{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:41:57Z","timestamp":1786466517847,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023ZD0506901"],"award-info":[{"award-number":["2023ZD0506901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802902"],"award-info":[{"award-number":["2024YFA1802902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202411024"],"award-info":[{"award-number":["SZSM202411024"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271611"],"award-info":[{"award-number":["82271611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jctejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical &amp; Translational Endocrinology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jcte.2026.100447","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:33:39Z","timestamp":1781224419000},"page":"100447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Change in circulating irisin level and its association with lipid metabolism after exenatide treatment in patients with type 2 diabetes mellitus"],"prefix":"10.1016","volume":"45","author":[{"given":"Yuting","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianpei","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcte.2026.100447_bb0005","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s00125-015-3525-8","article-title":"Pathophysiology of diabetic dyslipidaemia: where are we?","volume":"58","author":"Verg\u00e8s","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcte.2026.100447_bb0010","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s12933-025-02928-w","article-title":"Associations of six insulin resistance-related indices with the risk and progression of cardio-renal-metabolic multimorbidity: evidence from the UK biobank","volume":"24","author":"Liu","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0015","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s12933-025-02903-5","article-title":"Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-year cohort study","volume":"24","author":"Wen","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0020","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41392-024-01931-z","article-title":"Glucagon-like peptide-1 receptor: mechanisms and advances in therapy","volume":"9","author":"Zheng","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jcte.2026.100447_bb0025","doi-asserted-by":"crossref","first-page":"4554996","DOI":"10.1155\/2022\/4554996","article-title":"Research Progress on the cardiovascular protective effect of glucagon-like Peptide-1 receptor agonists","volume":"2022","author":"Song","year":"2022","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jcte.2026.100447_bb0030","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1185\/03007995.2011.590127","article-title":"GLP-1 receptor agonists and HBA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials","volume":"27","author":"Esposito","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jcte.2026.100447_bb0035","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cmet.2017.04.013","article-title":"A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain Axis mechanism","volume":"25","author":"Grasset","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.jcte.2026.100447_bb0040","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tem.2022.06.003","article-title":"Irisin, a fascinating field in our times","volume":"33","author":"Bao","year":"2022","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jcte.2026.100447_bb0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jcte.2026.100447_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biom11020286","article-title":"Irisin and incretin hormones: similarities, differences, and implications in type 2 diabetes and obesity","volume":"11","author":"Marrano","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jcte.2026.100447_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10020258","article-title":"Irisin-A Pancreatic Islet Hormone","volume":"10","author":"Norman","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jcte.2026.100447_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2024.112225","article-title":"Liraglutide promotes UCP1 expression and lipolysis of adipocytes by promoting the secretion of irisin from skeletal muscle cells","volume":"588","author":"Zhang","year":"2024","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jcte.2026.100447_bb0065","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.jdiacomp.2016.07.020","article-title":"Exenatide treatment increases serum irisin levels in patients with obesity and newly diagnosed type 2 diabetes","volume":"30","author":"Liu","year":"2016","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.jcte.2026.100447_bb0070","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00592-020-01510-y","article-title":"Efficacy and safety of generic exenatide injection in Chinese patients with type 2 diabetes: a multicenter, randomized, controlled, non-inferiority trial","volume":"57","author":"Yang","year":"2020","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0075","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00592-020-01660-z","article-title":"High baseline FGF21 levels are associated with poor glucose-lowering efficacy of exenatide in patients with type 2 diabetes","volume":"58","author":"Yang","year":"2021","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2020.107797","article-title":"Non-targeted metabolomic analysis predicts the therapeutic effects of exenatide on endothelial injury in patients with type 2 diabetes","volume":"35","author":"Yang","year":"2021","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.jcte.2026.100447_bb0085","doi-asserted-by":"crossref","DOI":"10.1201\/9781003459361","article-title":"Assessing the impact of estimated glucose disposal rate (eGDR) on cognitive function in older adults: a NHANES-based machine learning study","volume":"31","author":"Wang","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jcte.2026.100447_bb0090","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12933-025-02768-8","article-title":"Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population","volume":"24","author":"Qiu","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0095","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12933-025-02870-x","article-title":"Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the MIMIC-IV database","volume":"24","author":"Cheng","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0100","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.12998\/wjcc.v7.i12.1444","article-title":"Relationship between circulating irisin levels and overweight\/obesity: a meta-analysis","volume":"7","author":"Jia","year":"2019","journal-title":"World J Clin Cases"},{"key":"10.1016\/j.jcte.2026.100447_bb0105","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.metabol.2013.12.007","article-title":"Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients","volume":"63","author":"Crujeiras","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.jcte.2026.100447_bb0110","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1210\/jc.2014-2544","article-title":"Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome","volume":"100","author":"Li","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jcte.2026.100447_bb0115","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/cen.12627","article-title":"Irisin: \u2018fat\u2019 or artefact","volume":"82","author":"Crujeiras","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jcte.2026.100447_bb0120","doi-asserted-by":"crossref","first-page":"E769","DOI":"10.1210\/jc.2012-2749","article-title":"Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance","volume":"98","author":"Moreno-Navarrete","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jcte.2026.100447_bb0125","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nrendo.2016.221","article-title":"Physiology and role of irisin in glucose homeostasis","volume":"13","author":"Perakakis","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jcte.2026.100447_bb0130","doi-asserted-by":"crossref","DOI":"10.1177\/11795514251344029","article-title":"Irisin in type 2 diabetes and obesity: a biomarker of metabolic and lipid dysregulation","volume":"18","author":"Stankovi\u0107","year":"2025","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"key":"10.1016\/j.jcte.2026.100447_bb0135","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12933-022-01684-5","article-title":"Personalized management of dyslipidemias in patients with diabetes-it is time for a new approach","volume":"21","author":"Banach","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0140","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12933-020-01054-z","article-title":"Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome","volume":"19","author":"Wang","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0145","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s42255-026-01491-2","article-title":"Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells","volume":"8","author":"Mu","year":"2026","journal-title":"Nat Metab"},{"key":"10.1016\/j.jcte.2026.100447_bb0150","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/db13-1106","article-title":"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jcte.2026.100447_bb0155","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.bbadis.2015.06.017","article-title":"FNDC5 overexpression and irisin ameliorate glucose\/lipid metabolic derangements and enhance lipolysis in obesity","volume":"1852","author":"Xiong","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcte.2026.100447_bb0160","doi-asserted-by":"crossref","first-page":"17368","DOI":"10.1038\/s41598-020-74588-7","article-title":"Disordered metabolism in mice lacking irisin","volume":"10","author":"Luo","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcte.2026.100447_bb0165","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/ijo.2014.42","article-title":"Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans","volume":"38","author":"Huh","year":"2014","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jcte.2026.100447_bb0170","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.cellsig.2015.04.010","article-title":"New role of irisin in hepatocytes: the protective effect of hepatic steatosis in vitro","volume":"27","author":"Park","year":"2015","journal-title":"Cell Signal"},{"key":"10.1016\/j.jcte.2026.100447_bb0175","article-title":"GLP-1 induces the expression of FNDC5 derivatives that execute lipolytic actions","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcte.2026.100447_bb0180","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12933-020-01014-7","article-title":"Comparison of the effects of twice-daily exenatide and insulin on carotid intima-media thickness in type 2 diabetes mellitus patients: a 52-week randomized, open-label, controlled trial","volume":"19","author":"Zhang","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0185","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/j.numecd.2021.07.015","article-title":"Effects of GLP-1 receptor agonists on myokine levels and pro-inflammatory cytokines in patients with type 2 diabetes mellitus","volume":"31","author":"Guarnotta","year":"2021","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jcte.2026.100447_bb0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/1753-0407.12256","article-title":"Lower irisin level in patients with type 2 diabetes mellitus: a case-control study and meta-analysis","volume":"8","author":"Zhang","year":"2016","journal-title":"J Diabetes"},{"key":"10.1016\/j.jcte.2026.100447_bb0195","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s11845-024-03626-4","article-title":"A case-control study to evaluate irisin levels in patients with type 1 diabetes mellitus","volume":"193","author":"Abdulabbas","year":"2024","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.jcte.2026.100447_bb0200","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.cell.2018.10.025","article-title":"Irisin mediates effects on bone and fat via alphaV integrin receptors","volume":"175","author":"Kim","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jcte.2026.100447_bb0205","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pnpbp.2018.03.004","article-title":"Central irisin administration affords antidepressant-like effect and modulates neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice","volume":"84","author":"Siteneski","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jcte.2026.100447_bb0210","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/CS20150009","article-title":"Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K\/Akt pathway in type 2 diabetic mice and hepatocytes","volume":"129","author":"Liu","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcte.2026.100447_bb0215","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/iub.2907","article-title":"Irisin alleviates the pyroptosis of beta cells in T2DM by inhibiting NLRP3 inflammasome through regulating miR-19b-3p\/SOCS3\/STAT3 axis mediated autophagy","volume":"76","author":"Yang","year":"2024","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jcte.2026.100447_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/1758-5996-6-133","article-title":"Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus \u2014 correlation with pancreatic \u03b2-cell function","volume":"6","author":"Yang","year":"2014","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.jcte.2026.100447_bb0225","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2616539","article-title":"Circulating levels of betatrophin and irisin are not associated with pancreatic beta-cell function in previously diagnosed type 2 diabetes mellitus patients","volume":"2016","author":"Wang","year":"2016","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jcte.2026.100447_bb0230","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12933-023-01886-5","article-title":"Non-linear association of atherogenic index of plasma with insulin resistance and type 2 diabetes: a cross-sectional study","volume":"22","author":"Yin","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jcte.2026.100447_bb0235","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1210\/endrev\/bnab003","article-title":"Progress and challenges in the biology of FNDC5 and irisin","volume":"42","author":"Maak","year":"2021","journal-title":"Endocr Rev"}],"container-title":["Journal of Clinical &amp; Translational Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623726000189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623726000189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:46:46Z","timestamp":1786463206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214623726000189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":47,"alternative-id":["S2214623726000189"],"URL":"https:\/\/doi.org\/10.1016\/j.jcte.2026.100447","relation":{},"ISSN":["2214-6237"],"issn-type":[{"value":"2214-6237","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Change in circulating irisin level and its association with lipid metabolism after exenatide treatment in patients with type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical & Translational Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcte.2026.100447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100447"}}