{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:56:24Z","timestamp":1790913384840,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T00:00:00Z","timestamp":1318636800000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.jcv.2010.09.007","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T01:45:26Z","timestamp":1287366326000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anti-Tax antibody levels in asymptomatic carriers, oligosymptomatic carriers, patients with rheumatologic disease or with HAM\/TSP do not correlate with HTLV-1 proviral load"],"prefix":"10.1016","volume":"50","author":[{"given":"Jaqueline Gontijo","family":"de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Guimar\u00e3es","family":"da Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Lobato","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Pacheco Silveira","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Debortoli","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana Grazziela Alves","family":"Coelho-dos-Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna B\u00e1rbara Freitas","family":"Carneiro-Proietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olindo Assis","family":"Martins-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edel Figueiredo","family":"Barbosa-Stancioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2010.09.007_bib0005","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0140-6736(98)09460-4","article-title":"Human T-lymphotropic virus type I infection","volume":"353","author":"Manns","year":"1999","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jcv.2010.09.007_bib0010","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/aid.1993.9.381","article-title":"An HTLV-I vaccine: why, how, for whom?","volume":"9","author":"De The","year":"1993","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"1","key":"10.1016\/j.jcv.2010.09.007_bib0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0736-4679(99)00173-0","article-title":"Global epidemic of human T-cell lymphotropic virus type-I (HTLV-I)","volume":"18","author":"Edlich","year":"2000","journal-title":"J Emerg Med"},{"issue":"11","key":"10.1016\/j.jcv.2010.09.007_bib0020","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/oxfordjournals.aje.a115824","article-title":"Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica. I. Demographic determinants","volume":"133","author":"Murphy","year":"1991","journal-title":"Am J Epidemiol"},{"issue":"11","key":"10.1016\/j.jcv.2010.09.007_bib0025","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1128\/JCM.38.11.4049-4057.2000","article-title":"Human T-cell lymphotropic virus type 1 Gag indeterminate Western blot patterns in Central Africa: relationship to Plasmodium falciparum infection","volume":"38","author":"Mathieux","year":"2000","journal-title":"J Clin Microbiol"},{"issue":"4","key":"10.1016\/j.jcv.2010.09.007_bib0030","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/JCM.39.4.1247-1253.2001","article-title":"Serological, epidemiological, and molecular differences between human T-cell lymphotropic virus type 1 (HTLV-1)-seropositive healthy carriers and persons with HTLV-1 Gag indeterminate western blot patterns from the Caribbean","volume":"39","author":"Rouet","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0035","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF02254986","article-title":"Human T cell lymphotropic viruses (HTLV-I\/II) in South America: should it be a public health concern?","volume":"9","author":"Carneiro-Proietti","year":"2002","journal-title":"J Biomed Sci"},{"issue":"5","key":"10.1016\/j.jcv.2010.09.007_bib0040","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1590\/S0102-311X2003000500002","article-title":"Human T-cell lymphotropic virus types I and II (HTLV-I\/II) in French Guiana: clinical and molecular epidemiology","volume":"19","author":"Kazanji","year":"2003","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"3","key":"10.1016\/j.jcv.2010.09.007_bib0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T-Cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"Uchiyama","year":"1977","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jcv.2010.09.007_bib0050","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00042560-199600001-00010","article-title":"HTLV-I uveitis","volume":"13","author":"Mochizuki","year":"1996","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"issue":"4","key":"10.1016\/j.jcv.2010.09.007_bib0055","doi-asserted-by":"crossref","first-page":"pA22","DOI":"10.1097\/00042560-199904010-00078","article-title":"The past, the present and the future of HAM\/TSP research","volume":"20","author":"Osame","year":"1999","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"2","key":"10.1016\/j.jcv.2010.09.007_bib0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1590\/S0482-50042005000200005","article-title":"Manifesta\u00e7\u00f5es Reum\u00e1ticas associadas ao V\u00edrus Linfotr\u00f3pico Humano de C\u00e9lulas T do Tipo I (HTLV-I)","volume":"45","author":"Cruz","year":"2005","journal-title":"Rev Bras Reumatol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0065","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1742-4690-5-76","article-title":"The HTLV-I Tax interactome","volume":"5","author":"Boxus","year":"2008","journal-title":"Retrovirology"},{"key":"10.1016\/j.jcv.2010.09.007_bib0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-\u03baB and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.jcv.2010.09.007_bib0075","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0166-0934(02)00097-6","article-title":"Efficient transfer of HTLV-1 tax gene in various primary and immortalized cells using a flap lentiviral vector","volume":"105","author":"Royer-Leveau","year":"2002","journal-title":"J Virol Methods"},{"issue":"1","key":"10.1016\/j.jcv.2010.09.007_bib0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1128\/jvi.65.1.31-41.1991","article-title":"Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses","volume":"65","author":"Earl","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jviromet.2010.02.021","article-title":"Diagnostic tool based on an HTLV-1 Tax expression system in eukaryotic cells using a poxvirus vector","volume":"166","author":"Souza","year":"2010","journal-title":"J Virol Methods"},{"key":"10.1016\/j.jcv.2010.09.007_bib0090","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/348245a0","article-title":"Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease","volume":"348","author":"Jacobson","year":"1990","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jcv.2010.09.007_bib0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nm0502-509","article-title":"Autoimmunity due to molecular mimicry as a cause of neurological disease","volume":"8","author":"Levin","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jcv.2010.09.007_bib0100","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/viro.1993.1105","article-title":"Expression of HTLV-I Env and tax recombinant peptides in yeast: identification of immunogenic domains","volume":"193","author":"Noraz","year":"1993","journal-title":"Virology"},{"issue":"96","key":"10.1016\/j.jcv.2010.09.007_bib0105","first-page":"1","article-title":"Anti-HTLV antibody profiling reveals an antibody signature for HTLV-I-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"5","author":"Burbelo","year":"2008","journal-title":"Retrovirology"},{"issue":"3","key":"10.1016\/j.jcv.2010.09.007_bib0110","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/infdis\/169.3.496","article-title":"Differential immune responsiveness to the immunodominant epitopes of regulatory proteins (tax and rex) in human T cell lymphotropic virus type I-associated myelopathy","volume":"169","author":"Lal","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2010.09.007_bib0115","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0952-7915(00)00107-2","article-title":"The immune response to HTLV-I","volume":"12","author":"Bangham Charles","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0120","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1098\/rspb.2001.1608","article-title":"Cytotoxic T-cell abundance immunodeficiency virus type 1 and human T-cell leukaemia virus type 1","volume":"268","author":"Wodarz","year":"2001","journal-title":"Proc R Soc Lond B Biol Sci"},{"issue":"2","key":"10.1016\/j.jcv.2010.09.007_bib0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1086\/344269","article-title":"Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease","volume":"186","author":"Jacobson","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jcv.2010.09.007_bib0130","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1099\/vir.0.80766-0","article-title":"A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human T-lymphotropic virus type 1 proviral load","volume":"86","author":"Asquith","year":"2005","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0135","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4049\/jimmunol.161.1.482","article-title":"Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy\/tropical spastic paraparesis patients by intracellular cytokine detection","volume":"161","author":"Kubota","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0165-5728(93)90004-I","article-title":"Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy","volume":"42","author":"Kubota","year":"1993","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0145","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1365-2249.2006.03208.x","article-title":"Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) in Peru","volume":"146","author":"Best","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jcv.2010.09.007_bib0150","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-4690-2-4","article-title":"Increased proviral load in HTLV-I-infected patients with rheumatoid arthritis or connective tissue disease","volume":"2","author":"Yakova","year":"2005","journal-title":"Retrovirology"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653210003689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653210003689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T03:09:46Z","timestamp":1761361786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653210003689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1386653210003689"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2010.09.007","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-Tax antibody levels in asymptomatic carriers, oligosymptomatic carriers, patients with rheumatologic disease or with HAM\/TSP do not correlate with HTLV-1 proviral load","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2010.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}