{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:04Z","timestamp":1791355744771,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jcv.2010.05.007","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:45:29Z","timestamp":1277081129000},"page":"239-245","source":"Crossref","is-referenced-by-count":212,"title":["Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection"],"prefix":"10.1016","volume":"48","author":[{"given":"Anna","family":"Franz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ortwin","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Willems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Bonzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Neuhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Schweizer-Krantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens U.","family":"Ruggeberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhart","family":"Willers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Henrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Schroten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Tenenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2010.05.007_bib1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00006454-200004000-00006","article-title":"Etiology of community-acquired pneumonia in 254 hospitalized children","volume":"19","author":"Juv\u00e9n","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/01.inf.0000168747.94999.aa","article-title":"Frequency of detection of picornaviruses and seven other respiratory pathogens in infants","volume":"24","author":"Legg","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1055\/s-2004-820352","article-title":"The descriptive epidemiology of severe lower respiratory tract infections in children in Kiel, Germany","volume":"217","author":"Weigl","year":"2005","journal-title":"Klin Padiatr"},{"key":"10.1016\/j.jcv.2010.05.007_bib4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/89098","article-title":"A newly discovered human pneumovirus isolated from young children with respiratory tract disease","volume":"7","author":"van den Hoogen","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jcv.2010.05.007_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1586\/14787210.5.2.245","article-title":"Identification of new human coronaviruses","volume":"5","author":"Pyrc","year":"2007","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jcv.2010.05.007_bib6","doi-asserted-by":"crossref","first-page":"12891","DOI":"10.1073\/pnas.0504666102","article-title":"Cloning of a human parvovirus by molecular screening of respiratory tract samples","volume":"102","author":"Allander","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jcv.2010.05.007_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jcv.2008.03.012","article-title":"Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain","volume":"42","author":"Calvo","year":"2008","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jcv.2010.05.007_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jcv.2007.10.018","article-title":"Correlation of viral load as determined by real-time RT-PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy","volume":"41","author":"Gerna","year":"2008","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jcv.2010.05.007_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.inf.0000168741.59747.2d","article-title":"Single versus dual respiratory virus infections in hospitalized infants: impact on clinical course of disease and interferon-gamma response","volume":"24","author":"Aberle","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00006454-199506000-00003","article-title":"Bacterial antibody assays in the diagnosis of acute lower respiratory tract infection in children","volume":"14","author":"Nohynek","year":"1995","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib11","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nm1077","article-title":"Vaccine trialist group. A role for Streptococcus pneumoniae in virus-associated pneumonia","volume":"10","author":"Madhi","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.jcv.2010.05.007_bib12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/INF.0b013e3181694fb9","article-title":"Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction","volume":"27","author":"Bonzel","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib13","series-title":"Textbook of pediatric infectious diseases","year":"2009"},{"key":"10.1016\/j.jcv.2010.05.007_bib14","series-title":"Global strategy for asthma management and prevention","author":"Global Initiative for Asthma","year":"2008"},{"key":"10.1016\/j.jcv.2010.05.007_bib15","unstructured":"World Health Organization Pneumonia Vaccine Trial Investigators\u2019 Group. Standardization of interpretation of chest radiographs for the diagnosis of pneumonia in children. Available at: http:\/\/www.who.int\/vaccines-documents\/DocsPDF01\/www616.pdf."},{"key":"10.1016\/j.jcv.2010.05.007_bib16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1469-0691.2008.02016.x","article-title":"Role of respiratory pathogens in infants hospitalized for a first episode of wheezing and their impact on recurrences","volume":"14","author":"Bosis","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jcv.2010.05.007_bib17","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/INF.0b013e31812e52e6","article-title":"Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain","volume":"26","author":"Calvo","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib18","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1086\/511821","article-title":"Rhinovirus-associated hospitalizations in young children","volume":"195","author":"Miller","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2010.05.007_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/INF.0b013e31818ffc1b","article-title":"Rhinovirus associated with severe lower respiratory tract infections in children","volume":"28","author":"Louie","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/INF.0b013e318195e26e","article-title":"Respiratory pathogens in respiratory tract illnesses during the first year of life: a birth cohort study","volume":"28","author":"van der Zalm","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1034\/j.1399-3038.2003.00064.x","article-title":"Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants","volume":"14","author":"van Benten","year":"2003","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jcv.2010.05.007_bib22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1399-3038.2007.00512.x","article-title":"Efficacy of prednisolone in children hospitalized for recurrent wheezing","volume":"18","author":"Jartti","year":"2007","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jcv.2010.05.007_bib23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1086\/342414","article-title":"Correlation between respiratory syncytial virus genotype and severity of illness","volume":"186","author":"Martinello","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2010.05.007_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jcv.2007.03.009","article-title":"Human respiratory syncytial virus (hRSV) RNA quantification in nasopharyngeal secretions identifies the hRSV etiologic role in acute respiratory tract infections of hospitalized infants","volume":"39","author":"Campanini","year":"2007","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jcv.2010.05.007_bib25","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1086\/512196","article-title":"Human bocavirus and acute wheezing in children","volume":"44","author":"Allander","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcv.2010.05.007_bib26","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/INF.0b013e31817acfaa","article-title":"Human bocavirus infection in children with respiratory tract disease","volume":"27","author":"Brieu","year":"2008","journal-title":"Pediatr Infect Dis J"},{"issue":"October","key":"10.1016\/j.jcv.2010.05.007_bib27","article-title":"Quantitation of respiratory viruses to clinical course in children with acute respiratory tract infections","author":"Jansen","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib28","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1128\/JVI.78.8.4363-4369.2004","article-title":"Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]","volume":"78","author":"Spann","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.jcv.2010.05.007_bib29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/01.inf.0000258627.23337.00","article-title":"Lack of usefulness of an abnormal white blood cell count for predicting a concurrent serious bacterial infection in infants and young children hospitalized with respiratory syncytial virus lower respiratory tract infection","volume":"26","author":"Purcell","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jcv.2010.05.007_bib30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0022-3476(05)81360-5","article-title":"Cytokines in adenoviral disease in children: association of interleukin-6, interleukin-8, and tumor necrosis factor alpha levels with clinical outcome","volume":"124","author":"Mistchenko","year":"1994","journal-title":"J Pediatr"},{"issue":"Suppl. S2","key":"10.1016\/j.jcv.2010.05.007_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/dkf506","article-title":"Dynamics of nasopharyngeal colonization by potential respiratory pathogens","volume":"50","author":"Garc\u00eda-Rodr\u00edguez","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jcv.2010.05.007_bib32","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1016\/j.vaccine.2009.04.057","article-title":"Reduction in the incidence of invasive pneumococcal disease after general vaccination with 7-valent pneumococcal conjugate vaccine in Germany","volume":"27","author":"R\u00fcckinger","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.jcv.2010.05.007_bib33","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1017\/S0950268807000271","article-title":"Invasive pneumococcal and meningococcal disease: association with influenza virus and respiratory syncytial virus activity?","volume":"136","author":"Jansen","year":"2008","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jcv.2010.05.007_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1086\/498897","article-title":"New South Wales Pneumococcal Network. The association of respiratory viruses, temperature, and other climatic parameters with the incidence of invasive pneumococcal disease in Sydney, Australia","volume":"42","author":"Watson","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcv.2010.05.007_bib35","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1128\/JVI.80.4.1629-1636.2006","article-title":"Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner","volume":"80","author":"Avadhanula","year":"2006","journal-title":"J Virol"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653210002027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653210002027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T07:56:12Z","timestamp":1544428572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653210002027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1386653210002027"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2010.05.007","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}