-title":"Sci Rep"},{"issue":"24","key":"10.1016\/j.jcrc.2025.155116_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415687","article-title":"Shrunken pore syndrome is frequently occurring in severe COVID-19","volume":"23","author":"Larsson","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155116_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/prca.202000089","article-title":"Proteins linked to atherosclerosis and cell proliferation are associated with the shrunken pore syndrome in heart failure patients: shrunken pore syndrome and proteomic associations","volume":"15","author":"Xhakollari","year":"2021","journal-title":"Proteomics Clin Appl"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155116_bb0185","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/ckj\/sfad086","article-title":"Muscle mass, creatinine, cystatin C and selective glomerular hypofiltration syndromes","volume":"16","author":"Malmgren","year":"2023","journal-title":"Clin Kidney J"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155116_bb0190","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12877-021-02276-w","article-title":"Sarcopenia as a predictor of mortality among the critically ill in an intensive care unit: a systematic review and meta-analysis","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Geriatr"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155116_bb0195","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1186\/cc4971","article-title":"Corticosteroids influence the mortality and morbidity of acute critical illness","volume":"10","author":"Rady","year":"2006","journal-title":"Crit Care"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155116_bb0200","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2215\/CJN.0000000000000217","article-title":"Discrepancies between cystatin C-based and creatinine-based eGFR","volume":"18","author":"Farrington","year":"2023","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10S","key":"10.1016\/j.jcrc.2025.155116_bb0205","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.20248pxz6d0y","article-title":"Association between eGFRcystatin C-to-eGFRcreatinine ratio and the nonkidney factors muscle mass, muscle strength, and sarcopenia: SA-PO909","volume":"35","author":"Dawar","year":"2024","journal-title":"JASN"},{"key":"10.1016\/j.jcrc.2025.155116_bb0210","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1093\/clinchem\/47.11.2055","article-title":"Effects of glucocorticoid immunosuppression on serum cystatin C concentrations in renal transplant patients","volume":"47","author":"Risch","year":"2001","journal-title":"Clin Chem"},{"issue":"5","key":"10.1016\/j.jcrc.2025.155116_bb0215","doi-asserted-by":"crossref","DOI":"10.1530\/EC-24-0698","article-title":"Estimation of kidney function in Graves\u2019 disease using creatinine and cystatin C","volume":"14","author":"Abbaszadeh","year":"2025","journal-title":"Endocr Connect"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:10:25Z","timestamp":1762312225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944125001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":43,"alternative-id":["S0883944125001030"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155116","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cystatin C-derived measures of renal function as risk factors for mortality and renal replacement therapy in the critically ill \u2013 An analysis of the SWECRIT cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"155116"}}