{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:30:52Z","timestamp":1787927452190,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Critical Care"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jcrc.2026.155700","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:18:45Z","timestamp":1785309525000},"page":"155700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Terminal complement inhibition is associated with renal, hematologic, and thrombotic complications during septic shock: A global propensity score-matched cohort study"],"prefix":"10.1016","volume":"96","author":[{"given":"Carl","family":"Vahldieck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp Bernd","family":"Radermacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Steinmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buntaro","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Fels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcrc.2026.155700_bb0005","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.jcrc.2026.155700_bb0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13054-018-2292-6","article-title":"The glycocalyx: a novel diagnostic and therapeutic target in sepsis","volume":"23","author":"Uchimido","year":"2019","journal-title":"Crit. Care"},{"key":"10.1016\/j.jcrc.2026.155700_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2021.100094","article-title":"Endothelial glycocalyx degradation during sepsis: causes and consequences","volume":"12","author":"Sullivan","year":"2021","journal-title":"Matrix Biol. Plus"},{"key":"10.1016\/j.jcrc.2026.155700_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.70155","article-title":"Glycocalyx and endothelial biomarkers as prognostic indicators in sepsis: a systematic review and meta-analysis","volume":"14","author":"Daniyarova","year":"2025","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.jcrc.2026.155700_bb0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41540-025-00488-z","article-title":"Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms","volume":"11","author":"Fonseca","year":"2025","journal-title":"NPJ Syst. Biol. Appl."},{"key":"10.1016\/j.jcrc.2026.155700_bb0030","article-title":"Prognostic value of syndecan-1 in the prediction of sepsis-related complications and mortality: a meta-analysis","volume":"10","author":"Sun","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.jcrc.2026.155700_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-26623-y","article-title":"Elevated endothelial dysfunction-related biomarker levels indicate the severity and predict sepsis incidence","volume":"12","author":"Zhou","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jcrc.2026.155700_bb0040","article-title":"Endothelial glycocalyx degradation and its association with clinical outcomes and host response aberrations in community-acquired pneumonia across different care settings","author":"Wang","year":"2026","journal-title":"Crit. Care"},{"key":"10.1016\/j.jcrc.2026.155700_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110081","article-title":"The anaphylatoxin C5a: structure, function, signaling, physiology, disease, and therapeutics","volume":"118","author":"Ghosh","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0050","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.1096\/fj.201902397R","article-title":"In response to complement anaphylatoxin peptides C3a and C5a, human vascular endothelial cells migrate and mediate the activation of B-cells and polarization of T-cells","volume":"34","author":"Shivshankar","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.jcrc.2026.155700_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26209931","article-title":"Functional roles of the complement immune system in cardiac inflammation and hypertrophy","volume":"26","author":"Hok","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jcrc.2026.155700_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1426526","article-title":"Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axis","volume":"15","author":"Vahldieck","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0065","first-page":"337","article-title":"Unraveling the intricate web: complement activation shapes the pathogenesis of sepsis-induced coagulopathy","volume":"16","author":"Wei","year":"2024","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.jcrc.2026.155700_bb0070","doi-asserted-by":"crossref","DOI":"10.1177\/10760296251396143","article-title":"Complement overactivation as a causal driver of sepsis-associated coagulopathy: a Mendelian randomization study from the UK biobank","volume":"31","author":"Liufu","year":"2025","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.jcrc.2026.155700_bb0075","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.3390\/biomedicines11112924","article-title":"Prolonged door-to-balloon time leads to endothelial glycocalyx damage and endothelial dysfunction in patients with ST-elevation myocardial infarction","volume":"11","author":"Vahldieck","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jcrc.2026.155700_bb0080","doi-asserted-by":"crossref","first-page":"e341","DOI":"10.1097\/TXD.0000000000000881","article-title":"Complement-mediated damage to the glycocalyx plays a role in renal ischemia-reperfusion injury in mice","volume":"5","author":"Bongoni","year":"2019","journal-title":"Transplant. Direct"},{"key":"10.1016\/j.jcrc.2026.155700_bb0085","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-026-01181-w","article-title":"Activation of the C3a-C3aReceptor-axis is associated with endothelial dysfunction and glycocalyx damage in ST-elevation myocardial infarction","author":"Vahldieck","year":"2026","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0090","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1182\/blood-2014-02-522128","article-title":"Paroxysmal nocturnal hemoglobinuria","volume":"124","author":"Brodsky","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jcrc.2026.155700_bb0095","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40265-019-01068-2","article-title":"Ravulizumab: first global approval","volume":"79","author":"McKeage","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.jcrc.2026.155700_bb0100","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1182\/blood.2021012860","article-title":"Advancing therapeutic complement inhibition in hematologic diseases: PNH and beyond","volume":"139","author":"Gavriilaki","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jcrc.2026.155700_bb0105","first-page":"81","article-title":"Ravulizumab demonstrates long-term efficacy, safety and favorable patient survival in patients with paroxysmal nocturnal hemoglobinuria","volume":"104","author":"Kulasekararaj","year":"2025","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0110","article-title":"Incidence of infection associated with eculizumab: a meta-analysis of 9 randomized controlled trials","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0332073","article-title":"Eculizumab and ravulizumab clinical trial and real-world pharmacovigilance of meningococcal infections across indications","volume":"20","author":"Carrillo Infante","year":"2025","journal-title":"PloS One"},{"key":"10.1016\/j.jcrc.2026.155700_bb0120","article-title":"Complement C5 inhibition with eculizumab or ravulizumab is associated with increased cardiovascular and thromboembolic risk after ST-elevation myocardial infarction: a propensity-matched global retrospective cohort study","year":"2026","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.jcrc.2026.155700_bb0125","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00415-025-12922-7","article-title":"Myasthenia gravis in 2025: five new things and four hopes for the future","volume":"272","author":"Binks","year":"2025","journal-title":"J. Neurol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0130","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/aje\/kwv254","article-title":"Using big data to emulate a target trial when a randomized trial is not available","volume":"183","author":"Hern\u00e1n","year":"2016","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0135","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jacc.2016.10.060","article-title":"Comparison of propensity score methods and covariate adjustment: evaluation in 4 cardiovascular studies","volume":"69","author":"Elze","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0140","doi-asserted-by":"crossref","DOI":"10.1093\/jamiaopen\/ooad035","article-title":"A global federated real-world data and analytics platform for research","volume":"6","author":"Palchuk","year":"2023","journal-title":"JAMIA Open"},{"key":"10.1016\/j.jcrc.2026.155700_bb0145","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s40262-019-00742-8","article-title":"Pharmacology, pharmacokinetics and pharmacodynamics of eculizumab, and possibilities for an individualized approach to eculizumab","volume":"58","author":"Wijnsma","year":"2019","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jcrc.2026.155700_bb0150","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/bjh.16711","article-title":"Pharmacokinetic and pharmacodynamic effects of ravulizumab and eculizumab on complement component 5 in adults with paroxysmal nocturnal haemoglobinuria: results of two phase 3 randomised, multicentre studies","volume":"191","author":"Peffault de Latour","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1516126","article-title":"A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX","volume":"16","author":"Ludwig","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1812643","article-title":"Complement C5 inhibition in generalized myasthenia gravis is associated with improved survival and increased cardiovascular risk","volume":"17","author":"Vahldieck","year":"2026","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijtm6020023","article-title":"Complement C5 inhibition and short-term cardiovascular outcomes after acute limb ischemia: a real-world cohort study","volume":"6","author":"Vahldieck","year":"2026","journal-title":"Int. J. Transl. Med."},{"key":"10.1016\/j.jcrc.2026.155700_bb0170","article-title":"Inhibition of classical and alternative complement pathway by ravulizumab and eculizumab","author":"Gerischer","year":"2025","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.jcrc.2026.155700_bb0175","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.2147\/NDT.S374694","article-title":"Ravulizumab in myasthenia gravis: a review of the current evidence","volume":"19","author":"Vu","year":"2023","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.jcrc.2026.155700_bb0180","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1097\/TP.0000000000003302","article-title":"Complement 5 inhibition ameliorates hepatic ischemia\/reperfusion injury in mice, dominantly via the C5a-mediated cascade","volume":"104","author":"Kusakabe","year":"2020","journal-title":"Transplantation"},{"key":"10.1016\/j.jcrc.2026.155700_bb0185","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/jnnp-2024-334404","article-title":"C5 complement inhibition versus FcRn modulation in generalised myasthenia gravis","volume":"96","author":"Huntemann","year":"2025","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jcrc.2026.155700_bb0190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2006.06.010","article-title":"Complement mediators in ischemia-reperfusion injury","volume":"374","author":"Arumugam","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jcrc.2026.155700_bb0195","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13613-024-01301-6","article-title":"Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines","volume":"14","author":"Iba","year":"2024","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.jcrc.2026.155700_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11247362","article-title":"Acute and long-term cardiovascular complications among patients with sepsis and septic shock","volume":"11","author":"Merdji","year":"2022","journal-title":"J. Clin. Med."}],"container-title":["Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944126002789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0883944126002789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:57:50Z","timestamp":1787925470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0883944126002789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S0883944126002789"],"URL":"https:\/\/doi.org\/10.1016\/j.jcrc.2026.155700","relation":{},"ISSN":["0883-9441"],"issn-type":[{"value":"0883-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Terminal complement inhibition is associated with renal, hematologic, and thrombotic complications during septic shock: A global propensity score-matched cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Critical Care","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcrc.2026.155700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"155700"}}