{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:10:24Z","timestamp":1791213024060,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.jcv.2008.08.014","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T08:54:42Z","timestamp":1223024082000},"page":"411-414","source":"Crossref","is-referenced-by-count":85,"title":["Clinical effects of rhinovirus infections"],"prefix":"10.1016","volume":"43","author":[{"given":"Ville","family":"Peltola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Waris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"\u00d6sterback","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"Susi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Hyypi\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Ruuskanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2008.08.014_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/oxfordjournals.aje.a121047","article-title":"Acute respiratory illness in nursery school children: a longitudinal study of the occurrence of illness and respiratory viruses","volume":"90","author":"Beem","year":"1969","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jcv.2008.08.014_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/oxfordjournals.aje.a120928","article-title":"Rhinovirus infections in an industrial population (IV): infections within families of employees during two fall peaks of respiratory illness","volume":"89","author":"Hendley","year":"1969","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jcv.2008.08.014_bib3","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/oxfordjournals.aje.a114166","article-title":"Rhinoviruses in Seattle families, 1975\u20131979","volume":"122","author":"Fox","year":"1985","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jcv.2008.08.014_bib4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/JCM.36.2.539-542.1998","article-title":"Viruses and bacteria in the etiology of the common cold","volume":"36","author":"M\u00e4kel\u00e4","year":"1998","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jcv.2008.08.014_bib5","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/00006454-200106000-00006","article-title":"Epidemiology of documented viral respiratory infections and acute otitis media in a cohort of children followed from two to twenty-four months of age","volume":"20","author":"Vesa","year":"2001","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2008.08.014_bib6","series-title":"The microbe\u2013host interface in respiratory tract infections","first-page":"291","article-title":"Rhinovirus: is it really a relevant pathogen?","author":"Ruuskanen","year":"2005"},{"key":"10.1016\/j.jcv.2008.08.014_bib7","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1128\/JCM.35.11.2864-2868.1997","article-title":"Frequency and natural history of rhinovirus infections in adults during autumn","volume":"35","author":"Arruda","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jcv.2008.08.014_bib8","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/01.inf.0000226912.88900.a3","article-title":"Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study","volume":"25","author":"Kusel","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2008.08.014_bib9","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/infdis\/164.2.252","article-title":"Acute respiratory viral infections in ambulatory children of urban northeast Brazil","volume":"164","author":"de Arruda","year":"1991","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1001\/archinte.163.4.487","article-title":"The economic burden of non-influenza-related viral respiratory tract infection in the United States","volume":"163","author":"Fendrick","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jcv.2008.08.014_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1465-9921-9-11","article-title":"The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children","volume":"9","author":"Lambert","year":"2008","journal-title":"Respir Res"},{"key":"10.1016\/j.jcv.2008.08.014_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jmv.2140","article-title":"Virological and serological analysis of rhinovirus infections during the first two years of life in a cohort of children","volume":"66","author":"Blomqvist","year":"2002","journal-title":"J Med Virol"},{"key":"10.1016\/j.jcv.2008.08.014_bib13","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1086\/509332","article-title":"Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria and viruses","volume":"43","author":"Ruohola","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1086\/511821","article-title":"Rhinovirus-associated hospitalizations in young children","volume":"195","author":"Miller","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/INF.0b013e3181586b63","article-title":"Rhinovirus infection in hospitalized children in Hong Kong: a prospective study","volume":"26","author":"Cheuk","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2008.08.014_bib16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/INF.0b013e31812e52e6","article-title":"Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain","volume":"26","author":"Calvo","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2008.08.014_bib17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3201\/eid1006.030629","article-title":"Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children","volume":"10","author":"Jartti","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib18","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1086\/368411","article-title":"Asthma exacerbations in children associated with rhinovirus but not human metapneumovirus infection","volume":"187","author":"Rawlinson","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib19","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/bmj.307.6910.982","article-title":"Respiratory viruses and exacerbations of asthma in adults","volume":"307","author":"Nicholson","year":"1993","journal-title":"BMJ"},{"key":"10.1016\/j.jcv.2008.08.014_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1067\/mai.2003.33","article-title":"Rhinovirus-induced wheezing in infancy\u2014the first sign of childhood asthma?","volume":"111","author":"Kotaniemi-Syrj\u00e4nen","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jcv.2008.08.014_bib21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"Lemanske","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jcv.2008.08.014_bib22","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/archpedi.158.11.1070","article-title":"Asthma and lung function 20 years after wheezing in infancy: results from a prospective follow-up study","volume":"158","author":"Piippo-Savolainen","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jcv.2008.08.014_bib23","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1086\/503809","article-title":"The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking","volume":"193","author":"Venarske","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib24","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1378\/chest.07-0530","article-title":"Viral etiology of acute exacerbations of COPD in Hong Kong","volume":"132","author":"Ko","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jcv.2008.08.014_bib25","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1378\/chest.125.3.1033","article-title":"Respiratory viruses and severe lower respiratory tract complications in hospitalized patients","volume":"125","author":"Garbino","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.jcv.2008.08.014_bib26","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1086\/339881","article-title":"Rhinovirus and coronavirus infection-associated hospitalizations among older adults","volume":"185","author":"Falsey","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib27","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1164\/rccm.200604-489OC","article-title":"Chronic rhinoviral infection in lung transplant recipients","volume":"174","author":"Kaiser","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcv.2008.08.014_bib28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jaci.2006.04.032","article-title":"Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms","volume":"118","author":"Malmstr\u00f6m","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jcv.2008.08.014_bib29","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1164\/rccm.200407-970OC","article-title":"Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues","volume":"171","author":"Mosser","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcv.2008.08.014_bib30","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1086\/315513","article-title":"Rhinoviruses infect the lower airways","volume":"181","author":"Papadopoulos","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00006454-200004000-00006","article-title":"Etiology of community-acquired pneumonia in 254 hospitalized children","volume":"19","author":"Juv\u00e9n","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2008.08.014_bib32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1086\/422996","article-title":"Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections","volume":"39","author":"Tsolia","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1086\/431588","article-title":"Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction","volume":"41","author":"Templeton","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/thx.2006.075077","article-title":"Incidence and characteristics of viral community-acquired pneumonia in adults","volume":"63","author":"Jennings","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.jcv.2008.08.014_bib35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00431-003-1397-2","article-title":"Clinical response to antibiotic therapy for community-acquired pneumonia","volume":"163","author":"Juven","year":"2004","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jcv.2008.08.014_bib36","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1086\/379833","article-title":"Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells","volume":"188","author":"Ishizuka","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/thx.2007.081752","article-title":"Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages","volume":"63","author":"Oliver","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.jcv.2008.08.014_bib38","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1099\/0022-1317-83-2-333","article-title":"Genetic clustering of all 102 human rhinovirus prototype strains: Serotype 87 is close to human enterovirus 70","volume":"83","author":"Savolainen","year":"2002","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jcv.2008.08.014_bib39","series-title":"Textbook of pediatric infectious diseases","first-page":"2042","article-title":"Rhinoviruses","author":"Atmar","year":"2004"},{"key":"10.1016\/j.jcv.2008.08.014_bib40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-1702(02)00016-3","article-title":"Phylogenetic analysis of rhinovirus isolates collected during successive epidemic seasons","volume":"85","author":"Savolainen","year":"2002","journal-title":"Virus Res"},{"key":"10.1016\/j.jcv.2008.08.014_bib41","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1086\/508551","article-title":"MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York state during 2004\u20132005","volume":"194","author":"Lamson","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib42","doi-asserted-by":"crossref","first-page":"e966","DOI":"10.1371\/journal.pone.0000966","article-title":"A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jcv.2008.08.014_bib43","doi-asserted-by":"crossref","first-page":"e1847","DOI":"10.1371\/journal.pone.0001847","article-title":"Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C)","volume":"3","author":"McErlean","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jcv.2008.08.014_bib44","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3201\/eid1406.080271","article-title":"Global distribution of novel rhinovirus genotype","volume":"14","author":"Briese","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jcv.2007.03.012","article-title":"Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis","volume":"39","author":"McErlean","year":"2007","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jcv.2008.08.014_bib46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<378::AID-JMV19>3.0.CO;2-I","article-title":"Diagnosis of enterovirus and rhinovirus infections by RT-PCR and time-resolved fluorometry with lanthanide chelate labeled probes","volume":"59","author":"L\u00f6nnrot","year":"1999","journal-title":"J Med Virol"},{"key":"10.1016\/j.jcv.2008.08.014_bib47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1128\/JCM.01739-07","article-title":"Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses","volume":"46","author":"Lu","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jcv.2008.08.014_bib48","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1128\/JVI.78.7.3663-3674.2004","article-title":"VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds","volume":"78","author":"Ledford","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.jcv.2008.08.014_bib49","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1099\/vir.0.80445-0","article-title":"Phylogenetic analysis of human rhinovirus capsid protein VP1 and 2A protease coding sequences confirms shared genus-like relationships with human enteroviruses","volume":"86","author":"Laine","year":"2005","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jcv.2008.08.014_bib50","unstructured":"Waris M, \u00d6sterback R, Vuorinen T, Ruuskanen O, Peltola V. Comparison of different sampling types for the detection of rhinovirus infections using quantitative RT-PCR. [Abstract] ESCV 2008: clinical virology annual meeting. Saariselk\u00e4, Finland, March 12\u201315, 2008."},{"key":"10.1016\/j.jcv.2008.08.014_bib51","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1086\/525542","article-title":"Rhinovirus transmission within families with children: incidence of symptomatic and asymptomatic infections","volume":"197","author":"Peltola","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2008.08.014_bib52","unstructured":"Jartti T, Jartti L, Peltola V, Waris M, Ruuskanen O. Respiratory viruses in asymptomatic subjects. Pediatr Infect Dis J; in press."},{"key":"10.1016\/j.jcv.2008.08.014_bib53","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1183\/09031936.00161907","article-title":"Serial viral infections in infants with recurrent respiratory illnesses.","volume":"32","author":"Jartti","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcv.2008.08.014_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1086\/524020","article-title":"Respiratory viral infections in developing countries: common, severe, and unrecognized","volume":"46","author":"Peltola","year":"2008","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653208003181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653208003181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:17:38Z","timestamp":1588969058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653208003181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S1386653208003181"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2008.08.014","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}