{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:01:18Z","timestamp":1790114478961,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010805","name":"Research Council of Southeast Sweden","doi-asserted-by":"publisher","award":["FORSS-940428"],"award-info":[{"award-number":["FORSS-940428"]}],"id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010805","name":"Research Council of Southeast Sweden","doi-asserted-by":"publisher","award":["FORSS-845251"],"award-info":[{"award-number":["FORSS-845251"]}],"id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010805","name":"Research Council of Southeast Sweden","doi-asserted-by":"publisher","award":["FORSS-968754"],"award-info":[{"award-number":["FORSS-968754"]}],"id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jctejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical &amp; Translational Endocrinology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jcte.2026.100457","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:20:09Z","timestamp":1788970809000},"page":"100457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["High plasma levels of soluble triggering receptor expressed on Myeloid Cells 2 were associated with depression in patients with newly diagnosed type 2 diabetes mellitus"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-2650","authenticated-orcid":false,"given":"Eva O.","family":"Melin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Landin-Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Hillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcte.2026.100457_bb0005","first-page":"1","article-title":"Severity of depression, anxious distress and the risk of type 2 diabetes\u2013a population-based cohort study in Sweden","volume":"19","author":"Deleskog","year":"2019","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jcte.2026.100457_bb0010","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.psyneuen.2011.03.005","article-title":"The relationship of depression and diabetes: pathophysiological and treatment implications","volume":"36","author":"Rustad","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jcte.2026.100457_bb0015","article-title":"Immuno-metabolic depression: from concept to implementation","volume":"48","author":"Penninx","year":"2025","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.jcte.2026.100457_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104758","article-title":"Insulin resistance in depression: a large meta-analysis of metabolic parameters and variation","volume":"139","author":"Fernandes","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jcte.2026.100457_bb0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S2213-8587(19)30405-X","article-title":"Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression","volume":"8","author":"van Sloten","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jcte.2026.100457_bb0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41398-020-0839-1","article-title":"Depression\u2014an underrecognized target for prevention of dementia in Alzheimer\u2019s disease","volume":"10","author":"Dafsari","year":"2020","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jcte.2026.100457_bb0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11596-020-2193-1","article-title":"Microglia: a central player in depression","volume":"40","author":"Deng","year":"2020","journal-title":"Curr Med Sci"},{"key":"10.1016\/j.jcte.2026.100457_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00270","article-title":"Microglia: an interface between the loss of neuroplasticity and depression","volume":"11","author":"Singhal","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jcte.2026.100457_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00306","article-title":"Switching of the microglial activation phenotype is a possible treatment for depression disorder","volume":"12","author":"Zhang","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jcte.2026.100457_bb0050","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","article-title":"Depression as a microglial disease","volume":"38","author":"Yirmiya","year":"2015","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jcte.2026.100457_bb0055","doi-asserted-by":"crossref","first-page":"13050","DOI":"10.1038\/s41598-021-92101-6","article-title":"The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer\u2019s disease","volume":"11","author":"Park","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcte.2026.100457_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105630","article-title":"Soluble TREM2: innocent bystander or active player in neurological diseases?","volume":"165","author":"Filipello","year":"2022","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jcte.2026.100457_bb0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2337\/db13-1869","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity","volume":"64","author":"Park","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.jcte.2026.100457_bb0070","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41580-021-00390-6","article-title":"The aetiology and molecular landscape of insulin resistance","volume":"22","author":"James","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcte.2026.100457_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2019.00057","article-title":"Insulin resistance as a shared pathogenic mechanism between depression and type 2 diabetes","volume":"10","author":"Lyra e Silva","year":"2019","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.jcte.2026.100457_bb0080","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41380-022-01812-3","article-title":"Insulin modulates emotional behavior through a serotonin-dependent mechanism","volume":"29","author":"Martin","year":"2024","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jcte.2026.100457_bb0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrneurol.2017.185","article-title":"Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums","volume":"14","author":"Arnold","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jcte.2026.100457_bb0090","article-title":"The brain as an insulin-sensitive metabolic organ 100th anniv discov insul","volume":"52","author":"Milstein","year":"2021"},{"key":"10.1016\/j.jcte.2026.100457_bb0095","series-title":"Depress Syst Illn","article-title":"The brain and body on stress: Allostatic load and mechanisms for depression and dementia","volume":"14","author":"McEwen","year":"2018"},{"key":"10.1016\/j.jcte.2026.100457_bb0100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s13668-019-0276-z","article-title":"Impact of brain insulin signaling on dopamine function, food intake, reward, and emotional behavior","volume":"8","author":"Kleinridders","year":"2019","journal-title":"Curr Nutr Rep"},{"key":"10.1016\/j.jcte.2026.100457_bb0105","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.psyneuen.2008.01.002","article-title":"Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes","volume":"33","author":"Okereke","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jcte.2026.100457_bb0110","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.3390\/ijms22189987","article-title":"Insulin and insulin resistance in Alzheimer\u2019s disease","volume":"22","author":"S\u0119dzikowska","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcte.2026.100457_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1205481","article-title":"Serum C-peptide level and the risk of cardiovascular diseases mortality and all-cause mortality: a meta-analysis and systematic review","volume":"10","author":"Ahmadirad","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jcte.2026.100457_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2024.101566","article-title":"Insulin-based or non-insulin-based insulin resistance indicators and risk of long-term cardiovascular and all-cause mortality in the general population: a 25-year cohort study","volume":"50","author":"Lin","year":"2024","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.jcte.2026.100457_bb0125","doi-asserted-by":"crossref","DOI":"10.1111\/dom.16347","article-title":"Low levels of soluble neuropilin-1 were associated with depression in adults with newly diagnosed type 2 diabetes","author":"Melin","year":"2025","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jcte.2026.100457_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-022-01184-3","article-title":"Depression was associated with younger age, female sex, obesity, smoking, and physical inactivity, in 1027 patients with newly diagnosed type 2 diabetes: a Swedish multicentre cross-sectional study","volume":"22","author":"Melin","year":"2022","journal-title":"BMC Endocr Disord"},{"issue":"Suppl. 1","key":"10.1016\/j.jcte.2026.100457_bb0135","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.2337\/dc14-S081","article-title":"Diagnosis and classification of diabetes mellitus","volume":"37","author":"American Diabetes Association","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcte.2026.100457_bb0140","doi-asserted-by":"crossref","unstructured":"Thunander M, Petersson C, Jonzon K, Fornander J, Ossiansson B, Torn C, et al. Incidence of type 1 and type 2 diabetes in adults and children in Kronoberg, Sweden Diabetes Res Clin Pract 2008;82:247\u201355. Doi: https:\/\/doi-org.ludwig.lub.lu.se\/https:\/\/doi.org\/10.1016\/j.diabres.2008.07.022.","DOI":"10.1016\/j.diabres.2008.07.022"},{"key":"10.1016\/j.jcte.2026.100457_bb0145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12955-017-0759-9","article-title":"Is the hospital anxiety and depression scale (HADS) a valid measure in a general population 65\u201380 years old? A psychometric evaluation study","volume":"15","author":"Djukanovic","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.jcte.2026.100457_bb0150","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1177\/2047487317711334","article-title":"Psychosocial risk factors in relation to other cardiovascular risk factors in coronary heart disease: results from the EUROASPIRE IV survey. A registry from the European Society of Cardiology","volume":"24","author":"Pogosova","year":"2017","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jcte.2026.100457_bb0155","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jpsychores.2008.07.012","article-title":"The relationship between abdominal fat, obesity, and common mental disorders: results from the HUNT study","volume":"66","author":"Rivenes","year":"2009","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.jcte.2026.100457_bb0160","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1530\/EJE-13-0137","article-title":"Depression, obesity and smoking were independently associated with inadequate glycemic control in patients with type 1 diabetes","volume":"168","author":"Melin","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jcte.2026.100457_bb0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/02698811211069110","article-title":"Modulation of microglial activation by antidepressants","volume":"36","author":"Mariani","year":"2022","journal-title":"J Psychopharmacol (Oxf)"},{"key":"10.1016\/j.jcte.2026.100457_bb0170","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/mp.2016.162","article-title":"Insulin resistance\u2014a missing link no more","volume":"21","author":"Rasgon","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jcte.2026.100457_bb0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.diabres.2018.10.007","article-title":"A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: the Hisayama study","volume":"146","author":"Tanaka","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jcte.2026.100457_bb0185","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3390\/ijerph20021603","article-title":"Physical inactivity and depression: the gloomy dual with rising costs in a large-scale emergency","volume":"20","author":"Codella","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jcte.2026.100457_bb0190","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.040555","article-title":"Soluble triggering receptor expressed on myeloid cells 2 as a promising biomarker for poststroke depression after acute ischemic stroke","volume":"14","author":"Wang","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jcte.2026.100457_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004200","article-title":"Prevalence and natural history of depression after stroke: a systematic review and meta-analysis of observational studies","volume":"20","author":"Liu","year":"2023","journal-title":"PLoS Med"},{"key":"10.1016\/j.jcte.2026.100457_bb0200","doi-asserted-by":"crossref","first-page":"eabq2923","DOI":"10.1126\/sciadv.abq2923","article-title":"Mapping microglia and astrocyte activation in vivo using diffusion MRI","volume":"8","author":"Garcia-Hernandez","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jcte.2026.100457_bb0205","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer\u2019s disease continuum","volume":"19","author":"Gustavsson","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jcte.2026.100457_bb0210","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1038\/s41467-022-31563-2","article-title":"Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor","volume":"13","author":"Guo","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcte.2026.100457_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084334","article-title":"The role of Glp-1 receptor agonists in insulin resistance with concomitant obesity treatment in polycystic ovary syndrome","volume":"23","author":"Bednarz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcte.2026.100457_bb0220","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jagp.2023.08.010","article-title":"The antidepressant effects of GLP-1 receptor agonists: a systematic review and Meta-analysis","volume":"32","author":"Chen","year":"2024","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.jcte.2026.100457_bb0180","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.3390\/jcm12216855","article-title":"The levels of leptin, cystatin C, Neuropilin-1 and tau protein in relation to dietary habits in patients with Alzheimer\u2019s disease","volume":"12","author":"Bogdan","year":"2023","journal-title":"J Clin Med"}],"container-title":["Journal of Clinical &amp; Translational Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623726000281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214623726000281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:08:19Z","timestamp":1790111299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214623726000281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S2214623726000281"],"URL":"https:\/\/doi.org\/10.1016\/j.jcte.2026.100457","relation":{},"ISSN":["2214-6237"],"issn-type":[{"value":"2214-6237","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High plasma levels of soluble triggering receptor expressed on Myeloid Cells 2 were associated with depression in patients with newly diagnosed type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical & Translational Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcte.2026.100457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100457"}}