{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:26:11Z","timestamp":1787142371857,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023ZD0506200- 04"],"award-info":[{"award-number":["2023ZD0506200- 04"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202201020513"],"award-info":[{"award-number":["202201020513"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jcrc.2025.155260","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T01:29:42Z","timestamp":1758072582000},"page":"155260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The association between albumin-corrected anion gap and in-hospital mortality in critically ill COPD patients: A multicenter retrospective study from eICU collaborative research database"],"prefix":"10.1016","volume":"91","author":[{"given":"Zhiwei","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisheng","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqing","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2025.155260_bb0005","series-title":"GOLD-2024_v1.2-11Jan24_WMV.pdf","author":"GOLD","year":"2024"},{"key":"10.1016\/j.jcrc.2025.155260_bb0010","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.2147\/COPD.S366126","article-title":"Pathological mechanism and targeted drugs of COPD","volume":"17","author":"Guo","year":"2022","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0015","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12875-021-01583-w","article-title":"COPD - do the right thing","volume":"22","author":"Sandelowsky","year":"2021","journal-title":"BMC Fam Pract"},{"issue":"7","key":"10.1016\/j.jcrc.2025.155260_bb0020","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/thx.2010.152876","article-title":"Lung function impairment, COPD hospitalisations and subsequent mortality","volume":"66","author":"Garcia-Aymerich","year":"2011","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155260_bb0025","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1378\/chest.128.4.2005","article-title":"Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001","volume":"128","author":"Holguin","year":"2005","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13613-024-01394-z","article-title":"Predicting outcomes in patients with exacerbation of COPD requiring mechanical ventilation","volume":"14","author":"Alzaabi","year":"2024","journal-title":"Ann Intensive Care"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12931-021-01657-4","article-title":"Predictors of mortality in COPD exacerbation cases presenting to the respiratory intensive care unit","volume":"22","author":"Cao","year":"2021","journal-title":"Respir Res"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0040","doi-asserted-by":"crossref","first-page":"16903","DOI":"10.1038\/s41598-023-44182-8","article-title":"The relationship between albumin corrected anion gap levels and mortality in patients with asthma in the ICU","volume":"13","author":"Wang","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0045","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2215\/CJN.03020906","article-title":"Serum anion gap: its uses and limitations in clinical medicine","volume":"2","author":"Kraut","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155260_bb0050","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/08850666221123483","article-title":"Serum anion gap level predicts all-cause mortality in septic patients: a retrospective study based on the MIMIC III database","volume":"38","author":"Zhu","year":"2023","journal-title":"J Intensive Care Med"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0055","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1038\/s41598-022-11081-3","article-title":"The association between anion gap and in-hospital mortality of post-cardiac arrest patients: a retrospective study","volume":"12","author":"Chen","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcrc.2025.155260_bb0060","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4598462","article-title":"Anion gap was associated with Inhospital mortality and adverse clinical outcomes of coronary care unit patients","volume":"2020","author":"Sun","year":"2020","journal-title":"Biomed Res Int"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155260_bb0065","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ki.2012.196","article-title":"The serum anion gap is altered in early kidney disease and associates with mortality","volume":"82","author":"Abramowitz","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.jcrc.2025.155260_bb0070","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cca.2021.07.021","article-title":"Albumin corrected anion gap for predicting in-hospital mortality among intensive care patients with sepsis: a retrospective propensity score matching analysis","volume":"521","author":"Hu","year":"2021","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"10.1016\/j.jcrc.2025.155260_bb0075","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2147\/COPD.S85831","article-title":"Severe hypoalbuminemia is a strong independent risk factor for acute respiratory failure in COPD: a nationwide cohort study","volume":"10","author":"Chen","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.jcrc.2025.155260_bb0080","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.178","article-title":"The eICU collaborative research database, a freely available multi-center database for critical care research","volume":"5","author":"Pollard","year":"2018","journal-title":"Sci Data"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155260_bb0085","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/ehf2.14639","article-title":"The correlation between albumin-corrected anion gap and prognosis in patients with acute myocardial infarction","volume":"11","author":"Sheng","year":"2024","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jcrc.2025.155260_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1099003","article-title":"Elevated albumin corrected anion gap is associated with poor in-hospital prognosis in patients with cardiac arrest: a retrospective study based on MIMIC-IV database","volume":"10","author":"Hu","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155260_bb0095","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s11739-022-03093-8","article-title":"The association between albumin corrected anion gap and ICU mortality in acute kidney injury patients requiring continuous renal replacement therapy","volume":"17","author":"Zhong","year":"2022","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jcrc.2025.155260_bb0100","series-title":"Physiology, Metabolic Alkalosis. StatPearls. Treasure Island (FL) Ineligible Companies. Disclosure: Sandeep Sharma Declares no Relevant Financial Relationships with Ineligible Companies.: StatPearls Publishing Copyright \u00a9 2024","author":"Brinkman","year":"2024"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155260_bb0105","first-page":"161","article-title":"Understanding acid-base disorders","volume":"86","author":"Hamilton","year":"2017","journal-title":"Ulster Med J"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0110","doi-asserted-by":"crossref","first-page":"16670","DOI":"10.1038\/s41598-023-43928-8","article-title":"Serum anion gap is associated with mortality in intensive care unit patients with diastolic heart failure","volume":"13","author":"Xu","year":"2023","journal-title":"Sci Rep"},{"issue":"30","key":"10.1016\/j.jcrc.2025.155260_bb0115","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000039029","article-title":"Association between the anion-gap and 28-day mortality in critically ill adult patients with sepsis: a retrospective cohort study","volume":"103","author":"Lou","year":"2024","journal-title":"Medicine"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155260_bb0120","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000734","article-title":"Serum anion gap at admission predicts all-cause mortality in critically ill patients with cirrhosis: a retrospective cohort study","volume":"15","author":"Kou","year":"2024","journal-title":"Clin Transl Gastroenterol"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155260_bb0125","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.lab.2005.07.008","article-title":"Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap","volume":"146","author":"Feldman","year":"2005","journal-title":"J Lab Clin Med"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155260_bb0130","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/adc.87.6.526","article-title":"Correction of the anion gap for albumin in order to detect occult tissue anions in shock","volume":"87","author":"Hatherill","year":"2002","journal-title":"Arch Dis Child"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155260_bb0135","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/0310057X0203000213","article-title":"Association of serum albumin concentration and mortality risk in critically ill patients","volume":"30","author":"Yap","year":"2002","journal-title":"Anaesth Intensive Care"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0140","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12872-023-03200-3","article-title":"Association between albumin corrected anion gap and 30-day all-cause mortality of critically ill patients with acute myocardial infarction: a retrospective analysis based on the MIMIC-IV database","volume":"23","author":"Jian","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155260_bb0145","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2023.2282708","article-title":"Association between albumin corrected anion gap and all-cause mortality in critically ill patients with acute kidney injury: a retrospective study based on MIMIC-IV database","volume":"45","author":"Gao","year":"2023","journal-title":"Ren Fail"},{"issue":"24","key":"10.1016\/j.jcrc.2025.155260_bb0150","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1056\/NEJMra1309483","article-title":"Lactic acidosis","volume":"371","author":"Kraut","year":"2014","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155260_bb0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0889-8529(18)30163-4","article-title":"Lactic acidosis","volume":"22","author":"Stacpoole","year":"1993","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"10082","key":"10.1016\/j.jcrc.2025.155260_bb0160","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/S0140-6736(17)31222-9","article-title":"Chronic obstructive pulmonary disease","volume":"389","author":"Rabe","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.jcrc.2025.155260_bb0165","doi-asserted-by":"crossref","first-page":"15076","DOI":"10.1038\/nrdp.2015.76","article-title":"Chronic obstructive pulmonary disease","volume":"1","author":"Barnes","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"158","key":"10.1016\/j.jcrc.2025.155260_bb0170","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0171-2019","article-title":"The effects of lung volume reduction treatment on diffusing capacity and gas exchange","volume":"29","author":"van Dijk","year":"2020","journal-title":"Eur Respir Rev"},{"issue":"161","key":"10.1016\/j.jcrc.2025.155260_bb0175","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0031-2021","article-title":"Measuring pulmonary function in COPD using quantitative chest computed tomography analysis","volume":"30","author":"Bakker","year":"2021","journal-title":"Eur Respir Rev"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155260_bb0180","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1378\/chest.13-1967","article-title":"Exertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin","volume":"146","author":"Stolz","year":"2014","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155260_bb0185","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1164\/rccm.202006-2248OC","article-title":"Mucus plugs and emphysema in the pathophysiology of airflow obstruction and hypoxemia in smokers","volume":"203","author":"Dunican","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155260_bb0190","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/resp.14534","article-title":"Elevated blood lactate in COPD exacerbations associates with adverse clinical outcomes and signals excessive treatment with \u03b2(2) -agonists","volume":"28","author":"MacDonald","year":"2023","journal-title":"Respirol (Carlton, Vic)"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155260_bb0195","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/thx.2010.153114","article-title":"Acidosis, non-invasive ventilation and mortality in hospitalised COPD exacerbations","volume":"66","author":"Roberts","year":"2011","journal-title":"Thorax"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155260_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/nu9080829","article-title":"Evaluation of blood biomarkers associated with risk of malnutrition in older adults: a systematic review and meta-analysis","volume":"9","author":"Zhang","year":"2017","journal-title":"Nutrients"},{"issue":"9B","key":"10.1016\/j.jcrc.2025.155260_bb0205","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1111\/j.1582-4934.2008.00417.x","article-title":"Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings","volume":"13","author":"Rossi","year":"2009","journal-title":"J Cell Mol Med"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155260_bb0210","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcrc.2025.155260_bb0215","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2147\/COPD.S181322","article-title":"Nutritional status, dietary intake, and health-related quality of life in outpatients with COPD","volume":"14","author":"Nguyen","year":"2019","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155260_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10020269","article-title":"Serum albumin concentrations in stable chronic obstructive pulmonary Disease: a systematic review and meta-analysis","volume":"10","author":"Zinellu","year":"2021","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155260_bb0225","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/17512433.2018.1412827","article-title":"Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients","volume":"11","author":"Ferrer","year":"2018","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"10","key":"10.1016\/j.jcrc.2025.155260_bb0230","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-050216","article-title":"Synergistic effect of hypoalbuminaemia and hypotension in predicting in-hospital mortality and intensive care admission: a retrospective cohort study","volume":"11","author":"Klang","year":"2021","journal-title":"BMJ Open"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125002473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125002473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:40:13Z","timestamp":1787139613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944125002473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":46,"alternative-id":["S0883944125002473"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155260","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between albumin-corrected anion gap and in-hospital mortality in critically ill COPD patients: A multicenter retrospective study from eICU collaborative research database","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155260"}}