{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T19:59:17Z","timestamp":1787255957370,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jctejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical &amp; Translational Endocrinology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jcte.2023.100317","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T03:13:14Z","timestamp":1680232394000},"page":"100317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Symptomatic versus asymptomatic primary hyperparathyroidism: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-2334","authenticated-orcid":false,"given":"Pallavi","family":"Kulkarni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcte.2023.100317_b0005","doi-asserted-by":"crossref","unstructured":"Minisola S, Pepe J, Piemonte S, Cipriani C. The diagnosis and management of hypercalcaemia.BMJ. 2015;350:h2723. 2015. doi:10.1136\/bmj.h2723.","DOI":"10.1136\/bmj.h2723"},{"issue":"2","key":"10.1016\/j.jcte.2023.100317_b0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrendo.2017.104","article-title":"Primary hyperparathyroidism","volume":"14","author":"Walker","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jcte.2023.100317_b0015","doi-asserted-by":"crossref","unstructured":"Madkhali T, Alhefdhi A, Chen H, Elfenbein D. Primary hyperparathyroidism.Ulus Cerrahi Derg. 2016;32(1):58-66. 2016. doi:10.5152\/UCD.2015.3032.","DOI":"10.5152\/UCD.2015.3032"},{"issue":"9","key":"10.1016\/j.jcte.2023.100317_b0020","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.mpsur.2011.06.015","article-title":"Hyperparathyroidism","volume":"29","author":"Gopinath","year":"2011","journal-title":"Surgery (Oxford)"},{"issue":"17","key":"10.1016\/j.jcte.2023.100317_b0025","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1056\/NEJMcp032200","article-title":"Clinical practice. Asymptomatic primary hyperparathyroidism","volume":"350","author":"Bilezikian","year":"2004","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.jcte.2023.100317_b0030","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1002\/jbmr.4677","article-title":"Evaluation and management of primary hyperparathyroidism: summary statement and guidelines from the fifth international workshop","volume":"37","author":"Bilezikian","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"3","key":"10.1016\/j.jcte.2023.100317_b0035","doi-asserted-by":"crossref","first-page":"D13","DOI":"10.1530\/EJE-15-0277","article-title":"Is surgery necessary for 'mild' or 'asymptomatic' hyperparathyroidism?","volume":"173","author":"Niederle","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10.1016\/j.jcte.2023.100317_b0040","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/lary.26617","article-title":"Early neurocognitive improvements following parathyroidectomy for primary hyperparathyroidism","volume":"128","author":"Shah-Becker","year":"2018","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.jcte.2023.100317_b0045","first-page":"1674","article-title":"The effect of parathyroidectomy on bone mineral density in primary hyperparathyroidism. Turk","volume":"49","author":"\u00c7ali\u015fkan","year":"2019","journal-title":"J Med Sci"},{"issue":"1","key":"10.1016\/j.jcte.2023.100317_b0050","doi-asserted-by":"crossref","first-page":"32","DOI":"10.7812\/TPP\/07-091","article-title":"Current status and treatment of primary hyperparathyroidism","volume":"12","author":"Elaraj","year":"2008","journal-title":"Perm J"},{"issue":"5","key":"10.1016\/j.jcte.2023.100317_b0055","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00000658-200211000-00002","article-title":"Surgery for primary hyperparathyroidism: what is the best approach?","volume":"236","author":"Chen","year":"2002","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcte.2023.100317_b0060","unstructured":"Centre for Evidence-Based Medicine. OCEBM Levels of Evidence. https:\/\/www.cebm.ox.ac.uk\/resources\/levels-of-evidence\/ocebm-levels-of-evidence. Accessed 05\/31\/2022."},{"key":"10.1016\/j.jcte.2023.100317_b0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"issue":"4","key":"10.1016\/j.jcte.2023.100317_b0070","first-page":"368","article-title":"Clinical characteristics of the patients with asymptomatic primary hyperparathyroidism","volume":"46","author":"Yao","year":"2021","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.jcte.2023.100317_b0075","doi-asserted-by":"crossref","unstructured":"Saponaro F, Pardi E, Mazoni L, et al. Do patients with atypical parathyroid adenoma need close follow-up?. J Clin Endocrinol Metab. 2021;106(11):e4565-e4579. doi:10.1210\/clinem\/dgab452.","DOI":"10.1210\/clinem\/dgab452"},{"issue":"2","key":"10.1016\/j.jcte.2023.100317_b0080","first-page":"148","article-title":"Diagnostic value of clinical parameters and parathyroid scintigraphy for asymptomatic primary hyperparathyroidism","volume":"23","author":"Ning","year":"2020","journal-title":"Hell J Nucl Med"},{"key":"10.1016\/j.jcte.2023.100317_b0085","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jss.2020.12.023","article-title":"Impact on quality of life after parathyroidectomy for asymptomatic primary hyperparathyroidism","volume":"261","author":"Vadhwana","year":"2021","journal-title":"J Surg Res"},{"key":"10.1016\/j.jcte.2023.100317_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7617254","article-title":"Symptomatic hypercalcemia in patients with primary hyperparathyroidism is associated with severity of disease, polypharmacy, and comorbidity","volume":"2019","author":"Aresta","year":"2019","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jcte.2023.100317_b0095","first-page":"1","article-title":"Do symptoms and serum calcium levels affect the results of surgical treatment of primary hyperparathyroidism?","volume":"2019","author":"Yu","year":"2019","journal-title":"Biomed Res Int"},{"issue":"5","key":"10.1016\/j.jcte.2023.100317_b0100","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s40618-015-0423-3","article-title":"Clinical presentation and management of patients with primary hyperparathyroidism of the Swiss Primary Hyperparathyroidism Cohort: a focus on neuro-behavioral and cognitive symptoms","volume":"39","author":"Trombetti","year":"2016","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"10.1016\/j.jcte.2023.100317_b0105","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4158\/EP14447.OR","article-title":"Asymptomatic primary hyperparathyroidism exists in North India: retrospective data from 2 tertiary care centers","volume":"21","author":"Mithal","year":"2015","journal-title":"Endocr Pract"},{"issue":"4","key":"10.1016\/j.jcte.2023.100317_b0110","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/BOR.0000000000000511","article-title":"Primary hyperparathyroidism: recent advances","volume":"30","author":"Walker","year":"2018","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"10.1016\/j.jcte.2023.100317_b0115","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s11154-022-09750-9","article-title":"Cognitive deficits in primary hyperparathyroidism \u2013 what we know and what we do not know: a narrative review","volume":"23","author":"Chandran","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"10.1016\/j.jcte.2023.100317_b0120","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00198-017-4322-7","article-title":"Characteristics, management, and outcome of primary hyperparathyroidism at a single clinical center from 2005 to 2016","volume":"29","author":"Sun","year":"2018","journal-title":"Osteoporos Int"},{"issue":"2","key":"10.1016\/j.jcte.2023.100317_b0125","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1210\/jc.2012-2914","article-title":"The changing clinical patterns of primary hyperparathyroidism in Chinese patients: data from 2000 to 2010 in a single clinical center","volume":"98","author":"Zhao","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.jcte.2023.100317_b0130","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1210\/jc.2014-1415","article-title":"Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop","volume":"99","author":"Silverberg","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.jcte.2023.100317_b0135","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1007\/s00268-018-4575-0","article-title":"Changing profile of primary hyperparathyroidism over two and half decades: a study in tertiary referral center of North India","volume":"42","author":"Yadav","year":"2018","journal-title":"World J Surg"},{"issue":"3","key":"10.1016\/j.jcte.2023.100317_b0140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.amjsurg.2018.09.010","article-title":"Degree of hypercalcemia correlates with parathyroidectomy but not with symptoms","volume":"217","author":"Yan","year":"2019","journal-title":"Am J Surg"},{"issue":"2","key":"10.1016\/j.jcte.2023.100317_b0145","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/qjmed\/hcx200","article-title":"The impact of vitamin D status and parameters of calcium metabolism in patients with primary hyperparathyroidism","volume":"111","author":"Tripto-Shkolnik","year":"2018","journal-title":"QJM"},{"issue":"9","key":"10.1016\/j.jcte.2023.100317_b0150","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1001\/jamasurg.2017.1721","article-title":"Indications for surgical management of hyperparathyroidism: a review","volume":"152","author":"Stephen","year":"2017","journal-title":"JAMA Surg"},{"issue":"4","key":"10.1016\/j.jcte.2023.100317_b0155","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/SLA.0000000000000812","article-title":"Trends in the frequency and quality of parathyroid surgery: analysis of 17,082 cases over 10 years","volume":"261","author":"Abdulla","year":"2015","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.jcte.2023.100317_b0160","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.suc.2019.04.007","article-title":"Who benefits from treatment of primary hyperparathyroidism?","volume":"99","author":"Zhu","year":"2019","journal-title":"Surg Clin North Am"},{"issue":"2","key":"10.1016\/j.jcte.2023.100317_b0165","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/000313480407000215","article-title":"Major depression due to primary hyperparathyroidism: a frequent and correctable disorder","volume":"70","author":"Wilhelm","year":"2004","journal-title":"Am Surg"},{"issue":"10","key":"10.1016\/j.jcte.2023.100317_b0170","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1210\/jc.2014-2000","article-title":"The surgical management of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop","volume":"99","author":"Udelsman","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.jcte.2023.100317_b0175","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.surg.2006.07.032","article-title":"Cost-effectiveness analysis of parathyroidectomy for asymptomatic primary hyperparathyroidism","volume":"140","author":"Zanocco","year":"2006","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.jcte.2023.100317_b0180","first-page":"105","article-title":"Primary hyperparathyroidism in developing world: a systematic review on the changing clinical profile of the disease","volume":"64","author":"Yadav","year":"2020","journal-title":"Arch Endocrinol Metab"}],"container-title":["Journal of Clinical &amp; Translational Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623723000054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623723000054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:57:15Z","timestamp":1762005435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214623723000054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":36,"alternative-id":["S2214623723000054"],"URL":"https:\/\/doi.org\/10.1016\/j.jcte.2023.100317","relation":{},"ISSN":["2214-6237"],"issn-type":[{"value":"2214-6237","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptomatic versus asymptomatic primary hyperparathyroidism: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical & Translational Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcte.2023.100317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100317"}}