{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:25:48Z","timestamp":1787142348180,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070665"],"award-info":[{"award-number":["82070665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jcrc.2025.155265","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:14:13Z","timestamp":1758582853000},"page":"155265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Early energy delivery and 28-day mortality in critically ill patients with sepsis: Post hoc analysis of a multicenter cluster-randomised controlled trial"],"prefix":"10.1016","volume":"91","author":[{"given":"Qiuhui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingye","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10219","key":"10.1016\/j.jcrc.2025.155265_bb0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155265_bb0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"22","key":"10.1016\/j.jcrc.2025.155265_bb0015","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMra2403213","article-title":"Sepsis and septic shock","volume":"391","author":"Meyer","year":"2024","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155265_bb0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.amjms.2020.11.007","article-title":"Hyperglycemia, insulin, and insulin resistance in Sepsis","volume":"361","author":"Rivas","year":"2021","journal-title":"Am J Med Sci"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155265_bb0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0749-0704(05)70112-3","article-title":"Metabolic derangements in sepsis and septic shock","volume":"16","author":"Mizock","year":"2000","journal-title":"Crit Care Clin"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155265_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/nu12020395","article-title":"Nutrition in Sepsis: a bench-to-bedside review","volume":"12","author":"De Waele","year":"2020","journal-title":"Nutrients"},{"issue":"18","key":"10.1016\/j.jcrc.2025.155265_bb0035","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1056\/NEJMoa1409860","article-title":"Trial of the route of early nutritional support in critically ill adults","volume":"371","author":"Harvey","year":"2014","journal-title":"N Engl J Med"},{"issue":"10116","key":"10.1016\/j.jcrc.2025.155265_bb0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(17)32146-3","article-title":"Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)","volume":"391","author":"Reignier","year":"2018","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jcrc.2025.155265_bb0045","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.2012.137","article-title":"Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial","volume":"307","author":"Rice","year":"2012","journal-title":"JAMA"},{"issue":"25","key":"10.1016\/j.jcrc.2025.155265_bb0050","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1056\/NEJMoa1502826","article-title":"Permissive underfeeding or standard enteral feeding in critically ill adults","volume":"372","author":"Arabi","year":"2015","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.jcrc.2025.155265_bb0055","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1056\/NEJMoa1811687","article-title":"Energy-dense versus routine enteral nutrition in the critically ill","volume":"379","author":"Chapman","year":"2018","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jcrc.2025.155265_bb0060","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMra2406954","article-title":"Enteral nutrition in hospitalized adults","volume":"392","author":"Gramlich","year":"2025","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.jcrc.2025.155265_bb0065","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMra1304623","article-title":"Nutrition in the acute phase of critical illness","volume":"370","author":"Casaer","year":"2014","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155265_bb0070","doi-asserted-by":"crossref","first-page":"R268","DOI":"10.1186\/cc10546","article-title":"Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool","volume":"15","author":"Heyland","year":"2011","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0075","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13054-022-03921-5","article-title":"Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial","volume":"26","author":"Ke","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155265_bb0080","article-title":"A nomogram to predict prolonged stay of obesity patients with sepsis in ICU: relevancy for predictive, personalized, preventive, and participatory healthcare strategies","volume":"10","author":"Chen","year":"2022","journal-title":"Front Public Health"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155265_bb0085","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s11154-020-09566-5","article-title":"The use of Broca index to assess cut- off points for overweight in adults: a short review","volume":"21","author":"Laurent","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"issue":"5","key":"10.1016\/j.jcrc.2025.155265_bb0090","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1097\/CCM.0b013e3181a40116","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: society of critical care medicine and American Society for Parenteral and Enteral Nutrition: executive summary","volume":"37","author":"Martindale","year":"2009","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155265_bb0095","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.clnu.2016.08.004","article-title":"Association of modified NUTRIC score with 28-day mortality in critically ill patients","volume":"36","author":"Mukhopadhyay","year":"2017","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0100","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1186\/s12871-024-02866-2","article-title":"Effect of the modified NUTRIC score in predicting the prognosis of patients admitted to intensive care units","volume":"24","author":"Yildirim","year":"2024","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.jcrc.2025.155265_bb0105","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.clnesp.2022.02.014","article-title":"The modified NUTRIC score (mNUTRIC) is associated with increased 28-day mortality in critically ill COVID-19 patients: internal validation of a prediction model","volume":"48","author":"Leoni","year":"2022","journal-title":"Clin Nutr ESPEN"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155265_bb0110","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/TA.0000000000002937","article-title":"Application of the modified nutrition risk in critically ill score to nutritional risk stratification of trauma victims: a multicenter observational study","volume":"89","author":"Iwuchukwu","year":"2020","journal-title":"J Trauma Acute Care Surg"},{"issue":"10","key":"10.1016\/j.jcrc.2025.155265_bb0115","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/0885066620966957","article-title":"Relationship between nutrition intake and outcome after subarachnoid hemorrhage: results from the international nutritional survey","volume":"36","author":"Badjatia","year":"2021","journal-title":"J Intensive Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155265_bb0120","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.clnu.2020.08.022","article-title":"Association between ultrasound quadriceps muscle status with premorbid functional status and 60-day mortality in mechanically ventilated critically ill patient: a single-center prospective observational study","volume":"40","author":"Lee","year":"2021","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0125","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s12933-024-02538-y","article-title":"Exploring the prognostic impact of triglyceride-glucose index in critically ill patients with first-ever stroke: insights from traditional methods and machine learning-based mortality prediction","volume":"23","author":"Chen","year":"2024","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0130","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12933-025-02831-4","article-title":"Remnant\u2013to\u2013LDL cholesterol discordance as a predictor of thromboembolic events in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF project III (MAFP-III) cohort study","volume":"24","author":"Soler-Espejo","year":"2025","journal-title":"Cardiovasc Diabetol"},{"issue":"13","key":"10.1016\/j.jcrc.2025.155265_bb0135","doi-asserted-by":"crossref","first-page":"e040099","DOI":"10.1161\/JAHA.124.040099","article-title":"Associations of sarcopenia and its components with cardiovascular risk: five-year longitudinal evidence from china health and retirement longitudinal study","volume":"14","author":"Chen","year":"2025","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0140","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/s13054-016-1538-4","article-title":"Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study","volume":"20","author":"Zusman","year":"2016","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.jcrc.2025.155265_bb0145","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1164\/rccm.201304-0651OC","article-title":"Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up","volume":"188","author":"Needham","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155265_bb0150","first-page":"101","article-title":"Current insights in ICU nutrition: tailored nutrition","volume":"29","author":"Hermans","year":"2023","journal-title":"Curr Opin Crit Care"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0155","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s13054-019-2657-5","article-title":"Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases","volume":"23","author":"van Zanten","year":"2019","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155265_bb0160","first-page":"165","article-title":"Enteral nutrition in septic shock: a call for a paradigm shift","volume":"30","author":"Patel","year":"2024","journal-title":"Curr Opin Crit Care"},{"issue":"7","key":"10.1016\/j.jcrc.2025.155265_bb0165","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S2213-2600(23)00092-9","article-title":"Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3)","volume":"11","author":"Reignier","year":"2023","journal-title":"Lancet Respir Med"},{"issue":"11","key":"10.1016\/j.jcrc.2025.155265_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10112412","article-title":"Metabolic alterations in Sepsis","volume":"10","author":"Wasyluk","year":"2021","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155265_bb0175","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/MNH.0000000000000801","article-title":"When a calorie isn\u2019t just a calorie: a revised look at nutrition in critically ill patients with sepsis and acute kidney injury","volume":"31","author":"Nadamuni","year":"2022","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155265_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu17030545","article-title":"Unlocking the predictive power of nutritional scores in septic patients","volume":"17","author":"Toscano","year":"2025","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0185","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13054-022-04298-1","article-title":"Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study","volume":"27","author":"Pardo","year":"2023","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155265_bb0190","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.mayocp.2020.07.033","article-title":"Hormonal and metabolic changes of aging and the influence of lifestyle modifications","volume":"96","author":"Pataky","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155265_bb0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/jpen.2267","article-title":"Guidelines for the provision of nutrition support therapy in the adult critically ill patient: the American Society for Parenteral and Enteral Nutrition","volume":"46","author":"Compher","year":"2022","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"16","key":"10.1016\/j.jcrc.2025.155265_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/nu17162716","article-title":"Leveraging deep learning to enhance malnutrition detection via nutrition risk screening 2002: insights from a National Cohort","volume":"17","author":"Yal\u00e7\u0131n","year":"2025","journal-title":"Nutrients"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125002527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125002527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:38:36Z","timestamp":1787139516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944125002527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":40,"alternative-id":["S0883944125002527"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155265","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early energy delivery and 28-day mortality in critically ill patients with sepsis: Post hoc analysis of a multicenter cluster-randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"155265"}}