{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:02:45Z","timestamp":1792141365043,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jctejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical &amp; Translational Endocrinology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jcte.2020.100228","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T22:04:26Z","timestamp":1589839466000},"page":"100228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Genetic risk factors for venous thromboembolism among infertile men with Klinefelter syndrome"],"prefix":"10.1016","volume":"20","author":[{"given":"Tarek M.","family":"Hussein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Abd Elmoaty Elneily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Mohamed Abdelfattah Elsayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama M.","family":"El-Attar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcte.2020.100228_b0005","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jcem-2-11-615","article-title":"Syndrome characterized by gynecomastia, aspermatogenesis without a-leydigsm and increased secretion of follicle-stimulating hormone","author":"Klinefelter","year":"1942","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jcte.2020.100228_b0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.ejhg.5201956","article-title":"Is the prevalence of Klinefelter syndrome increasing?","volume":"16","author":"Morris","year":"2008","journal-title":"Eur J Hum Genet"},{"issue":"6","key":"10.1016\/j.jcte.2020.100228_b0015","first-page":"93","article-title":"Chromosome abnormalities and male infertility","author":"Yoshida","year":"1996","journal-title":"Assist Reprod Rev"},{"key":"10.1016\/j.jcte.2020.100228_b0020","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study","volume":"88","author":"Bojesen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.jcte.2020.100228_b0025","first-page":"209","article-title":"Sex chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark","volume":"26","author":"Nielsen","year":"1990","journal-title":"Birth Defects. Orig Artic Ser"},{"key":"10.1016\/j.jcte.2020.100228_b0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fertnstert.2012.05.026","article-title":"It's not all about the testes: medical issues in Klinefelter patients","volume":"98","author":"Sokol","year":"2012","journal-title":"Fertil Steril"},{"issue":"12","key":"10.1016\/j.jcte.2020.100228_b0035","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1210\/jc.2005-1077","article-title":"United Kingdom clinical cytogenetics group. Mortality in patients with Klinefelter syndrome in Britain: a cohort study","volume":"90","author":"Swerdlow","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jcte.2020.100228_b0040","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1210\/jc.2005-0697","article-title":"Morbidity in Klinefelter syndrome: a Danish register study based on hospital discharge diagnoses","volume":"91","author":"Bojesen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.jcte.2020.100228_b0045","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1210\/er.2017-00212","article-title":"Klinefelter syndrome: integrating genetics, neuropsychology, and endocrinology","volume":"39","author":"Gravholt","year":"2018","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jcte.2020.100228_b0050","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(04)16678-6","article-title":"Klinefelter's syndrome","volume":"364","author":"Lanfranco","year":"2004","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jcte.2020.100228_b0055","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003567","article-title":"High risk of venous thromboembolism in Klinefelter syndrome","volume":"5","author":"Z\u00f6ller","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"8","key":"10.1016\/j.jcte.2020.100228_b0060","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/archderm.1997.03890440135027","article-title":"Thrombotic Klinefelter syndrome associated with factor V Leiden mutation","volume":"133","author":"Depaire-Duclos","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jcte.2020.100228_b0065","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1001\/jama.2009.853","article-title":"Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review","volume":"301","author":"Segal","year":"2009","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.jcte.2020.100228_b0070","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/107602960300900405","article-title":"The PAI-1 gene 4G\/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia","volume":"9","author":"Sartori","year":"2003","journal-title":"Clin Appl Thromb Hemost"},{"issue":"7","key":"10.1016\/j.jcte.2020.100228_b0075","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1515\/cclm-2013-1124","article-title":"The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G\/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analysis","volume":"52","author":"Nikolopoulos","year":"2014","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jcte.2020.100228_b0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2141.2002.03797.x","article-title":"Factor XIII Val34Leu polymorphism, factor XIII antigen levels and activity and the risk of deep venous thrombosis","volume":"119","author":"Van Hylckama","year":"2002","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.jcte.2020.100228_b0085","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/1076029607304750","article-title":"Haznedaroglu IC. Severe arterial thrombophilia associated with a homozygous MTHFR gene mutation (A1298C) in a young man with Klinefelter syndrome","volume":"14","author":"Ozbek","year":"2008","journal-title":"Clin Appl Thromb Hemost"},{"issue":"19","key":"10.1016\/j.jcte.2020.100228_b0090","doi-asserted-by":"crossref","first-page":"10212","DOI":"10.1073\/pnas.93.19.10212","article-title":"The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex","volume":"93","author":"Stearns-Kurosawa","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7731","key":"10.1016\/j.jcte.2020.100228_b0095","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(71)90287-X","article-title":"A rapid banding technique for human chromosomes","volume":"2","author":"Seabright","year":"1971","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jcte.2020.100228_b0100","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s00059-012-3690-1","article-title":"Recurrent deep vein thrombosis and pulmonary embolism in a patient with Klinefelter\u2019s syndrome","volume":"38","author":"Chung","year":"2013","journal-title":"Herz"},{"key":"10.1016\/j.jcte.2020.100228_b0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1399-0004.1981.tb00709.x","article-title":"Venous thromboembolic disease in Klinefelter\u2019ssyndrome","volume":"19","author":"Campbell","year":"1981","journal-title":"Clin Genet"},{"key":"10.1016\/j.jcte.2020.100228_b0110","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1272\/jnms.82.64","article-title":"Refractory leg ulcers associated with klinefelter syndrome","volume":"82","author":"Yabuno","year":"2015","journal-title":"J Nippon Med Sch"},{"key":"10.1016\/j.jcte.2020.100228_b0115","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1160\/TH09-01-0013","article-title":"The genetics of venous thromboembolism.A meta-analysis involving approximately 120,000 cases and 180,000 controls","volume":"102","author":"Gohil","year":"2009","journal-title":"Thromb Haemost"},{"issue":"8","key":"10.1016\/j.jcte.2020.100228_b0120","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1177\/1076029616665923","article-title":"Thrombophilia in Klinefelter syndrome with deep venous thrombosis, pulmonary embolism, and mesenteric artery thrombosis on testosterone therapy: A pilot study","volume":"23","author":"Glueck","year":"2017","journal-title":"Clin Appl Thromb Hemost"},{"issue":"6","key":"10.1016\/j.jcte.2020.100228_b0125","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1177\/1557988318801158","article-title":"The effect of PAI-1 gene variants and PAI-1 plasma levels on development of thrombophilia in patients with Klinefelter syndrome","volume":"12","author":"Erkal","year":"2018","journal-title":"Am J Mens Health"},{"key":"10.1016\/j.jcte.2020.100228_b0130","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.mgene.2014.06.004","article-title":"Polymorphisms in thrombophilic genes are associated with deep venous thromboembolism in an Iranian population","volume":"2","author":"Farajzadeh","year":"2014","journal-title":"Meta Gene"},{"issue":"2","key":"10.1016\/j.jcte.2020.100228_b0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/aje\/kwj179","article-title":"Factor XIII Val34Leu variant is protective against venous thromboembolism: aHuGE review and meta-analysis","volume":"164","author":"Wells","year":"2006","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.jcte.2020.100228_b0140","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1182\/blood-2003-07-2520","article-title":"A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis","volume":"103","author":"Saposnik","year":"2004","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jcte.2020.100228_b0145","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.thromres.2011.08.001","article-title":"The endothelial cell protein C receptor: its role in thrombosis","volume":"128","author":"Navarro","year":"2011","journal-title":"Thromb Res"},{"key":"10.1016\/j.jcte.2020.100228_b0150","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1160\/TH03-10-0657","article-title":"Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk","volume":"91","author":"Medina","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jcte.2020.100228_b0155","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1160\/TH05-02-0089","article-title":"Influence of the 4600A\/G and 4678G\/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V Leiden","volume":"94","author":"Medina","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jcte.2020.100228_b0160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00001721-200301000-00017","article-title":"Severe venous thromboembolism in a young man with Klinefelter\u2019s syndrome and heterozygosis for both G20210A prothrombin and factor V Leiden mutations","volume":"14","author":"Lapecorella","year":"2003","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jcte.2020.100228_b0165","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.2169\/internalmedicine.48.1985","article-title":"Serious venous thromboembolism, heterozygous factor V Leiden and prothrombin G20210A mutations in a patient with Klinefelter syndrome and syndrome and type 2 diabetes","volume":"48","author":"Ayli","year":"2009","journal-title":"Intern Med"},{"issue":"6","key":"10.1016\/j.jcte.2020.100228_b0170","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1177\/1076029615572466","article-title":"Association of hemostatic gene polymorphisms with early-onset ischemic heart disease in Egyptian patients","volume":"22","author":"AlkhiaryW","year":"2016","journal-title":"Clin Appl Thromb Hemost"}],"container-title":["Journal of Clinical &amp; Translational Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623719301577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623719301577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:55:53Z","timestamp":1762005353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214623719301577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":34,"alternative-id":["S2214623719301577"],"URL":"https:\/\/doi.org\/10.1016\/j.jcte.2020.100228","relation":{},"ISSN":["2214-6237"],"issn-type":[{"value":"2214-6237","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic risk factors for venous thromboembolism among infertile men with Klinefelter syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical & Translational Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcte.2020.100228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100228"}}