{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:36:07Z","timestamp":1790501767666,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jctejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical &amp; Translational Endocrinology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jcte.2021.100288","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T12:36:56Z","timestamp":1638794216000},"page":"100288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["CF and male health: Sexual and reproductive health, hypogonadism, and fertility"],"prefix":"10.1016","volume":"27","author":[{"given":"Farah","family":"Naz Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea H.","family":"Roe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin","family":"Tangpricha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcte.2021.100288_b0005","unstructured":"Foundation. CF. Patient Registry 2019 Annual Report. Bethesda; 2019."},{"issue":"1","key":"10.1016\/j.jcte.2021.100288_b0010","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/andr.12450","article-title":"Congenital bilateral absence of the vas deferens as an atypical form of cystic fibrosis: reproductive implications and genetic counseling","volume":"6","author":"de Souza","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.jcte.2021.100288_b0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/biolre\/ioz062","article-title":"CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A\u2020","volume":"101","author":"Chen","year":"2019","journal-title":"Biol Reprod"},{"issue":"5","key":"10.1016\/j.jcte.2021.100288_b0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1530\/eje.0.1480551","article-title":"Sex steroids and body composition in men with cystic fibrosis","volume":"148","author":"Leifke","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jcte.2021.100288_b0025","unstructured":"Elkin S. Hypogonadism in adult males with cystic fibrosis. In: Burgess J, editor. Thorax; 2000."},{"issue":"4","key":"10.1016\/j.jcte.2021.100288_b0030","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jcf.2009.05.005","article-title":"Sexual and reproductive health in men with cystic fibrosis: consistent preferences, inconsistent practices","volume":"8","author":"Sawyer","year":"2009","journal-title":"J Cyst Fibros."},{"issue":"3","key":"10.1016\/j.jcte.2021.100288_b0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/GCO.0b013e32835f1745","article-title":"Cystic fibrosis and fertility","volume":"25","author":"Ahmad","year":"2013","journal-title":"Curr Opin Obstet Gynecol."},{"issue":"2","key":"10.1016\/j.jcte.2021.100288_b0040","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1164\/ajrccm.153.2.8564145","article-title":"Cystic fibrosis 3849+10kb C > T mutation associated with severe pulmonary disease and male fertility","volume":"153","author":"Dreyfus","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jcte.2021.100288_b0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1439-0272.2000.00327.x","article-title":"CFTR gene mutations and male infertility","volume":"32","author":"Stuhrmann","year":"2000","journal-title":"Andrologia"},{"issue":"3","key":"10.1016\/j.jcte.2021.100288_b0050","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1183\/09031936.05.10100004","article-title":"The CFTR 3849+10kbC->T and 2789+5G->A alleles are associated with a mild CF phenotype","volume":"25","author":"Dugu\u00e9p\u00e9roux","year":"2005","journal-title":"Eur Respir J."},{"issue":"2","key":"10.1016\/j.jcte.2021.100288_b0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM196807112790203","article-title":"Reproductive failure in males with cystic fibrosis","volume":"279","author":"Kaplan","year":"1968","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jcte.2021.100288_b0060","first-page":"569","article-title":"Abnormality of the epididymis and vas deferens in cystic fibrosis","volume":"88","author":"Landing","year":"1969","journal-title":"Arch Pathol"},{"issue":"1","key":"10.1016\/j.jcte.2021.100288_b0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1542\/peds.41.1.7","article-title":"Infertility in male patients with cystic fibrosis","volume":"41","author":"Denning","year":"1968","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.jcte.2021.100288_b0070","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2605.2004.00485.x","article-title":"CFTR mutations and polymorphisms in male infertility","volume":"27","author":"Cuppens","year":"2004","journal-title":"Int J Androl."},{"issue":"Suppl 2","key":"10.1016\/j.jcte.2021.100288_b0075","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1016\/j.jcf.2019.08.007","article-title":"Male reproductive health in cystic fibrosis","volume":"10","author":"Yoon","year":"2019","journal-title":"J Cyst Fibros"},{"issue":"5","key":"10.1016\/j.jcte.2021.100288_b0080","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.urology.2013.01.001","article-title":"Sensitivity and specificity of ultrasonography in predicting etiology of azoospermia","volume":"81","author":"Abdulwahed","year":"2013","journal-title":"Urology."},{"issue":"5","key":"10.1016\/j.jcte.2021.100288_b0085","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/humrep\/dei453","article-title":"Results of assisted reproductive technique in men with cystic fibrosis","volume":"21","author":"Hubert","year":"2006","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.jcte.2021.100288_b0090","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1378\/chest.118.4.1059","article-title":"Fertility in men with cystic fibrosis: an update on current surgical practices and outcomes","volume":"118","author":"McCallum","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.jcte.2021.100288_b0095","article-title":"Techniques for surgical retrieval of sperm prior to intra-cytoplasmic sperm injection (ICSI) for azoospermia","volume":"2","author":"Van Peperstraten","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.jcte.2021.100288_b0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ucl.2019.12.003","article-title":"Sperm Extraction in Obstructive Azoospermia: What's Next?","volume":"47","author":"Akerman","year":"2020","journal-title":"Urol Clin North Am"},{"issue":"10","key":"10.1016\/j.jcte.2021.100288_b0105","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1093\/humrep\/deh405","article-title":"Fertility and pregnancy outcomes in men and women with cystic fibrosis in the United Kingdom","volume":"19","author":"Boyd","year":"2004","journal-title":"Hum Reprod."},{"issue":"4","key":"10.1016\/j.jcte.2021.100288_b0110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/14647270701510033","article-title":"Infertility and its management in men with cystic fibrosis: review of literature and clinical practices in the UK","volume":"10","author":"Popli","year":"2007","journal-title":"Hum Fertil (Camb)."},{"issue":"2","key":"10.1016\/j.jcte.2021.100288_b0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1513\/AnnalsATS.201909-671CME","article-title":"The Extrapulmonary Effects of Cystic Fibrosis Transmembrane Conductance Regulator Modulators in Cystic Fibrosis","volume":"17","author":"Sergeev","year":"2020","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"10.1016\/j.jcte.2021.100288_b0120","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/jc.2018-00229","article-title":"Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline","volume":"103","author":"Bhasin","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.jcte.2021.100288_b0125","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1099-0496(199804)25:4<226::AID-PPUL2>3.0.CO;2-I","article-title":"Reproductive health in males with cystic fibrosis: knowledge, attitudes, and experiences of patients and parents","volume":"25","author":"Sawyer","year":"1998","journal-title":"Pediatr Pulmonol."},{"issue":"4","key":"10.1016\/j.jcte.2021.100288_b0130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/thx.2004.027599","article-title":"A survey of sexual and reproductive health in men with cystic fibrosis: new challenges for adolescent and adult services","volume":"60","author":"Sawyer","year":"2005","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.jcte.2021.100288_b0135","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/ejhg.2015.160","article-title":"Attitudes of cystic fibrosis patients and parents toward carrier screening and related reproductive issues","volume":"24","author":"Janssens","year":"2016","journal-title":"Eur J Hum Genet."},{"issue":"8","key":"10.1016\/j.jcte.2021.100288_b0140","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/ppul.24344","article-title":"Pursuing parenthood with cystic fibrosis: Reproductive health and parenting concerns in individuals with cystic fibrosis","volume":"54","author":"Hailey","year":"2019","journal-title":"Pediatr Pulmonol"},{"issue":"11","key":"10.1016\/j.jcte.2021.100288_b0145","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/ppul.20911","article-title":"Reproductive and sexual health in boys with cystic fibrosis: what do parents know and say?","volume":"43","author":"Frayman","year":"2008","journal-title":"Pediatr Pulmonol."},{"issue":"4","key":"10.1016\/j.jcte.2021.100288_b0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1099-0496(199904)27:4<293::AID-PPUL13>3.0.CO;2-3","article-title":"Reproductive health in males with cystic fibrosis: knowledge, attitudes, and experience of patients and parents","volume":"27","author":"Madge","year":"1999","journal-title":"Pediatr Pulmonol."},{"issue":"1","key":"10.1016\/j.jcte.2021.100288_b0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1054-139X(00)00172-5","article-title":"Reproductive and sexual health in males with cystic fibrosis: a case for health professional education and training","volume":"28","author":"Sawyer","year":"2001","journal-title":"J Adolesc Health."},{"issue":"10","key":"10.1016\/j.jcte.2021.100288_b0160","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.pec.2018.06.004","article-title":"Cystic fibrosis-related education: Are we meeting patient and caregiver expectations?","volume":"101","author":"Lonabaugh","year":"2018","journal-title":"Patient Educ Couns"},{"issue":"3","key":"10.1016\/j.jcte.2021.100288_b0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S1526-0542(02)00184-7","article-title":"Fertility issues in cystic fibrosis","volume":"3","author":"Lyon","year":"2002","journal-title":"Paediatr Respir Rev."},{"key":"10.1016\/j.jcte.2021.100288_b0170","article-title":"Men's health in the modern era of cystic fibrosis","author":"Khan","year":"2020","journal-title":"J Cyst Fibros."}],"container-title":["Journal of Clinical &amp; Translational Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623721000405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623721000405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:58:29Z","timestamp":1762005509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214623721000405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":34,"alternative-id":["S2214623721000405"],"URL":"https:\/\/doi.org\/10.1016\/j.jcte.2021.100288","relation":{},"ISSN":["2214-6237"],"issn-type":[{"value":"2214-6237","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CF and male health: Sexual and reproductive health, hypogonadism, and fertility","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical & Translational Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcte.2021.100288","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100288"}}