{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:01:35Z","timestamp":1781114495880,"version":"3.54.1"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jcrc.2025.155353","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:10:48Z","timestamp":1763165448000},"page":"155353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["What every intensivist should know about\u2026methylene blue in septic shock"],"prefix":"10.1016","volume":"92","author":[{"given":"Shannon M.","family":"Fernando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salmaan","family":"Kanji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Rochwerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jcrc.2025.155353_bb0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"10219","key":"10.1016\/j.jcrc.2025.155353_bb0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jcrc.2025.155353_bb0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/CCM.0000000000004777","article-title":"Sepsis-associated mortality, resource use, and healthcare costs: a propensity-matched cohort study","volume":"49","author":"Farrah","year":"2021","journal-title":"Crit Care Med"},{"issue":"10459","key":"10.1016\/j.jcrc.2025.155353_bb0020","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0140-6736(24)01754-9","article-title":"Long-term ill health in sepsis survivors: an ignored health-care challenge?","volume":"404","author":"Beane","year":"2024","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.jcrc.2025.155353_bb0025","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.jcrc.2025.155353_bb0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12630-019-01546-x","article-title":"Canadian critical care society clinical practice guideline: the use of vasopressin and vasopressin analogues in critically ill adults with distributive shock","volume":"67","author":"Honarmand","year":"2020","journal-title":"Can J Anaesth"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155353_bb0035","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/CCM.0000000000005317","article-title":"Association of Catecholamine Dose, lactate, and shock duration at vasopressin initiation with mortality in patients with septic shock","volume":"50","author":"Sacha","year":"2022","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.jcrc.2025.155353_bb0040","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/0885066606290671","article-title":"Use of methylene blue in sepsis: a systematic review","volume":"21","author":"Kwok","year":"2006","journal-title":"J Intensive Care Med"},{"issue":"9","key":"10.1016\/j.jcrc.2025.155353_bb0045","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1007\/s12325-020-01422-x","article-title":"Vasopressor-sparing action of methylene blue in severe Sepsis and shock: a narrative review","volume":"37","author":"Puntillo","year":"2020","journal-title":"Adv Ther"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155353_bb0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13054-024-04839-w","article-title":"Administration of methylene blue in septic shock: pros and cons","volume":"28","author":"Arias-Ortiz","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2025.155353_bb0055","article-title":"Methylene blue administration in septic shock - A retrospective cohort study","author":"Fernando","year":"2025","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155353_bb0060","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13054-023-04397-7","article-title":"Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial","volume":"27","author":"Ibarra-Estrada","year":"2023","journal-title":"Crit Care"},{"issue":"7","key":"10.1016\/j.jcrc.2025.155353_bb0065","article-title":"Methylene blue in septic shock: a systematic review and Meta-analysis","volume":"6","author":"Fernando","year":"2024","journal-title":"Crit Care Explor"},{"issue":"1","key":"10.1016\/j.jcrc.2025.155353_bb0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.CCM.0000105581.01815.C6","article-title":"Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock","volume":"32","author":"L\u00f3pez","year":"2004","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.jcrc.2025.155353_bb0075","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.niox.2010.01.006","article-title":"A dose-finding study of methylene blue to inhibit nitric oxide actions in the hemodynamics of human septic shock","volume":"22","author":"Juffermans","year":"2010","journal-title":"Nitric Oxide"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125003405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944125003405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T19:39:42Z","timestamp":1768851582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944125003405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":15,"alternative-id":["S0883944125003405"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155353","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What every intensivist should know about\u2026methylene blue in septic shock","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2025.155353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"155353"}}