{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:22:23Z","timestamp":1788175343571,"version":"build-2803163510"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014103","name":"Emergency Medicine Research Fund Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jcrc.2026.155502","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T19:26:43Z","timestamp":1771702003000},"page":"155502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Serum testosterone as early predictor of sepsis severity in male patients in the emergency department"],"prefix":"10.1016","volume":"93","author":[{"given":"Sabine","family":"van der Linden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrien","family":"Blokland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Holkenborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Roerink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"van Borren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2026.155502_bb0005","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.jcrc.2026.155502_bb0010","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/bja\/84.5.663","article-title":"Prospective evaluation of a modified early warning score to aid earlier detection of patients developing critical illness on a general surgical ward","volume":"84","author":"Stenhouse","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jcrc.2026.155502_bb0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jcrc.2026.155502_bb0020","doi-asserted-by":"crossref","DOI":"10.1186\/s13613-017-0316-z","article-title":"Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis","volume":"7","author":"Wu","year":"2017","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jcrc.2026.155502_bb0025","article-title":"Accuracy of quick sequential organ failure assessment score to predict sepsis mortality in 121 studies including 1,716,017 individuals: a systematic review and meta-analysis","volume":"1","author":"Herwanto","year":"2019","journal-title":"Crit Care Explor"},{"key":"10.1016\/j.jcrc.2026.155502_bb0030","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.5191","article-title":"Comparison of early warning scoring systems for hospitalized patients with and without infection at risk for in-hospital mortality and transfer to the intensive care unit","volume":"3","author":"Liu","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jcrc.2026.155502_bb0035","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.chest.2017.12.015","article-title":"A comparison of the quick-SOFA and systemic inflammatory response syndrome criteria for the diagnosis of sepsis and prediction of mortality: a systematic review and meta-analysis","volume":"153","author":"Serafim","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.jcrc.2026.155502_bb0040","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/CCM.0000000000006216","article-title":"Biomarkers improve diagnostics of sepsis in adult patients with suspected organ dysfunction based on the quick sepsis-related organ failure assessment (qSOFA) score in the emergency department\u2217","volume":"52","author":"Bolanaki","year":"2024","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jcrc.2026.155502_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10102075","article-title":"Sepsis as a pan-endocrine illness\u2014endocrine disorders in septic patients","volume":"10","author":"Wasyluk","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcrc.2026.155502_bb0050","article-title":"Time course of gonadal hormone profiles in male patients with sepsis","volume":"28","author":"Bech","year":"2020","journal-title":"Neth J Crit Care"},{"key":"10.1016\/j.jcrc.2026.155502_bb0055","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jcrc.2026.155502_bb0060","article-title":"Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy","volume":"10","author":"Wang","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jcrc.2026.155502_bb0065","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s40618-021-01700-7","article-title":"Low testosterone predicts hypoxemic respiratory insufficiency and mortality in patients with COVID-19 disease: another piece in the COVID puzzle","volume":"45","author":"Vena","year":"2022","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jcrc.2026.155502_bb0070","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-016-1525-9","article-title":"Bioavailable estradiol concentrations are elevated and predict mortality in septic patients: a prospective cohort study","volume":"20","author":"Tsang","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.jcrc.2026.155502_bb0075","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/er.2017-00025","article-title":"A reappraisal of testosterone\u2019s binding in circulation: physiological and clinical implications","volume":"38","author":"Goldman","year":"2017","journal-title":"Endocr Rev"}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944126000808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944126000808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:12:17Z","timestamp":1788174737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944126000808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":15,"alternative-id":["S0883944126000808"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2026.155502","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum testosterone as early predictor of sepsis severity in male patients in the emergency department","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2026.155502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155502"}}