{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:20:22Z","timestamp":1783938022870,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["CC002-AD"],"award-info":[{"award-number":["CC002-AD"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK125013"],"award-info":[{"award-number":["P30DK125013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["3UL1TR002378-05S2"],"award-info":[{"award-number":["3UL1TR002378-05S2"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jctejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical &amp; Translational Endocrinology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jcte.2024.100362","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T08:47:42Z","timestamp":1721810862000},"page":"100362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Impact of high-dose cholecalciferol (vitamin D3) and inulin prebiotic on intestinal and airway microbiota in adults with cystic fibrosis: A 2\u00a0\u00d7\u00a02 randomized, placebo-controlled, double-blind pilot study"],"prefix":"10.1016","volume":"37","author":[{"given":"Pichatorn","family":"Suppakitjanusant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa K.","family":"Sivapiromrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Binongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishaan","family":"Jathal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Chassaing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Gewirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin","family":"Tangpricha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcte.2024.100362_b0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12950-015-0107-y","article-title":"CFTR Knockdown induces proinflammatory changes in intestinal epithelial cells","volume":"12","author":"Crites","year":"2015","journal-title":"J Inflamm (London, England)"},{"key":"10.1016\/j.jcte.2024.100362_b0010","doi-asserted-by":"crossref","first-page":"G539","DOI":"10.1152\/ajpgi.00060.2015","article-title":"Vitamin D attenuates inflammation in CFTR knockdown intestinal epithelial cells but has no effect in cells with intact CFTR","volume":"310","author":"Morin","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"10.1016\/j.jcte.2024.100362_b0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198457","article-title":"Altered intestinal microbiota composition, antibiotic therapy and intestinal inflammation in children and adolescents with cystic fibrosis","volume":"13","author":"de Freitas","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jcte.2024.100362_b0020","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.clinthera.2016.02.008","article-title":"Neonatal gastrointestinal and respiratory microbiome in cystic fibrosis: potential interactions and implications for systemic health","volume":"38","author":"Madan","year":"2016","journal-title":"Clin Ther"},{"key":"10.1016\/j.jcte.2024.100362_b0025","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.biocel.2014.02.005","article-title":"Cystic fibrosis: evidence for gut inflammation","volume":"52","author":"Munck","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"10.1016\/j.jcte.2024.100362_b0030","article-title":"Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis","volume":"4","author":"Nielsen","year":"2016","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.jcte.2024.100362_b0035","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1073\/pnas.1714373115","article-title":"Adaptation of commensal proliferating Escherichia coli to the intestinal tract of young children with cystic fibrosis","volume":"115","author":"Matamouros","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.jcte.2024.100362_b0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12866-017-0968-8","article-title":"The altered gut microbiota in adults with cystic fibrosis","volume":"17","author":"Burke","year":"2017","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jcte.2024.100362_b0045","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jsbmb.2016.11.001","article-title":"Role of vitamin D on gut microbiota in cystic fibrosis","volume":"175","author":"Kanhere","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.jcte.2024.100362_b0050","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/jc.2017-01983","article-title":"Bolus weekly vitamin D3 supplementation impacts gut and airway microbiota in adults with cystic fibrosis: a double-blind, randomized, placebo-controlled clinical trial","volume":"103","author":"Kanhere","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jcte.2024.100362_b0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.metabol.2017.02.006","article-title":"Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: a pilot randomized study of high-dose vitamin D3 administration","volume":"70","author":"Alvarez","year":"2017","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.jcte.2024.100362_b0060","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jcf.2014.02.007","article-title":"Improvement of digestive health and reduction in proteobacterial populations in the gut microbiota of cystic fibrosis patients using a Lactobacillus reuteri probiotic preparation: a double blind prospective study","volume":"13","author":"del Campo","year":"2014","journal-title":"J Cyst Fibros"},{"issue":"2","key":"10.1016\/j.jcte.2024.100362_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087796","article-title":"Disrupted intestinal microbiota and intestinal inflammation in children with cystic fibrosis and its restoration with Lactobacillus GG: a randomised clinical trial","volume":"9","author":"Bruzzese","year":"2014","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.jcte.2024.100362_b0070","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1177\/0956462415590725","article-title":"The potential risks of probiotics among HIV-infected persons: bacteraemia due to Lactobacillus acidophilus and review of the literature","volume":"27","author":"Haghighat","year":"2016","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.jcte.2024.100362_b0075","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7630.1","article-title":"Probiotics in critically ill children","volume":"5","author":"Singhi","year":"2016","journal-title":"F1000Res"},{"issue":"6","key":"10.1016\/j.jcte.2024.100362_b0080","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1542\/peds.2010-2548","article-title":"American academy of pediatrics committee on nutrition; American academy of pediatrics section on gastroenterology, hepatology, and nutrition","volume":"126","author":"Thomas","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jcte.2024.100362_b0085","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.micpath.2016.01.002","article-title":"Microbiota manipulation for weight change","volume":"106","author":"Dror","year":"2017","journal-title":"Microb Pathog"},{"issue":"2","key":"10.1016\/j.jcte.2024.100362_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/nu10020201","article-title":"The effect of oligofructose-enriched inulin on faecal bacterial counts and microbiota-associated characteristics in celiac disease children following a gluten-free diet: results of a randomized, placebo-controlled trial","volume":"10","author":"Drabi\u0144ska","year":"2018","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.jcte.2024.100362_b0095","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1136\/gutjnl-2016-313271","article-title":"Prebiotic inulin-type fructans induce specific changes in the human gut microbiota","volume":"66","author":"Vandeputte","year":"2017","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.jcte.2024.100362_b0100","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1053\/j.gastro.2017.05.055","article-title":"Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity","volume":"153","author":"Nicolucci","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcte.2024.100362_b0105","doi-asserted-by":"crossref","first-page":"101278","DOI":"10.1016\/j.conctc.2024.101278","volume":"38","author":"Sivapiromrat","year":"2024","journal-title":"Contemporary clinical trials communications"},{"key":"10.1016\/j.jcte.2024.100362_b0110","unstructured":"Macklaim J, Mikalauskas A, Cunningham L, Egloff C, Doukhanine E. OMNIgeneTMGUT provides ambient temperature stabilization of pediatric fecal samples for microbiome profiling. PD-WP-00057. DNA Genotek Inc."},{"issue":"1","key":"10.1016\/j.jcte.2024.100362_b0115","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2221429","article-title":"The effect of vitamin D supplementation on the gut microbiome in older Australians \u2013 results from analyses of the D-Health Trial","volume":"15","author":"Pham","year":"2023","journal-title":"Gut Microbes"},{"issue":"9","key":"10.1016\/j.jcte.2024.100362_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/nu15092059","article-title":"Association of vitamin D level and maternal gut microbiome during pregnancy: findings from a randomized controlled trial of antenatal vitamin D supplementation","volume":"15","author":"Aparicio","year":"2023","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jcte.2024.100362_b0125","article-title":"High dose intramuscular vitamin D3 supplementation impacts the gut microbiota of patients with Clostridioides Difficile infection","volume":"6","author":"Lee","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jcte.2024.100362_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2022.100842","article-title":"Colorectal cancer, Vitamin D and microbiota: a double-blind Phase II randomized trial (ColoViD) in colorectal cancer patients","volume":"34","author":"Bellerba","year":"2022","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.jcte.2024.100362_b0135","doi-asserted-by":"crossref","first-page":"551","DOI":"10.21873\/anticanres.13984","article-title":"The effect of various doses of oral vitamin d3 supplementation on gut microbiota in healthy adults: a randomized, double-blinded, dose-response study","volume":"40","author":"Charoenngam","year":"2020","journal-title":"Anticancer Res"},{"issue":"12","key":"10.1016\/j.jcte.2024.100362_b0140","first-page":"3464","article-title":"Pilot trial of vitamin D3 and calcifediol in healthy vitamin D deficient adults: does it change the fecal microbiome?","volume":"106","author":"Shieh","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.jcte.2024.100362_b0145","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jcf.2012.03.007","article-title":"Gut dysbiosis in cystic fibrosis","volume":"11","author":"Scanlan","year":"2012","journal-title":"J Cyst Fibr"},{"issue":"6","key":"10.1016\/j.jcte.2024.100362_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011044","article-title":"Airway microbiota and pathogen abundance in age-stratified cystic fibrosispatients","volume":"5","author":"Cox","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jcte.2024.100362_b0155","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00251-12","article-title":"Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: interaction between intestinal and respiratory tracts and impact of nutritional exposures","volume":"3","author":"Madan","year":"2012","journal-title":"MBio."},{"issue":"5","key":"10.1016\/j.jcte.2024.100362_b0160","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s10620-022-07812-1","article-title":"Cystic fibrosis-related gut dysbiosis: a systematic review","volume":"68","author":"Caley","year":"2023","journal-title":"Digestive Dis. Sci."},{"issue":"24","key":"10.1016\/j.jcte.2024.100362_b0165","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.3390\/nu15245013","article-title":"Association between dietary intake and faecal microbiota in children with cystic fibrosis","volume":"15","author":"Viteri-Echeverr\u00eda","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jcte.2024.100362_b0170","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55028-7","article-title":"Gut microbiota in children with cystic fibrosis: a taxonomic and functional dysbiosis","volume":"9","author":"Coffey","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jcte.2024.100362_b0175","article-title":"Probiotics for people with cystic fibrosis","volume":"1","author":"Coffey","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.jcte.2024.100362_b0180","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/nu14030480","article-title":"What do we know about the microbiome in cystic fibrosis? Is there a role for probiotics and prebiotics","volume":"14","author":"van Dorst","year":"2022","journal-title":"Nutrients"},{"issue":"13","key":"10.1016\/j.jcte.2024.100362_b0185","article-title":"The gut-lung axis in the CFTR modulator era","volume":"15","author":"Lussac-Sorton","year":"2023","journal-title":"Front. Cell Infect Microbiol."},{"issue":"10","key":"10.1016\/j.jcte.2024.100362_b0190","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.3390\/molecules25102300","article-title":"Effects of vitamin D supplementation on inflammation, colonic cell kinetics, and microbiota in colitis: a review","volume":"25","author":"Garcia","year":"2020","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.jcte.2024.100362_b0195","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphys.2014.00151","article-title":"Hewison MImpact of vitamin D on immune function: lessons learned from genome-wide analysis","volume":"5","author":"Chun","year":"2014","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.jcte.2024.100362_b0200","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MIB.0000000000000282","article-title":"Vitamin D deficiency predisposes to adherent-invasive Escherichia coli-induced barrier dysfunction and experimental colonic injury","volume":"21","author":"Assa","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"9","key":"10.1016\/j.jcte.2024.100362_b0205","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1096\/fj.04-3284com","article-title":"Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3","volume":"19","author":"Gombart","year":"2005","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.jcte.2024.100362_b0210","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/bbb\/zbac019","article-title":"Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D","volume":"86","author":"Takita","year":"2022","journal-title":"Biosci. Biotech. Biochem."}],"container-title":["Journal of Clinical &amp; Translational Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623724000334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623724000334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:16:56Z","timestamp":1778861816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214623724000334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":42,"alternative-id":["S2214623724000334"],"URL":"https:\/\/doi.org\/10.1016\/j.jcte.2024.100362","relation":{},"ISSN":["2214-6237"],"issn-type":[{"value":"2214-6237","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of high-dose cholecalciferol (vitamin D3) and inulin prebiotic on intestinal and airway microbiota in adults with cystic fibrosis: A 2\u00a0\u00d7\u00a02 randomized, placebo-controlled, double-blind pilot study","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical & Translational Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcte.2024.100362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100362"}}